A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks - Results from the Lassa fever pilot

BMC Medicine

Volumn 17, Issue 1, 2019, Pages

  Sigfrid, Louise ^a   Moore, Catrin ^a   Salam, Alex P ^a,b   Maayan, Nicola ^c   Hamel, Candyce ^d   Garritty, Chantelle ^d   Lutje, Vittoria ^e   Buckley, Brian ^f   Soares Weiser, Karla ^g   Marshall, Rachel ^h   Clarke, Mike ⁱ   Horby, Peter ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b Public Health Action Support Team   (United Kingdom)

^c Cochrane Response ^*  (United Kingdom)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^f UNIVERSITY OF THE PHILIPPINES MANILA   (Philippines)

^g Editorial and Methods Department   (United Kingdom)

^h London   (United Kingdom)

ⁱ QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Clinical research priorities; Emerging infectious diseases; Lassa fever; Outbreak response; Rapid research needs appraisal methodology

Indexed keywords

ARTICLE; CANADA; CLINICAL RESEARCH; DATA EXTRACTION; DISEASE RE-EMERGENCE; DISEASE TRANSMISSION; EPIDEMIC; HUMAN; INFECTION; LASSA FEVER; PHILIPPINES; PILOT STUDY; PRACTICE GAP; RESEARCH PRIORITY; RISK FACTOR; SCREENING; STUDY DESIGN; UNITED KINGDOM; EVIDENCE BASED PRACTICE; FACTUAL DATABASE; FEASIBILITY STUDY; HEALTH CARE DELIVERY; HEALTH CARE PLANNING; HEALTH STATUS INDICATOR; KNOWLEDGE MANAGEMENT; NEEDS ASSESSMENT; ORGANIZATION AND MANAGEMENT; PROCEDURES; RESEARCH; SOFTWARE; TIME FACTOR;

CANADA; DATABASES, FACTUAL; DELIVERY OF HEALTH CARE; DISEASE OUTBREAKS; EPIDEMICS; EVIDENCE-BASED PRACTICE; FEASIBILITY STUDIES; HEALTH RESOURCES; HEALTH STATUS INDICATORS; HUMANS; KNOWLEDGE MANAGEMENT; LASSA FEVER; NEEDS ASSESSMENT; PHILIPPINES; PILOT PROJECTS; RESEARCH; SOFTWARE; SYSTEMATIC REVIEWS AS TOPIC; TIME FACTORS; UNITED KINGDOM;

EID: 85067131976     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-019-1338-1     Document Type: Article

References (135)

1. Lant T, Lurie N. Science preparedness and science response: perspectives on the dynamics of preparedness conference. J Public Health Manag Pract. 2013;19(Suppl 2):S3-5.
2. Rishu AH, Marinoff N, Julien L, Dumitrascu M, Marten N, Eggertson S, et al. Time required to initiate outbreak and pandemic observational research. J Crit Care. 2017;40:7-10.
3. Rojek AM, Castle L, Dunning J, Horby PW, Leliogdowicz A, Carson G, et al. Regulatory and operational complexities of conducting a clinical treatment trial during an Ebola virus disease epidemic. Clin Infect Dis. 2017;66(9):1454-7.
4. Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gulmezoglu AM, et al. How to increase value and reduce waste when research priorities are set. Lancet. 2014;383(9912):156-65.
5. Ganann R, Ciliska D, Thomas H. Expediting systematic reviews: methods and implications of rapid reviews. Implement Sci. 2010;5:56.
6. Khangura S, Konnyu K, Cushman R, Grimshaw J, Moher D. Evidence summaries: the evolution of a rapid review approach. Syst Rev. 2012;1:10.
7. Garritty CM, Norris SL, Moher D. Developing WHO rapid advice guidelines in the setting of a public health emergency. J Clin Epidemiol. 2017;82:47-60.
8. Tricco AC, Antony J, Zarin W, Strifler L, Ghassemi M, Ivory J, et al. A scoping review of rapid review methods. BMC Med. 2015;13:224.
