Angiotensin Receptor Neprilysin Inhibitor for Functional Mitral Regurgitation: PRIME Study

Circulation

Volumn 139, Issue 11, 2019, Pages 1354-1365

  Kang, Duk Hyun ^a   Park, Sung Ji ^b   Shin, Sung Hee ^d   Hong, Geu Ru ^c   Lee, Sahmin ^a   Kim, Min Seok ^a   Yun, Sung Cheol ^a   Song, Jong Min ^a   Park, Seung Woo ^b   Kim, Jae Joong ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

^c Severance Medical Center   (South Korea)

^d Inha University School of Medicine   (South Korea)

Author keywords

Angiotensin receptor antagonists; Heart failure; Mitral valve insufficiency; Neprilysin

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATININE; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FUROSEMIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOOP DIURETIC AGENT; POTASSIUM; SACUBITRIL PLUS VALSARTAN; VALSARTAN; AMINOBUTYRIC ACID DERIVATIVE; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; MEMBRANE METALLOENDOPEPTIDASE; PROTEINASE INHIBITOR; SACUBITRIL-VALSARTAN; TETRAZOLE DERIVATIVE;

ACUTE CHOLECYSTITIS; ACUTE GASTROENTERITIS; ACUTE KIDNEY FAILURE; ACUTE PYELONEPHRITIS; ADULT; ARTICLE; ATRIAL FIBRILLATION; BLOOD PRESSURE; BRAIN INFARCTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; FUNCTIONAL DISEASE; HEART FAILURE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART VENTRICLE FIBRILLATION; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MITRAL VALVE; MITRAL VALVE REGURGITATION; MULTICENTER STUDY; PLEURA EFFUSION; PNEUMONIA; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SIDE EFFECT; THORAX PAIN; AGED; CHRONIC DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CONVALESCENCE; DIAGNOSTIC IMAGING; DRUG EFFECT; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; PATHOPHYSIOLOGY; SOUTH KOREA; TIME FACTOR; TREATMENT OUTCOME;

AGED; AMINOBUTYRATES; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; CHRONIC DISEASE; DOUBLE-BLIND METHOD; FEMALE; HEART FAILURE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED; MITRAL VALVE; MITRAL VALVE INSUFFICIENCY; NEPRILYSIN; PROSPECTIVE STUDIES; PROTEASE INHIBITORS; RECOVERY OF FUNCTION; REPUBLIC OF KOREA; TETRAZOLES; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 85062859473     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.118.037077     Document Type: Article

References (33)

