Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Cell Reports

Volumn 27, Issue 7, 2019, Pages 2092-2104.e10

  Braun, Elisabeth ^a   Hotter, Dominik ^a   Koepke, Lennart ^a   Zech, Fabian ^a   Groß, Rüdiger ^a   Sparrer, Konstantin M J ^a   Müller, Janis A ^a   Pfaller, Christian K ^b   Heusinger, Elena ^a   Wombacher, Rebecka ^c   Sutter, Kathrin ^d   Dittmer, Ulf ^d   Winkler, Michael ^e   Simmons, Graham ^f   Jakobsen, Martin R ^g   Conzelmann, Karl Klaus ^h   Pöhlmann, Stefan ^e,i   Münch, Jan ^a   Fackler, Oliver T ^c,j   Kirchhoff, Frank ^a   Sauter, Daniel ^a   more..

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b PAUL EHRLICH INSTITUT   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

^e GERMAN PRIMATE CENTER   (Germany)

^f BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^g AARHUS UNIVERSITY   (Denmark)

^h UNIVERSITY OF MUNICH   (Germany)

ⁱ UNIVERSITY OF GÖTTINGEN   (Germany)

^j Partner Site Heidelberg   (Germany)

more..

Author keywords

furin; GBPs; HIV; influenza A virus; measles virus; restriction factor; viral envelope proteins; Zika virus

Indexed keywords

FURIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; GLYCOPROTEIN GP 41; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANYLATE BINDING PROTEIN 2; GUANYLATE BINDING PROTEIN 5; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; FURIN PROTEIN, HUMAN; GBP2 PROTEIN, HUMAN; GBP5 PROTEIN, HUMAN; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; GP41 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNITY; INFLUENZA A VIRUS; MARBURGVIRUS; MEASLES VIRUS; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; UPREGULATION; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS PARTICLE; VIRUS REPLICATION; ZIKA VIRUS; GENETICS; HEK293 CELL LINE; METABOLISM;

FURIN; GTP-BINDING PROTEINS; HEK293 CELLS; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; INFLUENZA A VIRUS; MEASLES VIRUS; ZIKA VIRUS;

EID: 85065235566     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2019.04.063     Document Type: Article

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