9. Pham MT, Rajić A, Greig JD, Sargeant JM, Papadopoulos A, McEwen SA. A scoping review of scoping reviews: advancing the approach and enhancing the consistency. Res Synth Methods. 2014;5(4):371-85.
10. Polisena J, Garritty C, Kamel C, Stevens A, Abou-Setta AM. Rapid review programs to support health care and policy decision making: a descriptive analysis of processes and methods. Syst Rev. 2015;4:26.
11. Tricco A, Langlois E, Straus S. Rapid reviews to strengthen health policy and systems: a practical guide. Geneva: WHO; 2017.
12. World Health Organisation. Lassa Fever R&D: WHO; 2019. Available from: https://www.who.int/blueprint/priority-diseases/key-action/lassa-fever/en/. [cited 2019 Feb.]
13. Centres for Disease Control and Prevention. Lassa Fever US: US CDC; 2019. Available from: https://www.cdc.gov/vhf/lassa/index.html. [cited 2019 Feb.]
14. World Health Organisation. List of Blueprint priority diseases: WHO; 2018. Available from: http://www.who.int/blueprint/priority-diseases/en/. [cited 2019 Feb.]
15. Nigeria Centre for Disease Control. 2018Lassa fever outbreak in Nigeria Nigeria: Nigeria CDC; 2018. Available from: file:///C:/Users/user/Downloads/An%20update%20of%20Lassa%20fever%20outbreak%20in%20Nigeria-100618-24.pdf. [updated 10 June 2018; cited 2018 11 June.]
16. Sigfrid L, Moore C, Garritty C, Maayan N, Lutje V, Marshall R, et al. Rapid research needs appraisal methodology UK: Open Science Framework; 2017. Available from: osf.io/8qn6v. [cited 2018 11 June]
17. The Global Health Network. CREDO - rapid 'Evidence needs' Appraisal 2018. Available from: (https://globalhealthtrainingcentre.tghn.org/credo-rapid-evidence-needs-appraisal/). [cited 2018 11 June]
18. Ibekwe TS, Okokhere PO, Asogun D, Blackie FF, Nwegbu MM, Wahab KW, et al. Early-onset sensorineural hearing loss in Lassa fever. Eur Arch Otorhinolaryngol. 2011;268(2):197-201.
19. Asogun DA, Adomeh DI, Ehimuan J, Odia I, Hass M, Gabriel M, et al. Molecular diagnostics for Lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. PLoS Negl Trop Dis. 2012;6(9):e1839.
20. Cummins D, McCormick JB, Bennett D, Samba JA, Farrar B, Machin SJ, et al. Acute sensorineural deafness in Lassa fever. JAMA. 1990;264(16):2093-6.
21. Ehichioya DU, Asogun DA, Ehimuan J, Okokhere PO, Pahlmann M, Olschlager S, et al. Hospital-based surveillance for Lassa fever in Edo State, Nigeria, 2005-2008. Tropical Med Int Health. 2012;17(8):1001-4.
22. Fisher-Hoch SP, Tomori O, Nasidi A, Perez-Oronoz GI, Fakile Y, Hutwagner L, et al. Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. BMJ. 1995;311(7009):857-9.
23. Frame JD. Clinical features of Lassa fever in Liberia. Rev Infect Dis. 1989;11(Suppl 4):S783-9.
24. Inegbenebor U, Okosun J, Inegbenebor J. Prevention of Lassa fever in Nigeria. Trans R Soc Trop Med Hyg. 2010;104(1):51-4.
25. McCormick JB, King IJ, Webb PA, Johnson KM, O'Sullivan R, Smith ES, et al. A case-control study of the clinical diagnosis and course of Lassa fever. J Infect Dis. 1987;155(3):445-55.
26. Okokhere P, Ugheoke J, Erameh C. Pulmonary manifestation of Lassa fever and the impact on mortality. Eur Respir J Conf. 2012;40(no pagination).
