Arguments for routine administration of probiotics for NEC prevention

Current Opinion in Pediatrics

Volumn 31, Issue 2, 2019, Pages 188-194

  Underwood, Mark A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bifidobacterium; Lactobacillus; Necrotizing enterocolitis; Probiotic

Indexed keywords

PLACEBO; PROBIOTIC AGENT;

DRUG ADMINISTRATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HUMAN; NECROTIZING ENTEROCOLITIS; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEPSIS; ANIMAL; DISEASE MODEL; NEWBORN;

ANIMALS; DISEASE MODELS, ANIMAL; ENTEROCOLITIS, NECROTIZING; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; PROBIOTICS; SEPSIS;

EID: 85062623627     PISSN: 10408703     EISSN: 1531698X     Source Type: Journal    
DOI: 10.1097/MOP.0000000000000732     Document Type: Review

References (64)

1. Patel RM, Kandefer S, Walsh MC, et al. Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med 2015; 372:331–340.
2. Yee WH, Soraisham AS, Shah VS, et al. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics 2012; 129:e298–e304.
3. La Rosa PS, Warner BB, Zhou Y, et al. Patterned progression of bacterial populations in the premature infant gut. Proc Natl Acad Sci 2014; 111:12522–12527.
4. MohanKumar K, Namachivayam K, Ho TT, et al. Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis. Semin Perinatol 2017; 41:52–60.
5. Heida FH, Beyduz G, Bulthuis ML, et al. Paneth cells in the developing gut: when do they arise and when are they immune competent? Pediatr Res 2016; 80:306–310.
6. Hoyos AB. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis 1999; 3:197–202.
7. Caplan MS, Miller-Catchpole R, Kaup S, et al. Bifidobacterial supplementation reduces the incidence of necrotizing enterocolitis in a neonatal rat model. Gastroenterology 1999; 117:577–583.
8. Ares GJ, McElroy SJ, Hunter CJ. The science and necessity of using animal models in the study of necrotizing enterocolitis. Semin Pediatr Surg 2018; 27:29–33.
9. Underwood MA. Probiotics and innate and adaptive immune responses in premature infants. For Immunopathol Dis Ther 2016; 7:1–15.
10. Underwood MA. Probiotics and the prevention of necrotizing enterocolitis. J Pediatr Surg 2018. [Epub ahead of print]
11. Athalye-Jape G, Rao S, Patole S. Effects of probiotics on experimental necrotizing enterocolitis: a systematic review and meta-analysis. Pediatr Res 2018; 83:16–22.
12. Wu W, Wang Y, Zou J, et al. Bifidobacterium adolescentis protects against necrotizing enterocolitis and upregulates TOLLIP and SIGIRR in premature neonatal rats. BMC Pediatr 2017; 17:1.
13. Hoang TK, He B, Wang T, et al. Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by Toll-like receptor 2. Am J Physiol Gastrointest Liver Physiol 2018; 315:G231–G240.
14. Olson JK, Navarro JB, Allen JM, et al. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 2018; 315:G408–G419.
15. Pammi M, Cope J, Tarr PI, et al. Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis. Microbiome 2017; 5:31.
16. Graspeuntner S, Waschina S, Kunzel S, et al. Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants. Clin Infect Dis 2018. [Epub ahead of print]
17. Underwood MA, German JB, Lebrilla CB, Mills DA. Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut. Pediatr Res 2015; 77:229–235.
18. Frese SA, Hutton AA, Contreras LN, et al. Persistence of supplemented Bifidobacterium longum subsp. infantis EVC001 in breastfed infants. mSphere 2017; 2:e00501–e517.
19. Underwood MA, Kalanetra KM, Bokulich NA, et al. A comparison of two probiotic strains of bifidobacteria in premature infants. J Pediatr 2013; 163:1585–1591.
20. Casaburi G, Frese SA. Colonization of breastfed infants by Bifidobacterium longum subsp. infantis EVC001 reduces virulence gene abundance. Human Microbiome J 2018; 9:7–10.
21. Karav S, Casaburi G, Frese SA. Reduced colonic mucin degradation in breastfed infants colonized by Bifidobacterium longum subsp. infantis EVC001. FEBS Open Bio 2018; 8:1649–1657.
22. Vallabhaneni S, Walker TA, Lockhart SR, et al. Notes from the Field: Fatal Gastrointestinal Mucormycosis in a Premature Infant Associated with a Contaminated Dietary Supplement — Connecticut, 2014. MMWR Morb Mortal Wkly Rep 2015; 64:155–156.
23. Dani C, Coviello CC, Corsini II, et al. Lactobacillus sepsis and probiotic therapy in newborns: two new cases and literature review. AJP Rep 2016; 6:e25–e29.
24. Esaiassen E, Cavanagh P, Hjerde E, et al. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016; 22:1664–1666.
25. Murad MH, Asi N, Alsawas M, Alahdab F. New evidence pyramid. Evid Based Med 2016; 21:125–127.
26. Alfaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev 2014; 4:CD005496.
27. Costeloe K, Bowler U, Brocklehurst P, et al. A randomised controlled trial of the probiotic Bifidobacterium breve BBG-001 in preterm babies to prevent sepsis, necrotising enterocolitis and death: the Probiotics in Preterm infantS (PiPS) trial. Health Technol Assess 2016; 20:1–194.
28. Sawh SC, Deshpande S, Jansen S, et al. Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis. PeerJ 2016; 4:e2429.
29. Olsen R, Greisen G, Schroder M, Brok J. Prophylactic probiotics for preterm infants: a systematic review and meta-analysis of observational studies. Neonatology 2016; 109:105–112.
30. Dermyshi E, Wang Y, Yan C, et al. The ‘Golden Age’ of probiotics: a systematic review and meta-analysis of randomized and observational studies in preterm infants. Neonatology 2017; 112:9–23.
