Antioxidant Potential and Angiotensin-Converting Enzyme (ACE) Inhibitory Activity of Orotic Acid-Loaded Gum Arabic Nanoparticles

AAPS PharmSciTech

Volumn 20, Issue 2, 2019, Pages

  Hassani, Abdelkader ^a   Hussain, Siti Aslina ^a   Abdullah, Norhafizah ^a   Kamarudin, Suryani ^a   Rosli, Rozita ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

antihypertensive; antioxidant; nanoparticles; radical scavenging

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; CAROTENE; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GALLIC ACID; GUM ARABIC; LINOLEIC ACID; NANOPARTICLE; NITRIC OXIDE; OROTIC ACID; PHENOL DERIVATIVE; TROLOX C; ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; PLANT EXTRACT;

ANIMAL CELL; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLEACHING; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; FREEZE DRYING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAW 264.7 CELL LINE; ANIMAL; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; MOUSE; PHYSIOLOGY;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GUM ARABIC; MICE; NANOPARTICLES; OROTIC ACID; PLANT EXTRACTS; RAW 264.7 CELLS;

EID: 85059929191     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-018-1238-2     Document Type: Article

References (49)

1. Usman MS, Hussein MZ, Fakurazi S, et al. Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system. Nano. 2017;7:244. 10.3390/nano7090244
2. Ali HA, Press D. Controlled release and angiotensin converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine layered double hydroxide nanocomposite. Int J Nanomedicine. 2012;7:2129–41. 10.2147/IJN.S30461
3. Kovanda F, Jindova E, Doušová B, Kolousek D, Plestil J, et al. Layered double hydroxides intercalated with organic anions and their application in preparation of ldh/polymer nanocomposites. Acta Geodyn Geomater. 2009;6:111–9 https://www.irsm.cas.cz/materialy/acta_content/2009_01/8_Kovanda.pdf. Accessed January 2009
4. Swierczewska M, Liu G, Chen X, et al. High-sensitivity nanosensors for biomarker detection w. Chem Soc Rev. 2011;41:1–10. 10.1039/c1cs15238f
5. Cheon J. Theranostic magnetic nanoparticles. Acc Chem Res. 2011;44(10):863–74. 10.1021/ar200085c
6. Links DA. Paramagnetic nanoparticle T 1 and T 2 MRI contrast agents. Phys Chem Chem Phys. 2012;14:12687–700. 10.1039/c2cp41357d
7. Jeong T, Seok K, Chang Y, Ho G, et al. Gadolinium oxide nanoparticles as potential multimodal imaging and therapeutic agents. Curr Top Med Chem. 2013;13:422–33
8. Usman MS, Hussein MZ, Fakurazi S, Ahmad Saad FF, et al. Gadolinium-based layered double hydroxide and graphene oxide nano-carriers for magnetic resonance imaging and drug delivery. Chem Cent J. 2017;11(1):1–10. 10.1186/s13065-017-0275-3
9. Elgqvist J. Nanoparticles as theranostic vehicles in experimental and clinical applications—focus on prostate and breast cancer. Int J Mol Sci. 2017;18:1–53. 10.3390/ijms18051102
10. Oberdörster G, Oberdörster E, Oberdörster J, et al. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113(7):823–39. 10.1289/ehp.7339
11. Vij N, Min T, Marasigan R, Belcher CN, Mazur S, Ding H, et al. Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis. J Nanobiotechnology. 2010:1–18. 10.1186/1477-3155-8-22
12. Chen J, Patil S, Seal S, Mcginnis JF, et al. Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol. 2006;1:142–50
13. Manuel P, Atul A, Sudip N, et al. Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties. Communications. 2008:552–6. 10.1002/smll.200700824
