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Volumn 58, Issue , 2019, Pages i17-i26

Clinical efficacy of launched JAK inhibitors in rheumatoid arthritis

Author keywords

baricitinib; efficacy; function; Janus kinase; patient reported outcomes; rheumatoid arthritis; small molecule kinase inhibitor; structural damage; symptoms and signs; tofacitinib

Indexed keywords

BARICITINIB; JANUS KINASE INHIBITOR; METHOTREXATE; TOFACITINIB; ANTIRHEUMATIC AGENT; AZETIDINE DERIVATIVE; JANUS KINASE 1; JANUS KINASE 2; JANUS KINASE 3; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; SULFONAMIDE;

EID: 85062187920     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/key225     Document Type: Article
Times cited : (139)

References (47)
  • 1
    • 84929023302 scopus 로고    scopus 로고
    • Rheumatoid arthritis therapy reappraisal: Strategies, opportunities and challenges
    • Smolen JS, Aletaha D. Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges. Nat Rev Rheumatol 2015;11:276-89.
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 276-289
    • Smolen, J.S.1    Aletaha, D.2
  • 2
    • 84956767541 scopus 로고    scopus 로고
    • 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis
    • Singh JA, Saag KG, Bridges SL Jr et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res 2016;68:1-25.
    • (2016) Arthritis Care Res , vol.68 , pp. 1-25
    • Singh, J.A.1    Saag, K.G.2    Bridges, S.L.3
  • 3
    • 85019702082 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
    • Smolen JS, Landewe R, Bijlsma J et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis 2017;76:960-77.
    • (2017) Ann Rheum Dis , vol.76 , pp. 960-977
    • Smolen, J.S.1    Landewe, R.2    Bijlsma, J.3
  • 4
    • 84930607509 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force
    • Smolen JS, Breedveld FC, Burmester GR et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis 2016;75:3-15.
    • (2016) Ann Rheum Dis , vol.75 , pp. 3-15
    • Smolen, J.S.1    Breedveld, F.C.2    Burmester, G.R.3
  • 5
    • 84953380615 scopus 로고    scopus 로고
    • A structured literature review of the burden of illness and unmet needs in patients with rheumatoid arthritis: A current perspective
    • Taylor PC, Moore A, Vasilescu R, Alvir J, Tarallo M. A structured literature review of the burden of illness and unmet needs in patients with rheumatoid arthritis: a current perspective. Rheumatol Int 2016;36:685-95.
    • (2016) Rheumatol Int , vol.36 , pp. 685-695
    • Taylor, P.C.1    Moore, A.2    Vasilescu, R.3    Alvir, J.4    Tarallo, M.5
  • 6
    • 84886304076 scopus 로고    scopus 로고
    • Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds
    • Migita K, Izumi Y, Torigoshi T et al. Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds. Clin Exp Immunol 2013;174:356-63.
    • (2013) Clin Exp Immunol , vol.174 , pp. 356-363
    • Migita, K.1    Izumi, Y.2    Torigoshi, T.3
  • 7
    • 33751300575 scopus 로고    scopus 로고
    • Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment
    • Walker JG, Ahern MJ, Coleman M et al. Changes in synovial tissue Jak-STAT expression in rheumatoid arthritis in response to successful DMARD treatment. Ann Rheum Dis 2006;65:1558-64.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1558-1564
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 8
    • 31144460322 scopus 로고    scopus 로고
    • Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: Unique JAK3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
    • Walker JG, Ahern MJ, Coleman M et al. Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique JAK3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. Ann Rheum Dis 2006;65:149-56.
    • (2006) Ann Rheum Dis , vol.65 , pp. 149-156
    • Walker, J.G.1    Ahern, M.J.2    Coleman, M.3
  • 9
    • 84903523652 scopus 로고    scopus 로고
    • Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
    • Clark JD, Flanagan ME, Telliez JB. Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem 2014;57:5023-38.
    • (2014) J Med Chem , vol.57 , pp. 5023-5038
    • Clark, J.D.1    Flanagan, M.E.2    Telliez, J.B.3
  • 10
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester GR, Blanco R, Charles-Schoeman C et al. Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 2013;381:451-60.
