-
1
-
-
85017469832
-
Systemic sclerosis
-
Denton CP, Khanna D. Systemic sclerosis. Lancet 2017;390:1685-99.
-
(2017)
Lancet
, vol.390
, pp. 1685-1699
-
-
Denton, C.P.1
Khanna, D.2
-
2
-
-
85011034656
-
Current perspectives on the immunopathogenesis of systemic sclerosis
-
Fuschiotti P. Current perspectives on the immunopathogenesis of systemic sclerosis. Immunotargets Ther 2016;5:21-35.
-
(2016)
Immunotargets Ther
, vol.5
, pp. 21-35
-
-
Fuschiotti, P.1
-
3
-
-
84886777196
-
2013 classification criteria for systemic sclerosis: An American College of Rheumatology/European League against Rheumatism collaborative initiative
-
van den Hoogen F, Khanna D, Fransen J et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 2013;65:2737-47.
-
(2013)
Arthritis Rheum
, vol.65
, pp. 2737-2747
-
-
Van Den Hoogen, F.1
Khanna, D.2
Fransen, J.3
-
4
-
-
56149118477
-
Systemic sclerosis/scleroderma: A treatable multisystem disease
-
Hinchcliff M, Varga J. Systemic sclerosis/scleroderma: a treatable multisystem disease. Am Fam Physician 2008;78:961-8.
-
(2008)
Am Fam Physician
, vol.78
, pp. 961-968
-
-
Hinchcliff, M.1
Varga, J.2
-
5
-
-
77957286169
-
Causes and risk factors for death in systemic sclerosis: A study from the EULAR Scleroderma Trials and Research (EUSTAR) database
-
Tyndall AJ, Bannert B, Vonk M et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 2010;69:1809-15.
-
(2010)
Ann Rheum Dis
, vol.69
, pp. 1809-1815
-
-
Tyndall, A.J.1
Bannert, B.2
Vonk, M.3
-
6
-
-
77950261786
-
Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: A retrospective cohort study
-
Nihtyanova SI, Tang EC, Coghlan JG et al. Improved survival in systemic sclerosis is associated with better ascertainment of internal organ disease: a retrospective cohort study. QJM 2010;103:109-15.
-
(2010)
QJM
, vol.103
, pp. 109-115
-
-
Nihtyanova, S.I.1
Tang, E.C.2
Coghlan, J.G.3
-
7
-
-
74449085877
-
Determinants of morbidity and mortality of systemic sclerosis in Canada
-
Al-Dhaher FF, Pope JE, Ouimet JM. Determinants of morbidity and mortality of systemic sclerosis in Canada. Semin Arthritis Rheum 2010;39:269-77.
-
(2010)
Semin Arthritis Rheum
, vol.39
, pp. 269-277
-
-
Al-Dhaher, F.F.1
Pope, J.E.2
Ouimet, J.M.3
-
9
-
-
67649671982
-
Pulmonary complications: One of the most challenging complications of systemic sclerosis
-
Wells AU, Steen V, Valentini G. Pulmonary complications: one of the most challenging complications of systemic sclerosis. Rheumatology 2009;48(Suppl 3):iii40-4.
-
(2009)
Rheumatology
, vol.48
, pp. iii40-iii44
-
-
Wells, A.U.1
Steen, V.2
Valentini, G.3
-
11
-
-
84937976482
-
Management of systemic-sclerosisassociated interstitial lung disease
-
Silver KC, Silver RM. Management of systemic-sclerosisassociated interstitial lung disease. Rheum Dis Clin North Am 2015;41:439-57.
-
(2015)
Rheum Dis Clin North Am
, vol.41
, pp. 439-457
-
-
Silver, K.C.1
Silver, R.M.2
-
12
-
-
84940665947
-
Interstitial lung disease in systemic sclerosis: Where do we stand?
