-
1
-
-
84902261143
-
The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study
-
Cross M, Smith E, Hoy D, et al. The global burden of rheumatoid arthritis:estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1316–1322.
-
(2014)
Ann Rheum Dis
, vol.73
, Issue.7
, pp. 1316-1322
-
-
Cross, M.1
Smith, E.2
Hoy, D.3
-
2
-
-
85013957711
-
Immunopathogenesis of rheumatoid arthritis
-
Firestein GS, McInnes IB., Immunopathogenesis of rheumatoid arthritis. Immunity. 2017;46(2):183–196.
-
(2017)
Immunity
, vol.46
, Issue.2
, pp. 183-196
-
-
Firestein, G.S.1
McInnes, I.B.2
-
3
-
-
84889683898
-
Proposal for a new nomenclature of disease-modifying antirheumatic drugs
-
Smolen JS, van der Heijde D, Machold KP, et al. Proposal for a new nomenclature of disease-modifying antirheumatic drugs. Ann Rheum Dis. 2014;73(1):3–5.
-
(2014)
Ann Rheum Dis
, vol.73
, Issue.1
, pp. 3-5
-
-
Smolen, J.S.1
van der Heijde, D.2
Machold, K.P.3
-
4
-
-
84964773927
-
Rheumatoid arthritis
-
Smolen JS, Aletaha D, McInnes IB., Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038.• An update of the pathogenesis of RA and its therapeutic implications.
-
(2016)
Lancet
, vol.388
, Issue.10055
, pp. 2023-2038
-
-
Smolen, J.S.1
Aletaha, D.2
McInnes, I.B.3
-
5
-
-
0037029418
-
Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study
-
Choi HK, Hernan MA, Seeger JD, et al. Methotrexate and mortality in patients with rheumatoid arthritis:a prospective study. Lancet. 2002;359(9313):1173–1177.
-
(2002)
Lancet
, vol.359
, Issue.9313
, pp. 1173-1177
-
-
Choi, H.K.1
Hernan, M.A.2
Seeger, J.D.3
-
6
-
-
84873854501
-
Propensity-adjusted association of methotrexate with overall survival in rheumatoid arthritis
-
Wasko MC, Dasgupta A, Hubert H, et al. Propensity-adjusted association of methotrexate with overall survival in rheumatoid arthritis. Arthritis and Rheumatism. 2013;65(2):334–342.
-
(2013)
Arthritis and Rheumatism
, vol.65
, Issue.2
, pp. 334-342
-
-
Wasko, M.C.1
Dasgupta, A.2
Hubert, H.3
-
7
-
-
85019702082
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
-
Smolen JS, Landewe R, Bijlsma J, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs:2016 update. Ann Rheum Dis. 2017;76:960–977.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 960-977
-
-
Smolen, J.S.1
Landewe, R.2
Bijlsma, J.3
-
8
-
-
84956767541
-
2015 American College of rheumatology guideline for the treatment of rheumatoid arthritis
-
Singh JA, Saag KG, Bridges SL, Jr., et al. 2015 American College of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2016;68(1):1–26.
-
(2016)
Arthritis Rheumatol
, vol.68
, Issue.1
, pp. 1-26
-
-
Singh, J.A.1
Saag, K.G.2
Bridges, S.L.3
-
9
-
-
80155128010
-
Remission of rheumatoid arthritis in clinical practice: application of the American College Of Rheumatology/European League Against Rheumatism 2011 remission criteria
-
Shahouri SH, Michaud K, Mikuls TR, et al. Remission of rheumatoid arthritis in clinical practice:application of the American College Of Rheumatology/European League Against Rheumatism 2011 remission criteria. Arthritis and Rheumatism. 2011;63(11):3204–3215.
-
(2011)
Arthritis and Rheumatism
, vol.63
, Issue.11
, pp. 3204-3215
-
-
Shahouri, S.H.1
Michaud, K.2
Mikuls, T.R.3
-
10
-
-
84858328629
-
Sustained rheumatoid arthritis remission is uncommon in clinical practice
-
Prince FH, Bykerk VP, Shadick NA, et al. Sustained rheumatoid arthritis remission is uncommon in clinical practice. Arthritis Res Ther. 2012;14(2):R68.
-
(2012)
Arthritis Res Ther
, vol.14
, Issue.2
, pp. R68
-
-
Prince, F.H.1
Bykerk, V.P.2
Shadick, N.A.3
-
11
-
-
84959860761
-
Efficacy and safety of baricitinib in Japanese patients with active rheumatoid arthritis receiving background methotrexate therapy: a 12-week, double-blind, randomized placebo-controlled study
-
Tanaka Y, Emoto K, Cai Z, et al. Efficacy and safety of baricitinib in Japanese patients with active rheumatoid arthritis receiving background methotrexate therapy:a 12-week, double-blind, randomized placebo-controlled study. J Rheumatol. 2016;43(3):504–511.
