Nicotine absorption during electronic cigarette use among regular users

PLoS ONE

Volumn 14, Issue 7, 2019, Pages

  Yingst, Jessica M ^a   Foulds, Jonathan ^a   Veldheer, Susan ^a   Hrabovsky, Shari ^a   Trushin, Neil ^a   Eissenberg, Thomas T ^b   Williams, Jill ^c   Richie, John P ^a   Nichols, Travis T ^d   Wilson, Stephen J ^d   Hobkirk, Andrea L ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE;

ABSORPTION; ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CRAVING; DIZZINESS; DSM-5; FEMALE; HEADACHE; HEART PALPITATION; HUMAN; MALE; MAXIMUM CONCENTRATION; NAUSEA; OUTCOME ASSESSMENT; SMOKING CESSATION; SWEAT GLAND DISEASE; VAPING; WITHDRAWAL SYNDROME; ADOLESCENT; BLOOD; BLOOD ANALYSIS; CLASSIFICATION; ELECTRONIC CIGARETTE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; RESPIRATORY FUNCTION; SMOKING; TOBACCO; TOBACCO DEPENDENCE; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD CHEMICAL ANALYSIS; ELECTRONIC NICOTINE DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINE; RESPIRATORY TRACT ABSORPTION; SMOKING; SMOKING CESSATION; TOBACCO PRODUCTS; TOBACCO USE DISORDER; VAPING; YOUNG ADULT;

EID: 85069971920     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0220300     Document Type: Article

References (41)

