Salt loading has a more deleterious effect on flow-mediated dilation in salt-resistant men than women

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 24, Issue 9, 2014, Pages 990-995

  Lennon Edwards, S ^a   Ramick, M G ^a   Matthews, E L ^a   Brian, M S ^a   Farquhar, W B ^a   Edwards, D G ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Flow mediated dilation; Sex; Sodium

Indexed keywords

ADULT; ARTICLE; CHLORIDE BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DEPENDENT DILATION; FEMALE; HIGH SODIUM INTAKE; HUMAN; MALE; MEAN ARTERIAL PRESSURE; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; SALT LOADING; SODIUM URINE LEVEL; URINE OSMOLALITY; VASODILATATION; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; BLOOD; BLOOD PRESSURE; BODY MASS; BRACHIAL ARTERY; CROSSOVER PROCEDURE; DRUG EFFECTS; NORMAL HUMAN; PATHOPHYSIOLOGY; POTASSIUM INTAKE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SODIUM INTAKE; SODIUM RESTRICTION; YOUNG ADULT;

POTASSIUM INTAKE; SODIUM INTAKE;

ADULT; BLOOD PRESSURE; BODY MASS INDEX; BRACHIAL ARTERY; CROSS-OVER STUDIES; DIET, SODIUM-RESTRICTED; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; POTASSIUM, DIETARY; SEX FACTORS; SODIUM, DIETARY; YOUNG ADULT;

EID: 84955740888     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2014.05.004     Document Type: Article

References (30)