-
(2016)
J Rheumatol
, vol.43
, Issue.3
, pp. 504-511
-
-
Tanaka, Y.1
Emoto, K.2
Cai, Z.3
-
12
-
-
84921475867
-
Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate
-
Keystone EC, Taylor PC, Drescher E, et al. Safety and efficacy of baricitinib at 24 weeks in patients with rheumatoid arthritis who have had an inadequate response to methotrexate. Ann Rheum Dis. 2015;74(2):333–340.
-
(2015)
Ann Rheum Dis
, vol.74
, Issue.2
, pp. 333-340
-
-
Keystone, E.C.1
Taylor, P.C.2
Drescher, E.3
-
13
-
-
84962375370
-
Baricitinib in patients with refractory rheumatoid arthritis
-
Genovese MC, Kremer J, Zamani O, et al. Baricitinib in patients with refractory rheumatoid arthritis. N Engl J Med. 2016;374(13):1243–1252.
-
(2016)
N Engl J Med
, vol.374
, Issue.13
, pp. 1243-1252
-
-
Genovese, M.C.1
Kremer, J.2
Zamani, O.3
-
14
-
-
84991491965
-
Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs: results from the RA-BUILD study
-
Dougados M, van der Heijde D, Chen YC, et al. Baricitinib in patients with inadequate response or intolerance to conventional synthetic DMARDs:results from the RA-BUILD study. Ann Rheum Dis. 2017;76(1):88–95.
-
(2017)
Ann Rheum Dis
, vol.76
, Issue.1
, pp. 88-95
-
-
Dougados, M.1
van der Heijde, D.2
Chen, Y.C.3
-
15
-
-
85014083376
-
Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment
-
Fleischmann R, Schiff M, van der Heijde D, et al. Baricitinib, methotrexate, or combination in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment. Arthritis Rheumatol. 2017;69(3):506–517.
-
(2017)
Arthritis Rheumatol
, vol.69
, Issue.3
, pp. 506-517
-
-
Fleischmann, R.1
Schiff, M.2
van der Heijde, D.3
-
16
-
-
85013393351
-
Baricitinib versus placebo or adalimumab in rheumatoid arthritis
-
Taylor PC, Keystone EC, van der Heijde D, et al. Baricitinib versus placebo or adalimumab in rheumatoid arthritis. N Engl J Med. 2017;376(7):652–662.
-
(2017)
N Engl J Med
, vol.376
, Issue.7
, pp. 652-662
-
-
Taylor, P.C.1
Keystone, E.C.2
van der Heijde, D.3
-
17
-
-
80051986566
-
A randomized dose-ranging, placebo-controlled study of INCB028050, a selective JAK1 and JAK2 inhibitor in subjects with active rheumatoid arthritis [abstract]
-
Greenwald MK, Fidelus-Gort R, Levy R, et al. A randomized dose-ranging, placebo-controlled study of INCB028050, a selective JAK1 and JAK2 inhibitor in subjects with active rheumatoid arthritis [abstract]. Arthritis Rheum. 2010;62(Suppl10):2172.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 2172
-
-
Greenwald, M.K.1
Fidelus-Gort, R.2
Levy, R.3
-
18
-
-
85016307327
-
Mechanisms and consequences of Jak-STAT signaling in the immune system
-
Villarino AV, Kanno Y, O’Shea JJ. Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol. 2017;18(4):374–384.•• Recent review of the knowledge of JAK-STAT signaling.
-
(2017)
Nat Immunol
, vol.18
, Issue.4
, pp. 374-384
-
-
Villarino, A.V.1
Kanno, Y.2
O’Shea, J.J.3
-
19
-
-
84954197710
-
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
-
Schwartz DM, Bonelli M, Gadina M, et al. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol. 2016;12(1):25–36.• Review of the involvement of JAKs in inflammatory diseases.
-
(2016)
Nat Rev Rheumatol
, vol.12
, Issue.1
, pp. 25-36
-
-
Schwartz, D.M.1
Bonelli, M.2
Gadina, M.3
-
20
-
-
84964315361
-
The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers
-
Shi JG, Chen X, Lee F, et al. The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers. J Clin Pharmacol. 2014;54(12):1354–1361.
-
(2014)
J Clin Pharmacol
, vol.54
, Issue.12
, pp. 1354-1361
-
-
Shi, J.G.1
Chen, X.2
Lee, F.3
-
21
-
-
85015034112
-
Baricitinib: first global approval
-
Markham A. Baricitinib:first global approval. Drugs. 2017;77(6):697–704.
