Human microbiota in aging and infection: A review

Critical Reviews in Food Science and Nutrition

Volumn 59, Issue 4, 2019, Pages 537-545

  Stavropoulou, Elisavet ^a   Bezirtzoglou, Eugenia ^b  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Ageing; CYP cytochromes; infection; microbiota; nutrition; probiotics

Indexed keywords

DEVELOPING COUNTRIES; PROBIOTICS;

AGEING; DEVELOPED COUNTRIES; HEALTH ISSUES; HORMONAL CHANGES; HUMAN MICROBIOTA; INFECTION; MICROBIOTAS; PRO-INFLAMMATORY CYTOKINES;

NUTRITION;

HORMONE; PROBIOTIC AGENT;

ADAPTIVE IMMUNITY; AGED; AGING; AUTOIMMUNITY; DRUG THERAPY; HUMAN; IMMUNOLOGY; IMMUNOSENESCENCE; INFECTION; INFLAMMATION; INNATE IMMUNITY; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; TELOMERE;

ADAPTIVE IMMUNITY; AGED; AGING; AUTOIMMUNITY; DRUG THERAPY; HORMONES; HUMANS; IMMUNITY, INNATE; IMMUNOSENESCENCE; INFECTION; INFLAMMATION; MICROBIOTA; PROBIOTICS; TELOMERE;

EID: 85064227818     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2017.1379469     Document Type: Review

References (79)