1. Sacks F.M., Svetkey L.P., Vollmer W.M., Appel L.J., Bray G.A., Harsha D., et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med 2001 Jan 4, 344(1):3-10.
2. DuPont J.J., Greaney J.L., Wenner M.M., Lennon-Edwards S.L., Sanders P.W., Farquhar W.B., et al. High dietary sodium intake impairs endothelium-dependent dilation in healthy salt-resistant humans. J Hypertens 2013 Mar, 31(3):530-536.
3. Greaney J.L., DuPont J.J., Lennon-Edwards S.L., Sanders P.W., Edwards D.G., Farquhar W.B. Dietary sodium loading impairs microvascular function independent of blood pressure in humans: role of oxidative stress. J Physiol 2012 Nov 1, 590(Pt 21):5519-5528.
4. Eisenach J.H., Gullixson L.R., Kost S.L., Joyner M.J., Turner S.T., Nicholson W.T. Sex differences in salt sensitivity to nitric oxide dependent vasodilation in healthy young adults. J Appl Physiol 2012 Mar, 112(6):1049-1053.
5. Luscher T.F., Tanner F.C., Tschudi M.R., Noll G. Endothelial dysfunction in coronary artery disease. Annu Rev Med 1993, 44:395-418.
6. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2002 Mar 5, 105(9):1135-1143.
7. Thijssen D.H., Bullens L.M., van Bemmel M.M., Dawson E.A., Hopkins N., Tinken T.M., et al. Does arterial shear explain the magnitude of flow-mediated dilation?: a comparison between young and older humans. Am J Physiol Heart Circ Physiol 2009 Jan, 296(1):H57-H64.
8. Green D.J., Jones H., Thijssen D., Cable N.T., Atkinson G. Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?. Hypertension 2011 Mar, 57(3):363-369.
9. Dickinson K.M., Keogh J.B., Clifton P.M. Effects of a low-salt diet on flow-mediated dilatation in humans. Am J Clin Nutr 2009 Feb, 89(2):485-490.
10. Jablonski K.L., Gates P.E., Pierce G.L., Seals D.R. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis 2009 Oct, 3(5):347-356.
11. Eaker E.D., Chesebro J.H., Sacks F.M., Wenger N.K., Whisnant J.P., Winston M. Cardiovascular disease in women. Circulation 1993 Oct, 88(4 Pt 1):1999-2009.
12. He J., Gu D., Chen J., Jaquish C.E., Rao D.C., Hixson J.E., et al. Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study. J Hypertens 2009 Jan, 27(1):48-54.
13. Moreau K.L., Hildreth K.L., Meditz A.L., Deane K.D., Kohrt W.M. Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab 2012 Dec, 97(12):4692-4700.
14. Feldman H.I., Appel L.J., Chertow G.M., Cifelli D., Cizman B., Daugirdas J., et al. The Chronic renal Insufficiency Cohort (CRIC) study: design and methods. J Am Soc Nephrol 2003 Jul, 14(7 Suppl 2):S148-S153.
15. Schmidlin O., Sebastian A.F., Morris R.C. What initiates the pressor effect of salt in salt-sensitive humans? Observations in normotensive blacks. Hypertension 2007 May, 49(5):1032-1039.
16. van den Munckhof I., Riksen N., Seeger J.P., Schreuder T.H., Borm G.F., Eijsvogels T.M., et al. Aging attenuates the protective effect of ischemic preconditioning against endothelial ischemia-reperfusion injury in humans. Am J Physiol Heart Circ Physiol 2013 Jun 15, 304(12):H1727-H1732.
17. Cook N.R., Cutler J.A., Obarzanek E., Buring J.E., Rexrode K.M., Kumanyika S.K., et al. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ 2007 Apr 28, 334(7599):885-888.
18. Todd A.S., Macginley R.J., Schollum J.B., Johnson R.J., Williams S.M., Sutherland W.H., et al. Dietary salt loading impairs arterial vascular reactivity. Am J Clin Nutr 2010 Mar, 91(3):557-564.
19. Tzemos N., Lim P.O., Wong S., Struthers A.D., MacDonald T.M. Adverse cardiovascular effects of acute salt loading in young normotensive individuals. Hypertension 2008 Jun, 51(6):1525-1530.
20. Jablonski K.L., Racine M.L., Geolfos C.J., Gates P.E., Chonchol M., McQueen M.B., et al. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol 2013 Jan 22, 61(3):335-343.
21. Lenda D.M., Sauls B.A., Boegehold M.A. Reactive oxygen species may contribute to reduced endothelium-dependent dilation in rats fed high salt. Am J Physiol Heart Circ Physiol 2000 Jul, 279(1):H7-H14.
22. Nurkiewicz T.R., Boegehold M.A. High salt intake reduces endothelium-dependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2007 Apr, 292(4):R1550-R1556.
23. Huskova Z., Kramer H., Vanourkova Z., Thumova M., Maly J., Opocensky M., et al. Effects of dietary salt load and salt depletion on the course of hypertension and angiotensin II levels in male and female heterozygous Ren-2 transgenic rats. Kidney Blood Press Res 2007, 30(1):45-55.
24. Celermajer D.S., Sorensen K.E., Spiegelhalter D.J., Georgakopoulos D., Robinson J., Deanfield J.E. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994 Aug, 24(2):471-476.
25. Perez-Lopez F.R., Larrad-Mur L., Kallen A., Chedraui P., Taylor H.S. Gender differences in cardiovascular disease: hormonal and biochemical influences. Reprod Sci 2010 Jun, 17(6):511-531.
26. Chirinos J.A., Zambrano J.P., Chakko S., Veerani A., Schob A., Willens H.J., et al. Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary artery disease. Hypertension 2005 May, 45(5):980-985.
27. Li J., White J., Guo L., Zhao X., Wang J., Smart E.J., et al. Salt inactivates endothelial nitric oxide synthase in endothelial cells. J Nutr 2009 Mar, 139(3):447-451.
28. Stachenfeld N.S., Splenser A.E., Calzone W.L., Taylor M.P., Keefe D.L. Sex differences in osmotic regulation of AVP and renal sodium handling. J Appl Physiol 2001 Oct, 91(4):1893-1901.
29. Pryer J.A., Vrijheid M., Nichols R., Kiggins M., Elliott P. Who are the 'low energy reporters' in the dietary and nutritional survey of British adults?. Int J Epidemiol 1997 Feb, 26(1):146-154.
30. Williams M.R., Westerman R.A., Kingwell B.A., Paige J., Blombery P.A., Sudhir K., et al. Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab 2001 Nov, 86(11):5389-5395.