14. Mousa SA. Nanotechnology-based detection and targeted therapy in cancer: nano-bio paradigms and applications. Cancers. 2011;3:2888–903. 10.3390/cancers3032888
15. Mohanpuria P, Rana NK. Biosynthesis of nanoparticles: technological concepts and future applications. J Nanopart Res. 2008;10:507–17. 10.1007/s11051-007-9275-x
16. Li G, Le G, Shi Y, Shrestha S, et al. Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr Res. 2004;24:469–86. 10.1016/j.nutres.2003.10.014
17. Unger T. The role of the renin–angiotensin system in the development of cardiovascular disease. Am J Cardiol. 2002;l((1)):3–9. 10.1016/S0002-9149(01)02321-9
18. Cadenas E, Davies KJA, Adenas ENC, et al. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29:222–30. 10.1016/S0891-5849(00)00317-8
19. Anderson DMW, Eastwood MA. The safety of gum arabic as a food additive and its energy value as an ingredient: a brief review. J Hum Nutr Diet. 1988;2:137–44
20. Motlagh S, Ravines P, Karamallah KA, Ma Q, et al. The analysis of Acacia gums using electrophoresis. Food Hydrocoll. 2006;20:848–54. 10.1111/j.1365-277X.1989.tb00017.x
21. Ali A, Maqbool M, Alderson PG, Zahid N, et al. Effect ofgum arabic as an edible coating on antioxidant capacity of tomato (Solanum lycopersicum L.) fruit during storage. Postharvest Biol Technol. 2013;76:119–24. 10.1016/j.postharvbio.2012.09.011
22. Gamal AM, Mostafa AM, Al-Shabanah OA, Al-Bekairi AM, Nagi MN, et al. Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. Pharmacol Res. 2003;48:631–5. 10.1016/S1043-6618(03)00226-3
23. Palmer S. Role of nitric oxide in intestinal water and electrolyte transport. Gut. 1999;44:143–7. 10.1136/gut.44.2.143
24. Rehman KU, Wingertzahn MA, Teichberg S, Harper RG, Wapnir RA, et al. Gum arabic (GA) modifies paracellular water and electrolyte transport in the small intestine. Dig Dis Sci. 2003;48:755–60
25. Rehman K, Wingertzahn MA, Harper RG, Wapnir RA, et al. Proabsorptive action of gum arabic: regulation of nitric oxide metabolism in the basolateral potassium channel of the small intestine. J Pediatr Gastroenterol Nutr. 2001;32:529–33
26. Ali AA, Ali KE, Fadlalla AE, Khalid KE. The effects of gum arabic oral treatment on the metabolic profile of chronic renal failure patients under regular haemodialysis in Central Sudan. Nat Prod Res. 2008;22:12–21. 10.1080/14786410500463544
27. Ali BH, Alqarawi AA, Ahmed IH, et al. Does treatment with gum arabic affect experimental chronic renal failure in rats? Fundam Clin Pharmacol. 2004;18:327–39. 10.1111/j.1472-8206.2004.00241.x
28. Verbeken MD. Exudate gums: occurrence, production, and applications. Appl Microbiol Biotechnol. 2003:10–21. 10.1007/s00253-003-1354-z
29. Arabia S, Arabia S. Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats histopathological examination. Pharmacol Res. 2002;46:445–51. 10.1016/S1043661802001251
30. Hueso-Urefia F, Moreno-Carretero MN, Salas-Peregrin JM, Inorgfinica DDQ, De Ciencias F, De Granada U, et al. Silver (I), palladium (II), platinurn (II) and platinum (IV) complexes with isoorotate and 2-thioisoorotate ligands: synthesis, I.R. and N.M.R. spectra, thermal behaviour and antimicrobial activity. Transit Met Chem. 1995;269:262–9
31. Dodin G, Dubois J. Tautomerism of orotic acid dianion. Effect of calcium and magnesium cations on the tautomeric constant and on tautomerization dynamics. J Am Chem Soc. 1980:3049–56. 10.1021/ja00529a030
32. Kostova I, Peica N, Kiefer W, et al. Theoretical and spectroscopic studies of lanthanum (III) complex of 5-aminoorotic acid. Chem Phys. 2006;327:494–505. 10.1016/j.chemphys.2006.05.029