1. Adlerberth, I., and A. E., Wold. 2009. Establishment of the gut microbiota in Western infants. Acta Paediatr 98:229–38. doi:10.1111/j.1651-2227.2008.01060.x.
2. Aitken, A. E., and E. T., Morgan. 2007. Gene-specific effects of inflammatory cytokines on cytochrome P4502C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab Disp 35 (9):1687–93. doi:10.1124/dmd.107.015511.
3. Aubert, G., and P. M., Landorp. 2008. Telomeres and aging. Physiol Rev 88 (2):557–9. doi:10.1152/physrev.00026.2007.
4. Balmer, S. E., and B. A., Wharton. 1989. Diet and faecal flora in the newborn: Breast milk and infant formula. Arch. Dis. Child 64:1672–7. doi:10.1136/adc.64.12.1672.
5. Baumgart, D. C., and A. U., Dignass. 2002. Intestinal barrier function. Curr Op Clin Nutr Metab Care 5 (6):685–94. doi:10.1097/00075197-200211000-00012.
6. Benno, Y., K., Sawada, and T., Mitsuoka. 1984. The intestinal microflora of infants: Composition of fecal flora in breast-fed and bottle-fed infants. Microbiol. Immunol 28:975–86. doi:10.1111/j.1348-0421.1984.tb00754.x.
7. Benedetti, M. S., and E. L., Baltes. 2003. Drug metabolism and disposition in children fund. Clin Pharmacol 17:281–99.
8. Bezirtzoglou, E., 2012. 450 regulating the intestinal microbiota and its probiotic profile. MEHD 23:18370–5.
9. Bezirtzoglou, E., M. B., Romond, and C., Romond. 1989. Modulation of C. perfringens intestinal colonization in infants delivered by cesarian section. Infection 17 (4):232–7. doi:10.1007/BF01639526.
10. Bezirtzoglou, E., and E., Stavropoulou. 2011. Immunology and probiotic impact of the newborn and young children intestinal microflora. Anaerobe 17 (6):369–74. doi:10.1016/j.anaerobe.2011.03.010.
11. Bezirtzoglou, E., A., Tsiotsias, and G. W., Welling. 2011. Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe 17 (6):478–83. doi:10.1016/j.anaerobe.2011.03.009.
12. Bezirtzoglou, E., and C., Romond. 1989. Effect of the feeding practices on the establishment of bacterial interactions in the intestine of the newborn delivered by cesarian section. J Perin Med 17:139–45.
13. Bezirtzoglou, E., 1997. The intestinal microflora during the first weeks of life. Anaerobe 3:173–7. doi:10.1006/anae.1997.0102.
14. Bezirtzoglou, E., V., Maipa, N., Chotoura, E., Apazidou, A., Tsiotsias, C., Voidarou, and D., Kostakis. 2006. Occurrence of Bifidobacerium in the intestine of newborns by fluorescence in situ hydridization. CIMID 29 (5–6):345–52.
15. Bezirtzoglou, E., V., Maipa, C., Voidarou, A., Tsiotsias, and M., Papapetropoulou. 2000. Foodborne intestinal pathogens. MEHD S2:96–104.
16. Bezirtzoglou, E., C., Voidarou, E., Papadaki, A., Tsiotsias, O., Kotsovolou, and M., Konstandi. 2008. Hormone therapy alters the composition of the vaginal microglora in ovarectomized rats. Microb Ecol 55 (4):751–9. doi:10.1007/s00248-007-9317-z.
17. Bergstrom, A., T. H., Skov, M. I., Bahl, H. M., Roager, L. B., Christensen, K. T., Ejlerskov, C., Molgaard, K. F., Michaelsen, and T. R., Licht. 2014. Establishment of the intestinal mictobiota during early life: A longitudinal, explorative study of a large cohort of Danish infants. Appl. Environ. Microbiol 80 (9):2889–900. doi:10.1128/AEM.00342-14.
18. Biagi, E., M., Candela, S., Turroni, P., Garahnani, C., Franceschi, and P., Brigidi. 2013. Ageing and gut microbes: Perspectives for health maintenance and longevity. Pharmacol Res 69:11–20. doi:10.1016/j.phrs.2012.10.005.
19. Butcher, S., H., Chahel, and J. M., Lord. 2000. Ageing and the neutrophil: No appetite for killing? Immunol 100:411–6. doi:10.1046/j.1365-2567.2000.00079.x.
20. Camerini, V., and I., Ishikawa. 2002. Extrathymic T cell development in mucosal tissue. Mucosal Immunol. Update 17(5):5–7.
21. Caruso, C., S., Buffa, G., Candore, G., Colonna-Romano, D., Dunn-Walters, D., Kipling, and G., Pawelec. 2009. Mechanisms of immunosenescence. Immun Ageing 6:10–15. doi:10.1186/1742-4933-6-10.
22. Chahal, H. S., and W. M., Drake. 2007. The endocrine system and aging. J Pathol 211:173–80. doi:10.1002/path.2110.
23. Chondrogianni, N., and E. S., Gonos. 2008. Proteasome activation as a novel anti-ageing strategy. IUBMB Life 60:651–5. doi:10.1002/iub.99.
24. Chondrogianni, N., I. P., Trougakos, D., Kletsas, Q. M., Chen, and E. M., Gonos. 2008. Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on the p53 and RB status. Aging Cell 7:717–32. doi:10.1111/j.1474-9726.2008.00425.x.
25. Chou, J. P., and R. B., Effros. 2013. Tcell replicative senescence in human aging. Curr Pharm Des 19 (9):1680–98.
26. Crossley, K. B., and P. K., Peterson. 1996. Infections in the elderly. Clin Inf Dis 22:209–15. doi:10.1093/clinids/22.2.209.
27. Culley, F. J., 2009. Natural killer cells in infection and inflammation of the lung. Immunol 128 (2):151–63. doi:10.1111/j.1365-2567.2009.03167.x.
