메뉴 건너뛰기




Volumn 50, Issue 11, 2018, Pages 1514-1523

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

(45)  Klarin, Derek a,b,c   Damrauer, Scott M d,e   Cho, Kelly f   Sun, Yan V g   Teslovich, Tanya M h   Honerlaw, Jacqueline f   Gagnon, David R f,i   DuVall, Scott L d,j   Li, Jin k,l   Peloso, Gina M i   Chaffin, Mark b   Small, Aeron M d,m   Huang, Jie f   Tang, Hua k   Lynch, Julie A d,n   Ho, Yuk Lam f   Liu, Dajiang J o   Emdin, Connor A a,b   Li, Alexander H h   Huffman, Jennifer E f   more..


Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COLESTYRAMINE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSCRIPTOME; TRIACYLGLYCEROL;

EID: 85054347138     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/s41588-018-0222-9     Document Type: Article
Times cited : (422)

References (60)
  • 1
    • 84859215798 scopus 로고    scopus 로고
    • What makes UK Biobank special?
    • Collins, R. What makes UK Biobank special? Lancet 379, 1173–1174 (2012)
    • (2012) Lancet , vol.379 , pp. 1173-1174
    • Collins, R.1
  • 2
    • 84957436835 scopus 로고    scopus 로고
    • Million Veteran Program: a mega-biobank to study genetic influences on health and disease
    • Gaziano, J. M. et al. Million Veteran Program: a mega-biobank to study genetic influences on health and disease. J. Clin. Epidemiol. 70, 214–223 (2016)
    • (2016) J. Clin. Epidemiol. , vol.70 , pp. 214-223
    • Gaziano, J.M.1
  • 3
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipoproteins, and risk of vascular disease
    • The Emerging Risk Factors Collaboration. Major lipids, apolipoproteins, and risk of vascular disease. J. Am. Med. Assoc. 302, 1993–2000 (2009)
    • (2009) J. Am. Med. Assoc. , vol.302 , pp. 1993-2000
  • 4
    • 77955505564 scopus 로고    scopus 로고
    • Biological, clinical and population relevance of 95 loci for blood lipids
    • COI: 1:CAS:528:DC%2BC3cXhtVSmurfI
    • Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707–713 (2010)
    • (2010) Nature , vol.466 , pp. 707-713
    • Teslovich, T.M.1
  • 5
    • 84887099827 scopus 로고    scopus 로고
    • Discovery and refinement of loci associated with lipid levels
    • Global Lipids Genetics Consortium. Discovery and refinement of loci associated with lipid levels. Nat. Genet. 45, 1274–1283 (2013)
    • (2013) Nat. Genet. , vol.45 , pp. 1274-1283
  • 6
    • 73649103089 scopus 로고    scopus 로고
    • Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    • Chasman, D. I. et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 5, e1000730 (2009)
    • (2009) PLoS Genet. , vol.5
    • Chasman, D.I.1
  • 7
    • 84876276050 scopus 로고    scopus 로고
    • Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
    • COI: 1:CAS:528:DC%2BC3sXlt1GksQ%3D%3D
    • Albrechtsen, A. et al. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia 56, 298–310 (2013)
    • (2013) Diabetologia , vol.56 , pp. 298-310
    • Albrechtsen, A.1
  • 8
    • 84893756641 scopus 로고    scopus 로고
    • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks
    • COI: 1:CAS:528:DC%2BC2cXitVyksbs%3D
    • Peloso, G. M. et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am. J. Hum. Genet. 94, 223–232 (2014)
    • (2014) Am. J. Hum. Genet. , vol.94 , pp. 223-232
    • Peloso, G.M.1
  • 9
    • 84868470681 scopus 로고    scopus 로고
    • Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    • COI: 1:CAS:528:DC%2BC38XhsV2qu73F