1. Piérard LA, Carabello BA, Ischaemic mitral regurgitation: Pathophysiology, outcomes and the conundrum of treatment. Eur Heart J 2010 31 2996 3005. doi: 10.1093/eurheartj/ehq411
2. Lamas GA, Mitchell GF, Flaker GC, Smith SC Jr, Gersh BJ, Basta L, Moyé L, Braunwald E, Pfeffer MA, Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators. Circulation 1997 96 827 833. doi: 10.1161/01.CIR.96.3.827
3. Bursi F, Enriquez-Sarano M, Nkomo VT, Jacobsen SJ, Weston SA, Meverden RA, Roger VL, Heart failure and death after myocardial infarction in the community: The emerging role of mitral regurgitation. Circulation 2005 111 295 301. doi: 10.1161/01.CIR.0000151097.30779.04
4. Rossi A, Dini FL, Faggiano P, Agricola E, Cicoira M, Frattini S, Simioniuc A, Gullace M, Ghio S, Enriquez-Sarano M, Temporelli PL, Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy. Heart 2011 97 1675 1680. doi: 10.1136/hrt.2011.225789
5. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, O'Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM 3rd, Thomas JD, ACC/AHA Task Force Members 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014 129 e521 e643. doi: 10.1161/CIR.0000000000000031
6. Doughty RN, Whalley GA, Walsh HA, Gamble GD, López-Sendón J, Sharpe N, CAPRICORN Echo Substudy Investigators Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: The CAPRICORN Echo Substudy. Circulation 2004 109 201 206. doi: 10.1161/01.CIR.0000108928.25690.94
7. Solomon SD, Skali H, Anavekar NS, Bourgoun M, Barvik S, Ghali JK, Warnica JW, Khrakovskaya M, Arnold JM, Schwartz Y, Velazquez EJ, Califf RM, McMurray JV, Pfeffer MA, Changes in ventricular size and function in patients treated with valsartan, captopril, or both after myocardial infarction. Circulation 2005 111 3411 3419. doi: 10.1161/CIRCULATIONAHA.104.508093
8. Levine RA, Schwammenthal E, Ischemic mitral regurgitation on the threshold of a solution: From paradoxes to unifying concepts. Circulation 2005 112 745 758. doi: 10.1161/CIRCULATIONAHA.104.486720
9. Asgar AW, Mack MJ, Stone GW, Secondary mitral regurgitation in heart failure: Pathophysiology, prognosis, and therapeutic considerations. J Am Coll Cardiol 2015 65 1231 1248. doi: 10.1016/j.jacc.2015.02.009
10. Agricola E, Ielasi A, Oppizzi M, Faggiano P, Ferri L, Calabrese A, Vizzardi E, Alfieri O, Margonato A, Long-term prognosis of medically treated patients with functional mitral regurgitation and left ventricular dysfunction. Eur J Heart Fail 2009 11 581 587. doi: 10.1093/eurjhf/hfp051
11. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, PARADIGM-HF Investigators and Committees Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 2014 371 993 1004. doi: 10.1056/NEJMoa1409077
12. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Colvin MM, Drazner MH, Filippatos GS, Fonarow GC, Givertz MM, Hollenberg SM, Lindenfeld J, Masoudi FA, McBride PE, Peterson PN, Stevenson LW, Westlake C, 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America. Circulation 2017 136 e137 e161. doi: 10.1161/CIR.0000000000000509
13. Hubers SA, Brown NJ, Combined angiotensin receptor antagonism and neprilysin inhibition. Circulation 2016 133 1115 1124. doi: 10.1161/CIRCULATIONAHA.115.018622
14. Sacks CA, Jarcho JA, Curfman GD, Paradigm shifts in heart-failure therapy-a timeline. N Engl J Med 2014 371 989 991. doi: 10.1056/NEJMp1410241
15. Ruilope LM, Dukat A, Böhm M, Lacourcière Y, Gong J, Lefkowitz MP, Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: A randomised, double-blind, placebo-controlled, active comparator study. Lancet 2010 375 1255 1266. doi: 10.1016/S0140-6736(09)61966-8
16. Solomon SD, Zile M, Pieske B, Voors A, Shah A, Kraigher-Krainer E, Shi V, Bransford T, Takeuchi M, Gong J, Lefkowitz M, Packer M, McMurray JJ, Prospective comparison of ARNI with ARB on Management Of heart failUre with preserved ejectioN fracTion (PARAMOUNT) Investigators The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: A phase 2 double-blind randomised controlled trial. Lancet 2012 380 1387 1395. doi: 10.1016/S0140-6736(12)61227-6
17. Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989 2 358 367. doi: 10.1016/S0894-7317(89)80014-8
18. Milani RV, Drazner MH, Lavie CJ, Morin DP, Ventura HO, Progression from concentric left ventricular hypertrophy and normal ejection fraction to left ventricular dysfunction. Am J Cardiol 2011 108 992 996. doi: 10.1016/j.amjcard.2011.05.038
