메뉴 건너뛰기




Volumn 315, Issue 2, 2018, Pages G231-G240

Protective effect of Lactobacillus reuteri DSM 17938 against experimental necrotizing enterocolitis is mediated by toll-like receptor 2

Author keywords

Inflammation; Intestinal mucosa; Lactobacillus; Necrotizing enterocolitis; Toll like receptor

Indexed keywords

AGENTS USED IN INFLAMMATORY BOWEL DISEASE; GAMMA INTERFERON; INTERLEUKIN 1BETA; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 2; ANTIINFLAMMATORY AGENT;

EID: 85051258942     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00084.2017     Document Type: Article
Times cited : (62)

References (49)
  • 1
    • 82155173521 scopus 로고    scopus 로고
    • A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization
    • Abrahamsson TR, Sandberg Abelius M, Forsberg A, Björkstén B, Jenmalm MC. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization. Clin Exp Allergy 41: 1729–1739, 2011. doi:10.1111/j.1365-2222.2011.03827.x.
    • (2011) Clin Exp Allergy , vol.41 , pp. 1729-1739
    • Abrahamsson, T.R.1    Sandberg Abelius, M.2    Forsberg, A.3    Björkstén, B.4    Jenmalm, M.C.5
  • 2
    • 84942743424 scopus 로고    scopus 로고
    • Probiotics for prevention of necrotizing enterocolitis in preterm infants
    • Alfaleh K, Anabrees J, Bassler D, Al-Kharfi T. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev (3): CD005496, 2011.10.1002/14651858.CD005496.pub3.
    • (2011) Cochrane Database Syst Rev , Issue.3
    • Alfaleh, K.1    Anabrees, J.2    Bassler, D.3    Al-Kharfi, T.4
  • 4
    • 38049162157 scopus 로고    scopus 로고
    • Toll-like receptor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model
    • Aprahamian CJ, Lorenz RG, Harmon CM, Dimmit RA. Toll-like receptor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model. Pediatr Crit Care Med 9: 105–109, 2008. doi:10.1097/01.PCC.0000288717.44702.C0.
    • (2008) Pediatr Crit Care Med , vol.9 , pp. 105-109
    • Aprahamian, C.J.1    Lorenz, R.G.2    Harmon, C.M.3    Dimmit, R.A.4
  • 6
    • 78650959870 scopus 로고    scopus 로고
    • Multifaceted regulation of T cells by CD44
    • Baaten BJ, Li CR, Bradley LM. Multifaceted regulation of T cells by CD44. Commun Integr Biol 3: 508–512, 2010. doi:10.4161/cib.3.6.13495.
    • (2010) Commun Integr Biol , vol.3 , pp. 508-512
    • Baaten, B.J.1    Li, C.R.2    Bradley, L.M.3
  • 7
    • 48649084357 scopus 로고    scopus 로고
    • Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells
    • Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M. Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J Leukoc Biol 84: 468–476, 2008. doi:10.1189/jlb.0108017.
    • (2008) J Leukoc Biol , vol.84 , pp. 468-476
    • Baba, N.1    Samson, S.2    Bourdet-Sicard, R.3    Rubio, M.4    Sarfati, M.5
  • 8
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 204: 1765–1774, 2007. doi:10.1084/jem.20070719.
    • (2007) J Exp Med , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 9
    • 0025296725 scopus 로고
    • Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis
    • Caplan MS, Sun XM, Hseuh W, Hageman JR. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr 116: 960–964, 1990. doi:10.1016/S0022-3476(05)80661-4.
    • (1990) J Pediatr , vol.116 , pp. 960-964
    • Caplan, M.S.1    Sun, X.M.2    Hseuh, W.3    Hageman, J.R.4
  • 10
    • 22644444207 scopus 로고    scopus 로고
    • Bacterial interactions with cells of the intestinal mucosa
    • Cario E. Bacterial interactions with cells of the intestinal mucosa: Tolllike receptors and NOD2. Gut 54: 1182–1193, 2005. doi:10.1136/gut.2004.062794.
    • (2005) Tolllike Receptors and NOD2. Gut , vol.54 , pp. 1182-1193
    • Cario, E.1
  • 11
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario E, Gerken G, Podolsky DK. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132: 1359–1374, 2007. doi:10.1053/j.gastro.2007.02.056.
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 12
    • 60449092285 scopus 로고    scopus 로고
    • Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: The role of dendritic cells
    • Chen CC, Chiu CH, Lin TY, Shi HN, Walker WA. Effect of probiotics Lactobacillus acidophilus on Citrobacter rodentium colitis: the role of dendritic cells. Pediatr Res 65: 169–175, 2009. doi:10.1203/PDR.0b013e31818d5a06.
