Reducing dietary sodium to 1000 mg per day reduces neurovascular transduction without stimulating sympathetic outflow

Hypertension

Volumn 73, Issue 3, 2019, Pages 587-593

  Babcock, Matthew C ^a   Robinson, Austin T ^a   Migdal, Kamila U ^a   Watso, Joseph C ^a   Wenner, Megan M ^a   Stocker, Sean D ^b   Farquhar, William B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

aldosterone; angiotensins; blood pressure; hypertension; renin

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; NORADRENALIN; RENIN; SODIUM;

ADULT; ANALYTIC METHOD; ARTICLE; BIOCHEMICAL ANALYSIS; BLOOD PRESSURE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DOPPLER FLOWMETRY; FEMALE; HEART HEMODYNAMICS; HUMAN; LEG BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MUSCLE SYMPATHETIC NERVE ACTIVITY; NEUROVASCULAR TRANSDUCTION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SODIUM INTAKE; SYMPATHETIC OUTFLOW; VASCULARIZATION; ADMINISTRATION AND DOSAGE; ADRENERGIC SYSTEM; CROSSOVER PROCEDURE; DOSE RESPONSE; HYPERTENSION; INNERVATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SALT INTAKE; SODIUM RESTRICTION; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE; YOUNG ADULT;

ADULT; BLOOD PRESSURE; CROSS-OVER STUDIES; DIET, SODIUM-RESTRICTED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYPERTENSION; MALE; MUSCLE, SMOOTH, VASCULAR; SODIUM CHLORIDE, DIETARY; SYMPATHETIC NERVOUS SYSTEM; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 85061515041     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.118.12074     Document Type: Article

References (41)