28. Cusack, S., M. J., Claersson, and P. W., O'Toole. 2011. How beneficial is the use of probiotic supplements for the aging gut? Aging Health 7 (2):179–86. doi:10.2217/ahe.11.8.
29. Deeks, S. G., 2011. HIV infection, inflammation, immunosenescence and aging. Annu Rev Med 62:141–55. doi:10.1146/annurev-med-042909-093756.
30. Dempsey, L. A., 2014. Aging B cells repertoires. Nature Immunol 15:142–50.
31. Do Nascimento, M. P., K. H., Pinke, M., Penitenti, M. R., Ikoma, and V. S., Lara. 2015. Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans. Aging Clin Exp Res 27 (6):785–9. doi:10.1007/s40520-015-0344-1.
32. Duncan, S. H., and H. J., Flint. 2013. Probiotics and prebiotics in ageing populations. Maturitas 75 (1):44–50. doi:10.1016/j.maturitas.2013.02.004.
33. Dunn, A. J., and A. H., Swiergiel. 1998. The role of cytokines in infection-related behavior. Ann NY Acad Sci 1 (840):577–85. doi:10.1111/j.1749-6632.1998.tb09596.x.
34. Dunston, C. R., and H. R., Griffiths. 2010. The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens. Curr Exp Immunol 161 (3):407–416. doi:10.1111/j.1365-2249.2010.04213.x.
35. Fallani, M., D., Young, J., Scott, E., Norin, R., Adam, M., Aguilera, et al. 2010. Intestinal microbiota of 6-week-old infants across Europe: Geographic influence beyond delivery mode, breast-feeding, and antibiotics. J. Pediatr. Gastroenterol. Nutr 51:77–84. doi:10.1097/MPG.0b013e3181d1b11e.
36. Fanaro, S., R., Chierci, P., Guerrini, and V., Vigi. 2003. Intestinal microflora in early infancy: Composition and development. Acta Paediatr Suppl 91 (441):48–55.
37. Freitas, A. A., and J. P., De Magalhaes. 2011. A review and appraisal of the DNA damage theory of ageing. Mutation Res 728:12–22. doi:10.1016/j.mrrev.2011.05.001.
38. Frye, R. F., N. K., Zgheib, G. R., Matzke, D., Chaves-Gnecco, M., Rabinovitz, O. S., Shaikh, and R. A., Branch. 2006. Liver disease selectively modulates cytochrome P450–mediated metabolism. Clin Pharmacol Ther 80 (3):235–45. doi:10.1016/j.clpt.2006.05.006.
39. Gavazzi, G., and K. H., Krause. 2002. Ageing and infection. Lancet Inf Dis 2:659–66. doi:10.1016/S1473-3099(02)00437-1.
40. Ginaldi, L., M., De Martinis, A., D’ Ostillio, L., Marini, and M. F., Loreto. 1999. The immune system in the elderly. Immun Res 20 (3):117–26. doi:10.1007/BF02786468.
41. Goronzy, J. J., 2012. Immune ageing and autoimmunity. Cell Mol Life Sci 69 (10):1615–23. doi:10.1007/s00018-012-0970-0.
42. Harmsen, H. J., A. C., Wildeboer-Veloo, A. A., Wagendorp, J. G., Bindels, and G. W., Welling. 2000. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr 30:61–67. doi:10.1097/00005176-200001000-00019.
43. Hebuterne, X., 2003. Gut changes attributed to ageing: Effects on intestinal microflora. Curr Op Clin Nutr Metab Care 6 (1):49–54. doi:10.1097/00075197-200301000-00008.
44. Hickson, M., 2006. Malnutrition and ageing. Postgrad Med. J 82 (963):2–8. doi:10.1136/pgmj.2005.037564.
45. High, K. P., 2002. Infection in the ageing world. Lancet Inf Dis 2 (11), 655. doi:10.1016/S1473-3099(02)00434-6.
46. Humblot, C., M., Murkovic, L., Rigotter-Gois, M., Bensaada, A., Bouclet, C., Andrieux, J., Anba, and S., Rabot. 2007. β-glucuronidase in human intestinal microbiota is necessary for the colonic genotoxicity of the food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinolone in rats. Carcinogenesis 28 (11):2419–25. doi:10.1093/carcin/bgm170.
47. Johnson, T. N., M. S., Tanner, C. J., Taylor, and G. T., Tucker. 2001. Enterocytic CYP3A4 in a paediatric population: Developmental changes and the effect of celiac disease and cystic fibrosis. Brit J Clin Pharmacol 51:451–60. doi:10.1046/j.1365-2125.2001.01370.x.
48. Kim, S. H., P., Kaminker, and J., Campisi. 2002. Telomeres, ageing and cancer: In search of a happy ending. Oncogene 21:503–11. doi:10.1038/sj.onc.1205077.
49. Kinirons, M. T., and M. S., O'Mahony. 2003. Drug metabolism and ageing. Brit J Clin Pharmacol 57 (5):540–4. doi:10.1111/j.1365-2125.2004.02096.x.
50. Konstandi, M., C., Voidarou, E., Papadaki, A., Tsiotsias, O., Kotsovolou, E., Evangelou, and E., Bezirtzoglou. 2006. Stress modifies the vaginal flora in cyclic female rats. MEHD 18:161–9.
51. Krishna, D. R., and U., Klotz. 1994. Extrahepatic metabolism of drugs in humans. Clin Pharmacokin 26:144–60. doi:10.2165/00003088-199426020-00007.
52. Kyle, U. G., L., Genton, D., Hans, V. L., Karsegard, J. P., Michel, D. O., Slosman, and C., Pichard. 2001. Total body mass, fat mass, fat‐free mass, and skeletal muscle in older people: Cross‐sectional differences in 60‐year‐old persons. J Am Geriatr Soc 49 (12):1633–40. doi:10.1111/j.1532-5415.2001.49272.x.