    • (2009) Pediatr Res , vol.65 , pp. 169-175
    • Chen, C.C.1    Chiu, C.H.2    Lin, T.Y.3    Shi, H.N.4    Walker, W.A.5
  • 13
    • 84992360076 scopus 로고    scopus 로고
    • Efficacy of probiotics versus placebo in the prevention of necrotizing enterocolitis in preterm very low birth weight infants: A double-blind randomized controlled trial
    • Chowdhury T, Ali MM, Hossain MM, Singh J, Yousuf AN, Yasmin F, Chowdhury FR. Efficacy of probiotics versus placebo in the prevention of necrotizing enterocolitis in preterm very low birth weight infants: a double-blind randomized controlled trial. J Coll Physicians Surg Pak 26: 770–774, 2016.
    • (2016) J Coll Physicians Surg Pak , vol.26 , pp. 770-774
    • Chowdhury, T.1    Ali, M.M.2    Hossain, M.M.3    Singh, J.4    Yousuf, A.N.5    Yasmin, F.6    Chowdhury, F.R.7
  • 14
    • 77954476426 scopus 로고    scopus 로고
    • Can we cut the incidence of necrotizing enterocolitis in half–today?
    • Christensen RD, Gordon PV, Besner GE. Can we cut the incidence of necrotizing enterocolitis in half–today? Fetal Pediatr Pathol 29: 185–198, 2010. doi:10.3109/15513815.2010.483874.
    • (2010) Fetal Pediatr Pathol , vol.29 , pp. 185-198
    • Christensen, R.D.1    Gordon, P.V.2    Besner, G.E.3
  • 15
  • 17
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Cárcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204: 1757–1764, 2007. doi:10.1084/jem.20070590.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Cárcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6    Powrie, F.7
  • 18
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
    • Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 174: 3237–3246, 2005. doi:10.4049/jimmunol.174.6.3237.
    • (2005) J Immunol , vol.174 , pp. 3237-3246
    • Di Giacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 19
    • 84893386165 scopus 로고    scopus 로고
    • FoxP3+ regulatory T cells attenuate experimental necrotizing enterocolitis
    • Dingle BM, Liu Y, Fatheree NY, Min J, Rhoads JM, Tran DQ. FoxP3+ regulatory T cells attenuate experimental necrotizing enterocolitis. PLoS One 8: e82963, 2013. doi:10.1371/journal.pone.0082963.
    • (2013) Plos One , vol.8
    • Dingle, B.M.1    Liu, Y.2    Fatheree, N.Y.3    Min, J.4    Rhoads, J.M.5    Tran, D.Q.6
  • 23
    • 84876721004 scopus 로고    scopus 로고
    • Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch
    • Hackam DJ, Good M, Sodhi CP. Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg 22: 76–82, 2013. doi:10.1053/j.sempedsurg.2013.01.003.
    • (2013) Semin Pediatr Surg , vol.22 , pp. 76-82
    • Hackam, D.J.1    Good, M.2    Sodhi, C.P.3
  • 24
    • 33644752602 scopus 로고    scopus 로고
    • Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway
    • Hoarau C, Lagaraine C, Martin L, Velge-Roussel F, Lebranchu Y. Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway. J Allergy Clin Immunol 117: 696–702, 2006. doi:10.1016/j.jaci.2005.10.043.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 696-702
    • Hoarau, C.1    Lagaraine, C.2    Martin, L.3    Velge-Roussel, F.4    Lebranchu, Y.5
  • 25
    • 84871402588 scopus 로고    scopus 로고
    • Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance
    • Kornete M, Piccirillo CA. Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Front Immunol 3: 165, 2012. doi:10.3389/fimmu.2012.00165.
    • (2012) Front Immunol , vol.3 , pp. 165
    • Kornete, M.1    Piccirillo, C.A.2
  • 26
    • 0026100092 scopus 로고
    • The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse
    • Lee WT, Vitetta ES. The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse. Cell Immunol 132: 215–222, 1991. doi:10.1016/0008-8749(91)90020-C.
    • (1991) Cell Immunol , vol.132 , pp. 215-222
    • Lee, W.T.1    Vitetta, E.S.2
  • 27
    • 84874244550 scopus 로고    scopus 로고
    • Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis
    • Liu Y, Fatheree NY, Dingle BM, Tran DQ, Rhoads JM. Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis. PLoS One 8: e56547, 2013. doi:10.1371/journal.pone.0056547.
    • (2013) Plos One , vol.8
    • Liu, Y.1    Fatheree, N.Y.2    Dingle, B.M.3    Tran, D.Q.4    Rhoads, J.M.5
