Enhanced interstitial fluid drainage in the hippocampus of spontaneously hypertensive rats

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Bedussi, Beatrice ^a   Naessens, Daphne M P ^a   De Vos, Judith ^a   Olde Engberink, Rik ^b   Wilhelmus, Micha M M ^c   Richard, Edo ^a,d   Ten Hove, Malyssa ^a   Vanbavel, Ed ^a   Bakker, Erik N T P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4; BIOLOGICAL MARKER; FLUORESCENT DYE; GLIAL FIBRILLARY ACID PROTEIN, RAT; GLIAL FIBRILLARY ACIDIC PROTEIN; ION;

ANIMAL; BLOOD PRESSURE; BRAIN; DIAGNOSTIC IMAGING; EXTRACELLULAR FLUID; FLUORESCENCE IMAGING; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; AQUAPORIN 4; BIOMARKERS; BLOOD PRESSURE; BRAIN; DRAINAGE; EXTRACELLULAR FLUID; FLUORESCENT DYES; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; HYPERTENSION; IONS; MICROSCOPY, FLUORESCENCE; OPTICAL IMAGING; RATS; RATS, INBRED SHR;

EID: 85019008215     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-00861-x     Document Type: Article

References (30)

1. Zlokovic, B. V. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12, 723-738, doi: 10.1038/nrn3114 (2011).
2. Iadecola, C. & Davisson, R. L. Hypertension and cerebrovascular dysfunction. Cell Metab 7, 476-484, doi: 10.1016/j.cmet.2008.03.010 (2008).
3. Feldstein, C. A. Association between chronic blood pressure changes and development of Alzheimer's disease. J Alzheimers Dis 32, 753-763, doi: 10.3233/JAD-2012-120613 (2012).
4. Peters, R. et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet Neurol 7, 683-689, doi: 10.1016/S1474-4422(08)70143-1 (2008).
5. Anderson, C. et al. Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies. Lancet Neurol 10, 43-53, doi: 10.1016/S1474-4422(10)70250-7 (2011).
6. Carnevale, D. et al. Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging 33, 205 e219-229, doi: 10.1016/j.neurobiolaging.2010.08.013 (2012).
7. Faraco, G. et al. Hypertension enhances Abeta-induced neurovascular dysfunction, promotes beta-secretase activity, and leads to amyloidogenic processing of APP. J Cereb Blood Flow Metab 36, 241-252, doi: 10.1038/jcbfm.2015.79 (2016).
8. Wiesmann, M. et al. Angiotensin II, hypertension, and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease. J Cereb Blood Flow Metab (2016).
9. Kruyer, A., Soplop, N., Strickland, S. & Norris, E. H. Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease. Hypertension 66, 175-182, doi: 10.1161/HYPERTENSIONAHA.115.05524 (2015).
10. Cifuentes, D. et al. Hypertension accelerates the progression of Alzheimer-like pathology in a mouse model of the disease. Hypertension 65, 218-224, doi: 10.1161/HYPERTENSIONAHA.114.04139 (2015).
11. Carnevale, D. et al. Hypertension induces brain beta-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension 60, 188-197, doi: 10.1161/HYPERTENSIONAHA.112.195511 (2012).
12. Kaiser, D. et al. Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease. Acta Neuropathol Commun 2, 169, doi: 10.1186/s40478-014-0169-8 (2014).
13. Schreiber, S. et al. Interplay between age, cerebral small vessel disease, parenchymal amyloid-beta, and tau pathology: longitudinal studies in hypertensive stroke-prone rats. J Alzheimers Dis 42(Suppl 3), S205-215, doi: 10.3233/JAD-132618 (2014).
14. Shibata, M. et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106, 1489-1499, doi: 10.1172/JCI10498 (2000).
15. Bedussi, B. et al. Clearance from the mouse brain by convection of interstitial fluid towards the ventricular system. Fluids Barriers CNS 12, 23, doi: 10.1186/s12987-015-0019-5 (2015).
16. Carare, R. O. et al. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol 34, 131-144, doi: 10.1111/nan.2008.34.issue-2 (2008).
17. Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 4, 147ra111-147ra111, doi: 10.1126/scitranslmed.3003748 (2012).
18. Hladky, S. B. & Barrand, M. A. Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence. Fluids Barriers CNS 11, 26, doi: 10.1186/2045-8118-11-26 (2014).
19. Abbott, N. J. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 45, 545-552, doi: 10.1016/j.neuint.2003.11.006 (2004).
20. Papadopoulos, M. C. & Verkman, A. S. Aquaporin water channels in the nervous system. Nat Rev Neurosci 14, 265-277, doi: 10.1038/nrn3468 (2013).
21. Bakker, E. N. et al. Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases. Cell Mol Neurobiol 36, 181-194, doi: 10.1007/s10571-015-0273-8 (2016).
22. Bedussi, B. et al. Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways. J Cereb Blood Flow Metab (2016).
23. Ritter, S. & Dinh, T. T. Progressive postnatal dilation of brain ventricles in spontaneously hypertensive rats. Brain Res 370, 327-332, doi: 10.1016/0006-8993(86)90488-9 (1986).
24. Yang, G. Y., Chen, S. F., Kinouchi, H., Chan, P. H. & Weinstein, P. R. Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats. Stroke 23, 1331-1336, doi: 10.1161/01.STR.23.9.1331 (1992).
25. de Lange, E. C. Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv Drug Deliv Rev 56, 1793-1809, doi: 10.1016/j.addr.2004.07.009 (2004).
26. Ye, L. et al. Persistence of Abeta seeds in APP null mouse brain. Nat Neurosci 18, 1559-1561, doi: 10.1038/nn.4117 (2015).
27. Charidimou, A. et al. White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden? Stroke 46, 1707-1709, doi: 10.1161/STROKEAHA.115.009090 (2015).
28. van Veluw, S. J. et al. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab 36, 576-580, doi: 10.1177/0271678X15620434 (2016).
29. Weller, R. O., Hawkes, C. A., Kalaria, R. N., Werring, D. J. & Carare, R. O. White matter changes in dementia: role of impaired drainage of interstitial fluid. Brain Pathol 25, 63-78, doi: 10.1111/bpa.2015.25.issue-1 (2015).
30. Maclullich, A. M. et al. Higher systolic blood pressure is associated with increased water diffusivity in normal-appearing white matter. Stroke 40, 3869-3871, doi: 10.1161/STROKEAHA.109.547877 (2009).