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Volumn 62, Issue , 2018, Pages 143-154

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

Author keywords

Analog of GLP 1; Gut microbiota; Liraglutide; NAFLD; Obesity

Indexed keywords

LIRAGLUTIDE;

EID: 85054354989     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2018.07.009     Document Type: Article
Times cited : (117)

References (51)
  • 1
    • 84994553261 scopus 로고    scopus 로고
    • Gut microbiome and liver diseases
    • Tilg, H., Cani, P.D., Mayer, E.A., Gut microbiome and liver diseases. Gut 65 (2016), 2035–2044, 10.1136/gutjnl-2016-312729.
    • (2016) Gut , vol.65 , pp. 2035-2044
    • Tilg, H.1    Cani, P.D.2    Mayer, E.A.3
  • 2
    • 15544369658 scopus 로고    scopus 로고
    • Host–bacterial mutualism in the human intestine
    • Bäckhed, F., Ley, R.E., Sonnenburg, J.L., Peterson, D.A., Gordon, J.I., Host–bacterial mutualism in the human intestine. Science 307 (2005), 1915–1920, 10.1126/science.1104816.
    • (2005) Science , vol.307 , pp. 1915-1920
    • Bäckhed, F.1    Ley, R.E.2    Sonnenburg, J.L.3    Peterson, D.A.4    Gordon, J.I.5
  • 3
    • 0036885585 scopus 로고    scopus 로고
    • The host-microbe interface within the gut
    • Shanahan, F., The host-microbe interface within the gut. Baillieres Best Pract Res Clin Gastroenterol 16 (2002), 915–931, 10.1053/bega.2002.0342.
    • (2002) Baillieres Best Pract Res Clin Gastroenterol , vol.16 , pp. 915-931
    • Shanahan, F.1
  • 4
    • 84952975141 scopus 로고    scopus 로고
    • Gut–liver axis, nutrition, and non-alcoholic fatty liver disease
    • Kirpich, I.A., Marsano, L.S., McClain, C.J., Gut–liver axis, nutrition, and non-alcoholic fatty liver disease. Clin Biochem 48 (2015), 923–930, 10.1016/j.clinbiochem.2015.06.023.
    • (2015) Clin Biochem , vol.48 , pp. 923-930
    • Kirpich, I.A.1    Marsano, L.S.2    McClain, C.J.3
  • 5
    • 84884414277 scopus 로고    scopus 로고
    • Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice
    • Le Roy, T., Llopis, M., Lepage, P., Bruneau, A., Rabot, S., Bevilacqua, C., et al. Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice. Gut 62 (2013), 1787–1794, 10.1136/gutjnl-2012-303816.
    • (2013) Gut , vol.62 , pp. 1787-1794
    • Le Roy, T.1    Llopis, M.2    Lepage, P.3    Bruneau, A.4    Rabot, S.5    Bevilacqua, C.6
  • 6
    • 84921626523 scopus 로고    scopus 로고
    • Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
    • Everard, A., Lazarevic, V., Gaïa, N., Johansson, M., Ståhlman, M., Backhed, F., et al. Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity. ISME J 8 (2014), 2116–2130, 10.1038/ismej.2014.45.
    • (2014) ISME J , vol.8 , pp. 2116-2130
    • Everard, A.1    Lazarevic, V.2    Gaïa, N.3    Johansson, M.4    Ståhlman, M.5    Backhed, F.6
  • 7
    • 85030998140 scopus 로고    scopus 로고
    • Effects of antidiabetic drugs on gut microbiota composition
    • Montandon, S.A., Jornayvaz, F.R., Effects of antidiabetic drugs on gut microbiota composition. Genes (Basel), 8, 2017, 250, 10.3390/genes8100250.
    • (2017) Genes (Basel) , vol.8 , pp. 250
    • Montandon, S.A.1    Jornayvaz, F.R.2
  • 8
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen, L.B., Nielsen, P.F., Huusfeldt, P.O., Johansen, N.L., Madsen, K., Pedersen, F.Z., et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 43 (2000), 1664–1669, 10.1021/jm9909645.
    • (2000) J Med Chem , vol.43 , pp. 1664-1669
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3    Johansen, N.L.4    Madsen, K.5    Pedersen, F.Z.6
  • 9
    • 0035462466 scopus 로고    scopus 로고
    • Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men
    • Rask, E., Olsson, T., Söderberg, S., Johnson, O., Seckl, J., Holst, J.J., et al. Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men. Diabetes Care 24 (2001), 1640–1645, 10.2337/diacare.24.9.1640.