    • Asselbergs, F. W. et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am. J. Hum. Genet. 91, 823–838 (2012)
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 823-838
    • Asselbergs, F.W.1
  • 10
    • 84955263526 scopus 로고    scopus 로고
    • Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs
    • COI: 1:CAS:528:DC%2BC28Xht1elsLY%3D
    • Below, J. E. et al. Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs. Sci. Rep. 6, 19429 (2016)
    • (2016) Sci. Rep. , vol.6
    • Below, J.E.1
  • 11
    • 85035766416 scopus 로고    scopus 로고
    • Exome-wide association study of plasma lipids in >300,000 individuals
    • COI: 1:CAS:528:DC%2BC2sXhslehtrjL
    • Liu, D. J. et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nat. Genet. 49, 1758–1766 (2017)
    • (2017) Nat. Genet. , vol.49 , pp. 1758-1766
    • Liu, D.J.1
  • 12
    • 85035814059 scopus 로고    scopus 로고
    • Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
    • COI: 1:CAS:528:DC%2BC2sXhslehtrjP
    • Lu, X. et al. Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. Nat. Genet. 49, 1722–1730 (2017)
    • (2017) Nat. Genet. , vol.49 , pp. 1722-1730
    • Lu, X.1
  • 13
    • 85017341929 scopus 로고    scopus 로고
    • Evolocumab and clinical outcomes in patients with cardiovascular disease
    • COI: 1:CAS:528:DC%2BC2sXhtlOns7nM
    • Sabatine, M. S. et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N. Engl. J. Med. 376, 1713–1722 (2017)
    • (2017) N. Engl. J. Med. , vol.376 , pp. 1713-1722
    • Sabatine, M.S.1
  • 14
    • 84962230620 scopus 로고    scopus 로고
    • Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease
    • Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators. Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. N. Engl. J. Med. 374, 1134–1144 (2016)
    • (2016) N. Engl. J. Med. , vol.374 , pp. 1134-1144
  • 15
    • 84961948174 scopus 로고    scopus 로고
    • Inactivating variants in ANGPTL4 and risk of coronary artery disease
    • COI: 1:CAS:528:DC%2BC28Xht1Cqu7jK
    • Dewey, F. E. et al. Inactivating variants in ANGPTL4 and risk of coronary artery disease. N. Engl. J. Med. 374, 1123–1133 (2016)
    • (2016) N. Engl. J. Med. , vol.374 , pp. 1123-1133
    • Dewey, F.E.1
  • 16
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • COI: 1:CAS:528:DC%2BD2sXhtlGns7bL
    • Barter, P. J. et al. Effects of torcetrapib in patients at high risk for coronary events. N. Engl. J. Med. 357, 2109–2122 (2007)
    • (2007) N. Engl. J. Med. , vol.357 , pp. 2109-2122
    • Barter, P.J.1
  • 17
    • 84890107642 scopus 로고    scopus 로고
    • Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data
    • COI: 1:CAS:528:DC%2BC3sXhvVaiu7jE
    • Denny, J. C. et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat. Biotechnol. 31, 1102–1111 (2013)
    • (2013) Nat. Biotechnol. , vol.31 , pp. 1102-1111
    • Denny, J.C.1
  • 18
    • 84903727023 scopus 로고    scopus 로고
    • Loss-of-function mutations in APOC3, triglycerides, and coronary disease
    • The TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N. Engl. J. Med. 371, 22–31 (2014)
    • (2014) N. Engl. J. Med. , vol.371 , pp. 22-31
  • 19
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • COI: 1:CAS:528:DC%2BD28Xislequr8%3D
    • Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr. & Hobbs, H. H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264–1272 (2006)
