An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain

Science China Life Sciences

Volumn 55, Issue 9, 2012, Pages 782-787

  Han, HongBin ^a,b   Li, Kai ^a,b   Yan, JunHao ^c   Zhu, Kai ^a,b   Fu, Yu ^a,b  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b Key Lab of Magnetic Resonance Imaging Device and Technique   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

diffusion; extracellular space; Gd DTPA; interstitial fluid; quantitative imaging

Indexed keywords

RATTUS;

EID: 84867137237     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-012-4361-4     Document Type: Article

References (30)

1. Abbott N J. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int, 2004, 45: 545-552.
2. Sykova E, Nicholson C. Diffusion in brain extracellular space. Physiol Rev, 2008, 88: 1277-1340.
3. Nicholson C, Phillips J M. Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J Physiol, 1981, 321: 225-257.
4. Nicholson C, Sykova E. Extracellular space structure revealed by diffusion analysis. Trends Neurosci, 1998, 21: 207-215.
5. Nicholson C. Factors governing diffusing molecular signals in brain extracellular space. J Neural Transm, 2005, 112: 29-44.
6. Kunwar S, Chang S, Westphal M, et al. Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma. Neuro Oncol, 2010, 12: 871-881.
7. Han H, Xia Z, Chen H, et al. Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia. Sci China Life Sci, 2011, 54: 235-239.
8. Bidros D S, Liu J K, Vogelbaum M A. Future of convection-enhanced delivery in the treatment of brain tumors. Future Oncol, 2010, 6: 117-125.
9. Lopez K A, Waziri A E, Canoll P D, et al. Convection-enhanced delivery in the treatment of malignant glioma. Neurol Res. 2006, 28: 542-548.
10. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 6th ed. London: Academic Press, 2007. 80-84.
11. Koshlyakov N S, Smirnov M M, Gliner E B. Differential equations of mathematical physics. Amsterdam: North-Holland Publishing Co., 1964. 509.
12. Pluim J P W, Maintz J B A, Viergever M A. Mutual-information-based registration of medical images: a survey. IEEE Trans Med Imag, 2003, 22: 986-1004.
13. Loeckx D, Slagmolen P, Maes F, et al. Nonrigid image registration using conditional mutual information. IEEE Trans Med Imag, 2010, 29: 19-29.
14. Patlak C S, Hospod F E, Trowbridge S D, et al. Diffusion of radiotracers in normal and ischemic brain slices. J Cereb Blood Flow Metab, 1998, 18: 776-802.
15. Ransom B R, Yamate C L, Connors B W. Activity-dependent shrinkage of extracellular space in rat optic nerve: a developmental study. J Neurosci, 1985, 5: 532-535.
16. + uptake. Can J Physiol Pharmacol, 1992, 70: S314-S322.
17. Nicholson C, Tao L. Hindered diffusion of high molecular weight compounds in brain extracellular microenvironment measured with integrative optical imaging. Biophys J, 1993, 65: 2277-2290.
18. 3+ ions. Contrast Media Mol Imaging, 2006, 1: 23-29.
19. Caravan P, Ellison J J, Mcmurry T J, et al. Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications. Chem Rev, 1999, 99: 2293-2352.
20. Xu F, Han H, Zhang H, et al. Quantification of Gd-DTPA concentration in neuroimaging using T1 3D MP-RAGE sequence at 3. 0 T. Magn Reson Imaging, 2011, 29: 827-834.
21. Weller R O, Galea I, Carare R O, et al. Pathophysiology of the lymphatic drainage of the central nervous system: implications for pathogenesis and therapy of multiple sclerosis. Pathophysiology, 2010, 17: 295-306.
22. Yamada S, Depasquale M, Patlak C S, et al. Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol, 1991, 261: H1197-H1204.
23. Schley D, Carare-Nnadi R, Please C P, et al. Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol, 2006, 238: 962-974.
24. Yamori Y, Horie R, Handa H, et al. Pathogenetic similarity of strokes in stroke-prone spontaneously hypertensive rats and humans. Stroke, 1976, 7: 46-53.
25. Tamura A, Graham D I, Mcculloch J, et al. Focal cerebral ischaemia in the rat: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab, 1981, 1: 53-60.
26. Berendse H W, Galis-De G Y, Groenewegen H J. Topographical organization and relationship with ventral striatal compartments of prefrontal corticostriatal projections in the rat. J Comp Neurol, 1992, 316: 314-347.
27. Berendse H W, Groenewegen H J, Lohman A H. Compartmental distribution of ventral striatal neurons projecting to the mesencephalon in the rat. J Neurosci, 1992, 12: 2079-2103.
28. Muldoon L L, Varallyay P, Kraemer D F, et al. Trafficking of superparamagnetic iron oxide particles (Combidex) from brain to lymph nodes in the rat. Neuropathol Appl Neurobiol, 2004, 30: 70-79.
29. Bobo R H, Laske D W, Akbasak A, et al. Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci USA, 1994, 91: 2076-2080.
30. Xu F, Han H, Yan J, et al. Greatly improved neuroprotective efficiency of citicoline by stereotactic delivery in treatment of ischemic injury. Drug Deliv, 2011, 18: 461-467.