    • (2001) Diabetes Care , vol.24 , pp. 1640-1645
    • Rask, E.1    Olsson, T.2    Söderberg, S.3    Johnson, O.4    Seckl, J.5    Holst, J.J.6
  • 10
    • 84888201085 scopus 로고    scopus 로고
    • Gut microbiota, enteroendocrine functions and metabolism
    • Cani, P.D., Everard, A., Duparc, T., Gut microbiota, enteroendocrine functions and metabolism. Curr Opin Pharmacol 13 (2013), 935–940, 10.1016/j.coph.2013.09.008.
    • (2013) Curr Opin Pharmacol , vol.13 , pp. 935-940
    • Cani, P.D.1    Everard, A.2    Duparc, T.3
  • 11
    • 84933505154 scopus 로고    scopus 로고
    • Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity
    • Hwang, I., Park, Y.J., Kim, Y.-R., Kim, Y.N., Ka, S., Lee, H.Y., et al. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J 29 (2015), 2397–2411, 10.1096/fj.14-265983.
    • (2015) FASEB J , vol.29 , pp. 2397-2411
    • Hwang, I.1    Park, Y.J.2    Kim, Y.-R.3    Kim, Y.N.4    Ka, S.5    Lee, H.Y.6
  • 12
  • 13
    • 84934437784 scopus 로고    scopus 로고
    • Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion
    • Tsuda, T., Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion. Mol Nutr Food Res 59 (2015), 1264–1273, 10.1002/mnfr.201400871.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 1264-1273
    • Tsuda, T.1
  • 14
    • 0347946721 scopus 로고    scopus 로고
    • Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients
    • Dalgaard, M., Thomsen, C., Rasmussen, B.M., Holst, J.J., Hermansen, K., Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients. Metabolism 53 (2004), 77–83, 10.1016/j.metabol.2003.08.011.
    • (2004) Metabolism , vol.53 , pp. 77-83
    • Dalgaard, M.1    Thomsen, C.2    Rasmussen, B.M.3    Holst, J.J.4    Hermansen, K.5
  • 15
    • 84867752550 scopus 로고    scopus 로고
    • Predicting efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes: association of glycated hemoglobin reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels
    • Iwasaki, M., Hoshian, F., Tsuji, T., Hirose, N., Matsumoto, T., Kitatani, N., et al. Predicting efficacy of dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes: association of glycated hemoglobin reduction with serum eicosapentaenoic acid and docosahexaenoic acid levels. J Diabetes Investig 3 (2012), 464–467, 10.1111/j.2040-1124.2012.00214.x.
    • (2012) J Diabetes Investig , vol.3 , pp. 464-467
    • Iwasaki, M.1    Hoshian, F.2    Tsuji, T.3    Hirose, N.4    Matsumoto, T.5    Kitatani, N.6
  • 16
    • 10744230106 scopus 로고    scopus 로고
    • GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics
    • Sturis, J., Gotfredsen, C.F., Rømer, J., Rolin, B., Ribel, U., Brand, C.L., et al. GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics. Br J Pharmacol 140 (2003), 123–132, 10.1038/sj.bjp.0705397.
    • (2003) Br J Pharmacol , vol.140 , pp. 123-132
    • Sturis, J.1    Gotfredsen, C.F.2    Rømer, J.3    Rolin, B.4    Ribel, U.5    Brand, C.L.6
  • 17
    • 0033961701 scopus 로고    scopus 로고
    • Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity
    • Bonora, E., Targher, G., Alberiche, M., Bonadonna, R.C., Saggiani, F., Zenere, M.B., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23 (2000), 57–63, 10.2337/diacare.23.1.57.
    • (2000) Diabetes Care , vol.23 , pp. 57-63
    • Bonora, E.1    Targher, G.2    Alberiche, M.3    Bonadonna, R.C.4    Saggiani, F.5    Zenere, M.B.6
  • 18
    • 0019488058 scopus 로고
    • A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans
    • Scott, A.M., Atwater, I., Rojas, E., A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia 21 (1981), 470–475.
    • (1981) Diabetologia , vol.21 , pp. 470-475
    • Scott, A.M.1    Atwater, I.2    Rojas, E.3
  • 19
    • 84878395817 scopus 로고    scopus 로고
    • Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets
    • Marçal, A.C., Camporez, J.P.G., Lima-Salgado, T.M., Cintra, D.E., Akamine, E.H., Ribeiro, L.M., et al. Changes in food intake, metabolic parameters and insulin resistance are induced by an isoenergetic, medium-chain fatty acid diet and are associated with modifications in insulin signalling in isolated rat pancreatic islets. Br J Nutr 109 (2013), 2154–2165, 10.1017/S0007114512004576.