1. Benjamin EJ, Blaha MJ, Chiuve SE, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2017 update: A report from the American Heart Association. Circulation. 2017;135:e146-e603. doi: 10.1161/CIR. 0000000000000485
2. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71:1269-1324. doi: 10.1161/HYP.0000000000000066
3. Whelton PK, Appel LJ, Sacco RL, et al. Sodium, blood pressure, and cardiovascular disease: Further evidence supporting the American Heart Association sodium reduction recommendations. Circulation. 2012;126:2880-2889.
4. Strazzullo P, D'Elia L, Kandala NB, Cappuccio FP. Salt intake, stroke, and cardiovascular disease: Meta-analysis of prospective studies. BMJ (Clinical research ed). 2009;339:b4567.
5. Cobb LK, Anderson CA, Elliott P, Hu FB, Liu K, Neaton JD, Whelton PK, Woodward M, Appel LJ; American Heart Association Council on Lifestyle and Metabolic Health. Methodological issues in cohort studies that relate sodium intake to cardiovascular disease outcomes: A science advisory from the American Heart Association. Circulation. 2014;129:1173-1186. doi: 10.1161/CIR.0000000000000015
6. Cook NR, Appel LJ, Whelton PK. Sodium intake and all-cause mortality over 20 years in the trials of hypertension prevention. J Am Coll Cardiol. 2016;68:1609-1617. doi: 10.1016/j.jacc.2016.07.745
7. He FJ, Li J, Macgregor GA. Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials. BMJ (Clinical research ed). 2013;346:f1325.
8. U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015-2020 Dietary Guidelines for Americans. https://health. gov/dietaryguidelines/2015/guidelines/. Accessed May 29, 2018.
9. Graudal N, Jürgens G, Baslund B, Alderman MH. Compared with usual sodium intake, low- A nd excessive-sodium diets are associated with increased mortality: A meta-analysis. Am J Hypertens. 2014;27:1129-1137. doi: 10.1093/ajh/hpu028
10. Mente A, O'Donnell M, Rangarajan S, et al. Urinary sodium excretion, blood pressure, cardiovascular disease, and mortality: A community-level prospective epidemiological cohort study. Lancet. 2018;392:496-506. doi: 10.1016/S0140-6736(18)31376-X
11. Stolarz-Skrzypek K, Kuznetsova T, Thijs L, Tikhonoff V, Seidlerová J, Richart T, Jin Y, Olszanecka A, Malyutina S, Casiglia E, Filipovský J, Kawecka-Jaszcz K, Nikitin Y, Staessen JA; European Project on Genes in Hypertension (EPOGH) Investigators. Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. JAMA. 2011;305:1777-1785. doi: 10.1001/jama.2011.574
12. He FJ, MacGregor GA. Salt reduction lowers cardiovascular risk: Meta-analysis of outcome trials. Lancet. 2011;378:380-382. doi: 10.1016/S0140-6736(11)61174-4
13. Farquhar WB, Edwards DG, Jurkovitz CT, Weintraub WS. Dietary sodium and health: More than just blood pressure. J Am Coll Cardiol. 2015;65:1042-1050. doi: 10.1016/j.jacc.2014.12.039
14. Abrahaõ SB, Tinucci T, Santello JL, Mion D Jr. Salt supresses baseline muscle sympathetic nerve activity in salt-sensitive and saltresistant hypertensives. J Hum Hypertens. 2002;16:843-850. doi: 10.1038/sj.jhh.1001492
15. Anderson EA, Sinkey CA, Lawton WJ, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension. 1989;14:177-183.
16. Grassi G, Cattaneo BM, Seravalle G, Lanfranchi A, Bolla G, Mancia G. Baroreflex impairment by low sodium diet in mild or moderate essential hypertension. Hypertension. 1997;29:802-807.
17. Matthews EL, Brian MS, Ramick MG, Lennon-Edwards S, Edwards DG, Farquhar WB. High dietary sodium reduces brachial artery flowmediated dilation in humans with salt-sensitive and salt-resistant blood pressure. J Appl Physiol (1985). 2015;118:1510-1515. doi: 10.1152/japplphysiol.00023.2015
18. DuPont JJ, Greaney JL, Wenner MM, Lennon-Edwards SL, Sanders PW, Farquhar WB, Edwards DG. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens. 2013;31:530-536. doi: 10.1097/HJH.0b013e32835c6ca8
19. Bernstein AM, Willett WC. Trends in 24-h urinary sodium excretion in the United States, 1957-2003: A systematic review. Am J Clin Nutr. 2010;92:1172-1180. doi: 10.3945/ajcn.2010.29367
20. Vranish JR, Holwerda SW, Young BE, Credeur DP, Patik JC, Barbosa TC, Keller DM, Fadel PJ. Exaggerated vasoconstriction to spontaneous bursts of muscle sympathetic nerve activity in healthy young black men. Hypertension. 2018;71:192-198. doi: 10.1161/HYPERTENSIONAHA.117.10229
21. Lennon-Edwards S, Ramick MG, Matthews EL, Brian MS, Farquhar WB, Edwards DG. Salt loading has a more deleterious effect on flow-mediated dilation in salt-resistant men than women. Nutr Metab Cardiovasc Dis. 2014;24:990-995. doi: 10.1016/j.numecd.2014.05.004