-
Cappelli S, Bellando Randone S, Camiciottoli G et al. Interstitial lung disease in systemic sclerosis: where do we stand? Eur Respir Rev 2015;24:411-9.
-
(2015)
Eur Respir Rev
, vol.24
, pp. 411-419
-
-
Cappelli, S.1
Bellando Randone, S.2
Camiciottoli, G.3
-
13
-
-
47549101707
-
Exercise-induced pulmonary arterial hypertension in patients with systemic sclerosis
-
Steen V, Chou M, Shanmugam V et al. Exercise-induced pulmonary arterial hypertension in patients with systemic sclerosis. Chest 2008;134:146-51.
-
(2008)
Chest
, vol.134
, pp. 146-151
-
-
Steen, V.1
Chou, M.2
Shanmugam, V.3
-
14
-
-
84946568792
-
Connective tissue disease-associated interstitial lung diseases (CTDILD)- report from OMERACT CTD-ILD Working Group
-
Khanna D, Mittoo S, Aggarwal R et al. Connective tissue disease-associated interstitial lung diseases (CTDILD)- report from OMERACT CTD-ILD Working Group. J Rheumatol 2015;42:2168-71.
-
(2015)
J Rheumatol
, vol.42
, pp. 2168-2171
-
-
Khanna, D.1
Mittoo, S.2
Aggarwal, R.3
-
15
-
-
85024859154
-
Short-term pulmonary function trends are predictive of mortality in interstitial lung disease associated with systemic sclerosis
-
Goh NS, Hoyles RK, Denton CP et al. Short-term pulmonary function trends are predictive of mortality in interstitial lung disease associated with systemic sclerosis. Arthritis Rheumatol 2017;69:1670-8.
-
(2017)
Arthritis Rheumatol
, vol.69
, pp. 1670-1678
-
-
Goh, N.S.1
Hoyles, R.K.2
Denton, C.P.3
-
16
-
-
84960345465
-
Recent treatments of interstitial lung disease with systemic sclerosis
-
Yasuoka H. Recent treatments of interstitial lung disease with systemic sclerosis. Clin Med Insights Circ Respir Pulm Med 2015;9(Suppl 1):97-110.
-
(2015)
Clin Med Insights Circ Respir Pulm Med
, vol.9
, pp. 97-110
-
-
Yasuoka, H.1
-
17
-
-
85064133906
-
-
Baxter Healthcare. Prescribing Information (25 May 2018, date last accessed)
-
Baxter Healthcare. Cyclophosphamide. Prescribing Information. 2013 https://www.accessdata.fda.gov/drugsatfda-docs/label/2013/012141s090,012142s112lbl.pdf (25 May 2018, date last accessed).
-
(2013)
Cyclophosphamide
-
-
-
18
-
-
84929192281
-
Safety and effectiveness of mycophenolate in systemic sclerosis. A systematic review
-
Omair MA, Alahmadi A, Johnson SR. Safety and effectiveness of mycophenolate in systemic sclerosis. A systematic review. PLoS One 2015;10:e0124205.
-
(2015)
PLoS One
, vol.10
, pp. e0124205
-
-
Omair, M.A.1
Alahmadi, A.2
Johnson, S.R.3
-
19
-
-
85041518443
-
Efficacy of mycophenolate mofetil and oral cyclophosphamide on skin thickness: Post-hoc analyses from the Scleroderma Lung Study i and II
-
Namas R, Tashkin DP, Furst DE et al. Efficacy of mycophenolate mofetil and oral cyclophosphamide on skin thickness: post-hoc analyses from the Scleroderma Lung Study I and II. Arthritis Care Res 2018;70:439-44.
-
(2018)
Arthritis Care Res
, vol.70
, pp. 439-444
-
-
Namas, R.1
Tashkin, D.P.2
Furst, D.E.3
-
20
-
-
79955066247
-
Cyclophosphamide as disease-modifying therapy for scleroderma: Pros and cons
-
Chighizola C, Ong VH, Denton CP. Cyclophosphamide as disease-modifying therapy for scleroderma: pros and cons. Int J Clin Rheumatol 2011;6:219-30.