    • (2013) Br J Nutr , vol.109 , pp. 2154-2165
    • Marçal, A.C.1    Camporez, J.P.G.2    Lima-Salgado, T.M.3    Cintra, D.E.4    Akamine, E.H.5    Ribeiro, L.M.6
  • 20
    • 37349018683 scopus 로고    scopus 로고
    • Gut microflora as a target for energy and metabolic homeostasis
    • Cani, P.D., Delzenne, N.M., Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10 (2007), 729–734, 10.1097/MCO.0b013e3282efdebb.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 729-734
    • Cani, P.D.1    Delzenne, N.M.2
  • 21
    • 84890041312 scopus 로고    scopus 로고
    • Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data
    • Robertson, C.E., Harris, J.K., Wagner, B.D., Granger, D., Browne, K., Tatem, B., et al. Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data. Bioinformatics 29 (2013), 3100–3101, 10.1093/bioinformatics/btt526.
    • (2013) Bioinformatics , vol.29 , pp. 3100-3101
    • Robertson, C.E.1    Harris, J.K.2    Wagner, B.D.3    Granger, D.4    Browne, K.5    Tatem, B.6
  • 23
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner, D.E., Brunt, E.M., Van Natta, M., Behling, C., Contos, M.J., Cummings, O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321, 10.1002/hep.20701.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 24
    • 84865503143 scopus 로고    scopus 로고
    • Is endogenous GLP-1 the only important enhancer of glucose-induced insulin secretion in type 2 diabetes?
    • Deacon, C.F., Is endogenous GLP-1 the only important enhancer of glucose-induced insulin secretion in type 2 diabetes?. Diabetes 61 (2012), 2219–2220, 10.2337/db12-0649.
    • (2012) Diabetes , vol.61 , pp. 2219-2220
    • Deacon, C.F.1
  • 25
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh, P.J., Ley, R.E., Mahowald, M.A., Magrini, V., Mardis, E.R., Gordon, J.I., An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444 (2006), 1027–1031, 10.1038/nature05414.
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 27
    • 84991406526 scopus 로고    scopus 로고
    • Gut microbiota of obese, type 2 diabetic individuals is enriched in Faecalibacterium prausnitzii, Akkermansia muciniphila and Peptostreptococcus anaerobius after weight loss
    • Remely, M., Hippe, B., Zanner, J., Aumueller, E., Brath, H.G., Haslberger, A., Gut microbiota of obese, type 2 diabetic individuals is enriched in Faecalibacterium prausnitzii, Akkermansia muciniphila and Peptostreptococcus anaerobius after weight loss. Endocr Metab Immune Disord Drug Targets 16 (2016), 99–106, 10.2174/1871530316666160831093813.
    • (2016) Endocr Metab Immune Disord Drug Targets , vol.16 , pp. 99-106
    • Remely, M.1    Hippe, B.2    Zanner, J.3    Aumueller, E.4    Brath, H.G.5    Haslberger, A.6
  • 28
    • 56549122798 scopus 로고    scopus 로고
    • Human colonic microbiota associated with diet, obesity and weight loss
    • Duncan, S.H., Lobley, G.E., Holtrop, G., Ince, J., Johnstone, A.M., Louis, P., et al. Human colonic microbiota associated with diet, obesity and weight loss. Int J Obes (Lond) 32 (2008), 1720–1724, 10.1038/ijo.2008.155.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 1720-1724
    • Duncan, S.H.1    Lobley, G.E.2    Holtrop, G.3    Ince, J.4    Johnstone, A.M.5    Louis, P.6
  • 29
    • 84942155749 scopus 로고    scopus 로고
    • Obesity alters the microbial community profile in Korean adolescents
    • Hu, H.-J., Park, S.-G., Jang, H.B., Choi, M.-G., Park, K.-H., Kang, J.H., et al. Obesity alters the microbial community profile in Korean adolescents. PLoS One, 10, 2015, e0134333, 10.1371/journal.pone.0134333.
    • (2015) PLoS One , vol.10
    • Hu, H.-J.1    Park, S.-G.2    Jang, H.B.3    Choi, M.-G.4    Park, K.-H.5    Kang, J.H.6
  • 30
    • 85034052972 scopus 로고    scopus 로고
    • Dietary uncoupling of gut microbiota and energy harvesting from obesity and glucose tolerance in mice
    • Dalby, M.J., Ross, A.W., Walker, A.W., Morgan, P.J., Dietary uncoupling of gut microbiota and energy harvesting from obesity and glucose tolerance in mice. Cell Rep 21 (2017), 1521–1533, 10.1016/j.celrep.2017.10.056.