27. Roth PJ, Grant DS, Ngegbai AS, Schieffelin J, McClelland RS, Jarrett OD. Factors associated with mortality in febrile patients in a government referral hospital in the Kenema district of Sierra Leone. Am J Trop Med Hyg. 2015;92(1):172-7.
28. Bausch DG, Demby AH, Coulibaly M, Kanu J, Goba A, Bah A, et al. Lassa fever in Guinea: I. Epidemiology of human disease and clinical observations. Vector Borne Zoonotic Dis. 2001;1(4):269-81.
29. Fraser DW, Campbell CC, Monath TP, Goff PA, Gregg MB. Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. I. Epidemiologic studies. Am J Trop Med Hyg. 1974;23(6):1131-9.
30. McCormick JB, Walker DH, King IJ, Webb PA, Elliott LH, Whitfield SG, et al. Lassa virus hepatitis: a study of fatal Lassa fever in humans. Am J Trop Med Hyg. 1986;35(2):401-7.
31. Webb PA, McCormick JB, King IJ, Bosman I, Johnson KM, Elliott LH, et al. Lassa fever in children in Sierra Leone, West Africa. Trans R Soc Trop Med Hyg. 1986;80(4):577-82.
32. Safronetz D, Sogoba N, Diawara SI, Bane S, Rosenke K, Maiga O, et al. Annual incidence of Lassa virus infection in southern Mali. Am J Trop Med Hyg. 2017;96(4):944-6.
33. Akpede G, Odike A, Okokhere P, Olomu SC, Asogun D, Happi C, et al. Prevalence and presentation of Lassa fever in Nigerian children. Int J Infect Dis. 2010;14:e380.
34. Asogun D, Okokhere P, Tobin E, Okogbenin SA, Akpede G, Happi C, et al. Lassa fever practice challenges in Nigeria. Int J Infect Dis. 2012;16:e69.
35. Getso KI, Balogun MS, Gidado SO, Oladejo J, Nasidi A, Nguku PM, et al. Lassa fever outbreak involving health care workers in Taraba state, Nigeria; March 2012. Am J Trop Med Hyg. 2013;1:132-3.
36. Okokhere PO, Bankole IA, Akpede GO. Central nervous system manifestations of Lassa fever in Nigeria and the effect on mortality. J Neurol Sci. 2013;333:e604.
37. Johnson KM, McCormick JB, Webb PA, Smith ES, Elliott LH, King IJ. Clinical virology of Lassa fever in hospitalized patients. J Infect Dis. 1987;155(3):456-64.
38. Price ME, Fisher-Hoch SP, Craven RB, McCormick JB. A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy. BMJ. 1988;297(6648):584-7.
39. Akhuemokhan OC, Ewah-Odiase RO, Akpede N, Ehimuan J, Adomeh DI, Odia I, et al. Prevalence of Lassa virus disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area. PLoS Negl Trop Dis. 2017;11(7):e0005711.
40. Brown BL, Boisen ML, Moses LM, Schieffelin JS, Goba A, Momoh M, et al. Suspected Lassa fever (LF) case outcomes: a comparison to a non-febrile population in Sierra Leone. Clin Chem. 2014;1:S38.
41. Akhuemokhan OC, Ehiemua J, Adomeh DI, Odia I, Olomu SC, Becker-Ziaja B, et al. Lassa fever and convulsions associated with fever: a case-control study. Arch Dis Child. 2017;102:A122.
42. Ajayi NA, Nwigwe CG, Azuogu BN, Onyire BN, Nwonwu EU, Ogbonnaya LU, et al. Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012). Int J Infect Dis. 2013;17(11):e1011-6.
43. Keane E, Gilles HM. Lassa fever in Panguma Hospital, Sierra Leone, 1973-6. Br Med J. 1977;1(6073):1399-402.
44. Kerneis S, Koivogui L, Magassouba N, Koulemou K, Lewis R, Aplogan A, et al. Prevalence and risk factors of Lassa seropositivity in inhabitants of the forest region of Guinea: a cross-sectional study. PLoS Negl Trop Dis. 2009;3(11):e548.
