Imprecise Spacer Acquisition Generates CRISPR-Cas Immune Diversity through Primed Adaptation

Cell Host and Microbe

Volumn 25, Issue 2, 2019, Pages 250-260.e4

  Jackson, Simon A ^a   Birkholz, Nils ^a   Malone, Lucía M ^a   Fineran, Peter C ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

adaptation; coevolution; CRISPR Cas; diversity; phage; primed; priming; slipping; spacer acquisition

Indexed keywords

ARTICLE; BACTERIOPHAGE; COEVOLUTION; CRISPR CAS SYSTEM; IMMUNE SYSTEM; MEMORY; NONHUMAN; GENETIC VARIATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; MOLECULAR EVOLUTION; PECTOBACTERIUM; SERRATIA; VIROLOGY;

SPACER DNA; VIRUS DNA;

BACTERIOPHAGES; CRISPR-CAS SYSTEMS; DNA, INTERGENIC; DNA, VIRAL; EVOLUTION, MOLECULAR; GENETIC VARIATION; PECTOBACTERIUM; SERRATIA;

EID: 85060878990     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2018.12.014     Document Type: Article

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