-
(2011)
Int J Clin Rheumatol
, vol.6
, pp. 219-230
-
-
Chighizola, C.1
Ong, V.H.2
Denton, C.P.3
-
21
-
-
65549124538
-
Current concepts in disease-modifying therapy for systemic sclerosis-associated interstitial lung disease: Lessons from clinical trials
-
Au K, Khanna D, Clements PJ, Furst DE, Tashkin DP. Current concepts in disease-modifying therapy for systemic sclerosis-associated interstitial lung disease: lessons from clinical trials. Curr Rheumatol Rep 2009;11:111-9.
-
(2009)
Curr Rheumatol Rep
, vol.11
, pp. 111-119
-
-
Au, K.1
Khanna, D.2
Clements, P.J.3
Furst, D.E.4
Tashkin, D.P.5
-
22
-
-
85052220883
-
Managing systemic sclerosis-related interstitial lung disease in the modern treatment era
-
Volkmann ER, Chung A, Tashkin DP. Managing systemic sclerosis-related interstitial lung disease in the modern treatment era. J Scleroderma Relat Disord 2017;2:72-83.
-
(2017)
J Scleroderma Relat Disord
, vol.2
, pp. 72-83
-
-
Volkmann, E.R.1
Chung, A.2
Tashkin, D.P.3
-
23
-
-
33745227399
-
Cyclophosphamide versus placebo in scleroderma lung disease
-
Tashkin DP, Elashoff R, Clements PJ et al. Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med 2006;354:2655-66.
-
(2006)
N Engl J Med
, vol.354
, pp. 2655-2666
-
-
Tashkin, D.P.1
Elashoff, R.2
Clements, P.J.3
-
24
-
-
36249001195
-
Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease
-
Tashkin DP, Elashoff R, Clements PJ et al. Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung disease. Am J Respir Crit Care Med 2007;176:1026-34.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 1026-1034
-
-
Tashkin, D.P.1
Elashoff, R.2
Clements, P.J.3
-
25
-
-
33845643063
-
A multicenter, prospective, randomized, double-blind, placebocontrolled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma
-
Hoyles RK, Ellis RW, Wellsbury J et al. A multicenter, prospective, randomized, double-blind, placebocontrolled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma. Arthritis Rheum 2006;54:3962-70.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3962-3970
-
-
Hoyles, R.K.1
Ellis, R.W.2
Wellsbury, J.3
-
26
-
-
84995487524
-
Update of EULAR recommendations for the treatment of systemic sclerosis
-
Kowal-Bielecka O, Fransen J, Avouac J et al. Update of EULAR recommendations for the treatment of systemic sclerosis. Ann Rheum Dis 2017;76:1327-39.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 1327-1339
-
-
Kowal-Bielecka, O.1
Fransen, J.2
Avouac, J.3
-
27
-
-
84989846173
-
Mycophenolate mofetil versus oral cyclophosphamide in sclerodermarelated interstitial lung disease (SLS II): A randomised controlled, double-blind, parallel group trial
-
Tashkin DP, Roth MD, Clements PJ et al. Mycophenolate mofetil versus oral cyclophosphamide in sclerodermarelated interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. Lancet Respir Med 2016;4:708-19.
-
(2016)
Lancet Respir Med
, vol.4
, pp. 708-719
-
-
Tashkin, D.P.1
Roth, M.D.2
Clements, P.J.3
-
28
-
-
56549120329
-
Enteric-coated mycophenolate sodium: A review of its use in the prevention of renal transplant rejection
-
Sanford M, Keating GM. Enteric-coated mycophenolate sodium: a review of its use in the prevention of renal transplant rejection. Drugs 2008;68:2505-33.
