Trial of prazosin for post-traumatic stress disorder in military veterans

New England Journal of Medicine

Volumn 378, Issue 6, 2018, Pages 507-517

  Raskind, M A ^a,b   Peskind, E R ^a,b   Chow, B ^c   Harris, C ^g   Davis Karim, A ^g   Holmes, H A ^a   Hart, K L ^a   McFall, M ^a,b   Mellman, T A ^h   Reist, C ^d   Romesser, J ^k,l   Rosenheck, R ^m   Shih, M C ^c,e   Stein, M B ^f   Swift, R ⁿ   Gleason, T ^j   Lu, Y ^c,e   Huang, G D ⁱ  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VA Cooperative Studies Program   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g University of New Mexico   (United States)

^h HOWARD UNIVERSITY   (United States)

ⁱ Office of Research and Development   (United States)

^j DEPARTMENT OF VETERANS AFFAIRS   (United States)

^k Education and Evaluation   (United States)

^l VA Northeast Program Evaluation Center   (United States)

^m YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ BROWN UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PRAZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARMY; ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; MORNING DOSAGE; PITTSBURGH SLEEP QUALITY INDEX; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STANDING; SUICIDAL IDEATION; SUPINE POSITION; SYSTOLIC BLOOD PRESSURE; TREATMENT OUTCOME; URINE INCONTINENCE; CLINICAL TRIAL; DOSE RESPONSE; DREAM; DRUG EFFECTS; MIDDLE AGED; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOTHERAPY; PUBLIC HOSPITAL; SLEEP; SLEEP DISORDER; TREATMENT FAILURE; UNITED STATES; VETERAN;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ADULT; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DREAMS; FEMALE; HOSPITALS, VETERANS; HUMANS; MALE; MIDDLE AGED; PRAZOSIN; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTHERAPY; SLEEP; SLEEP WAKE DISORDERS; STRESS DISORDERS, POST-TRAUMATIC; SUICIDAL IDEATION; TREATMENT FAILURE; UNITED STATES; VETERANS;

EID: 85042080166     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1507598     Document Type: Article

References (34)

1. Neylan TC, Marmar CR, Metzler TJ, et al. Sleep disturbances in the Vietnam generation: findings from a nationally representative sample of male Vietnam veterans. Am J Psychiatry 1998;155:929-33.
2. Ross RJ, Ball WA, Sullivan KA, Caroff SN. Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry 1989;146:697-707.
3. Geracioti TD Jr, Baker DG, Ekhator NN, et al. CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry 2001;158:1227-30.
4. Southwick SM, Krystal JH, Morgan CA, et al. Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry 1993;50:266-74.
5. Pietrzak RH, Gallezot JD, Ding YS, et al. Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. JAMA Psychiatry 2013;70:1199-205.
6. Mellman TA, Kumar A, Kulick-Bell R, Kumar M, Nolan B. Nocturnal/daytime urine noradrenergic measures and sleep in combat-related PTSD. Biol Psychiatry 1995;38:174-9.
7. Birnbaum S, Gobeske KT, Auerbach J, Taylor JR, Arnsten AF. A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Biol Psychiatry 1999;46:1266-74.
8. Hilakivi I, Leppävuori A. Effects of methoxamine, an alpha-1 adrenoceptor agonist, and prazosin, an alpha-1 antagonist, on the stages of the sleep-waking cycle in the cat. Acta Physiol Scand 1984;120:363-72.
9. Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Brunton LL, ed. Goodman & Gilman's the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill, 2006:237-96.
10. Raskind MA, Peskind ER, Kanter ED, et al. Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am J Psychiatry 2003;160:371-3.
11. Raskind MA, Peskind ER, Hoff DJ, et al. A parallel group placebo controlled study of prazosin for trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder. Biol Psychiatry 2007;61:928-34.
12. Taylor FB, Martin P, Thompson C, et al. Prazosin effects on objective sleep measures and clinical symptoms in civilian trauma posttraumatic stress disorder: a placebo-controlled study. Biol Psychiatry 2008;63:629-32.
13. Germain A, Richardson R, Moul DE, et al. Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US military veterans. J Psychosom Res 2012;72:89-96.
14. Raskind MA, Peterson K, Williams T, et al. A trial of prazosin for combat trauma PTSD with nightmares in active-duty soldiers returned from Iraq and Afghanistan. Am J Psychiatry 2013;170:1003-10.
15. Ahmadpanah M, Sabzeiee P, Hosseini SM, et al. Comparing the effect of prazosin and hydroxyzine on sleep quality in patients suffering from posttraumatic stress disorder. Neuropsychobiology 2014;69:235-42.
16. Blake DD, Weathers FW, Nagy LM, et al. The development of a Clinician-Administered PTSD Scale. J Trauma Stress 1995;8:75-90.
17. Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics 1975;31:103-15.
18. Buysse DJ, Reynolds C F I III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.
19. Guy W. CDEU assessment manual for psychopharmacology. Rockville, MD: National Institute of Mental Health, 1976.
20. Forbes D, Creamer M, Biddle D. The validity of the PTSD checklist as a measure of symptomatic change in combatrelated PTSD. Behav Res Ther 2001;39:977-86.
21. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 2001;16:606-13.
22. Frisch MB. Manual and treatment guide for the Quality of Life Inventory (QOLI). Minneapolis: Pearson Assessments, 1994.
23. Iqbal SU, Rogers W, Selim A, et al. The Veterans RAND 12 Item Health Survey (VR-12): what is it and how it is used (https://www.bu.edu/sph/files/2015/01/veterans-rand-12-item-health-survey-vr-12-2007.pdf).
24. Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Arch Intern Med 1998;158:1789-95.
25. Bernardy NC, Lund BC, Alexander B, Friedman MJ. Prescribing trends in veterans with posttraumatic stress disorder. J Clin Psychiatry 2012;73:297-303.
26. Jacobsen LK, Southwick SM, Kosten TR. Substance use disorders in patients with posttraumatic stress disorder: a review of the literature. Am J Psychiatry 2001;158:1184-90.
27. Colvonen PJ, Masino T, Drummond SP, Myers US, Angkaw AC, Norman SB. Obstructive sleep apnea and posttraumatic stress disorder among OEF/OIF/OND veterans. J Clin Sleep Med 2015;11:513-8.
28. Yesavage JA, Kinoshita LM, Kimball T, et al. Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder. Am J Geriatr Psychiatry 2012;20:199-204.
29. Friedman MJ, Marmar CR, Baker DG, Sikes CR, Farfel GM. Randomized, doubleblind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. J Clin Psychiatry 2007;68:711-20.
30. The Management of Posttraumatic Stress Disorder Working Group. VA/DoD clinical practice guideline for the management of posttraumatic stress disorder. Washington, DC: Department of Veterans Affairs, Department of Defense, 2010.
31. Schnurr PP, Friedman MJ, Foy DW, et al. Randomized trial of trauma-focused group therapy for posttraumatic stress disorder: results from a Department of Veterans Affairs cooperative study. Arch Gen Psychiatry 2003;60:481-9.
32. Krystal JH, Cramer JA, Krol WF, Kirk GF, Rosenheck RA. Naltrexone in the treatment of alcohol dependence. N Engl J Med 2001;345:1734-9.
33. Krystal JH, Rosenheck RA, Cramer JA, et al. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chron ic military service-related PTSD: a randomized trial. JAMA 2011;306:493-502.
34. Rosenheck RA, Krystal JH, Lew R, et al. Long-acting risperidone and oral antipsychotics in unstable schizophrenia. N Engl J Med 2011;364:842-51.