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1    Blanco, R.2    Charles-Schoeman, C.3
  • 11
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann R, Kremer J, Cush J et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012;367:495-507.
    • (2012) N Engl J Med , vol.367 , pp. 495-507
    • Fleischmann, R.1    Kremer, J.2    Cush, J.3
  • 12
    • 84882266430 scopus 로고    scopus 로고
    • Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial
    • Kremer J, Li ZG, Hall S et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Internal Med 2013;159:253-61.
    • (2013) Ann Internal Med , vol.159 , pp. 253-261
    • Kremer, J.1    Li, Z.G.2    Hall, S.3
  • 13
    • 85064379026 scopus 로고    scopus 로고
    • Remaining pain in DMARD-naive rheumatoid arthritis patients treated with baricitinib and methotrexate [abstract]
    • (date last accessed 26 July 2018)
    • Lee YCE, Emery P, Bradley JD et al. Remaining pain in DMARD-naive rheumatoid arthritis patients treated with baricitinib and methotrexate [abstract]. Arthritis Rheumatol 2017;69(Suppl 10):https://acrabstracts.org/ abstract/remaining-pain-in-dmard-naive-rheumatoid-arthritis- patients-treated-with-baricitinib-and-methotrexate/ (date last accessed 26 July 2018).
    • (2017) Arthritis Rheumatol , vol.69
    • Lee, Y.C.E.1    Emery, P.2    Bradley, J.D.3
  • 14
    • 84874402383 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
    • van der Heijde D, Tanaka Y, Fleischmann R et al. Tofacitinib (CP-690, 550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 2013;65:559-70.
    • (2013) Arthritis Rheum , vol.65 , pp. 559-570
    • Van Der Heijde, D.1    Tanaka, Y.2    Fleischmann, R.3
  • 15
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • van Vollenhoven RF, Fleischmann R, Cohen S et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 2012;367:508-19.
    • (2012) N Engl J Med , vol.367 , pp. 508-519
    • Van Vollenhoven, R.F.1    Fleischmann, R.2    Cohen, S.3
  • 16
    • 77954531991 scopus 로고    scopus 로고
    • Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: Preclinical characterization of INCB028050
    • Fridman JS, Scherle PA, Collins R et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol 2010;184:5298-307.
    • (2010) J Immunol , vol.184 , pp. 5298-5307
    • Fridman, J.S.1    Scherle, P.A.2    Collins, R.3
  • 17
    • 84991491965 scopus 로고    scopus 로고
    • Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: Results from the RA-BUILD study
    • Dougados M, van der Heijde D, Chen YC et al. Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study. Ann Rheum Dis 2017;76:88-95.
    • (2017) Ann Rheum Dis , vol.76 , pp. 88-95
    • Dougados, M.1    Van Der Heijde, D.2    Chen, Y.C.3
  • 18
    • 85014083376 scopus 로고    scopus 로고
    • Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment
    • Fleischmann R, Schiff M, van der Heijde D et al. Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment. Arthritis Rheum 2017;69:506-17.
    • (2017) Arthritis Rheum , vol.69 , pp. 506-517
    • Fleischmann, R.1    Schiff, M.2    Van Der Heijde, D.3
  • 19
    • 84962375370 scopus 로고    scopus 로고
    • Baricitinib in patients with refractory rheumatoid arthritis
    • Genovese MC, Kremer J, Zamani O et al. Baricitinib in patients with refractory rheumatoid arthritis. N Engl J Med 2016;374:1243-52.
    • (2016) N Engl J Med , vol.374 , pp. 1243-1252
    • Genovese, M.C.1    Kremer, J.2    Zamani, O.3
  • 20
    • 85013393351 scopus 로고    scopus 로고
    • Baricitinib versus placebo or adalimumab in rheumatoid arthritis
    • Taylor PC, Keystone EC, van der Heijde D et al. Baricitinib versus placebo or adalimumab in rheumatoid arthritis. N Engl J Med 2017;376:652-62.