-
(2008)
Drugs
, vol.68
, pp. 2505-2533
-
-
Sanford, M.1
Keating, G.M.2
-
29
-
-
0037397004
-
Azathioprine: Old drug, new actions
-
Maltzman JS, Koretzky GA. Azathioprine: old drug, new actions. J Clin Invest 2003;111:1122-4.
-
(2003)
J Clin Invest
, vol.111
, pp. 1122-1124
-
-
Maltzman, J.S.1
Koretzky, G.A.2
-
30
-
-
33644870428
-
A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis
-
Nadashkevich O, Davis P, Fritzler M, Kovalenko W. A randomized unblinded trial of cyclophosphamide versus azathioprine in the treatment of systemic sclerosis. Clin Rheumatol 2006;25:205-12.
-
(2006)
Clin Rheumatol
, vol.25
, pp. 205-212
-
-
Nadashkevich, O.1
Davis, P.2
Fritzler, M.3
Kovalenko, W.4
-
32
-
-
0036845156
-
Predictors and outcomes of scleroderma renal crisis: The high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial
-
DeMarco PJ, Weisman MH, Seibold JR et al. Predictors and outcomes of scleroderma renal crisis: the high-dose versus low-dose D-penicillamine in early diffuse systemic sclerosis trial. Arthritis Rheum 2002;46:2983-9.
-
(2002)
Arthritis Rheum
, vol.46
, pp. 2983-2989
-
-
DeMarco, P.J.1
Weisman, M.H.2
Seibold, J.R.3
-
33
-
-
0035674701
-
Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases
-
Reichenberger F, Schauer J, Kellner K et al. Different expression of endothelin in the bronchoalveolar lavage in patients with pulmonary diseases. Lung 2001;179:163-74.
-
(2001)
Lung
, vol.179
, pp. 163-174
-
-
Reichenberger, F.1
Schauer, J.2
Kellner, K.3
-
34
-
-
77954222367
-
Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis
-
Seibold JR, Denton CP, Furst DE et al. Randomized, prospective, placebo-controlled trial of bosentan in interstitial lung disease secondary to systemic sclerosis. Arthritis Rheum 2010;62:2101-8.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2101-2108
-
-
Seibold, J.R.1
Denton, C.P.2
Furst, D.E.3
-
35
-
-
33847345109
-
Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2
-
Ferguson GD, Jensen-Pergakes K, Wilkey C et al. Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2. J Clin Immunol 2007;27:210-20.
-
(2007)
J Clin Immunol
, vol.27
, pp. 210-220
-
-
Ferguson, G.D.1
Jensen-Pergakes, K.2
Wilkey, C.3
-
37
-
-
85063245959
-
A phase 2 study of pomalidomide (CC-4047) to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics and effectiveness in subjects with systemic sclerosis with interstitial lung disease
-
abstract 823
-
Hsu V, Denton CP, Domsic RT et al. A phase 2 study of pomalidomide (CC-4047) to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics and effectiveness in subjects with systemic sclerosis with interstitial lung disease. Arthritis Rheumatol 2016;68(Suppl 10):abstract 823.
-
(2016)
Arthritis Rheumatol
, vol.68
-
-
Hsu, V.1
Denton, C.P.2
Domsic, R.T.3
-
38
-
-
75749148783
-
CD20-depleting therapy in autoimmune diseases: From basic research to the clinic
-
Perosa F, Prete M, Racanelli V, Dammacco F. CD20-depleting therapy in autoimmune diseases: from basic research to the clinic. J Intern Med 2010;267:260-77.
-
(2010)
J Intern Med
, vol.267
, pp. 260-277
-
-
Perosa, F.1
Prete, M.2
Racanelli, V.3
Dammacco, F.4
-
39
-
-
77950443096
-
Experience with rituximab in scleroderma: Results from a 1-year, proof-of-principle study
-
Daoussis D, Liossis SN, Tsamandas AC et al. Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study. Rheumatology 2010;49:271-80.
