Stability of intravenous vitamin C solutions: A technical report

Critical Care and Resuscitation

Volumn 20, Issue 3, 2018, Pages 180-181

  Carr, Anitra ^a   Wohlrab, Christina ^a   Young, Paul ^b,c   Bellomo, Rinaldo ^d,e  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b WELLINGTON HOSPITAL   (New Zealand)

^c MEDICAL RESEARCH INSTITUTE OF NEW ZEALAND   (New Zealand)

^d AUSTIN HOSPITAL   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; SODIUM CHLORIDE;

CHEMISTRY; DRUG STABILITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; SOLUTION AND SOLUBILITY; SPECTROPHOTOMETRY;

ANTIOXIDANTS; ASCORBIC ACID; DRUG STABILITY; HUMANS; INFUSIONS, INTRAVENOUS; PHARMACEUTICAL SOLUTIONS; SALINE SOLUTION, HYPERTONIC; SPECTROPHOTOMETRY;

EID: 85054397397     PISSN: 14412772     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Carr AC, Shaw GM, Fowler AA, Natarajan R. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock? Crit Care 2015; 19: e418.
2. Carr AC, Rosengrave PC, Bayer S, et al. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care 2017; 21: 300.
3. Story DA, Ronco C, Bellomo R. Trace element and vitamin concentrations and losses in critically ill patients treated with continuous venovenous hemofiltration. Crit Care Med 1999; 27: 220-3.
4. Fowler AA, Syed AA, Knowlson S, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med 2014; 12: 32.
5. Zabet MH, Mohammadi M, Ramezani M, Khalili H. Effect of high-dose Ascorbic acid on vasopressor’s requirement in septic shock. J Res Pharm Pract 2016; 5: 94-100.
6. Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest 2017; 151: 1229-38.
7. de Grooth HJ, Manubulu-Choo WP, Zandvliet AS, et al. Vitamin-C pharmacokinetics in critically ill patients: a randomized trial of four intravenous regimens. Chest 2018; 153: 1368-77.
8. Pullar JM, Bayer S, Carr AC. Appropriate handling, processing and analysis of blood samples is essential to avoid oxidation of vitamin C to dehydroascorbic acid. Antioxidants 2018; 7: 29.
9. Carr A, Frei B. Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J 1999; 13: 1007-24.
10. New Zealand Datasheet for ASCOR L 500. http://www.medsafe. govt.nz/profs/Datasheet/a/ascorlinj.pdf(viewed March 2018).