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 20
    • 85007138010 scopus 로고    scopus 로고
    • Genetic identification of familial hypercholesterolemia within a single U.S. health care system
    • Abul-Husn, N. S. et al. Genetic identification of familial hypercholesterolemia within a single U.S. health care system. Science 354, aaf7000 (2016)
    • (2016) Science , vol.354 , pp. aaf7000
    • Abul-Husn, N.S.1
  • 21
    • 84943171338 scopus 로고    scopus 로고
    • A global reference for human genetic variation
    • The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 526, 68–74 (2015)
    • (2015) Nature , vol.526 , pp. 68-74
  • 22
    • 66249116333 scopus 로고    scopus 로고
    • The genetic structure and history of Africans and African Americans
    • COI: 1:CAS:528:DC%2BD1MXmtVKlsbs%3D
    • Tishkoff, S. A. et al. The genetic structure and history of Africans and African Americans. Science 324, 1035–1044 (2009)
    • (2009) Science , vol.324 , pp. 1035-1044
    • Tishkoff, S.A.1
  • 23
    • 84959547986 scopus 로고    scopus 로고
    • Integrative approaches for large-scale transcriptome-wide association studies
    • COI: 1:CAS:528:DC%2BC28Xit1ajtbc%3D
    • Gusev, A. et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat. Genet. 48, 245–252 (2016)
    • (2016) Nat. Genet. , vol.48 , pp. 245-252
    • Gusev, A.1
  • 24
    • 84899642574 scopus 로고    scopus 로고
    • Heritability and genomics of gene expression in peripheral blood
    • COI: 1:CAS:528:DC%2BC2cXmtlWrtb8%3D
    • Wright, F. A. et al. Heritability and genomics of gene expression in peripheral blood. Nat. Genet. 46, 430–437 (2014)
    • (2014) Nat. Genet. , vol.46 , pp. 430-437
    • Wright, F.A.1
  • 25
    • 85031313737 scopus 로고    scopus 로고
    • Genetic effects on gene expression across human tissues
    • GTEx Consortium. Genetic effects on gene expression across human tissues. Nature 550, 204–213 (2017)
    • (2017) Nature , vol.550 , pp. 204-213
  • 26
    • 85013638666 scopus 로고    scopus 로고
    • Integrating gene expression with summary association statistics to identify genes associated with 30 complex traits
    • COI: 1:CAS:528:DC%2BC2sXjtlGrtbw%3D
    • Mancuso, N. et al. Integrating gene expression with summary association statistics to identify genes associated with 30 complex traits. Am. J. Hum. Genet. 100, 473–487 (2017)
    • (2017) Am. J. Hum. Genet. , vol.100 , pp. 473-487
    • Mancuso, N.1
  • 27
    • 84982253941 scopus 로고    scopus 로고
    • Analysis of protein-coding genetic variation in 60,706 humans
    • COI: 1:CAS:528:DC%2BC28XhtlOnsbbP
    • Lek, M. et al. Analysis of protein-coding genetic variation in 60,706 humans. Nature 536, 285–291 (2016)
    • (2016) Nature , vol.536 , pp. 285-291
    • Lek, M.1
  • 28
    • 85012918562 scopus 로고    scopus 로고
    • Rare and low-frequency coding variants alter human adult height
    • COI: 1:CAS:528:DC%2BC2sXhvV2ht78%3D
    • Marouli, E. et al. Rare and low-frequency coding variants alter human adult height. Nature 542, 186–190 (2017)
    • (2017) Nature , vol.542 , pp. 186-190
    • Marouli, E.1
  • 29
    • 77955405475 scopus 로고    scopus 로고
    • Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor
    • COI: 1:CAS:528:DC%2BC3cXpvFSlsLc%3D
    • McLaren, W. et al. Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor. Bioinformatics 26, 2069–2070 (2010)
    • (2010) Bioinformatics , vol.26 , pp. 2069-2070
    • McLaren, W.1
