|
|
Volumn 32, Issue 2, 2014, Pages 347-354
|
|
Safety, tolerability, and pharmacokinetics of the novel αv-integrin antibody EMD 525797 (DI17E6) in healthy subjects after ascending single intravenous doses
a
a
MERCK KGAA
(Germany)
|
|
Author keywords
EMD 525797 (DI17E6); v integrins overexpression
|
|
Indexed keywords
C REACTIVE PROTEIN;
CD51 ANTIGEN;
COMPLEMENT FACTOR;
CREATINE KINASE;
CREATININE;
DI 17E6;
EMD 525797;
GLUCOSE;
GLUTAMATE DEHYDROGENASE;
HIGH DENSITY LIPOPROTEIN;
INTERLEUKIN 8;
MAGNESIUM;
MONOCLONAL ANTIBODY;
PLACEBO;
TRIACYLGLYCEROL;
TUMOR NECROSIS FACTOR ALPHA;
UNCLASSIFIED DRUG;
ABDOMINAL PAIN;
ABNORMAL LABORATORY RESULT;
ADULT;
AREA UNDER THE CURVE;
ARTICLE;
ASTHENIA;
BACKACHE;
CHILL;
COHORT ANALYSIS;
CONTROLLED STUDY;
CREATINE KINASE BLOOD LEVEL;
CREATININE CLEARANCE;
DECREASED APPETITE;
DIARRHEA;
DISTRIBUTION VOLUME;
DOSE RESPONSE;
DOUBLE BLIND PROCEDURE;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DOSE ESCALATION;
DRUG DOSE INCREASE;
DRUG ELIMINATION;
DRUG FATALITY;
DRUG HALF LIFE;
DRUG INFUSION;
DRUG SAFETY;
DRUG TARGETING;
DRUG TOLERABILITY;
EYE IRRITATION;
FIRST IN HUMAN STUDY;
FLATULENCE;
GASTROINTESTINAL SYMPTOM;
GLUCOSE BLOOD LEVEL;
HEADACHE;
HEMATOMA;
HOT FLUSH;
HUMAN;
HUMAN EXPERIMENT;
HYPERHIDROSIS;
HYPESTHESIA;
INFECTION;
INFESTATION;
INFUSION RELATED REACTION;
INJECTION SITE ERYTHEMA;
INJECTION SITE PAIN;
INJECTION SITE SWELLING;
LEUKOCYTE COUNT;
LIMB PAIN;
LIPOPROTEIN BLOOD LEVEL;
LYMPHOCYTE COUNT;
MALE;
MAXIMUM PLASMA CONCENTRATION;
NAUSEA;
NEUROLOGIC DISEASE;
NEUTROPHIL COUNT;
NORMAL HUMAN;
OUTCOME ASSESSMENT;
PAPULAR RASH;
PHARMACODYNAMICS;
PHASE 1 CLINICAL TRIAL;
PRIORITY JOURNAL;
PROTEIN BLOOD LEVEL;
RANDOMIZED CONTROLLED TRIAL;
RHINITIS;
RHINOPHARYNGITIS;
SINGLE DRUG DOSE;
SKIN IRRITATION;
SORE THROAT;
THORAX PAIN;
TOOTH PAIN;
TREATMENT DURATION;
TRIACYLGLYCEROL BLOOD LEVEL;
UNSPECIFIED SIDE EFFECT;
UPPER ABDOMINAL PAIN;
VOMITING;
ADOLESCENT;
ADULT;
ANTIBODIES, MONOCLONAL, HUMANIZED;
ANTINEOPLASTIC AGENTS;
DOUBLE-BLIND METHOD;
HEALTHY VOLUNTEERS;
HUMANS;
INFUSIONS, INTRAVENOUS;
INTEGRIN ALPHAV;
MALE;
MIDDLE AGED;
YOUNG ADULT;
|
|
EID: 84896402978
PISSN: 01676997
EISSN: 15730646
Source Type: Journal
DOI: 10.1007/s10637-013-0038-5 Document Type: Article |
|
Times cited : (23)
|
|
References (12)
|