    • (2017) N Engl J Med , vol.376 , pp. 652-662
    • Taylor, P.C.1    Keystone, E.C.2    Van Der Heijde, D.3
  • 21
    • 85062190913 scopus 로고    scopus 로고
    • Clinical efficacy of JAK inhibitors under development. Just more of the same?
    • Westhovens R. Clinical efficacy of JAK inhibitors under development. Just more of the same? Rheumatology 2019;58:i27-i33.
    • (2019) Rheumatology , vol.58 , pp. i27-i33
    • Westhovens, R.1
  • 22
    • 84960894417 scopus 로고    scopus 로고
    • Janus kinase inhibitors for rheumatoid arthritis
    • Yamaoka K. Janus kinase inhibitors for rheumatoid arthritis. Curr Opin Chem Biol 2016;32:29-33.
    • (2016) Curr Opin Chem Biol , vol.32 , pp. 29-33
    • Yamaoka, K.1
  • 23
    • 84988369665 scopus 로고    scopus 로고
    • Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis
    • Fleischmann RM, Huizinga TW, Kavanaugh AF et al. Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis. RMD Open 2016;2:e000262.
    • (2016) RMD Open , vol.2 , pp. e000262
    • Fleischmann, R.M.1    Huizinga, T.W.2    Kavanaugh, A.F.3
  • 24
    • 84872132785 scopus 로고    scopus 로고
    • FDA approves tofacitinib for rheumatoid arthritis
    • Traynor K. FDA approves tofacitinib for rheumatoid arthritis. Am J Health Syst Pharm 2012;69:2120.
    • (2012) Am J Health Syst Pharm , vol.69 , pp. 2120
    • Traynor, K.1
  • 25
    • 84990227017 scopus 로고    scopus 로고
    • Extended-release once-daily formulation of tofacitinib: Evaluation of pharmacokinetics compared with immediate-release tofacitinib and impact of food
    • Lamba M, Wang R, Fletcher T et al. Extended-release once-daily formulation of tofacitinib: evaluation of pharmacokinetics compared with immediate-release tofacitinib and impact of food. J Clin Pharm 2016;56:1362-71.
    • (2016) J Clin Pharm , vol.56 , pp. 1362-1371
    • Lamba, M.1    Wang, R.2    Fletcher, T.3
  • 26
    • 85015985399 scopus 로고    scopus 로고
    • Tofacitinib versus methotrexate in rheumatoid arthritis: Patient-reported outcomes from the randomised phase III ORAL Start trial
    • Strand V, Lee EB, Fleischmann R et al. Tofacitinib versus methotrexate in rheumatoid arthritis: patient-reported outcomes from the randomised phase III ORAL Start trial. RMD Open 2016;2:e000308.
    • (2016) RMD Open , vol.2 , pp. e000308
    • Strand, V.1    Lee, E.B.2    Fleischmann, R.3
  • 27
    • 85020770079 scopus 로고    scopus 로고
    • Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): A phase 3b/4, double-blind, head-to-head, randomised controlled trial
    • Fleischmann R, Mysler E, Hall S et al. Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial. Lancet 2017;390:457-68.
    • (2017) Lancet , vol.390 , pp. 457-468
    • Fleischmann, R.1    Mysler, E.2    Hall, S.3
  • 28
    • 84946214701 scopus 로고    scopus 로고
    • Effects of tofacitinib monotherapy on patient-reported outcomes in a randomized phase 3 study of patients with active rheumatoid arthritis and inadequate responses to DMARDs
    • Strand V, Kremer J, Wallenstein G et al. Effects of tofacitinib monotherapy on patient-reported outcomes in a randomized phase 3 study of patients with active rheumatoid arthritis and inadequate responses to DMARDs. Arthritis Res Ther 2015;17:307.
    • (2015) Arthritis Res Ther , vol.17 , pp. 307
    • Strand, V.1    Kremer, J.2    Wallenstein, G.3
  • 29
    • 84974817790 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo: Patient-reported outcomes from a phase 3 study of active rheumatoid arthritis
    • Strand V, van Vollenhoven RF, Lee EB et al. Tofacitinib or adalimumab versus placebo: patient-reported outcomes from a phase 3 study of active rheumatoid arthritis. Rheumatol 2016;55:1031-41.