45. Li WG, Chen WW, Li L, Ji D, Ji YJ, Li C, et al. The etiology of Ebola virus disease-like illnesses in Ebola virusnegative patients from Sierra Leone. Oncotarget. 2016;7(19):27910-5.
46. Monson MH, Frame JD, Jahrling PB, Alexander K. Endemic Lassa fever in Liberia. I. Clinical and epidemiological aspects at Curran Lutheran Hospital, Zorzor, Liberia. Trans R Soc Trop Med Hyg. 1984;78(4):549-53.
47. Sogoba N, Rosenke K, Adjemian J, Diawara SI, Maiga O, Keita M, et al. Lassa virus seroprevalence in Sibirilia commune, Bougouni District, southern Mali. Emerg Infect Dis. 2016;22(4):657-63.
48. Winn WC Jr, Walker DH. The pathology of human Lassa fever. Bull World Health Organ. 1975;52(4-6):535-45.
49. Bello OO, Akinajo OR, Odubamowo KH, Oluwasola TA. Lassa fever in pregnancy: report of 2 cases seen at the University College Hospital, Ibadan. Case Rep Obstet Gynecol. 2016;2016:9673683.
50. Ogunniyi AO, Nguku P, Gbadegesin O, Adedire EO. Lassa fever outbreak investigation in a Nigerian bakery - August, 2012. Int J Infect Dis. 2014;21:400.
51. Okokhere PO, Bankole IA, Iruolagbe CO, Muoebonam BE, Okonofua MO, Dawodu SO, et al. Aseptic meningitis caused by Lassa virus: case series report. Case Rep Neurol Med. 2016;2016:1978461.
52. Dongo AE, Kesieme EB, Iyamu CE, Okokhere PO, Akhuemokhan OC, Akpede GO. Lassa fever presenting as acute abdomen: a case series. Virol J. 2013;10:123.
53. Dzotsi EK, Ohene SA, Asiedu-Bekoe F, Amankwa J, Sarkodie B, Adjabeng M, et al. The first cases of Lassa fever in Ghana. Ghana Med J. 2012;46(3):166-70.
54. Akpede GO, Kayode-Adedeji BO, Dawodu SO. Manifestations and outcomes of Lassa fever in Nigerian children: a case series. Arch Dis Child. 2012;97:A38-A9.
55. Branco LM, Boisen ML, Andersen KG, Grove JN, Moses LM, Muncy IJ, et al. Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report. Virol J. 2011;8:404.
56. Okogbenin SA, Asogun D, Akpede G, Okokhere P, Gunther S, Happi C. New lessons from a case series review of Lassa fever in pregnancy. Int J Infect Dis. 2010;14:e380.
57. Monson MH, Cole AK, Frame JD, Serwint JR, Alexander S, Jahrling PB. Pediatric Lassa fever: a review of 33 Liberian cases. Am J Trop Med Hyg. 1987;36(2):408-15.
58. Bowen GS, Tomori O, Wulff H, Casals J, Noonan A, Downs WG. Lassa fever in Onitsha, East Central State, Nigeria in 1974. Bull World Health Organ. 1975;52(4-6):599-604.
59. Edington GM, White HA. The pathology of Lassa fever. Trans R Soc Trop Med Hyg. 1972;66(3):381-9.
60. White HA. Lassa fever. A study of 23 hospital cases. Trans R Soc Trop Med Hyg. 1972;66(3):390-401.
61. Mertens PE, Patton R, Baum JJ, Monath TP. Clinical presentation of Lassa fever cases during the hospital epidemic at Zorzor, Liberia, March-April 1972. Am J Trop Med Hyg. 1973;22(6):780-4.
62. Troup JM, White HA, Fom AL, Carey DE. An outbreak of Lassa fever on the Jos Plateau, Nigeria, in January-February 1970. A preliminary report. Am J Trop Med Hyg. 1970;19(4):695-6.
63. Frame JD. Lassa fever, a new virus disease of man from west africa. I Clinical description and pathological findings. AmerJTropMedHyg. 1970;19(4):339-50.