53. Larbi, A., P., Rymkiewicz, A., Vasudev, I., Low, N. B., Shadan, S., Mustafah, S., Ayyadhury, and T., Fulop. 2013. The immune system in the elderly: A fair fight against diseases? Aging Health 9 (1):35–47. doi:10.2217/ahe.12.78.
54. Laursen, M. F., M. I., Bahl, K. F., Michaelsen, and T. R., Licht. 2017. First foods and gut microbes. Front Microbiol 8:356. doi:10.3389/fmicb.2017.00356.
55. Lynch, H. E., G. L., Goldberg, and G. D., Sempowski. 2009. Thymic involution and immune reconstitution. Trends Immunol 30 (7):366–73. doi:10.1016/j.it.2009.04.003.
56. Mackie, R. I., A., Sghir, and H. R., Gaskins. 1999. Developmental microbial ecology of the neonatal gastrointestinal tract. Am. J. Clin. Nutr 69:1035S–45S.
57. Marengoni, A., S., Angleman, R., Melis, F., Manglalasche, A., Karp, A., Garmen, B., Meinow, and L., Fratiglioni. 2011. Aging with multimorbidity: A systematic review of the literature. Ageing Res Rev. 10 (4):430–9. doi:10.1016/j.arr.2011.03.003.
58. Mata, L. J., and J. J., Urrutia. 1971. Intestinal colonization of breast fed children in a rural area of low socioeconomic level. Annal N Y Acad Sci 176:93–108. doi:10.1111/j.1749-6632.1971.tb34996.x.
59. Midtvedt, T., 2003. Microbial P450: Does it exist, and what can it mean? In: Monograph 16 complete volume, ed. J. P., Heidt, T., Midtvedt, V., Rusch, and V. D., Der Waalj, 51–56. Herborn Litterae, Herborn-Dill, Germany:Old Herborn University. Old Herborn University Seminar, 16.
60. Mullie, C., M. B., Romond, A., Yazourh, , Libersa, E., Bezirtzoglou, and C., Romond. 2002. Influence of stress on faecal carriage of C. perfringens. MEHD 14:118–21.
61. Nicolle, L. E., 2005. Complicated urinary tract infection in adults, AMMI, guideline paper. Can J Infect Dis Med Microbiol 16 (6):349–60.
62. Nikolich-Zugich, J., 2005. Tcell aging: Naïve but not young. J Exp Med 201 (6):837–40. doi:10.1084/jem.20050341.
63. Patel, P. J., S. K., Singh, S., Panaich, and L., Cardozo. 2014. The aging gut and the role of prebiotics, probiotics and synbiotics: A review. J Clin Ger Geriatr 5:3–6. doi:10.1016/j.jcgg.2013.08.003.
64. Plessas, S., L., Bosnea, A., Alexopoulos, and E., Bezirtzoglou. 2012. Potential effects of probiotics in cheese and yogurt production; A review. Eng Life Sci 12 (4):433–40. doi:10.1002/elsc.201100122.
65. Prior, T., and G., Baker. 2002. Interactions between the cytochrome P450 system and the second–generation antipsychotics. J Psych Neur 28:99–112.
66. Report: The 2012 ageing report. 2012. Underlying assumptions and projection methodologies. http://ec.europa.eu/economy_finance/publications/european_economy/2011/pdf/ee-2011-4.en.pdf.
67. Roubenoff, R., 1999. The pathophysiology of wasting in the elderly. J Nutr 129 (1S):256–9.
68. Sauerwein-Teissi, M., T. L., Lung, and F., Marx. 2002. Lack of antibody production following immunization in old age: Association with CD8(+)CD28(−)T clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 168 (11):5893–9. doi:10.4049/jimmunol.168.11.5893.
69. Segi, G., M., De Rui, S., Sarti, and E., Manzato. 2011. Polypharmacy in the elderly. Drugs Aging 28 (7):509–18. doi:10.2165/11592010-000000000-00000.
70. Shammas, M., 2011. Telomeres,lifestyle, cancer and aging. Curr Opin Nutr Metab Care 14 (1):28–34. doi:10.1097/MCO.0b013e32834121b1.
71. Simor, A. S., S. E., Bradley, L. J., Strausbaugh, K., Crossley, and L., Nicolle. 2002. Clostridiumdifficile in long-term–care Facilities for the elderly, SHEA position paper. Inf Control Hosp Epidemiol 23 (11):696–703. doi:10.1086/501997.
72. Stark, C. A., C., Edlund, S., Sjostedt, G., Kristensen, and C. E., Nord. 1993. Antimicrobial resistance in human oral and intestinal anaerobic microfloras. Antimicrob Agents Chem 37 (8):1665–9. doi:10.1128/AAC.37.8.1665.
73. Stavropoulou, E., and E., Bezirtzoglou. 2015. The mosaic of cytochromes expression from bacteria to man. Chem Sci Rev Lett 4 (14):459–73.
74. Vasto, S., and C., Caruso. 2004. Immunity & ageing: A new journal looking at ageing from an immunological point of view. Immun Ageing 25:406–10, 1:1.
75. Wauthier, V., R. K., Verbeeck, and P. B., Calderon. 2017. The effect of ageing on cytochrome P450 enzymes: Consequences for drug biotrasformation in the elderly. Curr Med Chem 14:745–57. doi:10.2174/092986707780090981.
76. WHO: 10 facts on ageing and the life course. 2012. http://www.who.int/features/factfiles/ageing_facts/en/index.html.
77. Wollscheid-Lengeling, E., and K., Kerksiek. 2009. Infectious diseases and aging. www.infection-research.de.
78. Yoshikawa, T. T., and D. C., Norman. 2001. Infectious disease in the aging: A clinical handbook. Totowa, NJ: Humana Press.
79. Zhang, L., and C. C., Wang. 2014. Inflammatory response of macrophages in infection. Hepatobil Pancreat Dis Int 13 (2):138–52. doi:10.1016/S1499-3872(14)60024-2.