Widespread sucralose exposure in a randomized clinical trial in healthy young adults

American Journal of Clinical Nutrition

Volumn 105, Issue 4, 2017, Pages 820-823

  Sylvetsky, Allison C ^a,b   Walter, Peter J ^b   Garraffo, H Martin ^b   Robien, Kim ^a   Rother, Kristina I ^b  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Artificial sweeteners; Diet; Diet soda; Low calorie sweeteners; Nonnutritive sweeteners; Sucralose

Indexed keywords

CARBONATED WATER; SUCRALOSE; NONNUTRITIVE SWEETENER; SUCROSE; TRICHLOROSUCROSE;

ADULT; ARTICLE; ARTIFICIALLY SWEETENED BEVERAGE; CARBOHYDRATE INTAKE; CARBONATED BEVERAGE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LOW CALORY DIET; MALE; NAUSEA; NORMAL HUMAN; PATIENT COUNSELING; RANDOMIZED CONTROLLED TRIAL; SUGAR-SWEETENED BEVERAGE; URINE LEVEL; URINE SAMPLING; WEIGHT CHANGE; YOUNG ADULT; ADOLESCENT; ANALOGS AND DERIVATIVES; ANALYSIS; CALORIC INTAKE; DIET; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; NUTRITION; REFERENCE VALUE; URINE;

ADOLESCENT; ADULT; CARBONATED BEVERAGES; DIET; ENERGY INTAKE; ENVIRONMENTAL EXPOSURE; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; NON-NUTRITIVE SWEETENERS; NUTRITION SURVEYS; REFERENCE VALUES; SUCROSE; YOUNG ADULT;

EID: 85020506148     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.116.144402     Document Type: Article

References (12)

1. Rogers PJ, Hogenkamp PS, de Graaf C, Higgs S, Lluch A, Ness AR, Penfold C, Perry R, Putz P, Yeomans MR, et al. Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int J Obes (Lond) 2016;40:381-94.
2. Fowler SP. Low-calorie sweetener use and energy balance: results from experimental studies in animals, and large-scale prospective studies in humans. Physiol Behav 2016;164:517-23.
3. Swithers SE. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol Metab 2013; 24:431-41.
4. Sylvetsky AC, Blau JE, Rother KI. Understanding the metabolic and health effects of low-calorie sweeteners: methodological considerations and implications for future research. Rev Endocr Metab Disord 2016;17:187-94.
5. Sylvetsky AC, Jin Y, Clark EJ, Welsh JA, Rother KI, Talegawkar SA. Consumption of low-calorie sweeteners among children and adults in the United States. J Acad Nutr Diet 2017 Jan 6 (Epub ahead of print; DOI: 10.1016/j.jand.2016.11.004).
6. Sylvetsky AC, Dietz WH. Nutrient-content claims-guidance or cause for confusion? N Engl J Med 2014;371:195-8.
7. Sylvetsky AC, Greenberg M, Zhao X, Rother KI. What parents think about giving nonnutritive sweeteners to their children: a pilot study. Int J Pediatr 2014;2014:819872.
8. Sylvetsky AC, Bauman V, Blau JE, Garraffo HM,Walter PJ, Rother KI.Plasma concentrations of sucralose in children and adults. Toxicol Environ Chem 2016;99:535-42.
9. Sylvetsky AC, Gardner AL, Bauman V, Blau JE, Garraffo HM, Walter PJ, Rother KI. Nonnutritive sweeteners in breast milk. J Toxicol Environ Health A 2015;78:1029-32.
10. Rother KI, Sylvetsky AC, Schiffman SS. Non-nutritive sweeteners in breast milk: perspective on potential implications of recent findings.Arch Toxicol 2015;89:2169-71.
11. Lange FT, Scheurer M, Brauch HJ. Artificial sweeteners-a recently recognized class of emerging environmental contaminants: a review.Anal Bioanal Chem 2012;403:2503-18.
12. Roberts A, Renwick AG, Sims J, Snodin DJ. Sucralose metabolism and pharmacokinetics in man. Food Chem Toxicol 2000;38(Suppl 2):S31-41.