31. Zeng L, Tian J, Song F, et al. Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis. Arch Dis Child Fetal Neonatal Ed 2018; 103:F506–F511.
32. Lester BM, Salisbury AL, Hawes K, et al. 18-Month follow-up of infants cared for in a single-family room neonatal intensive care unit. J Pediatr 2016; 177:84–89.
33. Gianni ML, Sannino P, Bezze E, et al. Does parental involvement affect the development of feeding skills in preterm infants? A prospective study. Early Hum Dev 2016; 103:123–128.
34. Raiskila S, Axelin A, Rapeli S, et al. Trends in care practices reflecting parental involvement in neonatal care. Early Hum Dev 2014; 90:863–867.
35. Franck LS, McNulty A, Alderdice F. The perinatal-neonatal care journey for parents of preterm infants: what is working and what can be improved. J Perinat Neonatal Nurs 2017; 31:244–255.
36. Umberger E, Canvasser J, Hall SL. Enhancing NICU parent engagement and empowerment. Semin Pediatr Surg 2018; 27:19–24.
37. Franck LS, McNulty A, Alderdice F. The perinatal-neonatal journey for parents of preterm infants: what is working and what can be improved. J Perinat Neonatal Nurs 2017; 31:244–255.
38. Zmora N, Zilberman-Schapira G, Suez J, et al. Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features. Cell 2018; 174:1388–1405.
39. Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature 2016; 535:65–74.
40. Tordesillas L, Berin MC. Mechanisms of oral tolerance. Clin Rev Allery Immunol 2018; 55:107–117.
41. Huda MN, Lewis Z, Kalanetra KM, et al. Stool microbiota and vaccine responses of infants. Pediatrics 2014; 134:E362–E372.
42. Henrick BM, Hutton AA, Palumbo MC, et al. Elevated fecal pH indicates a profound change in the breastfed infant gut microbiome due to reduction of Bifidobacterium over the past century. mSphere 2018; 3:; e00041-18.
43. Yu JC, Khodadadi H, Malik A, et al. Innate immunity of neonates and infants. Front Immunol 2018; 9:1759.
44. Hodzic Z, Bolock AM, Good M. The role of mucosal immunity in the pathogenesis of necrotizing enterocolitis. Front Pediatr 2017; 5:40.
45. Villamor-Martinez E, Pierro M, Cavallaro G, et al. Probiotic supplementation in preterm infants does not affect the risk of bronchopulmonary dysplasia: a meta-analysis of randomized controlled trials. Nutrients 2017; 9:e1197.
46. Cavallaro G, Villamor-Martinez E, Filippi L, et al. Probiotic supplementation in preterm infants does not affect the risk of retinopathy of prematurity: a meta-analysis of randomized controlled trials. Sci Rep 2017; 7:13014.
47. Sun J, Marwah G, Westgarth M, et al. Effects of probiotics on necrotizing enterocolitis, sepsis, intraventricular hemorrhage, mortality, length of hospital stay, and weight gain in very preterm infants: a meta-analysis. Adv Nutr 2017; 8:749–763.
48. Athalye-Jape G, Deshpande G, Rao S, Patole S. Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review. Am J Clin Nutr 2014; 100:1508–1519.
49. Morgan J, Young L, McGuire W. Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants. Cochrane Database Syst Rev 2011; 3:CD001241.
50. Quigley M, McGuire W. Formula versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev 2014; 4:CD002971.
51. Abrams SA, Schanler RJ, Lee ML, Rechtman DJ. Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products. Breastfeed Med 2014; 9:281–285.
52. Battersby C, Longford N, Mandalia S, et al. Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study. Lancet Gastroenterol Hepatol 2017; 2:43 – 51.
53. Kantorowska A, Wei JC, Cohen RS, et al. Impact of donor milk availability on breast milk use and necrotizing enterocolitis rates. Pediatrics 2016; 137:e20153123.
54. Assad M, Elliott MJ, Abraham JH. Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet. J Perinatol 2016; 36:216–220.
55. Hair AB, Peluso AM, Hawthorne KM, et al. Beyond necrotizing enterocolitis prevention: improving outcomes with an exclusive human milk-based diet. Breastfeed Med 2016; 11:70–74.
56. Herrmann K, Carroll K. An exclusively human milk diet reduces necrotizing enterocolitis. Breastfeed Med 2014; 9:184–190.
57. Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; 1:CD003311.
58. Aldana-Aguirre JC, Pinto M, Featherstone RM, Kumar M. Less invasive surfactant administration versus intubation for surfactant delivery in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 2017; 102:F17–F23.
59. Ohlsson A, Jacobs SE. NIDCAP: a systematic review and meta-analyses of randomized controlled trials. Pediatrics 2013; 131:e881–e893.
60. Jensen EA, Foglia EE, Schmidt B. Association between prophylactic indomethacin and death or bronchopulmonary dysplasia: A systematic review and meta-analysis of observational studies. Semin Perinatol 2018; 42:228–234.
61. Nakamura H, Lim T, Puri P. Probiotics for the prevention of Hirschsprung-associated enterocolitis: a systematic review and meta-analysis. Pediatr Surg Int 2018; 34:189–193.
62. Goldenberg JZ, Yap C, Lytvyn L, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev 2017; 12:CD006095.
63. Saab S, Suraweera D, Au J, et al. Probiotics are helpful in hepatic encephalopathy: a meta-analysis of randomized trials. Liver Int 2016; 36:986–993.
64. Sun S, Yang K, He X, et al. Probiotics in patients with severe acute pancreatitis: a meta-analysis. Langenbecks Arch Surg 2009; 394:171–177.