The effect of aquaporin-4 knockout on interstitial fluid flow and the structure of the extracellular space in the deep brain

Aging and Disease

Volumn 9, Issue 5, 2018, Pages 808-816

  Teng, Ze ^a,b   Wang, Aibo ^a,b   Wang, Peng ^a   Wang, Rui ^b   Wang, Wei ^b   Han, Hongbin ^a,b  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics   (China)

Author keywords

Aquaporin 4; Extracellular space; Interstitial fluid; Tracer based magnetic resonance imaging

Indexed keywords

EID: 85054872624     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: 10.14336/AD.2017.1115     Document Type: Article

References (32)

1. Lei Y, Han H, Yuan F, Javeed A, Zhao Y (2017). The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications. Prog Neurobiol, 157:230-246
2. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. (2012). A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med, 4: 147ra111
3. Holter KE, Kehlet B, Devor A, Sejnowski TJ, Dale AM, Omholt SW, et al. (2017). Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow. Proc Natl Acad Sci USA, 114: 9894-9899
4. Kress BT, Iliff JJ, Xia M, Wang M, Wei HS, Zeppenfeld D, et al. (2014). Impairment of paravascular clearance pathways in the aging brain. Ann Neurol, 76: 845-861
5. Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. (2013). Sleep drives metabolite clearance from the adult brain. Science, 342: 373-377
6. Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, et al. (2015). The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci, 35: 11034-11044
7. Wolak DJ, Thorne RG (2013). Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm, 10: 1492-1504
8. Bedussi B, Naessens DM, de Vos J, Olde Engberink R, Wilhelmus MM, Richard E, et al. (2017). Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats. Sci Rep, 7: 744
9. Nedergaard M (2013). Neuroscience. Garbage truck of the brain. Science, 340: 1529-1530
10. Iliff JJ, Wang M, Zeppenfeld DM, Venkataraman A, Plog BA, Liao Y, et al. (2013). Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain. J Neurosci, 33: 18190-18199
11. Pollock H, Hutchings M, Weller RO, Zhang ET (1997). Perivascular spaces in the basal ganglia of the human brain: their relationship to lacunes. J Anat, 191 (Pt 3): 337-346
12. Yang S, Wang Y, Li K, Tang X, Zhang K, Shi C, et al. (2016). Extracellular space diffusion analysis in the infant and adult rat striatum using magnetic resonance imaging. Int J Dev Neurosci, 53: 1-7
13. Ren R, Shi C, Cao J, Sun Y, Zhao X, Guo Y, et al. (2016). Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson's Disease. Sci Rep, 6: 22135
14. Han H, Shi C, Fu Y, Zuo L, Lee K, He Q, et al. (2014). A novel MRI tracer-based method for measuring water diffusion in the extracellular space of the rat brain. IEEE J Biomed Health Inform, 18: 978-983
15. Lv D, Li J, Li H, Fu Y, Wang W (2017). Imaging and Quantitative Analysis of the Interstitial Space in the Caudate Nucleus in a Rotenone-Induced Rat Model of Parkinson's Disease Using Tracer-based MRI. Aging Dis, 8: 1-6
16. Shi C, Lei Y, Han H, Zuo L, Yan J, He Q, et al. (2015). Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation. Sci Rep, 5: 17673
17. Igarashi H, Tsujita M, Kwee IL, Nakada T (2014). Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: O-17 JJVCPE MRI study in knockout mice. Neuroreport, 25: 39-43
18. Yao X, Hrabetova S, Nicholson C, Manley GT (2008). Aquaporin-4-deficient mice have increased extracellular space without tortuosity change. J Neurosci, 28: 5460-5464
19. Tesson L, Usal C, Menoret S, Leung E, Niles BJ, Remy S, et al. (2011). Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol, 29: 695-696
20. Sung YH, Baek IJ, Kim DH, Jeon J, Lee J, Lee K, et al. (2013). Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol, 31: 23-24
21. Han H, Li K, Yan J, Zhu K, Fu Y (2012). An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain. Sci China Life Sci, 55: 782-787
22. Tomura S, Nawashiro H, Otani N, Uozumi Y, Toyooka T, Ohsumi A, et al. (2011). Effect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats. J Neurotrauma, 28: 237-243
23. Papadopoulos MC, Verkman AS (2013). Aquaporin water channels in the nervous system. Nat Rev Neurosci, 14: 265-277
24. Nakada T, Kwee IL, Igarashi H, Suzuki Y (2017). Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. Int J Mol Sci, 18
25. Hubbard JA, Hsu MS, Seldin MM, Binder DK (2015). Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain. ASN Neuro, 7
26. Zhang C, Chen J, Lu H (2015). Expression of aquaporin-4 and pathological characteristics of brain injury in a rat model of traumatic brain injury. Mol Med Rep, 12: 7351-7357
27. Tang H, Shao C, He J (2017). Down-regulated expression of aquaporin-4 in the cerebellum after status epilepticus. Cogn Neurodyn, 11: 183-188
28. Kitaura H, Tsujita M, Huber VJ, Kakita A, Shibuki K, Sakimura K, et al. (2009). Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res, 64: 208-212
29. Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, Gundersen GA, Skare O, Laake P, et al. (2011). Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A, 108: 17815-17820
30. Nagelhus EA, Ottersen OP (2013). Physiological roles of aquaporin-4 in brain. Physiol Rev, 93: 1543-1562
31. Wen H, Nagelhus EA, Amiry-Moghaddam M, Agre P, Ottersen OP, Nielsen S (1999). Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel. Eur J Neurosci, 11: 935-945
32. Pavlin T, Nagelhus EA, Brekken C, Eyjolfsson EM, Thoren A, Haraldseth O, et al. (2017). Loss or Mislocalization of Aquaporin-4 Affects Diffusion Properties and Intermediary Metabolism in Gray Matter of Mice. Neurochem Res, 42: 77-91