  • 29
    • 84904367373 scopus 로고    scopus 로고
    • Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis
    • Liu Y, Tran DQ, Fatheree NY, Marc Rhoads J. Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 307: G177–G186, 2014. doi:10.1152/ajpgi.00038.2014.
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , pp. G177-G186
    • Liu, Y.1    Tran, D.Q.2    Fatheree, N.Y.3    Marc Rhoads, J.4
  • 30
    • 69749095677 scopus 로고    scopus 로고
    • Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis
    • Liu Y, Zhu L, Fatheree NY, Liu X, Pacheco SE, Tatevian N, Rhoads JM. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 297: G442–G450, 2009. doi:10.1152/ajpgi.00182.2009.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.297 , pp. G442-G450
    • Liu, Y.1    Zhu, L.2    Fatheree, N.Y.3    Liu, X.4    Pacheco, S.E.5    Tatevian, N.6    Rhoads, J.M.7
  • 31
    • 84874410778 scopus 로고    scopus 로고
    • Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men
    • Mann ER, Landy JD, Bernardo D, Peake ST, Hart AL, Al-Hassi HO, Knight SC. Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men. Immunol Lett 150: 30–40, 2013. doi:10.1016/j.imlet.2013.01.007.
    • (2013) Immunol Lett , vol.150 , pp. 30-40
    • Mann, E.R.1    Landy, J.D.2    Bernardo, D.3    Peake, S.T.4    Hart, A.L.5    Al-Hassi, H.O.6    Knight, S.C.7
  • 32
    • 70349972786 scopus 로고    scopus 로고
    • Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation
    • Messlik A, Schmechel S, Kisling S, Bereswill S, Heimesaat MM, Fischer A, Göbel U, Haller D. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J Proteome Res 8: 4406–4417, 2009. doi:10.1021/pr9000465.
    • (2009) J Proteome Res , vol.8 , pp. 4406-4417
    • Messlik, A.1    Schmechel, S.2    Kisling, S.3    Bereswill, S.4    Heimesaat, M.M.5    Fischer, A.6    Göbel, U.7    Haller, D.8
  • 33
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317: 256–260, 2007. doi:10.1126/science.1145697.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6    Cheroutre, H.7
  • 34
  • 35
    • 79952825184 scopus 로고    scopus 로고
    • The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: An immature innate immune response
    • Nanthakumar N, Meng D, Goldstein AM, Zhu W, Lu L, Uauy R, Llanos A, Claud EC, Walker WA. The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response. PLoS One 6: e17776, 2011. doi:10.1371/journal.pone.0017776.
    • (2011) Plos One , vol.6
    • Nanthakumar, N.1    Meng, D.2    Goldstein, A.M.3    Zhu, W.4    Lu, L.5    Uauy, R.6    Llanos, A.7    Claud, E.C.8    Walker, W.A.9
  • 36
    • 78751625682 scopus 로고    scopus 로고
    • Necrotizing enterocolitis
    • Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med 364: 255–264, 2011. doi:10.1056/NEJMra1005408.
    • (2011) N Engl J Med , vol.364 , pp. 255-264
    • Neu, J.1    Walker, W.A.2
  • 37
    • 84894038594 scopus 로고    scopus 로고
    • Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: A randomised controlled trial
    • Oncel MY, Sari FN, Arayici S, Guzoglu N, Erdeve O, Uras N, Oguz SS, Dilmen U. Lactobacillus Reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 99: F110–F115, 2014. doi:10.1136/archdischild-2013-304745.
    • (2014) Arch Dis Child Fetal Neonatal Ed , vol.99 , pp. F110-F115
    • Oncel, M.Y.1    Sari, F.N.2    Arayici, S.3    Guzoglu, N.4    Erdeve, O.5    Uras, N.6    Oguz, S.S.7    Dilmen, U.8
  • 38
    • 80051904734 scopus 로고    scopus 로고
    • Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation
    • Reardon C, Lechmann M, Brüstle A, Gareau MG, Shuman N, Philpott D, Ziegler SF, Mak TW. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity 35: 223–235, 2011. doi:10.1016/j.immuni.2011.05.015.
    • (2011) Immunity , vol.35 , pp. 223-235
    • Reardon, C.1    Lechmann, M.2    Brüstle, A.3    Gareau, M.G.4    Shuman, N.5    Philpott, D.6    Ziegler, S.F.7    Mak, T.W.8
  • 39
    • 54449092724 scopus 로고    scopus 로고
    • Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. Reuteri DSM 17938
    • Rosander A, Connolly E, Roos S. Removal of antibiotic resistance gene-carrying plasmids from Lactobacillus reuteri ATCC 55730 and characterization of the resulting daughter strain, L. reuteri DSM 17938. Appl Environ Microbiol 74: 6032–6040, 2008. doi:10.1128/AEM.00991-08.