-
(2017)
Drugs
, vol.77
, Issue.6
, pp. 697-704
-
-
Markham, A.1
-
22
-
-
84862276942
-
JAK inhibition for the treatment of rheumatoid arthritis: a new era in oral DMARD therapy
-
Vaddi K, Luchi M. JAK inhibition for the treatment of rheumatoid arthritis:a new era in oral DMARD therapy. Expert Opin Investig Drugs. 2012;21(7):961–973.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, Issue.7
, pp. 961-973
-
-
Vaddi, K.1
Luchi, M.2
-
23
-
-
77954531991
-
Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
-
Fridman JS, Scherle PA, Collins R, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis:preclinical characterization of INCB028050. J Immunol. 2010;184(9):5298–5307.
-
(2010)
J Immunol
, vol.184
, Issue.9
, pp. 5298-5307
-
-
Fridman, J.S.1
Scherle, P.A.2
Collins, R.3
-
24
-
-
84903523652
-
Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases
-
Clark JD, Flanagan ME, Telliez JB. Discovery and development of Janus kinase (JAK) inhibitors for inflammatory diseases. J Med Chem. 2014;57(12):5023–5038.
-
(2014)
J Med Chem
, vol.57
, Issue.12
, pp. 5023-5038
-
-
Clark, J.D.1
Flanagan, M.E.2
Telliez, J.B.3
-
25
-
-
85014097983
-
The emerging safety profile of JAK inhibitors in rheumatic disease
-
Winthrop KL. The emerging safety profile of JAK inhibitors in rheumatic disease. Nat Rev Rheumatol. 2017;13(4):234–243.
-
(2017)
Nat Rev Rheumatol
, vol.13
, Issue.4
, pp. 234-243
-
-
Winthrop, K.L.1
-
26
-
-
0032076183
-
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
-
Rodig SJ, Meraz MA, White JM, et al. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 1998;93(3):373–383.
-
(1998)
Cell
, vol.93
, Issue.3
, pp. 373-383
-
-
Rodig, S.J.1
Meraz, M.A.2
White, J.M.3
-
27
-
-
84886304076
-
Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds
-
Migita K, Izumi Y, Torigoshi T, et al. Inhibition of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway in rheumatoid synovial fibroblasts using small molecule compounds. Clin Exp Immunol. 2013;174(3):356–363.
-
(2013)
Clin Exp Immunol
, vol.174
, Issue.3
, pp. 356-363
-
-
Migita, K.1
Izumi, Y.2
Torigoshi, T.3
-
28
-
-
85028386465
-
Committee for medicinal products for human use (CHMP)
-
Dec, AfhweeedeG
-
European Medicines Agency. Committee for medicinal products for human use (CHMP). Olumiant assessment report. Dec 15. AfhweeedeG.
-
Olumiant assessment report
-
-
-
29
-
-
85028390984
-
-
Available from
-
EMABOsopcAf. Available from:http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004085/WC500223723.pdf
-
EMABOsopcAf
-
-
-
30
-
-
85018193398
-
Patient-reported outcomes as end points in clinical trials in rheumatoid arthritis
-
Gossec L, Dougados M, Dixon W. Patient-reported outcomes as end points in clinical trials in rheumatoid arthritis. RMD Open. 2015;1(1):e000019.
-
(2015)
RMD Open
, vol.1
, Issue.1
, pp. e000019
-
-
Gossec, L.1
Dougados, M.2
Dixon, W.3
-
31
-
-
84994904843
-
Patient-reported outcomes from a randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON)
-
Smolen JS, Kremer JM, Gaich CL, et al. Patient-reported outcomes from a randomised phase III study of baricitinib in patients with rheumatoid arthritis and an inadequate response to biological agents (RA-BEACON). Ann Rheum Dis. 2016;76(4):694–700.
-
(2016)
Ann Rheum Dis
, vol.76
, Issue.4
, pp. 694-700
-
-
Smolen, J.S.1
Kremer, J.M.2
Gaich, C.L.3
-
32
-
-
85028401939
-
SAT0055. Baricitinib showed rapid and greater reduction in pain compared to adalimumab or placebo in patients with rheumatoid arthritis [abstract]
-
Taylor P, Zhu B, Gaich C, et al. SAT0055. Baricitinib showed rapid and greater reduction in pain compared to adalimumab or placebo in patients with rheumatoid arthritis [abstract]. Ann Rheum Dis. 2017;76(Suppl2):788.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 788
-
-
Taylor, P.1
Zhu, B.2
Gaich, C.3
-
33
-
-
85028418459
-
THU0081. Differences in patient-reported outcomes between baricitinib and comparators among patients with rheumatoid arthritis who achieved low disease activity or remission [abstract]
-
Fautrel B, van de Laar MB, Kirkham B, et al. THU0081. Differences in patient-reported outcomes between baricitinib and comparators among patients with rheumatoid arthritis who achieved low disease activity or remission [abstract]. Ann Rheum Dis. 2017;76(Suppl2):230.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 230
-
-
Fautrel, B.1
van de Laar, M.B.2
Kirkham, B.3
-
34
-
-
85015756313
-
THU0166. Safety profile of baricitinib in patients with active RA: an integrated analysis [abstract]
-
Smolen J, Genovese MC, Takeuchi T, et al. THU0166. Safety profile of baricitinib in patients with active RA:an integrated analysis [abstract]. Ann Rheum Dis. 2016;75(Suppl2):243–244.