-
(2010)
Rheumatology
, vol.49
, pp. 271-280
-
-
Daoussis, D.1
Liossis, S.N.2
Tsamandas, A.C.3
-
40
-
-
85025445476
-
Myeloablative autologous transplantation of CD34+-selected hematopoietic stem cells (HSCT) vs monthly intravenous cyclophosphamide (CYC) for severe scleroderma with internal organ involvement: Outcomes of a randomized North American clinical trial
-
abstract 6L
-
Sullivan K, Keyes-Elstein L, McSweeney P et al. Myeloablative autologous transplantation of CD34+-selected hematopoietic stem cells (HSCT) vs monthly intravenous cyclophosphamide (CYC) for severe scleroderma with internal organ involvement: outcomes of a randomized North American clinical trial. Arthritis Rheumatol 2016;68(Suppl S10):abstract 6L.
-
(2016)
Arthritis Rheumatol
, vol.68
-
-
Sullivan, K.1
Keyes-Elstein, L.2
McSweeney, P.3
-
41
-
-
84902844800
-
Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: A randomized clinical trial
-
van Laar JM, Farge D, Sont JK et al. Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial. JAMA 2014;311:2490-8.
-
(2014)
JAMA
, vol.311
, pp. 2490-2498
-
-
Van Laar, J.M.1
Farge, D.2
Sont, J.K.3
-
42
-
-
84983540216
-
Autologous hematopoietic stem cell transplantation has better outcomes than conventional therapies in patients with rapidly progressive systemic sclerosis
-
Del Papa N, Onida F, Zaccara E et al. Autologous hematopoietic stem cell transplantation has better outcomes than conventional therapies in patients with rapidly progressive systemic sclerosis. Bone Marrow Transplant 2017;52:53-8.
-
(2017)
Bone Marrow Transplant
, vol.52
, pp. 53-58
-
-
Del Papa, N.1
Onida, F.2
Zaccara, E.3
-
43
-
-
85013743198
-
Oxygen therapy for interstitial lung disease: A systematic review
-
Bell EC, Cox NS, Goh N et al. Oxygen therapy for interstitial lung disease: a systematic review. Eur Respir Rev 2017;26:160080.
-
(2017)
Eur Respir Rev
, vol.26
, pp. 160080
-
-
Bell, E.C.1
Cox, N.S.2
Goh, N.3
-
44
-
-
60249091063
-
Pulmonary rehabilitation in interstitial lung disease: Benefits and predictors of response
-
Ferreira A, Garvey C, Connors GL et al. Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response. Chest 2009;135:442-7.
-
(2009)
Chest
, vol.135
, pp. 442-447
-
-
Ferreira, A.1
Garvey, C.2
Connors, G.L.3
-
46
-
-
79960192733
-
The use of opioids for dyspnea in advanced disease
-
Gallagher R. The use of opioids for dyspnea in advanced disease. Can Med Assoc J 2011;183:1170.
-
(2011)
Can Med Assoc J
, vol.183
, pp. 1170
-
-
Gallagher, R.1
-
47
-
-
84989339218
-
Lung transplant outcomes in systemic sclerosis with significant esophageal dysfunction. A comprehensive single-center experience
-
Miele CH, Schwab K, Saggar R et al. Lung transplant outcomes in systemic sclerosis with significant esophageal dysfunction. A comprehensive single-center experience. Ann Am Thorac Soc 2016;13:793-802.
-
(2016)
Ann Am Thorac Soc
, vol.13
, pp. 793-802
-
-
Miele, C.H.1
Schwab, K.2
Saggar, R.3
-
49
-
-
85027580376
-
Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): Study protocol for a randomised controlled trial
-
Saunders P, Tsipouri V, Keir GJ et al. Rituximab versus cyclophosphamide for the treatment of connective tissue disease-associated interstitial lung disease (RECITAL): study protocol for a randomised controlled trial. Trials 2017;18:275.