22. Gunn JP, Kuklina EV, Keenan NL, Labarthe DR. Sodium intake among adults-United States, 2005-2006. Morb Mortal Wkly Rep. 2010;59:746-749.
23. Mena LJ, Felix VG, Melgarejo JD, Maestre GE. 24-hour blood pressure variability assessed by average real variability: A systematic review and meta-analysis. J Am Heart Assoc. 2017;6:e006895. doi: 10.1161/JAHA.117.006895
24. Xia Y, Wu D, Gao Z, Liu X, Chen Q, Ren L, Wu W. Association between beat-to-beat blood pressure variability and vascular elasticity in normal young adults during the cold pressor test. Medicine (Baltimore). 2017;96:e6000. doi: 10.1097/MD.0000000000006000
25. Hart EC, Head GA, Carter JR, Wallin BG, May CN, Hamza SM, Hall JE, Charkoudian N, Osborn JW. Recording sympathetic nerve activity in conscious humans and other mammals: Guidelines and the road to standardization. Am J Physiol Heart Circ Physiol. 2017;312:H1031-H1051. doi: 10.1152/ajpheart.00703.2016
26. Fairfax ST, Padilla J, Vianna LC, Davis MJ, Fadel PJ. Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans. Am J Physiol Heart Circ Physiol. 2013;304:H759-H766. doi: 10.1152/ajpheart.00842.2012
27. Fairfax ST, Holwerda SW, Credeur DP, Zuidema MY, Medley JH, Dyke PC II, Wray DW, Davis MJ, Fadel PJ. The role of -adrenergic receptors in mediating beat-by-beat sympathetic vascular transduction in the forearm of resting man. J Physiol. 2013;591:3637-3649. doi: 10.1113/jphysiol.2013.250894
28. Wallin BG, Nerhed C. Relationship between spontaneous variations of muscle sympathetic activity and succeeding changes of blood pressure in man. J Auton Nerv Syst. 1982;6:293-302.
29. Fisher JP, Young CN, Fadel PJ. Central sympathetic overactivity: Maladies and mechanisms. Auton Neurosci. 2009;148:5-15. doi: 10.1016/j.autneu.2009.02.003
30. Charkoudian N, Wallin BG. Sympathetic neural activity to the cardiovascular system: Integrator of systemic physiology and interindividual characteristics. Compr Physiol. 2014;4:825-850. doi: 10.1002/cphy.c130038
31. Lerchl K, Rakova N, Dahlmann A, et al. Agreement between 24-hour salt ingestion and sodium excretion in a controlled environment. Hypertension. 2015;66:850-857. doi: 10.1161/HYPERTENSIONAHA.115.05851
32. Rakova N, Kitada K, Lerchl K, et al. Increased salt consumption induces body water conservation and decreases fluid intake. J Clin Invest. 2017;127:1932-1943. doi: 10.1172/JCI88530
33. Hall JE, Guyton AC, Mizelle HL. Role of the renin-angiotensin system in control of sodium excretion and arterial pressure. Acta Physiol Scand Suppl. 1990;591:48-62.
34. Walker WG, Moore MA, Horvath JS, Whelton PK. Arterial and venous angiotensin II in normal subjects. Relation to plasma renin activity and plasma aldosterone concentration, and response to posture and volume changes. Circ Res. 1976;38:477-483.
35. Rifkin DE, Khaki AR, Jenny NS, McClelland RL, Budoff M, Watson K, Ix JH, Allison MA. Association of renin and aldosterone with ethnicity and blood pressure: The Multi-Ethnic Study of Atherosclerosis. Am J Hypertens. 2014;27:801-810. doi: 10.1093/ajh/hpt276
36. Goessler K, Polito M, Cornelissen VA. Effect of exercise training on the renin-angiotensin-aldosterone system in healthy individuals: A systematic review and meta-analysis. Hypertens Res. 2016;39:119-126. doi: 10.1038/hr.2015.100
37. Friberg P, Meredith I, Jennings G, Lambert G, Fazio V, Esler M. Evidence for increased renal norepinephrine overflow during sodium restriction in humans. Hypertension. 1990;16:121-130.
38. Barrett-O'Keefe Z, Ives SJ, Trinity JD, Morgan G, Rossman MJ, Donato AJ, Runnels S, Morgan DE, Gmelch BS, Bledsoe AD, Richardson RS, Wray DW. Endothelin-A-mediated vasoconstriction during exercise with advancing age. J Gerontol A Biol Sci Med Sci. 2015;70:554-565. doi: 10.1093/gerona/glu065
39. Kooijman M, Thijssen DH, de Groot PC, Bleeker MW, van Kuppevelt HJ, Green DJ, Rongen GA, Smits P, Hopman MT. Flow-mediated dilatation in the superficial femoral artery is nitric oxide mediated in humans. J Physiol. 2008;586:1137-1145. doi: 10.1113/jphysiol.2007.145722
40. Greaney JL, DuPont JJ, Lennon-Edwards SL, Sanders PW, Edwards DG, Farquhar WB. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: Role of oxidative stress. J Physiol. 2012;590:5519-5528. doi: 10.1113/jphysiol.2012.236992
41. Eckel RH, Jakicic JM, Ard JD, et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(25 pt B):2960-2984. doi: 10.1016/j.jacc.2013.11.003