Recent evidence for the effects of nonnutritive sweeteners on glycaemic control

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 22, Issue 4, 2019, Pages 278-283

  Ahmad, Samar Y ^a   Azad, Meghan B ^a,b   Friel, James ^a   MacKay, Dylan ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

AceK; aspartame; glucose metabolism; glycaemic; randomized clinical trial; stevia; sucralose

Indexed keywords

ASPARTAME; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; NONNUTRITIVE SWEETENER; SUCRALOSE; SUGAR; SUCROSE; TRICHLOROSUCROSE;

BODY WEIGHT CONTROL; DECISION MAKING; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INSULIN RESISTANCE; REVIEW; SIRAITIA GROSVENORII; STEVIA; DRUG EFFECT; METABOLISM; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ASPARTAME; BLOOD GLUCOSE; HUMANS; INSULIN; NON-NUTRITIVE SWEETENERS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STEVIA; SUCROSE;

EID: 85067213751     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000566     Document Type: Review

References (24)

1. Giugliano D, Maiorino MI, Bellastella G, Esposito K. More sugar? No, thank you! The elusive nature of low carbohydrate diets. Endocrine 2018; 61:383-387.
2. Brisbois TD, Marsden SL, Anderson GH, Sievenpiper JL. Estimated intakes and sources of total and added sugars in the Canadian diet. Nutrients 2014; 6:1899-1912.
3. Bleich SN, Wolfson JA. U.S. adults and child snacking patterns among sugarsweetened beverage drinkers and nondrinkers. Prevent Med 2015; 72:8-14.
4. World Health Organisation. Guideline: sugars intake for adults and children. Geneva: WHO Guidelines Approved by the Guidelines Review Committee (2015); 2015.
5. Rippe JM, Angelopoulos TJ. Relationship between added sugars consumption and chronic disease risk factors: current understanding. Nutrients 2016; 8:; pii: E697.
6. Luger M, Lafontan M, Bes-Rastrollo M, et al. Sugar-sweetened beverages and weight gain in children and adults: a systematic review from 2013 to 2015 and a comparison with previous studies. Obes Facts 2017; 10:674-693.
7. Serra-Majem L, Raposo A, Aranceta-Bartrina J, et al. Ibero(-)American consensus on low-and no-calorie sweeteners: safety, nutritional aspects and benefits in food and beverages. Nutrients 2018; 10:.
8. Sylvetsky AC, Jin Y, Clark EJ, et al. Consumption of low-calorie sweeteners among children and adults in the United States. J Acad Nutr Diet 2017; 117:441.e2-448.e2.
9. Pearlman M, Obert J, Casey L. The association between artificial sweeteners and obesity. Curr Gastroenterol Rep 2017; 19:64.
10. Azad MB, Abou-Setta AM, Chauhan BF, et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ 2017; 189: E929-E939.
11. Nichol AD, Holle MJ, An R. Glycemic impact of nonnutritive sweeteners: a systematic review andmeta-analysis of randomized controlled trials. Eur J Clin Nutr 2018; 72:796-804.
12. Grotz VL, Pi-Sunyer X, Porte D Jr, et al. A 12-week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis. Regul Toxicol Pharmacol 2017; 88:22-33.
13. Tey SL, Salleh NB, Henry J, Forde CG. Effects of aspartame-, monk fruit-, stevia-and sucrose-sweetened beverages on postprandial glucose, insulin and energy intake. Int J Obes (Lond) 2017; 41:450-457.
14. Higgins KA, Considine RV, Mattes RD. Aspartame consumption for 12 weeks does not affect glycemia, appetite, or body weight of healthy, lean adults in a randomized controlled trial. J Nutr 2018; 148:650-657.
15. Bonnet F, Tavenard A, Esvan M, et al. Consumption of a carbonated beverage with high-intensity sweeteners has no effect on insulin sensitivity and secretion in nondiabetic adults. J Nutr 2018; 148:1293-1299.
16. Romo-Romo A, Aguilar-Salinas CA, Brito-Cordova GX, et al. Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial. Am J Clin Nutr 2018; 108:485-491.
17. Lertrit A, Srimachai S, Saetung S, et al. Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: a randomized, doubleblind, placebo-controlled trial. Nutrition 2018; 55-56:125-130.
18. Romo-Romo A, Aguilar-Salinas CA, Gomez-Diaz RA, et al. Non-nutritive sweeteners: evidence on their association with metabolic diseases and potential effects on glucose metabolism and appetite. Rev Invest Clin 2017; 69:129-138.
19. Elrick H, Stimmler L, Hlad CJ Jr, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964; 24:1076-1082.
20. Manell E, Hedenqvist P, Svensson A, Jensen-Waern M. Establishment of a refined oral glucose tolerance test in pigs, and assessment of insulin, glucagon and glucagon-like peptide-1 responses. PloS One 2016; 11:e0148896.
21. Lee AA, Owyang C. Sugars, sweet taste receptors, and brain responses. Nutrients 2017; 9:; pii: E653.
22. Romo-Romo A, Aguilar-Salinas CA, Brito-Có rdova GX, et al. Effects of the non-nutritive sweeteners on glucose metabolism and appetite regulating hormones: systematic review of observational prospective studies and clinical trials. PloS One 2016; 11:e0161264.
23. Magnuson BA, Carakostas MC, Moore NH, et al. Biological fate of low-calorie sweeteners. Nutr Rev 2016; 74:670-689.
24. Sylvetsky AC, Walter PJ, Garraffo HM, et al. Widespread sucralose exposure in a randomized clinical trial in healthy young adults. Am J Clin Nutrition 2017; 105:820-823.