64. Monath TP, Maher M, Casals J, Kissling RE, Cacciapuoti A. Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. II. Clinical observations and virological studies on selected hospital cases. Am J Trop Med Hyg. 1974;23(6):1140-9.
65. Carey DE, Kemp GE, White HA, Pinneo L, Addy RF, Fom AL, et al. Lassa fever. Epidemiological aspects of the 1970 epidemic, Jos, Nigeria. Trans R Soc Trop Med Hyg. 1972;66(3):402-8.
66. Kyei NN, Abilba MM, Kwawu FK, Agbenohevi PG, Bonney JH, Agbemaple TK, et al. Imported Lassa fever: a report of 2 cases in Ghana. BMC Infect Dis. 2015;15:217.
67. Oppenheimer L. A case of Lassa fever. Br Med J (Clin Res Ed). 1982;285(6354):1576-7.
68. Sharp PC. Lassa fever in children. J Inf Secur. 1982;4(1):73-7.
69. Macher AM, Wolfe MS. Historical Lassa fever reports and 30-year clinical update. Emerg Infect Dis. 2006;12(5):835-7.
70. Grahn A, Brave A, Lagging M, Dotevall L, Ekqvist D, Hammarstrom H, et al. Imported case of Lassa fever in Sweden with encephalopathy and sensorineural hearing deficit. Open Forum Infect Dis. 2016;3(4):ofw198.
71. Edo AE, Okaka E, Ezeani IU. Hyperglycemic crisis precipitated by Lassa fever in a patient with previously undiagnosed type 2 diabetes mellitus. Niger J Clin Pract. 2014;17(5):658-61.
72. Ajayi NA, Ukwaja KN, Ifebunandu NA, Nnabu R, Onwe FI, Asogun DA. Lassa fever - full recovery without ribavarin treatment: a case report. Afr Health Sci. 2014;14(4):1074-7.
73. Lotz E, Raffin H. Aeromedical evacuation using an aircraft transit isolator of a patient with Lassa fever. Aviat Space Environ Med. 2012;83(5):527-30.
74. Grove JN, Branco LM, Boisen ML, Muncy IJ, Henderson LA, Schieffellin JS, et al. Capacity building permitting comprehensive monitoring of a severe case of Lassa hemorrhagic fever in Sierra Leone with a positive outcome: case report. Virol J. 2011;8:314.
75. Amorosa V, MacNeil A, McConnell R, Patel A, Dillon KE, Hamilton K, et al. Imported Lassa fever, Pennsylvania, USA, 2010. Emerg Infect Dis. 2010;16(10):1598-600.
76. Okokhere PO, Ibekwe TS, Akpede GO. Sensorineural hearing loss in Lassa fever: two case reports. J Med Case Rep. 2009;3:36.
77. Kitching A, Addiman S, Cathcart S, Bischop L, Krahe D, Nicholas M, et al. A fatal case of Lassa fever in London, January 2009. Euro Surveill. 2009;14(6).
78. Lamb D. Evaluation of infection control practices during an AE. Br J Nurs. 2006;15(10):543-7.
79. Anonymous. Imported Lassa fever - New Jersey, 2004. Mmwr. 2004;Morb Mortal Wkly Rep 53(38):894-897.
80. Schmitz H, Kohler B, Laue T, Drosten C, Veldkamp PJ, Gunther S, et al. Monitoring of clinical and laboratory data in two cases of imported Lassa fever. Microbes Infect. 2002;4(1):43-50.
81. Swaan CM, van den Broek PJ, Kampert E, Berbee GA, Schippers EF, Beersma MF, et al. Management of a patient with Lassa fever to prevent transmission. J Hosp Infect. 2003;55(3):234-5.
82. Gunther S, Weisner B, Roth A, Grewing T, Asper M, Drosten C, et al. Lassa fever encephalopathy: Lassa virus in cerebrospinal fluid but not in serum. J Infect Dis. 2001;184(3):345-9.