-
(2017)
Trials
, vol.18
, pp. 275
-
-
Saunders, P.1
Tsipouri, V.2
Keir, G.J.3
-
51
-
-
0035253672
-
Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression
-
Assoian RK, Schwartz MA. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr Opin Genet Dev 2001;11:48-53.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 48-53
-
-
Assoian, R.K.1
Schwartz, M.A.2
-
53
-
-
0036488589
-
Role of integrins in cell invasion and migration
-
Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91-100.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 91-100
-
-
Hood, J.D.1
Cheresh, D.A.2
-
54
-
-
33644848599
-
ILK, PINCH and parvin: The tIPP of integrin signalling
-
Legate KR, Montanez E, Kudlacek O, Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 2006;7:20-31.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 20-31
-
-
Legate, K.R.1
Montanez, E.2
Kudlacek, O.3
Fassler, R.4
-
55
-
-
36248976197
-
Alpha-v integrins as therapeutic targets in oncology
-
Nemeth JA, Nakada MT, Trikha M et al. Alpha-v integrins as therapeutic targets in oncology. Cancer Invest 2007;25:632-46.
-
(2007)
Cancer Invest
, vol.25
, pp. 632-646
-
-
Nemeth, J.A.1
Nakada, M.T.2
Trikha, M.3
-
56
-
-
84855259695
-
Blocking TGFb via inhibition of the avb6 integrin: A possible therapy for systemic sclerosis interstitial lung disease
-
Katsumoto TR, Violette SM, Sheppard D. Blocking TGFb via inhibition of the avb6 integrin: a possible therapy for systemic sclerosis interstitial lung disease. Int J Rheumatol 2011;2011:208219.
-
(2011)
Int J Rheumatol
, vol.2011
, pp. 208219
-
-
Katsumoto, T.R.1
Violette, S.M.2
Sheppard, D.3
-
57
-
-
38049002642
-
Partial inhibition of integrin avb6 prevents pulmonary fibrosis without exacerbating inflammation
-
Horan GS, Wood S, Ona V et al. Partial inhibition of integrin avb6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 2008;177:56-65.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 56-65
-
-
Horan, G.S.1
Wood, S.2
Ona, V.3
-
58
-
-
1642329882
-
Increased expression levels of integrin avb5 on scleroderma fibroblasts
-
Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K. Increased expression levels of integrin avb5 on scleroderma fibroblasts. Am J Pathol 2004;164:1275-92.
-
(2004)
Am J Pathol
, vol.164
, pp. 1275-1292
-
-
Asano, Y.1
Ihn, H.2
Yamane, K.3
Kubo, M.4
Tamaki, K.5
-
59
-
-
28244449083
-
Increased expression of integrin avb3 contributes to the establishment of autocrine TGF-b signaling in scleroderma fibroblasts
-
Asano Y, Ihn H, Yamane K et al. Increased expression of integrin avb3 contributes to the establishment of autocrine TGF-b signaling in scleroderma fibroblasts. J Immunol 2005;175:7708-18.
-
(2005)
J Immunol
, vol.175
, pp. 7708-7718
-
-
Asano, Y.1
Ihn, H.2
Yamane, K.3
-
60
-
-
84896402978
-
Safety, tolerability, and pharmacokinetics of the novel avintegrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses
-
Uhl W, Zuhlsdorf M, Koernicke T, Forssmann U, Kovar A. Safety, tolerability, and pharmacokinetics of the novel avintegrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses. Invest New Drugs 2014;32:347-54.
-
(2014)
Invest New Drugs
, vol.32
, pp. 347-354
-
-
Uhl, W.1
Zuhlsdorf, M.2
Koernicke, T.3
Forssmann, U.4
Kovar, A.5
-
61
-
-
84896402680
-
A multicenter phase 1 study of EMD 525797 (DI17E6), a novel humanized monoclonal antibody targeting av integrins, in progressive castration-resistant prostate cancer with bone metastases after chemotherapy
-
Wirth M, Heidenreich A, Gschwend JE et al. A multicenter phase 1 study of EMD 525797 (DI17E6), a novel humanized monoclonal antibody targeting av integrins, in progressive castration-resistant prostate cancer with bone metastases after chemotherapy. Eur Urol 2014;65:897-904.
