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Volumn 69, Issue 2, 2018, Pages 396-405

Dysregulation of serum bile acids and FGF19 in alcoholic hepatitis

(30)  Brandl, Katharina a   Hartmann, Phillipp b,c   Jih, Lily J b,d   Pizzo, Donald P b   Argemi, Josepmaria e   Ventura Cots, Meritxell e   Coulter, Sally f   Liddle, Christopher f   Ling, Lei g   Rossi, Stephen J g   DePaoli, Alex M g   Loomba, Rohit c   Mehal, Wajahat Z h,i   Fouts, Derrick E j   Lucey, Michael R k   Bosques Padilla, Francisco l   Mathurin, Philippe m   Louvet, Alexander m   Garcia Tsao, Guadalupe h,i   Verna, Elizabeth C n   more..


Author keywords

Bile acids; FGF19; Microbiome

Indexed keywords

BILE ACID; BILE ACID CONJUGATE; BILE SALT EXPORT PUMP; BILIRUBIN; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; DEOXYCHOLIC ACID; FIBROBLAST GROWTH FACTOR 19; GAMMA GLUTAMYLTRANSFERASE; GLYCOCHOLIC ACID; GLYCODEOXYCHOLIC ACID; HYODEOXYCHOLIC ACID; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID; TAURODEOXYCHOLIC ACID; TAUROLITHOCHOLIC ACID; BIOLOGICAL MARKER; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR;

EID: 85047085514     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2018.03.031     Document Type: Article
Times cited : (149)