33. Kostova I, Valcheva-Traykova M. New samarium (III) complex of 5-aminoorotic acid with antioxidant activity. Appl Organomet Chem. 2015;29:815–24. 10.1002/aoc.3374
34. Tan C, Xie J, Zhang X, Cai J, Xia S, et al. Food hydrocolloids polysaccharide-based nanoparticles by chitosan and gum arabic polyelectrolyte complexation as carriers for curcumin. Food Hydrocoll. 2016;57:236–45. 10.1016/j.foodhyd.2016.01.021
35. Ranneh Y, Ali F, Al QM, Esa NM, Ismail A, et al. The inhibitory activity of cocoa phenolic extract against pro-inflammatory mediators secretion induced by lipopolysaccharide in RAW 264.7 cells. Springer plus. 2016:547. 10.1186/s40064-016-2138-0
36. Shon M, Kim T, Sung N, et al. Antioxidants and free radical scavenging activity of Phellinus baumii (Phellinus of Hymenochaetaceae) extracts. Food Chem. 2003;82:593–7. 10.1016/S0308-8146(03)00015-3
37. Barros L, Baptista P, Correia DM, Morais JS, Ferreira IC. Effects of conservation treatment and cooking on the chemical composition and antioxidant activity of Portuguese wild edible mushrooms. J Agric Food Chem. 2007;55:4781–8. 10.1021/jf070407o
38. Barros L, Queiro B, Ferreira ICFR, Baptista P, et al. Total phenols, ascorbic acid, B-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities. Food Chem. 2007;103:413–9. 10.1016/j.foodchem.2006.07.038
39. Sondi I, Salopek-Sondi B. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. J Colloid Interface Sci. 2004;275:177–82. 10.1016/j.jcis.2004.02.012
40. Andrzej LD, Dorota W, Barbara B. The antioxidant properties of alcoholic extracts from Sambucus nigra L. (antioxidant properties of extracts). Food Sci Technol. 2006;39(3):308–15. 10.1016/j.lwt.2005.01.005
41. Ara N, Nur H. In vitro antioxidant activity of methanolic leaves and flowers extracts of Lippia Alba. Res J Med Med Sci. 2009;4(1):107–10
42. Kong H, Yang J, Zhang Y, Fang Y, et al. Synthesis and antioxidant properties of gum arabic-stabilized selenium nanoparticles. Int J Biol Macromol [Internet]. 2014;65:155–62. 10.1016/j.ijbiomac.2014.01.011
43. Kumaran A, Joel R. Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus. Food Chem. 2006;97:109–14. 10.1016/j.foodchem.2005.03.032
44. Ao JIB, Ai YIC, Un MEIS, Ang GUW, Orke HAC, et al. Anthocyanins, flavonols, and free radical scavenging activity of Chinese bayberry (Myrica rubra) extracts and their color properties and stability. J Agric Food Chem. 2005:2–7. 10.1021/jf048312z
45. Soren S, Jena SR, Samanta L, et al. Antioxidant potential and toxicity study of the cerium oxide nanoparticles synthesized by microwave-mediated synthesis. Appl Biochem Biotechnol. 2015:148–61. 10.1007/s12010-015-1734-8
46. Zaid RM, Chin F, Yi E, Teo L, Ng E, Feng K, et al. Reduction of graphene oxide nanosheets by natural beta carotene and its potential use as supercapacitor electrode. Arab J Chem. 2015;8(4):560–9. 10.1016/j.arabjc.2014.11.036
47. Matsumura Y, Chikako Satak EM. Interaction of gum arabic, maltodextrin and pullulan with lipids in emulsions. Biosci Biotechnol Biochem. 2000;64:1827–35. 10.1271/bbb.64.1827
48. Abdel-Aziz MS, Shaheen MS, El-Nekeety AA, et al. Antioxidant and antibacterial activity of silver nanoparticles biosynthesized using Chenopodium murale leaf extract. J Saudi Chem Soc [Internet]. 2014;18(4):356–63. 10.1016/j.jscs.2013.09.011
49. Felipe C, Rodrigues C, Matias S, Alencar D, Thomazini M, De Carvalho JC, et al. Assessment of production efficiency, physicochemical properties and storage stability of spray-dried propolis, a natural food additive, using gum arabic and OSA starch-based carrier systems. Food Bioprod Process. 2012;91(1):28–36. 10.1016/j.fbp.2012.08.006