Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users

Tobacco Control

Volumn 26, Issue e1, 2017, Pages e23-e28

  Wagener, Theodore L ^a,b   Floyd, Evan L ^b   Stepanov, Irina ^c   Driskill, Leslie M ^a,b   Frank, Summer G ^b   Meier, Ellen ^b,c   Leavens, Eleanor L ^b,d   Tackett, Alayna P ^b,d   Molina, Neil ^a,b   Queimado, Lurdes ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; COTININE; NICOTINE;

ADULT; COMPARATIVE STUDY; ELECTRONIC CIGARETTE; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; QUESTIONNAIRE; SALIVA; SMOKING; TIME FACTOR; TOBACCO; YOUNG ADULT;

ADULT; CARBON MONOXIDE; COTININE; ELECTRONIC NICOTINE DELIVERY SYSTEMS; FEMALE; HUMANS; MALE; MIDDLE AGED; NICOTINE; SALIVA; SMOKERS; SMOKING; SURVEYS AND QUESTIONNAIRES; TIME FACTORS; TOBACCO PRODUCTS; YOUNG ADULT;

EID: 84991744601     PISSN: 09644563     EISSN: 14683318     Source Type: Journal    
DOI: 10.1136/tobaccocontrol-2016-053041     Document Type: Article

References (28)

1. Cheng T. Chemical evaluation of electronic cigarettes. Tob Control 2014;23(Suppl 2):ii11–17.
2. Orr MS. Electronic cigarettes in the USA: a summary of available toxicology data and suggestions for the future. Tob Control 2014;23(Suppl 2):ii18–22.
3. Farsalinos KE, Spyrou A, Stefopoulos C, et al. Nicotine absorption from electronic cigarette use: comparison between experienced consumers (vapers) and naive users (smokers). Sci Rep 2015;5:11269.
4. Bullen C, McRobbie H, Thornley S, et al. Effect of an electronic nicotine delivery device (e cigarette) on desire to smoke and withdrawal, user preferences and nicotine delivery: randomised cross-over trial. Tob Control 2010;19:98–103.
5. Vansickel AR, Cobb CO, Weaver MF, et al. A clinical laboratory model for evaluating the acute effects of electronic “cigarettes”: nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prev 2010;19:1945–53.
6. Hitchman SC, Brose LS, Brown J, et al. Associations between E-cigarette type, frequency of use, and quitting smoking: findings from a longitudinal online panel survey in Great Britain. Nicotine Tob Res 2015;17:1187–94.
7. Bullen C, Howe C, Laugesen M, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet 2013;382:1629–37.
8. Dawkins L, Corcoran O. Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology 2014;231:401–7.
9. Farsalinos KE, Spyrou A, Tsimopoulou K, et al. Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Sci Rep 2014;4:4133.
10. Adriaens K, Van Gucht D, Declerck P, et al. Effectiveness of the electronic cigarette: an eight-week Flemish study with six-month follow-up on smoking reduction, craving and experienced benefits and complaints. Int J Environ Res Public Health 2014;11:11220–48.
11. Tackett AP, Lechner WV, Meier E, et al. Biochemically verified smoking cessation and vaping beliefs among vape store customers. Addiction 2015;110:868–74.
12. Benowitz NL, Porchet H, Sheiner L, et al. Nicotine absorption and cardiovascular effects with smokeless tobacco use: comparison with cigarettes and nicotine gum. Clin Pharmacol Ther 1988;44:23–8.
13. Lopez AA, Hiler MM, Soule EK, et al. Effects of electronic cigarette liquid nicotine concentration on plasma nicotine and puff topography in tobacco cigarette smokers: a preliminary report. Nicotine Tob Res 2016;18:720–3.
14. Ramôa CP, Hiler MM, Spindle TR, et al. Electronic cigarette nicotine delivery can exceed that of combustible cigarettes: a preliminary report. Tob Control 2016;25:e6–9.
15. St Helen G, Havel C, Dempsey DA, et al. Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes. Addiction 2016;111:535–44.
16. Akopyan G, Bonavida B. Understanding tobacco smoke carcinogen NNK and lung tumorigenesis. Int J Oncol 2006;29:745–52.
17. Hecht SS, Carmella SG, Kotandeniya D, et al. Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers. Nicotine Tob Res 2015;17:704–9.
18. Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 2014;23:133–9.
19. McRobbie H, Phillips A, Goniewicz ML, et al. Effects of switching to electronic cigarettes with and without concurrent smoking on exposure to nicotine, carbon monoxide, and acrolein. Cancer Prev Res (Phila) 2015;8:873–8.
20. 0,3'-d (2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007;857:1–8.
21. Cox LS, Tiffany ST, Christen AG. Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 2001;3:7–16.
22. Vogel RI, Carmella SG, Stepanov I, et al. The ratio of a urinary tobacco-specific lung carcinogen metabolite to cotinine is significantly higher in passive than in active smokers. Biomarkers 2011;16:491–7.
23. Luke DA, Ribisl KM, Smith C, et al. Family smoking prevention and tobacco control act: banning outdoor tobacco advertising near schools and playgrounds. Am J Prev Med 2011;40:295–302.
24. Kosmider L, Sobczak A, Fik M, et al. Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res 2014;16:1319–26.
25. Costa H, Gilmore AB, Peeters S, et al. Quantifying the influence of the tobacco industry on EU governance: automated content analysis of the EU Tobacco Products Directive. Tob Control 2014;23:473–8.
26. Bagley JH. EU Tobacco Products Directive trumps debate on regulation of electronic cigarettes. BMJ 2014;349:g5897.
27. Arrazola RA, Singh T, Corey CG, et al. Tobacco use among middle and high school students—United States, 2011–2014. MMWR Morb Mortal Wkly Rep 2015;64:381–5.
28. Donny EC, Taylor TG, LeSage MG, et al. Impact of tobacco regulation on animal research: new perspectives and opportunities. Nicotine Tob Res 2012;14:1319–38.