    • (2017) Cell Rep , vol.21 , pp. 1521-1533
    • Dalby, M.J.1    Ross, A.W.2    Walker, A.W.3    Morgan, P.J.4
  • 31
    • 84988369638 scopus 로고    scopus 로고
    • Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment
    • Wang, L., Li, P., Tang, Z., Yan, X., Feng, B., Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment. Sci Rep, 6, 2016, 33251, 10.1038/srep33251.
    • (2016) Sci Rep , vol.6 , pp. 33251
    • Wang, L.1    Li, P.2    Tang, Z.3    Yan, X.4    Feng, B.5
  • 32
    • 85040668021 scopus 로고    scopus 로고
    • Featured article: structure moderation of gut microbiota in liraglutide-treated diabetic male rats
    • Zhang, Q., Xiao, X., Zheng, J., Li, M., Yu, M., Ping, F., et al. Featured article: structure moderation of gut microbiota in liraglutide-treated diabetic male rats. Exp Biol Med 243 (2018), 34–44, 10.1177/1535370217743765.
    • (2018) Exp Biol Med , vol.243 , pp. 34-44
    • Zhang, Q.1    Xiao, X.2    Zheng, J.3    Li, M.4    Yu, M.5    Ping, F.6
  • 33
    • 84858132726 scopus 로고    scopus 로고
    • Non-glycaemic effects mediated via GLP-1 receptor agonists and the potential for exploiting these for therapeutic benefit: focus on liraglutide
    • Vilsbøll, T., Garber, A.J., Non-glycaemic effects mediated via GLP-1 receptor agonists and the potential for exploiting these for therapeutic benefit: focus on liraglutide. Diabetes Obes Metab 14 (2012), 41–49, 10.1111/j.1463-1326.2012.01579.x.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 41-49
    • Vilsbøll, T.1    Garber, A.J.2
  • 34
    • 84929206792 scopus 로고    scopus 로고
    • Liraglutide and obesity: a review of the data so far
    • Ladenheim, E., Liraglutide and obesity: a review of the data so far. Drug Des Devel Ther, 9, 2015, 1867, 10.2147/DDDT.S58459.
    • (2015) Drug Des Devel Ther , vol.9 , pp. 1867
    • Ladenheim, E.1
  • 37
    • 84923570274 scopus 로고    scopus 로고
    • Mucin glycan foraging in the human gut microbiome
    • Tailford, L.E., Crost, E.H., Kavanaugh, D., Juge, N., Mucin glycan foraging in the human gut microbiome. Front Genet, 6, 2015, 10.3389/fgene.2015.00081.
    • (2015) Front Genet , vol.6
    • Tailford, L.E.1    Crost, E.H.2    Kavanaugh, D.3    Juge, N.4
  • 38
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • [Suppl]
    • Johansson, M.E.V., Larsson, J.M.H., Hansson, G.C., The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci U S A 108 (2011), 4659–4665, 10.1073/pnas.1006451107 [Suppl].
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4659-4665
    • Johansson, M.E.V.1    Larsson, J.M.H.2    Hansson, G.C.3
  • 39
    • 84903443172 scopus 로고    scopus 로고
    • Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy
    • Merga, Y., Campbell, B.J., Rhodes, J.M., Mucosal barrier, bacteria and inflammatory bowel disease: possibilities for therapy. Dig Dis 32 (2014), 475–483, 10.1159/000358156.
    • (2014) Dig Dis , vol.32 , pp. 475-483
    • Merga, Y.1    Campbell, B.J.2    Rhodes, J.M.3
  • 40
    • 84964263169 scopus 로고    scopus 로고
    • Changes in the intestinal microbiome and alcoholic and nonalcoholic liver diseases: causes or effects?
    • Betrapally, N.S., Gillevet, P.M., Bajaj, J.S., Changes in the intestinal microbiome and alcoholic and nonalcoholic liver diseases: causes or effects?. Gastroenterology 150 (2016), 1745–1755.e3, 10.1053/j.gastro.2016.02.073.
    • (2016) Gastroenterology , vol.150 , pp. 1745-1755.e3
    • Betrapally, N.S.1    Gillevet, P.M.2    Bajaj, J.S.3
  • 41
    • 84883110880 scopus 로고    scopus 로고
    • Richness of human gut microbiome correlates with metabolic markers
    • Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500 (2013), 541–546, 10.1038/nature12506.