-
(2014)
Eur Urol
, vol.65
, pp. 897-904
-
-
Wirth, M.1
Heidenreich, A.2
Gschwend, J.E.3
-
62
-
-
84977085543
-
Differential effect on bone lesions of targeting integrins: Randomized phase II trial of abituzumab in patients with metastatic castrationresistant prostate cancer
-
Hussain M, Le Moulec S, Gimmi C et al. Differential effect on bone lesions of targeting integrins: randomized phase II trial of abituzumab in patients with metastatic castrationresistant prostate cancer. Clin Cancer Res 2016;22:3192-200.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 3192-3200
-
-
Hussain, M.1
Le Moulec, S.2
Gimmi, C.3
-
63
-
-
84922561479
-
Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: The randomised phase I/II POSEIDON trial
-
Elez E, Kocakova I, Hohler T et al. Abituzumab combined with cetuximab plus irinotecan versus cetuximab plus irinotecan alone for patients with KRAS wild-type metastatic colorectal cancer: the randomised phase I/II POSEIDON trial. Ann Oncol 2015;26:132-40.
-
(2015)
Ann Oncol
, vol.26
, pp. 132-140
-
-
Elez, E.1
Kocakova, I.2
Hohler, T.3
-
64
-
-
84946758547
-
Modulatory effects of bortezomib on host immune cell functions
-
Pellom ST Jr, Dudimah DF, Thounaojam MC, Sayers TJ, Shanker A. Modulatory effects of bortezomib on host immune cell functions. Immunotherapy 2015;7:1011-22.
-
(2015)
Immunotherapy
, vol.7
, pp. 1011-1022
-
-
Pellom, S.T.1
Dudimah, D.F.2
Thounaojam, M.C.3
Sayers, T.J.4
Shanker, A.5
-
65
-
-
84856049288
-
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-b1 signalling
-
Mutlu GM, Budinger GR, Wu M et al. Proteasomal inhibition after injury prevents fibrosis by modulating TGF-b1 signalling. Thorax 2012;67:139-46.
-
(2012)
Thorax
, vol.67
, pp. 139-146
-
-
Mutlu, G.M.1
Budinger, G.R.2
Wu, M.3
-
66
-
-
84655175061
-
Understanding fibrosis in systemic sclerosis: Shifting paradigms, emerging opportunities
-
Bhattacharyya S, Wei J, Varga J. Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol 2011;8:42-54.
-
(2011)
Nat Rev Rheumatol
, vol.8
, pp. 42-54
-
-
Bhattacharyya, S.1
Wei, J.2
Varga, J.3
-
68
-
-
70350539686
-
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
-
Bogatkevich GS, Ludwicka-Bradley A, Silver RM. Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. Arthritis Rheum 2009;60:3455-64.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 3455-3464
-
-
Bogatkevich, G.S.1
Ludwicka-Bradley, A.2
Silver, R.M.3
-
69
-
-
79955558187
-
Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease
-
Bogatkevich GS, Ludwicka-Bradley A, Nietert PJ et al. Antiinflammatory and antifibrotic effects of the oral direct thrombin inhibitor dabigatran etexilate in a murine model of interstitial lung disease. Arthritis Rheum 2011;63:1416-25.
-
(2011)
Arthritis Rheum
, vol.63
, pp. 1416-1425
-
-
Bogatkevich, G.S.1
Ludwicka-Bradley, A.2
Nietert, P.J.3
-
70
-
-
84928995543
-
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
-
Wollin L, Wex E, Pautsch A et al. Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis. Eur Respir J 2015;45:1434-45.
