A pilot, randomized clinical trial of bedtime doses of prazosin versus placebo in suicidal posttraumatic stress disorder patients with nightmares

Journal of Clinical Psychopharmacology

Volumn 38, Issue 6, 2018, Pages 618-621

  McCall, William Vaughn ^a   Pillai, Anilkumar ^a   Case, Doug ^b   McCloud, Laryssa ^a   Nolla, Tiffany ^a   Branch, Fallon ^a   Youssef, Nagy A ^a   Moraczewski, Jason ^a   Tauhidul, Liniya ^a   Pandya, Chirayu D ^c   Rosenquist, Peter B ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c AUGUSTA UNIVERSITY   (United States)

Author keywords

nightmares; posttraumatic stress disorder; prazosin; suicide

Indexed keywords

PLACEBO; PRAZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; BEDTIME DOSAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FAINTNESS; FEMALE; HOSPITALIZATION; HUMAN; INSOMNIA; MALE; NIGHT; NIGHTMARE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; SUICIDAL IDEATION; TREATMENT OUTCOME; WEAKNESS; COMPLICATION; DREAM; DRUG EFFECT; MIDDLE AGED; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PILOT STUDY;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADULT; DOUBLE-BLIND METHOD; DREAMS; FEMALE; HUMANS; MALE; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PILOT PROJECTS; PRAZOSIN; SLEEP INITIATION AND MAINTENANCE DISORDERS; STRESS DISORDERS, POST-TRAUMATIC; SUICIDAL IDEATION;

EID: 85055845722     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0000000000000968     Document Type: Article

References (20)

1. McCallWV, Black CG. The link between suicide and insomnia: theoretical mechanisms. Curr Psychiatry Rep. 2013;15:389.
2. Ross RJ, BallWA, Sullivan KA, et al. Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry. 1989;146:697-707.
3. Krysinska K, Lester D. Post-traumatic stress disorder and suicide risk: a systematic review. Arch Suicide Res. 2010;14:1-23.
4. Aurora RN, Zak RS, Auerbach SH, et al. Best practice guide for the treatment of nightmare disorder in adults. J Clin SleepMed. 2010;6: 389-401.
5. Raskind MA, Peterson K, Williams T, et al. A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. Am J Psychiatry. 2013;170:1003-1010.
6. George KC, Kebejian L, Ruth LJ, et al. Meta-analysis of the efficacy and safety of prazosin versus placebo for the treatment of nightmares and sleep disturbances in adults with posttraumatic stress disorder. J Trauma Dissociation. 2016;17:494-510.
7. ColucciWS. Alpha-adrenergic receptor blockade with prazosin. Ann Intern Med. 1982;97:67-77.
8. Raskind MA, Peskind ER, Chow B, et al. Trial of prazosin for post-traumatic stress disorder in military veterans.NEngl JMed. 2018;378: 507-517.
9. Weathers FW, Keane TM, Davidson JR. Clinician-Administered PTSD Scale: a review of the first ten years of research. Depress Anxiety. 2001;13: 132-156.
10. Krakow BJ, Melendrez DC, Johnston LG, et al. Sleep dynamic therapy for Cerro Grande fire evacuees with posttraumatic stress symptoms: a preliminary report. J Clin Psychiatry. 2002;63: 673-684.
11. Beck AT, Kovacs M, Weissman A. Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol. 1979;47: 343-352.
12. Oquendo MA, Mann JJ. Intervention research for suicidal behaviour. Lancet. 2003;362:844-845.
13. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
14. Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001; 2:297-307.
15. Wilkins KC, Lang AJ, Norman SB. Synthesis of the psychometric properties of the PTSD Checklist (PCL) military, civilian, and specific versions. Depress Anxiety. 2011;28:596-606.
16. HamiltonM. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
17. Guy W. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: US Department ofhealth, Education, and Welfare Public health Service: Alcohol, Drug, and Mental Health Administration; 1976.
18. Hedeker D, Gibbons R. Application of random-effects pattern-mixture models for missing data in longitudinal studies. Psychol Methods. 1997;2:64-78.
19. Kosari S, Naunton M. Sleep disturbances and nightmares in a patient treated with prazosin. J Clin SleepMed. 2016;12:631-632.
20. KoolaMM, Varghese SP, Fawcett JA. High-dose prazosin for the treatment of post-traumatic stress disorder. Ther Adv Psychopharmacol. 2014;4:43-47.