    • (2013) Nature , vol.500 , pp. 541-546
    • Le Chatelier, E.1    Nielsen, T.2    Qin, J.3    Prifti, E.4    Hildebrand, F.5    Falony, G.6
  • 42
    • 84873296091 scopus 로고    scopus 로고
    • Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH
    • Zhu, L., Baker, S.S., Gill, C., Liu, W., Alkhouri, R., Baker, R.D., et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 57 (2013), 601–609, 10.1002/hep.26093.
    • (2013) Hepatology , vol.57 , pp. 601-609
    • Zhu, L.1    Baker, S.S.2    Gill, C.3    Liu, W.4    Alkhouri, R.5    Baker, R.D.6
  • 44
    • 84883418106 scopus 로고    scopus 로고
    • Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion
    • Yadav, H., Lee, J.H., Lloyd, J., Walter, P., Rane, S.G., Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem 288 (2013), 25088–25097, 10.1074/jbc.M113.452516.
    • (2013) J Biol Chem , vol.288 , pp. 25088-25097
    • Yadav, H.1    Lee, J.H.2    Lloyd, J.3    Walter, P.4    Rane, S.G.5
  • 45
    • 56549121232 scopus 로고    scopus 로고
    • Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice
    • Chichlowski, M., Sharp, J.M., Vanderford, D.A., Myles, M.H., Hale, L.P., Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. Comp Med 58 (2008), 534–541.
    • (2008) Comp Med , vol.58 , pp. 534-541
    • Chichlowski, M.1    Sharp, J.M.2    Vanderford, D.A.3    Myles, M.H.4    Hale, L.P.5
  • 46
    • 84992036214 scopus 로고    scopus 로고
    • Heritable components of the human fecal microbiome are associated with visceral fat
    • Beaumont, M., Goodrich, J.K., Jackson, M.A., Yet, I., Davenport, E.R., Vieira-Silva, S., et al. Heritable components of the human fecal microbiome are associated with visceral fat. Genome Biol, 17, 2016, 189, 10.1186/s13059-016-1052-7.
    • (2016) Genome Biol , vol.17 , pp. 189
    • Beaumont, M.1    Goodrich, J.K.2    Jackson, M.A.3    Yet, I.4    Davenport, E.R.5    Vieira-Silva, S.6
  • 47
    • 84971663701 scopus 로고    scopus 로고
    • Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach
    • Del Chierico, F., Nobili, V., Vernocchi, P., Russo, A., De Stefanis, C., Gnani, D., et al. Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach. Hepatology 65 (2017), 451–464, 10.1002/hep.28572.
    • (2017) Hepatology , vol.65 , pp. 451-464
    • Del Chierico, F.1    Nobili, V.2    Vernocchi, P.3    Russo, A.4    De Stefanis, C.5    Gnani, D.6
  • 48
    • 85018954191 scopus 로고    scopus 로고
    • Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease
    • Loomba, R., Seguritan, V., Li, W., Long, T., Klitgord, N., Bhatt, A., et al. Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease. Cell Metab 25 (2017), 1054–1062.e5, 10.1016/j.cmet.2017.04.001.
    • (2017) Cell Metab , vol.25 , pp. 1054-1062.e5
    • Loomba, R.1    Seguritan, V.2    Li, W.3    Long, T.4    Klitgord, N.5    Bhatt, A.6
  • 49
    • 84988462353 scopus 로고    scopus 로고
    • Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
    • Rotman, Y., Sanyal, A.J., Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. Gut 66 (2017), 180–190, 10.1136/gutjnl-2016-312431.
    • (2017) Gut , vol.66 , pp. 180-190
    • Rotman, Y.1    Sanyal, A.J.2
  • 50
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J.P., Druart, C., Bindels, L.B., et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. 2013, 10.1073/pnas.1219451110.
    • (2013)
    • Everard, A.1    Belzer, C.2    Geurts, L.3    Ouwerkerk, J.P.4    Druart, C.5    Bindels, L.B.6
  • 51
    • 84992157064 scopus 로고    scopus 로고
    • Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients
    • Smits, M.M., Tonneijck, L., Muskiet, M.H.A., Hoekstra, T., Kramer, M.H.H., Diamant, M., et al. Biliary effects of liraglutide and sitagliptin, a 12-week randomized placebo-controlled trial in type 2 diabetes patients. Diabetes Obes Metab 18 (2016), 1217–1225, 10.1111/dom.12748.
    • (2016) Diabetes Obes Metab , vol.18 , pp. 1217-1225
    • Smits, M.M.1    Tonneijck, L.2    Muskiet, M.H.A.3    Hoekstra, T.4    Kramer, M.H.H.5    Diamant, M.6


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