83. ter Meulen J, Lenz O, Koivogui L, Magassouba N, Kaushik SK, Lewis R, et al. Short communication: Lassa fever in Sierra Leone: UN peacekeepers are at risk. Tropical Med Int Health. 2001;6(1):83-4.
84. Anonymous. Lassa fever, case imported to Germany. Wkly Epidemiol Rec 2000;75(3):17-18.
85. Holmes GP, McCormick JB, Trock SC, Chase RA, Lewis SM, Mason CA, et al. Lassa fever in the United States. Investigation of a case and new guidelines for management. N Engl J Med. 1990;323(16):1120-3.
86. Lloyd G, Barber GN, Clegg JC, Kelly P. Identification of Lassa fever virus infection with recombinant nucleocapsid protein antigen. Lancet. 1989;2(8673):1222.
87. The Public Health Laboratory Service Communicable Disease Centre. Lassa fever 1982. Br Med J (Clin Res Ed) 1983;287(6384):48.
88. Emond RT, Weir WR, Bowen ET, Lloyd G, Southee T. Managing Lassa fever. Lancet. 1984;2(8408):926.
89. Fisher-Hoch SP, Price ME, Craven RB, Price FM, Forthall DN, Sasso DR, et al. Safe intensive-care management of a severe case of Lassa fever with simple barrier nursing techniques. Lancet. 1985;2(8466):1227-9.
90. Hirabayashi Y, Oka S, Goto H, Shimada K, Kurata T, Fisher-Hoch SP, et al. An imported case of Lassa fever with late appearance of polyserositis. J Infect Dis. 1988;158(4):872-5.
91. Cooper CB, Gransden WR, Webster M, King M, O'Mahony M, Young S, et al. A case of Lassa fever: experience at St Thomas's Hospital. Br Med J (Clin Res Ed). 1982;285(6347):1003-5.
92. Emond RT, Bannister B, Lloyd G, Southee TJ, Bowen ET. A case of Lassa fever: clinical and virological findings. Br Med J (Clin Res Ed). 1982;285(6347):1001-2.
93. Walker DH, McCormick JB, Johnson KM, Webb PA, Komba-Kono G, Elliott LH, et al. Pathologic and virologic study of fatal Lassa fever in man. Am J Pathol. 1982;107(3):349-56.
94. Woodruff AW, Monath TP, Mahmoud AA, Pain AK, Morris CA. Lassa fever in Britain: an imported case. Br Med J. 1973;3(5881):616-7.
95. Grundy DJ, Bowen ET, Lloyd G. Isolated case of Lassa fever in Zaria, Northern Nigeria. Lancet. 1980;2(8195 pt 1):649-50.
96. Leifer E, Gocke DJ, Bourne H. Lassa fever, a new virus disease of man from West Africa. II. Report of a laboratory-acquired infection treated with plasma from a person recently recovered from the disease. Am J Trop Med Hyg. 1970;19(4):677-9.
97. Atkin S, Anaraki S, Gothard P, Walsh A, Brown D, Gopal R, et al. The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. Euro Surveill. 2009;14(10).
98. Crowcroft NS, Meltzer M, Evans M, Shetty N, Maguire H, Bahl M, et al. The public health response to a case of Lassa fever in London in 2000. J Inf Secur. 2004;48(3):221-8.
99. Haas WH, Breuer T, Pfaff G, Schmitz H, Kohler P, Asper M, et al. Imported Lassa fever in Germany: surveillance and management of contact persons. Clin Infect Dis. 2003;36(10):1254-8.
100. Hadi CM, Goba A, Khan SH, Bangura J, Sankoh M, Koroma S, et al. Ribavirin for Lassa fever postexposure prophylaxis. Emerg Infect Dis. 2010;16(12):2009-11.
101. Iroezindu MO, Unigwe US, Okwara CC, Ozoh GA, Ndu AC, Ohanu ME, et al. Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. Tropical Med Int Health. 2015;20(11):1424-30.
102. Isa SE, Okwute A, Iraoyah KO, Nathan SY, Simji GS, Okolo MO, et al. Postexposure prophylaxis for Lassa fever: experience from a recent outbreak in Nigeria. Niger Med J. 2016;57(4):246-50.