19. Grayburn PA, Weissman NJ, Zamorano JL, Quantitation of mitral regurgitation. Circulation 2012 126 2005 2017. doi: 10.1161/CIRCULATIONAHA.112.121590
20. Kang DH, Sun BJ, Kim DH, Yun SC, Song JM, Choo SJ, Chung CH, Song JK, Lee JW, Park SW, Park SJ, Percutaneous versus surgical revascularization in patients with ischemic mitral regurgitation. Circulation 2011 124 11 Suppl S156 S162. doi: 10.1161/CIRCULATIONAHA.110.011254
21. Grigioni F, Detaint D, Avierinos JF, Scott C, Tajik J, Enriquez-Sarano M, Contribution of ischemic mitral regurgitation to congestive heart failure after myocardial infarction. J Am Coll Cardiol 2005 45 260 267. doi: 10.1016/j.jacc.2004.10.030
22. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Munõz D, Rosenhek R, Sjögren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, ESC Scientific Document Group 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J 2017 38 2739 2791. doi: 10.1093/eurheartj/ehx391
23. Nishimura RA, Vahanian A, Eleid MF, Mack MJ, Mitral valve disease-current management and future challenges. Lancet 2016 387 1324 1334. doi: 10.1016/S0140-6736(16)00558-4
24. Acker MA, Parides MK, Perrault LP, Moskowitz AJ, Gelijns AC, Voisine P, Smith PK, Hung JW, Blackstone EH, Puskas JD, Argenziano M, Gammie JS, Mack M, Ascheim DD, Bagiella E, Moquete EG, Ferguson TB, Horvath KA, Geller NL, Miller MA, Woo YJ, D'Alessandro DA, Ailawadi G, Dagenais F, Gardner TJ, O'Gara PT, Michler RE, Kron IL, CTSN Mitral-valve repair versus replacement for severe ischemic mitral regurgitation. N Engl J Med 2014 370 23 32. doi: 10.1056/NEJMoa1312808
25. Greenberg B, Quinones MA, Koilpillai C, Limacher M, Shindler D, Benedict C, Shelton B, Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction. Results of the SOLVD echocardiography substudy. Circulation 1995 91 2573 2581. doi: 10.1161/01.CIR.91.10.2573
26. Chaput M, Handschumacher MD, Tournoux F, Hua L, Guerrero JL, Vlahakes GJ, Levine RA, Mitral leaflet adaptation to ventricular remodeling: Occurrence and adequacy in patients with functional mitral regurgitation. Circulation 2008 118 845 852. doi: 10.1161/CIRCULATIONAHA.107.749440
27. Michler RE, Rouleau JL, Al-Khalidi HR, Bonow RO, Pellikka PA, Pohost GM, Holly TA, Oh JK, Dagenais F, Milano C, Wrobel K, Pirk J, Ali IS, Jones RH, Velazquez EJ, Lee KL, Di Donato M, STICH Trial Investigators Insights from the STICH trial: Change in left ventricular size after coronary artery bypass grafting with and without surgical ventricular reconstruction. J Thorac Cardiovasc Surg 2013 146 1139 1145.e6. doi: 10.1016/j.jtcvs.2012.09.007
28. Levine AB, Muller C, Levine TB, Effects of high-dose lisinopril-isosorbide dinitrate on severe mitral regurgitation and heart failure remodeling. Am J Cardiol 1998 82 1299 301, A10. doi: 10.1016/S0002-9149(98)00623-7
29. Lowes BD, Gill EA, Abraham WT, Larrain JR, Robertson AD, Bristow MR, Gilbert EM, Effects of carvedilol on left ventricular mass, chamber geometry, and mitral regurgitation in chronic heart failure. Am J Cardiol 1999 83 1201 1205. doi: 10.1016/S0002-9149(99)00059-4
30. Waagstein F, Strömblad O, Andersson B, Böhm M, Darius M, Delius W, Goss F, Osterziel KJ, Sigmund M, Trenkwalder SP, Wahlqvist I, Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure: A randomized, stratified, double-blind, placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy. Eur J Heart Fail 2003 5 679 691. doi: 10.1016/S1388-9842(03)00105-3
31. Martens P, Beliën H, Dupont M, Vandervoort P, Mullens W, The reverse remodeling response to sacubitril/valsartan therapy in heart failure with reduced ejection fraction. Cardiovasc Ther 2018 36 e12435. doi: 10.1111/1755-5922.12435
32. Smith PK, Puskas JD, Ascheim DD, Voisine P, Gelijns AC, Moskowitz AJ, Hung JW, Parides MK, Ailawadi G, Perrault LP, Acker MA, Argenziano M, Thourani V, Gammie JS, Miller MA, Pagé P, Overbey JR, Bagiella E, Dagenais F, Blackstone EH, Kron IL, Goldstein DJ, Rose EA, Moquete EG, Jeffries N, Gardner TJ, O'Gara PT, Alexander JH, Michler RE, Cardiothoracic Surgical Trials Network Investigators Surgical treatment of moderate ischemic mitral regurgitation. N Engl J Med 2014 371 2178 2188. doi: 10.1056/NEJMoa1410490
33. Grayburn PA, Carabello B, Hung J, Gillam LD, Liang D, Mack MJ, McCarthy PM, Miller DC, Trento A, Siegel RJ, Defining "severe" secondary mitral regurgitation: Emphasizing an integrated approach. J Am Coll Cardiol 2014 64 2792 2801. doi: 10.1016/j.jacc.2014.10.016