    • (2008) Appl Environ Microbiol , vol.74 , pp. 6032-6040
    • Rosander, A.1    Connolly, E.2    Roos, S.3
  • 40
    • 84992109091 scopus 로고    scopus 로고
    • Prevention of necrotizing enterocolitis with probiotics: A systematic review and meta-analysis
    • Sawh SC, Deshpande S, Jansen S, Reynaert CJ, Jones PM. Prevention of necrotizing enterocolitis with probiotics: a systematic review and meta-analysis. PeerJ 4: e2429, 2016. doi:10.7717/peerj.2429.
    • (2016) Peerj , vol.4
    • Sawh, S.C.1    Deshpande, S.2    Jansen, S.3    Reynaert, C.J.4    Jones, P.M.5
  • 41
    • 20444503737 scopus 로고    scopus 로고
    • Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
    • Smits HH, Engering A, van der Kleij D, de Jong EC, Schipper K, van Capel TM, Zaat BA, Yazdanbakhsh M, Wierenga EA, van Kooyk Y, Kapsenberg ML. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 115: 1260–1267, 2005. doi:10.1016/j.jaci.2005.03.036.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1260-1267
    • Smits, H.H.1    Engering, A.2    Van Der Kleij, D.3    De Jong, E.C.4    Schipper, K.5    Van Capel, T.M.6    Zaat, B.A.7    Yazdanbakhsh, M.8    Wierenga, E.A.9    Van Kooyk, Y.10    Kapsenberg, M.L.11
  • 43
    • 85009101769 scopus 로고    scopus 로고
    • Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner
    • Sun KY, Xu DH, Xie C, Plummer S, Tang J, Yang XF, Ji XH. Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner. Cytokine 92: 1–11, 2017. doi:10.1016/j.cyto.2017.01.003.
    • (2017) Cytokine , vol.92 , pp. 1-11
    • Sun, K.Y.1    Xu, D.H.2    Xie, C.3    Plummer, S.4    Tang, J.5    Yang, X.F.6    Ji, X.H.7
  • 44
    • 84964339327 scopus 로고    scopus 로고
    • Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response
    • Thakur BK, Saha P, Banik G, Saha DR, Grover S, Batish VK, Das S. Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response. Int Immunopharmacol 36: 39–50, 2016. doi:10.1016/j.intimp.2016.03.033.
    • (2016) Int Immunopharmacol , vol.36 , pp. 39-50
    • Thakur, B.K.1    Saha, P.2    Banik, G.3    Saha, D.R.4    Grover, S.5    Batish, V.K.6    Das, S.7
  • 45
    • 35448930435 scopus 로고    scopus 로고
    • Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype
    • Tran DQ, Ramsey H, Shevach EM. Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 110: 2983–2990, 2007. doi:10.1182/blood-2007-06-094656.
    • (2007) Blood , vol.110 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 46
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7: 179–190, 2007. doi:10.1038/nri2038.
    • (2007) Nat Rev Immunol , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 47
    • 84862915010 scopus 로고    scopus 로고
    • Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: An updated meta-analysis of 20 randomized, controlled trials
    • Wang Q, Dong J, Zhu Y. Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials. J Pediatr Surg 47: 241–248, 2012. doi:10.1016/j.jpedsurg.2011.09.064.
    • (2012) J Pediatr Surg , vol.47 , pp. 241-248
    • Wang, Q.1    Dong, J.2    Zhu, Y.3
  • 48
    • 77956301189 scopus 로고    scopus 로고
    • Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll-like receptor-2-dependent mechanism
    • Weiss G, Rasmussen S, Zeuthen LH, Nielsen BN, Jarmer H, Jespersen L, Frøkiaer H. Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll-like receptor-2-dependent mechanism. Immunology 131: 268–281, 2010. doi:10.1111/j.1365-2567.2010.03301.x.
    • (2010) Immunology , vol.131 , pp. 268-281
    • Weiss, G.1    Rasmussen, S.2    Zeuthen, L.H.3    Nielsen, B.N.4    Jarmer, H.5    Jespersen, L.6    Frøkiaer, H.7
  • 49
    • 84871162696 scopus 로고    scopus 로고
    • Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios
    • Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut 62: 73–82, 2013. doi:10.1136/gutjnl-2011-301551.
    • (2013) Gut , vol.62 , pp. 73-82
    • Weitkamp, J.H.1    Koyama, T.2    Rock, M.T.3    Correa, H.4    Goettel, J.A.5    Matta, P.6    Oswald-Richter, K.7    Rosen, M.J.8    Engelhardt, B.G.9    Moore, D.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.