-
(2015)
Eur Respir J
, vol.45
, pp. 1434-1445
-
-
Wollin, L.1
Wex, E.2
Pautsch, A.3
-
71
-
-
85031689905
-
Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS)
-
Distler O, Brown KK, Distler JHW et al. Design of a randomised, placebo-controlled clinical trial of nintedanib in patients with systemic sclerosis-associated interstitial lung disease (SENSCIS). Clin Exp Rheumatol 2017;35(Suppl 106):75-81.
-
(2017)
Clin Exp Rheumatol
, vol.35
, pp. 75-81
-
-
Distler, O.1
Brown, K.K.2
Distler, J.H.W.3
-
72
-
-
84984998138
-
An open-label, phase II study of the safety and tolerability of pirfenidone in patients with scleroderma-associated interstitial lung disease: The LOTUSS trial
-
Khanna D, Albera C, Fischer A et al. An open-label, phase II study of the safety and tolerability of pirfenidone in patients with scleroderma-associated interstitial lung disease: the LOTUSS trial. J Rheumatol 2016;43:1672-9.
-
(2016)
J Rheumatol
, vol.43
, pp. 1672-1679
-
-
Khanna, D.1
Albera, C.2
Fischer, A.3
-
73
-
-
84985964590
-
Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis
-
Sakkas LI. Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis. Drug Des Devel Ther 2016;10:2723-8.
-
(2016)
Drug des Devel Ther
, vol.10
, pp. 2723-2728
-
-
Sakkas, L.I.1
-
74
-
-
85019178369
-
IL-13 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies
-
Passalacqua G, Mincarini M, Colombo D et al. IL-13 and idiopathic pulmonary fibrosis: possible links and new therapeutic strategies. Pulm Pharmacol Ther 2017;45:95-100.
-
(2017)
Pulm Pharmacol Ther
, vol.45
, pp. 95-100
-
-
Passalacqua, G.1
Mincarini, M.2
Colombo, D.3
-
75
-
-
84903780105
-
InterMune and Boehringer blaze trails for idiopathic pulmonary fibrosis drugs
-
Kingwell K. InterMune and Boehringer blaze trails for idiopathic pulmonary fibrosis drugs. Nat Rev Drug Discov 2014;13:483-4.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 483-484
-
-
Kingwell, K.1
-
76
-
-
85031028845
-
Interstitial lung disease points to consider for clinical trials in systemic sclerosis
-
Khanna D, Seibold J, Goldin J et al. Interstitial lung disease points to consider for clinical trials in systemic sclerosis. Rheumatology 2017;56(Suppl-5):v27-32.
-
(2017)
Rheumatology
, vol.56
, pp. v27-32
-
-
Khanna, D.1
Seibold, J.2
Goldin, J.3
-
77
-
-
84997683928
-
An autotaxin/lysophosphatidic acid/interleukin-6 amplification loop drives scleroderma fibrosis
-
Castelino FV, Bain G, Pace VA et al. An autotaxin/lysophosphatidic acid/interleukin-6 amplification loop drives scleroderma fibrosis. Arthritis Rheumatol 2016;68:2964-74.
-
(2016)
Arthritis Rheumatol
, vol.68
, pp. 2964-2974
-
-
Castelino, F.V.1
Bain, G.2
Pace, V.A.3
-
78
-
-
85019239756
-
Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-b production
-
Du J, Paz K, Flynn R et al. Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-b production. Blood 2017;129:2570-80.
-
(2017)
Blood
, vol.129
, pp. 2570-2580
-
-
Du, J.1
Paz, K.2
Flynn, R.3
-
79
-
-
77950332103
-
Rituximab: Mechanism of action
-
Weiner GJ. Rituximab: mechanism of action. Semin Hematol 2010;47:115-23.
-
(2010)
Semin Hematol
, vol.47
, pp. 115-123
-
-
Weiner, G.J.1
|