  • 30
    • 85015922086 scopus 로고    scopus 로고
    • Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease
    • COI: 1:CAS:528:DC%2BC2sXhtlyktLbI
    • Khera, A. V. et al. Association of rare and common variation in the lipoprotein lipase gene with coronary artery disease. J. Am. Med. Assoc. 317, 937–946 (2017)
    • (2017) J. Am. Med. Assoc. , vol.317 , pp. 937-946
    • Khera, A.V.1
  • 31
    • 85007028930 scopus 로고    scopus 로고
    • Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study
    • Dewey, F. E. et al. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science 354, aaf6814 (2016)
    • (2016) Science , vol.354 , pp. aaf6814
    • Dewey, F.E.1
  • 32
    • 84945370533 scopus 로고    scopus 로고
    • Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers
    • COI: 1:CAS:528:DC%2BC2MXhsV2lt7zM
    • Sidore, C. et al. Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers. Nat. Genet. 47, 1272–1281 (2015)
    • (2015) Nat. Genet. , vol.47 , pp. 1272-1281
    • Sidore, C.1
  • 33
    • 84893904007 scopus 로고    scopus 로고
    • A polygenic burden of rare disruptive mutations in schizophrenia
    • COI: 1:CAS:528:DC%2BC2cXisVamurc%3D
    • Purcell, S. M. et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185–190 (2014)
    • (2014) Nature , vol.506 , pp. 185-190
    • Purcell, S.M.1
  • 35
    • 85042368356 scopus 로고    scopus 로고
    • Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC1cXnsVGrsbc%3D
    • Mahajan, A. et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat. Genet. 50, 559–571 (2018)
    • (2018) Nat. Genet. , vol.50 , pp. 559-571
    • Mahajan, A.1
  • 36
    • 84936755918 scopus 로고    scopus 로고
    • Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
    • Bowden, J., Davey Smith, G. & Burgess, S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol. 44, 512–525 (2015)
    • (2015) Int. J. Epidemiol. , vol.44 , pp. 512-525
    • Bowden, J.1    Davey Smith, G.2    Burgess, S.3
  • 38
    • 85028693072 scopus 로고    scopus 로고
    • Association analyses based on false discovery rate implicate new loci for coronary artery disease
    • COI: 1:CAS:528:DC%2BC2sXhtFOru7vE
    • Nelson, C. P. et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat. Genet. 49, 1385–1391 (2017)
    • (2017) Nat. Genet. , vol.49 , pp. 1385-1391
    • Nelson, C.P.1
  • 39
    • 79952000272 scopus 로고    scopus 로고
    • Perilipin deficiency and autosomal dominant partial lipodystrophy
    • COI: 1:CAS:528:DC%2BC3MXis1ymsbo%3D
    • Gandotra, S. et al. Perilipin deficiency and autosomal dominant partial lipodystrophy. N. Engl. J. Med. 364, 740–748 (2011)
    • (2011) N. Engl. J. Med. , vol.364 , pp. 740-748
    • Gandotra, S.1
  • 40
    • 85026557006 scopus 로고    scopus 로고
    • T2DiACoD: a gene atlas of type 2 diabetes mellitus associated complex disorders
    • Rani, J. et al. T2DiACoD: a gene atlas of type 2 diabetes mellitus associated complex disorders. Sci. Rep. 7, 6892 (2017)
    • (2017) Sci. Rep. , vol.7
    • Rani, J.1
  • 41
    • 78649755576 scopus 로고    scopus 로고
    • Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia
    • COI: 1:CAS:528:DC%2BC3cXhsFaju7zM
    • Musunuru, K. et al. Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N. Engl. J. Med. 363, 2220–2227 (2010)
    • (2010) N. Engl. J. Med. , vol.363 , pp. 2220-2227
    • Musunuru, K.1
  • 42
    • 85025630463 scopus 로고    scopus 로고