    • (2016) Rheumatol , vol.55 , pp. 1031-1041
    • Strand, V.1    Van Vollenhoven, R.F.2    Lee, E.B.3
  • 30
    • 85016252656 scopus 로고    scopus 로고
    • Tofacitinib in combination with conventional disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: Patient-reported outcomes from a phase III randomized controlled trial
    • Strand V, Kremer JM, Gruben D et al. Tofacitinib in combination with conventional disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: patient-reported outcomes from a phase III randomized controlled trial. Arthritis Care Res 2017;69:592-8.
    • (2017) Arthritis Care Res , vol.69 , pp. 592-598
    • Strand, V.1    Kremer, J.M.2    Gruben, D.3
  • 31
    • 84925443908 scopus 로고    scopus 로고
    • Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: Patient-reported outcomes from a phase III trial
    • Strand V, Burmester GR, Zerbini CA et al. Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: patient-reported outcomes from a phase III trial. Arthritis Care Res 2015;67:475-83.
    • (2015) Arthritis Care Res , vol.67 , pp. 475-483
    • Strand, V.1    Burmester, G.R.2    Zerbini, C.A.3
  • 32
    • 84902593564 scopus 로고    scopus 로고
    • Tofacitinib versus methotrexate in rheumatoid arthritis
    • Lee EB, Fleischmann R, Hall S et al. Tofacitinib versus methotrexate in rheumatoid arthritis. N Engl J Med 2014;370:2377-86.
    • (2014) N Engl J Med , vol.370 , pp. 2377-2386
    • Lee, E.B.1    Fleischmann, R.2    Hall, S.3
  • 34
    • 85012201917 scopus 로고    scopus 로고
    • Baricitinib dose stepdown following disease control in patients with rheumatoid arthritis
    • Takeuchi T, Genovese M, Xie LI, et al. Baricitinib dose stepdown following disease control in patients with rheumatoid arthritis. Ann Rheum Dis 2016;75(Suppl 2):144.
    • (2016) Ann Rheum Dis , vol.75 , pp. 144
    • Takeuchi, T.1    Genovese, M.2    Xie, L.I.3
  • 35
    • 85030999408 scopus 로고    scopus 로고
    • Patient-reported outcomes from a phase 3 study of baricitinib versus placebo or adalimumab in rheumatoid arthritis: Secondary analyses from the RA-BEAM study
    • Keystone EC, Taylor PC, Tanaka Y et al. Patient-reported outcomes from a phase 3 study of baricitinib versus placebo or adalimumab in rheumatoid arthritis: secondary analyses from the RA-BEAM study. Ann Rheum Dis 2017;76:1853-61.
    • (2017) Ann Rheum Dis , vol.76 , pp. 1853-1861
    • Keystone, E.C.1    Taylor, P.C.2    Tanaka, Y.3
  • 36
    • 84994904843 scopus 로고    scopus 로고
    • Patient-reported outcomes from a randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON)
    • Smolen JS, Kremer JM, Gaich CL et al. Patient-reported outcomes from a randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON). Ann Rheum Dis 2017;76:694-700.
    • (2017) Ann Rheum Dis , vol.76 , pp. 694-700
    • Smolen, J.S.1    Kremer, J.M.2    Gaich, C.L.3
  • 37
    • 85062165650 scopus 로고    scopus 로고
    • Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis
    • Harigai M. Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis. Rheumatology 2019;58:i34-i42.
    • (2019) Rheumatology , vol.58 , pp. i34-i42
    • Harigai, M.1
  • 38
    • 85021853917 scopus 로고    scopus 로고
    • Analysis of haematological changes in tofacitinib-treated patients with rheumatoid arthritis across phase 3 and long-term extension studies
    • Schulze-Koops H, Strand V, Nduaka C et al. Analysis of haematological changes in tofacitinib-treated patients with rheumatoid arthritis across phase 3 and long-term extension studies. Rheumatol 2017;56:46-57.