-
(2016)
Ann Rheum Dis
, vol.75
, pp. 243-244
-
-
Smolen, J.1
Genovese, M.C.2
Takeuchi, T.3
-
35
-
-
85009869156
-
Herpes zoster in patients with moderate to severe rheumatoid arthritis treated with baricitinib [abstract]
-
Winthrop KL, Lindsey S, Weinblatt M, et al. Herpes zoster in patients with moderate to severe rheumatoid arthritis treated with baricitinib [abstract]. Arthritis Rheumatol. 2016;68(suppl 10, abstr 3027).
-
(2016)
Arthritis Rheumatol
, vol.68
-
-
Winthrop, K.L.1
Lindsey, S.2
Weinblatt, M.3
-
36
-
-
85015795355
-
THU0209. Characterization of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in a phase 3 study (RA-beam)
-
Tanaka Y, Fleischmann R, Schiff M, et al. THU0209. Characterization of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in a phase 3 study (RA-beam). Ann Rheum Dis. 2016;75(Suppl2):262.
-
(2016)
Ann Rheum Dis
, vol.75
, pp. 262
-
-
Tanaka, Y.1
Fleischmann, R.2
Schiff, M.3
-
37
-
-
84983471461
-
Characterization of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in two phase 3 studies [abstract]
-
Emery PMI, Genovese MC, Smolen JS, et al. Characterization of changes in lymphocyte subsets in baricitinib-treated patients with rheumatoid arthritis in two phase 3 studies [abstract]. Arthritis Rheumatol. 2015;67(suppl 10, abstr 1047).
-
(2015)
Arthritis Rheumatol
, vol.67
-
-
Emery, P.M.I.1
Genovese, M.C.2
Smolen, J.S.3
-
38
-
-
84877847008
-
A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis
-
Bannwarth B, Kostine M, Poursac N. A pharmacokinetic and clinical assessment of tofacitinib for the treatment of rheumatoid arthritis. Expert Opin Drug Metab Toxicol. 2013;9(6):753–761.
-
(2013)
Expert Opin Drug Metab Toxicol
, vol.9
, Issue.6
, pp. 753-761
-
-
Bannwarth, B.1
Kostine, M.2
Poursac, N.3
-
39
-
-
84864703156
-
Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
-
van Vollenhoven RF, Fleischmann R, Cohen S, et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med. 2012;367(6):508–519.
-
(2012)
N Engl J Med
, vol.367
, Issue.6
, pp. 508-519
-
-
van Vollenhoven, R.F.1
Fleischmann, R.2
Cohen, S.3
-
40
-
-
84965060726
-
Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis
-
Curtis JR, Xie F, Yun H, et al. Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis. Ann Rheum Dis. 2016;75(10):1843–1847.
-
(2016)
Ann Rheum Dis
, vol.75
, Issue.10
, pp. 1843-1847
-
-
Curtis, J.R.1
Xie, F.2
Yun, H.3
-
41
-
-
84966501435
-
Patient preferences regarding rheumatoid arthritis therapies: a conjoint analysis
-
Louder AM, Singh A, Saverno K, et al. Patient preferences regarding rheumatoid arthritis therapies:a conjoint analysis. Am Health Drug Benefits. 2016;9(2):84–93.
-
(2016)
Am Health Drug Benefits
, vol.9
, Issue.2
, pp. 84-93
-
-
Louder, A.M.1
Singh, A.2
Saverno, K.3
-
42
-
-
84995695072
-
Examining patient preferences in the treatment of rheumatoid arthritis using a discrete-choice approach
-
Alten R, Kruger K, Rellecke J, et al. Examining patient preferences in the treatment of rheumatoid arthritis using a discrete-choice approach. Patient Prefer Adherence. 2016;10:2217–2228.
-
(2016)
Patient Prefer Adherence
, vol.10
, pp. 2217-2228
-
-
Alten, R.1
Kruger, K.2
Rellecke, J.3
-
43
-
-
85020744211
-
Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials
-
Cohen SB, Tanaka Y, Mariette X, et al. Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years:integrated analysis of data from the global clinical trials. Ann Rheum Dis. 2017;76:1253–1262.•• Long-term safety data of tofacitinib.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 1253-1262
-
-
Cohen, S.B.1
Tanaka, Y.2
Mariette, X.3
|