References (30)
  • 1
    • 84973549992 scopus 로고    scopus 로고
    • Spectrum of alcoholic liver disease
    • Chacko, K.R., Reinus, J., Spectrum of alcoholic liver disease. Clin Liver Dis 20 (2016), 419–427.
    • (2016) Clin Liver Dis , vol.20 , pp. 419-427
    • Chacko, K.R.1    Reinus, J.2
  • 2
    • 84937045860 scopus 로고    scopus 로고
    • Prednisolone or pentoxifylline for alcoholic hepatitis
    • Thursz, M.R., Forrest, E.H., Ryder, S., STOPAH investigators. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med 373 (2015), 282–283.
    • (2015) N Engl J Med , vol.373 , pp. 282-283
    • Thursz, M.R.1    Forrest, E.H.2    Ryder, S.3
  • 4
    • 55349133034 scopus 로고    scopus 로고
    • A new scoring system for prognostic stratification of patients with alcoholic hepatitis
    • Dominguez, M., Rincon, D., Abraldes, J.G., Miquel, R., Colmenero, J., Bellot, P., et al. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am J Gastroenterol 103 (2008), 2747–2756.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2747-2756
    • Dominguez, M.1    Rincon, D.2    Abraldes, J.G.3    Miquel, R.4    Colmenero, J.5    Bellot, P.6
  • 5
    • 84856492849 scopus 로고    scopus 로고
    • Management of alcoholic hepatitis
    • Mathurin, P., Lucey, M.R., Management of alcoholic hepatitis. J Hepatol 56 (2012), S39–S45.
    • (2012) J Hepatol , vol.56 , pp. S39-S45
    • Mathurin, P.1    Lucey, M.R.2
  • 7
    • 84875599882 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in cholestatic liver diseases
    • Halilbasic, E., Baghdasaryan, A., Trauner, M., Nuclear receptors as drug targets in cholestatic liver diseases. Clin Liver Dis 17 (2013), 161–189.
    • (2013) Clin Liver Dis , vol.17 , pp. 161-189
    • Halilbasic, E.1    Baghdasaryan, A.2    Trauner, M.3
  • 8
    • 0028076991 scopus 로고
    • Serum bile acids and cholestasis in alcoholic hepatitis. Relationship with usual liver tests and histological features
    • Trinchet, J.C., Gerhardt, M.F., Balkau, B., Munz, C., Poupon, R.E., Serum bile acids and cholestasis in alcoholic hepatitis. Relationship with usual liver tests and histological features. J Hepatol 21 (1994), 235–240.
    • (1994) J Hepatol , vol.21 , pp. 235-240
    • Trinchet, J.C.1    Gerhardt, M.F.2    Balkau, B.3    Munz, C.4    Poupon, R.E.5
  • 9
    • 65449177586 scopus 로고    scopus 로고
    • High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis
    • Schaap, F.G., van der Gaag, N.A., Gouma, D.J., Jansen, P.L., High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology 49 (2009), 1228–1235.
    • (2009) Hepatology , vol.49 , pp. 1228-1235
    • Schaap, F.G.1    van der Gaag, N.A.2    Gouma, D.J.3    Jansen, P.L.4
  • 10
    • 84940040449 scopus 로고    scopus 로고
    • Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease
    • Wunsch, E., Milkiewicz, M., Wasik, U., Trottier, J., Kempinska-Podhorodecka, A., Elias, E., et al. Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease. Sci Rep, 5, 2015, 13462.
    • (2015) Sci Rep , vol.5 , pp. 13462
    • Wunsch, E.1    Milkiewicz, M.2    Wasik, U.3    Trottier, J.4    Kempinska-Podhorodecka, A.5    Elias, E.6
  • 11
    • 85020017384 scopus 로고    scopus 로고
    • Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis
    • Li, Z., Lin, B., Lin, G., Wu, Y., Jie, Y., Li, X., et al. Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. PLoS One, 12, 2017, e0178580.
    • (2017) PLoS One , vol.12
    • Li, Z.1    Lin, B.2    Lin, G.3    Wu, Y.4    Jie, Y.5    Li, X.6
  • 12
    • 85031109936 scopus 로고    scopus 로고
    • Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis
    • Bajaj, J.S., Kakiyama, G., Zhao, D., Takei, H., Fagan, A., Hylemon, P., et al. Continued alcohol misuse in human cirrhosis is associated with an impaired gut-liver axis. Alcohol Clin Exp Res 41 (2017), 1857–1865.
    • (2017) Alcohol Clin Exp Res , vol.41 , pp. 1857-1865
    • Bajaj, J.S.1    Kakiyama, G.2    Zhao, D.3    Takei, H.4    Fagan, A.5    Hylemon, P.6
  • 13
    • 84925507991 scopus 로고    scopus 로고
    • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
    • Fang, S., Suh, J.M., Reilly, S.M., Yu, E., Osborn, O., Lackey, D., et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21 (2015), 159–165.
    • (2015) Nat Med , vol.21 , pp. 159-165
    • Fang, S.1    Suh, J.M.2    Reilly, S.M.3    Yu, E.4    Osborn, O.5    Lackey, D.6
  • 14
    • 85049581475 scopus 로고    scopus 로고
    • R: A language and environment for statistical computing [computer program].
    • R: A language and environment for statistical computing [computer program]. http://www.R-project.org/2014.
  • 16
    • 84982253561 scopus 로고    scopus 로고
    • Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma
    • Li, Y., Zhang, W., Doughtie, A., Cui, G., Li, X., Pandit, H., et al. Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma. Oncotarget 7 (2016), 52329–52339.
    • (2016) Oncotarget , vol.7 , pp. 52329-52339
    • Li, Y.1    Zhang, W.2    Doughtie, A.3    Cui, G.4    Li, X.5    Pandit, H.6