1. National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US); 2014.
2. United States Food and Drug Administration (FDA). Family Smoking Prevention and Tobacco Control Act 2009 [Available from: http://www.fda.gov/TobaccoProducts/GuidanceComplianceRegulatoryInformation/ucm237092.htm.
3. United States Food and Drug Administration (FDA). Healthy Innovation, Safer Families: FDA’s 2018 Strategic Policy Roadmap 2018 [Available from: https://www.fda.gov/downloads/AboutFDA/ReportsManualsForms/Reports/UCM592001.pdf.
4. National Academies of Science. Public Health Consequences of e-cigarettes. Washington DC; 2018.
5. Yingst, Veldheer S, Hrabovsky S, Nichols TT, Wilson SJ, Foulds J. Factors Associated With Electronic Cigarette Users’ Device Preferences and Transition From First Generation to Advanced Generation Devices. Nicotine Tob Res. 2015; 17(10):1242–6. https://doi.org/10.1093/ntr/ntv052 PMID: 25744966
6. Breland A, Soule E, Lopez A, Ramôa C, El-Hellani A, Eissenberg T. Electronic cigarettes: what are they and what do they do? Ann N Y Acad Sci. 2017; 1394(1):5–30. https://doi.org/10.1111/nyas.12977PMID: 26774031
7. Dawkins L, Turner J, Roberts A, Soar K.’Vaping’ profiles and preferences: an online survey of electronic cigarette users. Addiction. 2013; 108(6):1115–25. https://doi.org/10.1111/add.12150 PMID: 23551515
8. Zare S, Nemati M, Zheng Y. A systematic review of consumer preference for e-cigarette attributes: Flavor, nicotine strength, and type. PLoS One. 2018; 13(3):e0194145. https://doi.org/10.1371/journal.pone.0194145 PMID: 29543907
9. Stiles MF, Campbell LR, Graff DW, Jones BA, Fant RV, Henningfield JE. Pharmacodynamic and phar-macokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability. Psychopharmacology (Berl). 2017; 234(17):2643–55.
10. Bullen C, McRobbie H, Thornley S, Glover M, Lin R, Laugesen M. Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tob Control. 2010; 19(2):98–103. https://doi.org/10.1136/tc.2009.031567PMID: 20378585
11. Vansickel AR, Cobb CO, Weaver MF, Eissenberg TE. A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prev. 2010; 19(8):1945–53. https://doi.org/10.1158/1055-9965. EPI-10-0288 PMID: 20647410
12. Hajek P, Goniewicz ML, Phillips A, Myers Smith K, West O, McRobbie H. Nicotine Intake From Electronic Cigarettes on Initial Use and After 4 Weeks of Regular Use. Nicotine Tob Res. 2014.
13. Farsalinos KE, Spyrou A, Tsimopoulou K, Stefopoulos C, Romagna G, Voudris V. Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Sci Rep. 2014; 4:4133. https://doi.org/10.1038/srep04133 PMID: 24569565
14. Dawkins L, Corcoran O. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology (Berl). 2014; 231(2):401–7.
15. Vansickel AR, Eissenberg T. Electronic cigarettes: effective nicotine delivery after acute administration. Nicotine Tob Res. 2013; 15(1):267–70. https://doi.org/10.1093/ntr/ntr316 PMID: 22311962
16. St Helen G, Havel C, Dempsey DA, Jacob P 3rd, Benowitz NL. Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes. Addiction. 2016; 111(3):535–44. https://doi.org/10.1111/add.13183 PMID: 26430813
17. Wagener TL, Floyd EL, Stepanov I, Driskill LM, Frank SG, Meier E, et al. Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users. Tob Control. 2017; 26(e1):e23–e8. https://doi.org/10.1136/tobaccocontrol-2016-053041 PMID: 27729564
18. Hiler M, Breland A, Spindle T, Maloney S, Lipato T, Karaoghlanian N, et al. Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience. Exp Clin Psychopharmacol. 2017; 25(5):380–92. https://doi.org/10.1037/pha0000140 PMID: 29048187
19. Ramoa CP, Hiler MM, Spindle TR, Lopez AA, Karaoghlanian N, Lipato T, et al. Electronic cigarette nicotine delivery can exceed that of combustible cigarettes: a preliminary report. Tob Control. 2016; 25(e1): e6–9. https://doi.org/10.1136/tobaccocontrol-2015-052447 PMID: 26324250
20. Hajek P, Przulj D, Phillips A, Anderson R, McRobbie H. Nicotine delivery to users from cigarettes and from different types of e-cigarettes. Psychopharmacology (Berl). 2017; 234(5):773–9.
21. St Helen G, Ross KC, Dempsey DA, Havel CM, Jacob P 3rd, Benowitz NL. Nicotine Delivery and Vaping Behavior During ad Libitum E-cigarette Access. Tob Regul Sci. 2016; 2(4):363–76. https://doi.org/10.18001/TRS.2.4.8 PMID: 28393086
22. Dawkins L, Kimber C, Puwanesarasa Y, Soar K. First-versus second-generation electronic cigarettes: predictors of choice and effects on urge to smoke and withdrawal symptoms. Addiction. 2015; 110 (4):669–77. https://doi.org/10.1111/add.12807 PMID: 25407505
