RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy

Skeletal Muscle

Volumn 9, Issue 1, 2019, Pages

  Llano Diez, Monica ^a   Fury, Wen ^b   Okamoto, Haruka ^b   Bai, Yu ^b   Gromada, Jesper ^b   Larsson, Lars ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Critical illness myopathy; Gene expression; Intensive care unit; Mechanical loading; Muscle atrophy; RNA sequencing; Skeletal muscle transcriptomics

Indexed keywords

CHAPERONE; MUSCLE PROTEIN; TRANSCRIPTOME; UBIQUITIN PROTEIN LIGASE;

ADULT; AGED; APOPTOSIS; AUTOPHAGY; CRITICAL ILLNESS; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE DISEASE; MUSCLE WEAKNESS; SEQUENCE ANALYSIS; SKELETAL MUSCLE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; AUTOPHAGY; CRITICAL ILLNESS; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MUSCULAR DISEASES; SEQUENCE ANALYSIS, RNA; TRANSCRIPTOME; UBIQUITIN-PROTEIN LIGASES;

EID: 85064467917     PISSN: None     EISSN: 20445040     Source Type: Journal    
DOI: 10.1186/s13395-019-0194-1     Document Type: Article

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