    • Cardiovascular and metabolic effects of ANGPTL3 antisense oligonucleotides
    • COI: 1:CAS:528:DC%2BC2sXhtlyksrnJ
    • Graham, M. J. et al. Cardiovascular and metabolic effects of ANGPTL3 antisense oligonucleotides. N. Engl. J. Med. 377, 222–232 (2017)
    • (2017) N. Engl. J. Med. , vol.377 , pp. 222-232
    • Graham, M.J.1
  • 43
    • 34548829636 scopus 로고    scopus 로고
    • Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A
    • COI: 1:CAS:528:DC%2BD2sXhtVSgsbzI
    • Zhang, W. & Colman, R. W. Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A. Blood 110, 1475–1482 (2007)
    • (2007) Blood , vol.110 , pp. 1475-1482
    • Zhang, W.1    Colman, R.W.2
  • 44
    • 84930065286 scopus 로고    scopus 로고
    • PDE3A mutations cause autosomal dominant hypertension with brachydactyly
    • COI: 1:CAS:528:DC%2BC2MXht1Wltb7F
    • Maass, P. G. et al. PDE3A mutations cause autosomal dominant hypertension with brachydactyly. Nat. Genet. 47, 647–653 (2015)
    • (2015) Nat. Genet. , vol.47 , pp. 647-653
    • Maass, P.G.1
  • 45
    • 84889660239 scopus 로고    scopus 로고
    • Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms
    • COI: 1:CAS:528:DC%2BC3sXhvFKms7zJ
    • Vandeput, F. et al. Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms. Proc. Natl Acad. Sci. USA 110, 19778–19783 (2013)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 19778-19783
    • Vandeput, F.1
  • 46
    • 84965187422 scopus 로고    scopus 로고
    • Cilostazol for intermittent claudication
    • Bedenis, R. et al. Cilostazol for intermittent claudication. Cochrane Database Syst. Rev. 10, CD003748 (2014)
    • (2014) Cochrane Database Syst. Rev. , vol.10 , pp. CD003748
    • Bedenis, R.1
  • 47
    • 0033529402 scopus 로고    scopus 로고
    • Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty
    • COI: 1:CAS:528:DyaK1MXksFyltbY%3D
    • Tsuchikane, E. et al. Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty. Circulation 100, 21–26 (1999)
    • (1999) Circulation , vol.100 , pp. 21-26
    • Tsuchikane, E.1
  • 48
    • 77956884231 scopus 로고    scopus 로고
    • Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial
    • COI: 1:CAS:528:DC%2BC3cXhtFOntbvK
    • Shinohara, Y. et al. Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial. Lancet Neurol. 9, 959–968 (2010)
    • (2010) Lancet Neurol. , vol.9 , pp. 959-968
    • Shinohara, Y.1
  • 49
    • 84975492597 scopus 로고    scopus 로고
    • Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
    • COI: 1:CAS:528:DC%2BC28XhtVahu7nI
    • Ahmad, F. et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci. Rep. 6, 28056 (2016)
    • (2016) Sci. Rep. , vol.6
    • Ahmad, F.1
  • 50
    • 84928558139 scopus 로고    scopus 로고
    • Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury
    • COI: 1:CAS:528:DC%2BC2MXmsFSmsrw%3D
    • Chung, Y. W. et al. Targeted disruption of PDE3B, but not PDE3A, protects murine heart from ischemia/reperfusion injury. Proc. Natl Acad. Sci. USA 112, E2253–E2262 (2015)
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. E2253-E2262
    • Chung, Y.W.1
  • 51
    • 85041475144 scopus 로고    scopus 로고
    • Genetic association of lipids and lipid drug targets with abdominal aortic aneurysm: a meta-analysis
    • Harrison, S. C. et al. Genetic association of lipids and lipid drug targets with abdominal aortic aneurysm: a meta-analysis. JAMA Cardiol. 3, 26–33 (2018)
    • (2018) JAMA Cardiol. , vol.3 , pp. 26-33
