SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

Cardiovascular Diabetology

Volumn 18, Issue 1, 2019, Pages

  Li, Chenguang ^a   Zhang, Jie ^a   Xue, Mei ^a   Li, Xiaoyu ^a   Han, Fei ^a   Liu, Xiangyang ^a   Xu, Linxin ^a   Lu, Yunhong ^a   Cheng, Ying ^a   Li, Ting ^a   Yu, Xiaochen ^a   Sun, Bei ^a   Chen, Liming ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Empagliflozin; Myocardial fibrosis; Oxidative stress; SGLT2; Type 2 diabetes mellitus

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CHOLESTEROL; COLLAGEN TYPE 1; COLLAGEN TYPE 3; EMPAGLIFLOZIN; GLUCOSE; GLUTATHIONE PEROXIDASE; HEME OXYGENASE 1; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYPROLINE; INSULIN; LIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; SODIUM GLUCOSE COTRANSPORTER 2; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; ANTIOXIDANT; BENZHYDRYL DERIVATIVE; GLUCOSIDE; NFE2L2 PROTEIN, MOUSE; SLC5A2 PROTEIN, MOUSE; SMAD PROTEIN; TGFB1 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BODY WEIGHT GAIN; CARDIAC MUSCLE; CELL NUCLEUS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ECHOCARDIOGRAPHY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART PROTECTION; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; KK-AY MOUSE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN TRANSPORT; STAINING; TGF BETA SIGNALING; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; FIBROSIS; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; PATHOPHYSIOLOGY; PHARMACOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; BENZHYDRYL COMPOUNDS; DIABETES MELLITUS, TYPE 2; DIABETIC CARDIOMYOPATHIES; DISEASE MODELS, ANIMAL; FIBROSIS; GLUCOSIDES; MICE, INBRED C57BL; MYOCARDIUM; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD PROTEINS; SODIUM-GLUCOSE TRANSPORTER 2; SODIUM-GLUCOSE TRANSPORTER 2 INHIBITORS; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 85061009147     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-019-0816-2     Document Type: Article

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