23. Foulds J, Veldheer S, Yingst J, Hrabovsky S, Wilson SJ, Nichols TT, et al. Development of a questionnaire for assessing dependence on electronic cigarettes among a large sample of ex-smoking E-cigarette users. Nicotine Tob Res. 2015; 17(2):186–92. https://doi.org/10.1093/ntr/ntu204 PMID: 25332459
24. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)—a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inf. 2009; 42(2):377–81.
25. Hughes JR, Hatsukami D. Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry. 1986; 43 (3):289–94. https://doi.org/10.1001/archpsyc.1986.01800030107013 PMID: 3954551
26. Hobkirk AL, Nichols TT, Foulds J, Yingst JM, Veldheer S, Hrabovsky S, et al. Changes in resting state functional brain connectivity and withdrawal symptoms are associated with acute electronic cigarette use. Brain Res Bull. 2017.
27. Nichols TT, Foulds J, Yingst JM, Veldheer S, Hrabovsky S, Richie J, et al. Cue-reactivity in experienced electronic cigarette users: Novel stimulus videos and a pilot fMRI study. Brain Res Bull. 2016; 123:23–32. https://doi.org/10.1016/j.brainresbull.2015.10.003 PMID: 26478134
28. Williams JM, Gandhi KK, Lu SE, Kumar S, Shen J, Foulds J, et al. Higher nicotine levels in schizophrenia compared with controls after smoking a single cigarette. Nicotine Tob Res. 2010; 12(8):855–9. https://doi.org/10.1093/ntr/ntq102 PMID: 20584771
29. Foulds J, Veldheer S, Berg A. Electronic cigarettes (e-cigs): views of aficionados and clinical/public health perspectives. Int J Clin Pract. 2011; 65(10):1037–42. https://doi.org/10.1111/j.1742-1241.2011.02751.x PMID: 21801287
30. St. Helen G, Dempsey DA, Havel CM, Jacob P, Benowitz NL. Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes. Drug Alcohol Depend. 2017; 178:391–8. https://doi.org/10.1016/j.drugalcdep.2017.05.042 PMID: 28704768
31. Morean ME, Krishnan-Sarin S, Sussman S, Foulds J, Fishbein H, Grana R, et al. Development and psychometric validation of a novel measure of sensory expectancies associated with E-cigarette use. Addict Behav. 2018.
32. Spindle TR, Talih S, Hiler MM, Karaoghlanian N, Halquist MS, Breland AB, et al. Effects of electronic cigarette liquid solvents propylene glycol and vegetable glycerin on user nicotine delivery, heart rate, subjective effects, and puff topography. Drug Alcohol Depend. 2018; 188:193–9. https://doi.org/10.1016/j.drugalcdep.2018.03.042 PMID: 29778773
33. Chaffee BW, Watkins SL, Glantz SA. Electronic Cigarette Use and Progression From Experimentation to Established Smoking. Pediatrics. 2018; 141(4).
34. Hughes JR, Callas PW. Prevalence of withdrawal symptoms from electronic cigarette cessation: A cross-sectional analysis of the US Population Assessment of Tobacco and Health. Addict Behav. 2018.
35. Coleman B, Rostron B, Johnson SE, Persoskie A, Pearson J, Stanton C, et al. Transitions in electronic cigarette use among adults in the Population Assessment of Tobacco and Health (PATH) Study, Waves 1 and 2 (2013–2015). Tob Control. 2018.
36. Coleman BN, Rostron B, Johnson SE, Ambrose BK, Pearson J, Stanton CA, et al. Electronic cigarette use among US adults in the Population Assessment of Tobacco and Health (PATH) Study, 2013–2014. Tob Control. 2017; 26(e2):e117–e26. https://doi.org/10.1136/tobaccocontrol-2016-053462 PMID: 28624763
37. Pericot-Valverde I, Gaalema DE, Priest JS, Higgins ST. E-cigarette awareness, perceived harmfulness, and ever use among U.S. adults. Prev Med. 2017; 104:92–9. https://doi.org/10.1016/j.ypmed.2017.07. 014 PMID: 28729198
38. Bullen C, Howe C, Laugesen M, McRobbie H, Parag V, Williman J, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. 2013; 382(9905):1629–37. https://doi.org/10.1016/S0140-6736(13)61842-5 PMID: 24029165
39. Kalkhoran S, Glantz SA. E-cigarettes and smoking cessation in real-world and clinical settings: a systematic review and meta-analysis. Lancet Respir Med. 2016; 4(2):116–28. https://doi.org/10.1016/S2213-2600(15)00521-4 PMID: 26776875
40. Liu G, Wasserman E, Kong L, Foulds J. A comparison of nicotine dependence among exclusive E-cigarette and cigarette users in the PATH study. Prev Med. 2017.
41. Etter JF, Eissenberg T. Dependence levels in users of electronic cigarettes, nicotine gums and tobacco cigarettes. Drug Alcohol Depend. 2015; 147:68–75. https://doi.org/10.1016/j.drugalcdep.2014.12.007PMID: 25561385