103. Zweighaft RM, Fraser DW, Hattwick MA, Winkler WG, Jordan WC, Alter M, et al. Lassa fever: response to an imported case. N Engl J Med. 1977;297(15):803-7.
104. Monath TP, Mertens PE, Patton R, Moser CR, Baum JJ, Pinneo L, et al. A hospital epidemic of Lassa fever in Zorzor, Liberia, March-April 1972. Am J Trop Med Hyg. 1973;22(6):773-9.
105. Gilles HM, Kent JC. Lassa fever: retrospective diagnosis of two patients seen in Great Britain in 1971. Br Med J. 1976;2(6045):1173.
106. Balasegaram M, Dejene S, Tinnemann P, Perkins S, Davidson R. Examples of tropical disease control in the humanitarian medical programmes of MSF and Merlin. Trans R Soc Trop Med Hyg. 2006;100(4):327-34.
107. Branco LM, Grove JN, Boisen ML, Shaffer JG, Goba A, Fullah M, et al. Emerging trends in Lassa fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection. Virol J. 2011;8:478.
108. Ter Meulen J, Koulemou K, Wittekindt T, Windisch K, Strigl S, Conde S, et al. Detection of Lassa virus antinucleoprotein immunoglobulin G (IgG) and IgM antibodies by a simple recombinant immunoblot assay for field use. J Clin Microbiol. 1998;36(11):3143-8.
109. Trappier SG, Conaty AL, Farrar BB, Auperin DD, McCormick JB, Fisher-Hoch SP. Evaluation of the polymerase chain reaction for diagnosis of Lassa virus infection. Am J Trop Med Hyg. 1993;49(2):214-21.
110. Ibekwe TS, Nwegbu MM, Asogun D, Adomeh DI, Okokhere PO. The sensitivity and specificity of Lassa virus IgM by ELISA as screening tool at early phase of Lassa fever infection. Niger Med J. 2012;53(4):196-9.
111. Demby AH, Chamberlain J, Brown DW, Clegg CS. Early diagnosis of Lassa fever by reverse transcription-PCR. J Clin Microbiol. 1994;32(12):2898-903.
112. Panning M, Emmerich P, Olschlager S, Bojenko S, Koivogui L, Marx A, et al. Laboratory diagnosis of Lassa fever, Liberia. Emerg Infect Dis. 2010;16(6):1041-3.
113. Kimura M, Sakamoto M, Adachi T, Sagara H. Diagnosis of febrile illnesses in returned travelers using the PC software GIDEON. Travel Med Infect Dis. 2005;3(3):157-60.
114. Mahanty S, Bausch DG, Thomas RL, Goba A, Bah A, Peters CJ, et al. Low levels of interleukin-8 and interferon-inducible protein-10 in serum are associated with fatal infections in acute Lassa fever. J Infect Dis. 2001;183(12):1713-21.
115. Bond N, Schieffelin JS, Moses LM, Bennett AJ, Bausch DG. A historical look at the first reported cases of Lassa fever: IgG antibodies 40 years after acute infection. Am J Trop Med Hyg. 2013;88(2):241-4.
116. Jahrling PB, Niklasson BS, McCormick JB. Early diagnosis of human Lassa fever by ELISA detection of antigen and antibody. Lancet. 1985;1(8423):250-2.
117. Wulff H, Johnson KM. Immunoglobulin M and G responses measured by immunofluorescence in patients with Lassa or Marburg virus infections. Bull World Health Organ. 1979;57(4):631-5.
118. Fabiyi A, Tomori O. Use of the complement fixation (CF) test in Lassa fever surveillance. Evidence for persistent CF antibodies. Bull World Health Organ. 1975;52(4-6):605-8.
119. McCormick JB, King IJ, Webb PA, Scribner CL, Craven RB, Johnson KM, et al. Lassa fever. Effective therapy with ribavirin. N Engl J Med. 1986;314(1):20-6.