    • (2017) Rheumatol , vol.56 , pp. 46-57
    • Schulze-Koops, H.1    Strand, V.2    Nduaka, C.3
  • 39
    • 85064378254 scopus 로고    scopus 로고
    • Effects of baricitinib on haemoglobin and related laboratory parameters in rheumatoid arthritis patients
    • Kay J, Harigai M, Rancourt J et al. Effects of baricitinib on haemoglobin and related laboratory parameters in rheumatoid arthritis patients. Ann Rheum Dis 2017;76(Suppl 2):513-4.
    • (2017) Ann Rheum Dis , vol.76 , pp. 513-514
    • Kay, J.1    Harigai, M.2    Rancourt, J.3
  • 40
    • 85023610992 scopus 로고    scopus 로고
    • Characterisation of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in two phase 3 studies
    • Emery P, McInnes I, Genovese M et al. Characterisation of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in two phase 3 studies. Ann Rheum Dis 2016;75(Suppl 1):A62-A.
    • (2016) Ann Rheum Dis , vol.75 , pp. A62-A
    • Emery, P.1    McInnes, I.2    Genovese, M.3
  • 41
    • 84997713674 scopus 로고    scopus 로고
    • Relationship between NK cell count and important safety events in rheumatoid arthritis patients treated with tofacitinib
    • van Vollenhoven RF, Tanaka Y, Lamba M et al. Relationship between NK cell count and important safety events in rheumatoid arthritis patients treated with tofacitinib. Ann Rheum Dis 2015;74(Suppl 2):258-9.
    • (2015) Ann Rheum Dis , vol.74 , pp. 258-259
    • Van Vollenhoven, R.F.1    Tanaka, Y.2    Lamba, M.3
  • 42
    • 84889645613 scopus 로고    scopus 로고
    • Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: A randomised study
    • McInnes IB, Kim HY, Lee SH et al. Open-label tofacitinib and double-blind atorvastatin in rheumatoid arthritis patients: a randomised study. Ann Rheum Dis 2014;73:124-31.
    • (2014) Ann Rheum Dis , vol.73 , pp. 124-131
    • McInnes, I.B.1    Kim, H.Y.2    Lee, S.H.3
  • 43
    • 85018684594 scopus 로고    scopus 로고
    • Effects of baricitinib on lipid, apolipoprotein, and lipoprotein particle profiles in a phase IIb study of patients with active rheumatoid arthritis
    • Kremer JM, Genovese MC, Keystone E et al. Effects of baricitinib on lipid, apolipoprotein, and lipoprotein particle profiles in a phase IIb study of patients with active rheumatoid arthritis. Arthritis Rheum 2017;69:943-52.
    • (2017) Arthritis Rheum , vol.69 , pp. 943-952
    • Kremer, J.M.1    Genovese, M.C.2    Keystone, E.3
  • 44
    • 84997501359 scopus 로고    scopus 로고
    • Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor
    • Charles-Schoeman C, Wicker P, Gonzalez-Gay MA et al. Cardiovascular safety findings in patients with rheumatoid arthritis treated with tofacitinib, an oral Janus kinase inhibitor. Semin Arthritis Rheum 2016;46:261-71.
    • (2016) Semin Arthritis Rheum , vol.46 , pp. 261-271
    • Charles-Schoeman, C.1    Wicker, P.2    Gonzalez-Gay, M.A.3
  • 45
    • 85047873374 scopus 로고    scopus 로고
    • Lipid profile and effect of statin treatment in pooled phase 2 and phase 3 baricitinib studies
    • Taylor PC, Kremer J, Emery P et al. Lipid profile and effect of statin treatment in pooled phase 2 and phase 3 baricitinib studies. Ann Rheum Dis 2018;77:988-995.
    • (2018) Ann Rheum Dis , vol.77 , pp. 988-995
    • Taylor, P.C.1    Kremer, J.2    Emery, P.3
  • 46
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • Breedveld FC, Weisman MH, Kavanaugh AF et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006;54:26-37.
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3
  • 47
    • 68049124945 scopus 로고    scopus 로고
    • Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
    • van Vollenhoven RF, Ernestam S, Geborek P et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial. Lancet 2009;374:459-66.
    • (2009) Lancet , vol.374 , pp. 459-466
    • Van Vollenhoven, R.F.1    Ernestam, S.2    Geborek, P.3


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