    • Harrison, S.C.1
  • 52
    • 84983780951 scopus 로고    scopus 로고
    • Hypercholesterolemia induced by a PCSK9 gain-of-function mutation augments angiotensin II-induced abdominal aortic aneurysms in C57BL/6 mice—brief report
    • COI: 1:CAS:528:DC%2BC28Xhtl2msLvP
    • Lu, H. et al. Hypercholesterolemia induced by a PCSK9 gain-of-function mutation augments angiotensin II-induced abdominal aortic aneurysms in C57BL/6 mice—brief report. Arterioscler. Thromb. Vasc. Biol. 36, 1753–1757 (2016)
    • (2016) Arterioscler. Thromb. Vasc. Biol. , vol.36 , pp. 1753-1757
    • Lu, H.1
  • 53
    • 84864845456 scopus 로고    scopus 로고
    • Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
    • COI: 1:CAS:528:DC%2BC38Xnt1Cmsrc%3D
    • Voight, B. F. et al. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380, 572–580 (2012)
    • (2012) Lancet , vol.380 , pp. 572-580
    • Voight, B.F.1
  • 54
    • 84887058576 scopus 로고    scopus 로고
    • Common variants associated with plasma triglycerides and risk for coronary artery disease
    • COI: 1:CAS:528:DC%2BC3sXhsFOiur%2FN
    • Do, R. et al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat. Genet. 45, 1345–1352 (2013)
    • (2013) Nat. Genet. , vol.45 , pp. 1345-1352
    • Do, R.1
  • 55
    • 84976331409 scopus 로고    scopus 로고
    • Fast and accurate long-range phasing in a UK Biobank cohort
    • COI: 1:CAS:528:DC%2BC28XpsVCrsrs%3D
    • Loh, P. R., Palamara, P. F. & Price, A. L. Fast and accurate long-range phasing in a UK Biobank cohort. Nat. Genet. 48, 811–816 (2016)
    • (2016) Nat. Genet. , vol.48 , pp. 811-816
    • Loh, P.R.1    Palamara, P.F.2    Price, A.L.3
  • 56
    • 84864417548 scopus 로고    scopus 로고
    • Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
    • COI: 1:CAS:528:DC%2BC38XhtVKnt7jI
    • Howie, B., Fuchsberger, C., Stephens, M., Marchini, J. & Abecasis, G. R. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat. Genet. 44, 955–959 (2012)
    • (2012) Nat. Genet. , vol.44 , pp. 955-959
    • Howie, B.1    Fuchsberger, C.2    Stephens, M.3    Marchini, J.4    Abecasis, G.R.5
  • 57
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • COI: 1:CAS:528:DC%2BD28XnsVCgsrg%3D
    • Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904–909 (2006)
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1
  • 58
    • 84899540947 scopus 로고    scopus 로고
    • Quality control and conduct of genome-wide association meta-analyses
    • Winkler, T. W. et al. Quality control and conduct of genome-wide association meta-analyses. Nat. Protoc. 9, 1192–1212 (2014)
    • (2014) Nat. Protoc. , vol.9 , pp. 1192-1212
    • Winkler, T.W.1
  • 59
    • 84980347551 scopus 로고    scopus 로고
    • Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
    • COI: 1:CAS:528:DC%2BC28Xht1KlsrrJ
    • Hyde, C. L. et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat. Genet. 48, 1031–1036 (2016)
    • (2016) Nat. Genet. , vol.48 , pp. 1031-1036
    • Hyde, C.L.1
  • 60
    • 84874783818 scopus 로고    scopus 로고
    • Polygenic modeling with Bayesian sparse linear mixed models
    • COI: 1:CAS:528:DC%2BC3sXktlSksLw%3D
    • Zhou, X., Carbonetto, P. & Stephens, M. Polygenic modeling with Bayesian sparse linear mixed models. PLoS Genet. 9, e1003264 (2013)
    • (2013) PLoS Genet. , vol.9
    • Zhou, X.1    Carbonetto, P.2    Stephens, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.