120. Frame JD, Verbrugge GP, Gill RG, Pinneo L. The use of Lassa fever convalescent plasma in Nigeria. Trans R Soc Trop Med Hyg. 1984;78(3):319-24.
121. U.S. Army Medical Research and Materiel Command. Treatment of Viral Hemorrhagic Fevers With Intravenous Ribavirin in Military Treatment Facilities US: ClinicalTrials.gov; 2009. Available from: https://clinicaltrials.gov/ct2/show/NCT00992693?cond=Lassa+Fever&rank=1. [cited 2017 July]
122. U.S. Army Medical Research and Materiel Command. Intravenous Ribavirin Protocol to Treat Individuals With Viral Hemorrhagic Fever US: ClinicalTrials.gov; 2015. Available from: https://clinicaltrials.gov/ct2/show/NCT02483260?cond=Lassa+Fever. [cited 2017 July]
123. Dahmane A, van Griensven J, Van Herp M, Van den Bergh R, Nzomukunda Y, Prior J, et al. Constraints in the diagnosis and treatment of Lassa fever and the effect on mortality in hospitalized children and women with obstetric conditions in a rural district hospital in Sierra Leone. Trans R Soc Trop Med Hyg. 2014;108(3):126-32.
124. Fisher-Hoch SP, Gborie S, Parker L, Huggins J. Unexpected adverse reactions during a clinical trial in rural West Africa. Antivir Res. 1992;19(2):139-47.
125. Clayton AJ. Lassa immune serum. Bull World Health Organ. 1977;55(4):435-9.
126. Cummins D, Fisher-Hoch SP, Walshe KJ, Mackie IJ, McCormick JB, Bennett D, et al. A plasma inhibitor of platelet aggregation in patients with Lassa fever. Br J Haematol. 1989;72(4):543-8.
127. Getso KI, Balogun MS, Nasidi A, Gidado S, Nguku P, Oladejo J, et al. Lassa fever outbreak involving healthcare workers in Taraba State, Nigeria, March 2012. Int J Infect Dis. 2014;21:216.
128. Bausch DG, Rollin PE, Demby AH, Coulibaly M, Kanu J, Conteh AS, et al. Diagnosis and clinical virology of Lassa fever as evaluated by enzyme-linked immunosorbent assay, indirect fluorescent-antibody test, and virus isolation. J Clin Microbiol. 2000;38(7):2670-7.
129. Bonney JHK, Nyarko EO, Ohene SA, Amankwa J, Ametepi RK, Nimo-Paintsil SC, et al. Molecular confirmation of Lassa fever imported into Ghana. Afr J Lab Med. 2016;5(1):288.
130. Ehichioya D, Asogun D, Hass M, Becker-Ziaja B, Gunther S, Omilabu S. A retrospective laboratory analysis of clinically diagnosed Lassa fever cases in a tertiary hospital in Nigeria. Int J Infect Dis. 2010;14:e209-e10.
131. Emmerich P, Gunther S, Schmitz H. Strain-specific antibody response to Lassa virus in the local population of West Africa. J Clin Virol. 2008;42(1):40-4.
132. Emmerich P, Thome-Bolduan C, Drosten C, Gunther S, Ban E, Sawinsky I, et al. Reverse ELISA for IgG and IgM antibodies to detect Lassa virus infections in Africa. J Clin Virol. 2006;37(4):277-81.
133. Olschlager S, Lelke M, Emmerich P, Panning M, Drosten C, Hass M, et al. Improved detection of Lassa virus by reverse transcription-PCR targeting the 5′ region of S RNA. J Clin Microbiol. 2010;48(6):2009-13.
134. Shaffer JG, Grant DS, Schieffelin JS, Boisen ML, Goba A, Hartnett JN, et al. Lassa fever in post-conflict sierra leone. PLoS Negl Trop Dis. 2014;8(3):e2748.
135. Tobin EA, Asogun D, Happi C, Ogbaini E, Gunther S. Risk factors for Lassa fever in endemic communities of Edo state, Nigeria. Int J Infect Dis. 2014;21:258-9.