  • 17
    • 84929938016 scopus 로고    scopus 로고
    • Bile acid metabolism and signaling in cholestasis, inflammation, and cancer
    • Li, T., Apte, U., Bile acid metabolism and signaling in cholestasis, inflammation, and cancer. Adv Pharmacol 74 (2015), 263–302.
    • (2015) Adv Pharmacol , vol.74 , pp. 263-302
    • Li, T.1    Apte, U.2
  • 18
    • 58949097425 scopus 로고    scopus 로고
    • Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
    • Song, K.H., Li, T., Owsley, E., Strom, S., Chiang, J.Y., Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology 49 (2009), 297–305.
    • (2009) Hepatology , vol.49 , pp. 297-305
    • Song, K.H.1    Li, T.2    Owsley, E.3    Strom, S.4    Chiang, J.Y.5
  • 19
    • 0033980287 scopus 로고    scopus 로고
    • Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
    • Lee, J.M., Trauner, M., Soroka, C.J., Stieger, B., Meier, P.J., Boyer, J.L., Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 118 (2000), 163–172.
    • (2000) Gastroenterology , vol.118 , pp. 163-172
    • Lee, J.M.1    Trauner, M.2    Soroka, C.J.3    Stieger, B.4    Meier, P.J.5    Boyer, J.L.6
  • 20
    • 1642316825 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat
    • Denk, G.U., Soroka, C.J., Takeyama, Y., Chen, W.S., Schuetz, J.D., Boyer, J.L., Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 40 (2004), 585–591.
    • (2004) J Hepatol , vol.40 , pp. 585-591
    • Denk, G.U.1    Soroka, C.J.2    Takeyama, Y.3    Chen, W.S.4    Schuetz, J.D.5    Boyer, J.L.6
  • 21
    • 0141814990 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis
    • Bohan, A., Chen, W.S., Denson, L.A., Held, M.A., Boyer, J.L., Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis. J Biol Chem 278 (2003), 36688–36698.
    • (2003) J Biol Chem , vol.278 , pp. 36688-36698
    • Bohan, A.1    Chen, W.S.2    Denson, L.A.3    Held, M.A.4    Boyer, J.L.5
  • 23
    • 84939833035 scopus 로고    scopus 로고
    • Fibroblast growth factor signaling controls liver size in mice with humanized livers
    • e715
    • Naugler, W.E., Tarlow, B.D., Fedorov, L.M., Taylor, M., Pelz, C., Li, B., et al. Fibroblast growth factor signaling controls liver size in mice with humanized livers. Gastroenterology 149 (2015), 728–740 e715.
    • (2015) Gastroenterology , vol.149 , pp. 728-740
    • Naugler, W.E.1    Tarlow, B.D.2    Fedorov, L.M.3    Taylor, M.4    Pelz, C.5    Li, B.6
  • 24
    • 84929607468 scopus 로고    scopus 로고
    • Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure
    • Mutanen, A., Lohi, J., Heikkila, P., Jalanko, H., Pakarinen, M.P., Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure. J Hepatol 62 (2015), 1391–1397.
    • (2015) J Hepatol , vol.62 , pp. 1391-1397
    • Mutanen, A.1    Lohi, J.2    Heikkila, P.3    Jalanko, H.4    Pakarinen, M.P.5
  • 25
    • 84949884025 scopus 로고    scopus 로고
    • Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice
    • Zhou, M., Learned, R.M., Rossi, S.J., DePaoli, A.M., Tian, H., Ling, L., Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2-deficient mice. Hepatology 63 (2016), 914–929.
    • (2016) Hepatology , vol.63 , pp. 914-929
    • Zhou, M.1    Learned, R.M.2    Rossi, S.J.3    DePaoli, A.M.4    Tian, H.5    Ling, L.6
  • 26
    • 85049562292 scopus 로고    scopus 로고
    • Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice
    • [Epub ahead of print]
    • Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C.T., Llorente, C., et al. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology, 2017 Nov 21 [Epub ahead of print].
    • (2017) Hepatology
    • Hartmann, P.1    Hochrath, K.2    Horvath, A.3    Chen, P.4    Seebauer, C.T.5    Llorente, C.6
  • 27
    • 85035029737 scopus 로고    scopus 로고
    • Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice
    • Alvarez-Sola, G., Uriarte, I., Latasa, M.U., Jimenez, M., Barcena-Varela, M., Santamaria, E., et al. Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice. Cell Death Dis, 8, 2017, e3083.
    • (2017) Cell Death Dis , vol.8
    • Alvarez-Sola, G.1    Uriarte, I.2    Latasa, M.U.3    Jimenez, M.4    Barcena-Varela, M.5    Santamaria, E.6
  • 29
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri, B.A., Loomba, R., Sanyal, A.J., Lavine, J.E., Van Natta, M.L., Abdelmalek, M.F., et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 385 (2015), 956–965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    Van Natta, M.L.5    Abdelmalek, M.F.6
  • 30
    • 85042864144 scopus 로고    scopus 로고
    • NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
    • Harrison, S.A., Rinella, M.E., Abdelmalek, M.F., Trotter, J.F., Paredes, A.H., Arnold, H.L., et al. NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 391 (2018), 1174–1185.
    • (2018) Lancet , vol.391 , pp. 1174-1185
    • Harrison, S.A.1    Rinella, M.E.2    Abdelmalek, M.F.3    Trotter, J.F.4    Paredes, A.H.5    Arnold, H.L.6


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