메뉴 건너뛰기




Volumn 8, Issue 1, 2018, Pages

Ulinastatin is effective in reducing mortality for critically ill patients with sepsis: a causal mediation analysis

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLYCOPROTEIN; ULINASTATIN;

EID: 85053850637     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-018-32533-9     Document Type: Article
Times cited : (15)

References (37)
  • 1
    • 84991244889 scopus 로고    scopus 로고
    • AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital
    • Zhang, Z. et al. AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital. J Thorac Dis 8, 2654–2665 (2016)
    • (2016) J Thorac Dis , vol.8 , pp. 2654-2665
    • Zhang, Z.1
  • 2
    • 85013468576 scopus 로고    scopus 로고
    • Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting
    • Yébenes, J. C. et al. Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting. Ann Intensive Care 7, 19 (2017)
    • (2017) Ann Intensive Care , vol.7
    • Yébenes, J.C.1
  • 3
    • 84873714375 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    • COI: 1:STN:280:DC%2BC3szjs1Witw%3D%3D
    • Dellinger, R. P. et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive care medicine 39, 165–228 (2013)
    • (2013) Intensive care medicine , vol.39 , pp. 165-228
    • Dellinger, R.P.1
  • 4
    • 85014121208 scopus 로고    scopus 로고
    • Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002
    • Zhang, Z. et al. Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002. J Thorac Dis 9, 392–405 (2017)
    • (2017) J Thorac Dis , vol.9 , pp. 392-405
    • Zhang, Z.1
  • 5
    • 84979197941 scopus 로고    scopus 로고
    • The Japanese guidelines for the management of sepsis
    • Oda, S. et al. The Japanese guidelines for the management of sepsis. J Intensive Care 2, 55 (2014)
    • (2014) J Intensive Care , vol.2
    • Oda, S.1
  • 6
    • 84925535576 scopus 로고    scopus 로고
    • Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC2MXhs1alu74%3D
    • Zhang, Z., Ni, H. & Qian, Z. Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial. Intensive Care Med 41, 444–451 (2015)
    • (2015) Intensive Care Med , vol.41 , pp. 444-451
    • Zhang, Z.1    Ni, H.2    Qian, Z.3
  • 7
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • COI: 1:STN:280:DC%2BD3Mvgs12gtg%3D%3D
    • Angus, D. C. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29, 1303–1310 (2001)
    • (2001) Crit. Care Med. , vol.29 , pp. 1303-1310
    • Angus, D.C.1
  • 8
    • 84956616365 scopus 로고    scopus 로고
    • Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
    • Delano, M. J. & Ward, P. A. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J. Clin. Invest. 126, 23–31 (2016)
    • (2016) J. Clin. Invest. , vol.126 , pp. 23-31
    • Delano, M.J.1    Ward, P.A.2
  • 9
    • 84962580213 scopus 로고    scopus 로고
    • Ulinastatin-a newer potential therapeutic option for multiple organ dysfunction syndrome
    • COI: 1:CAS:528:DC%2BC28XktFGmtbk%3D
    • Atal, S. S. & Atal, S. Ulinastatin-a newer potential therapeutic option for multiple organ dysfunction syndrome. J Basic Clin Physiol Pharmacol 27, 91–99 (2016)
    • (2016) J Basic Clin Physiol Pharmacol , vol.27 , pp. 91-99
    • Atal, S.S.1    Atal, S.2
  • 10
    • 85012048367 scopus 로고    scopus 로고
    • Ulinastatin post-treatment attenuates lipopolysaccharide-induced acute lung injury in rats and human alveolar epithelial cells
    • COI: 1:CAS:528:DC%2BC1cXivVehs7w%3D
    • Luo, Y., Che, W. & Zhao, M. Ulinastatin post-treatment attenuates lipopolysaccharide-induced acute lung injury in rats and human alveolar epithelial cells. International Journal of Molecular Medicine 39, 297–306 (2017)
    • (2017) International Journal of Molecular Medicine , vol.39 , pp. 297-306
    • Luo, Y.1    Che, W.2    Zhao, M.3
  • 11
    • 84957430576 scopus 로고    scopus 로고
    • Ulinastatin and/or thymosin α1 for severe sepsis: A systematic review and meta-analysis
    • Feng, Z., Shi, Q., Fan, Y., Wang, Q. & Yin, W. Ulinastatin and/or thymosin α1 for severe sepsis: A systematic review and meta-analysis. J Trauma Acute Care Surg 80, 335–340 (2016)
    • (2016) J Trauma Acute Care Surg , vol.80 , pp. 335-340
    • Feng, Z.1    Shi, Q.2    Fan, Y.3    Wang, Q.4    Yin, W.5
  • 12
    • 85008655979 scopus 로고    scopus 로고
    • Effect of ulinastatin combined with thymosin alpha1 on sepsis: A systematic review and meta-analysis of Chinese and Indian patients
    • COI: 1:CAS:528:DC%2BC2sXmsVyjtg%3D%3D
    • Liu, D. et al. Effect of ulinastatin combined with thymosin alpha1 on sepsis: A systematic review and meta-analysis of Chinese and Indian patients. J Crit Care 39, 259–266 (2017)
    • (2017) J Crit Care , vol.39 , pp. 259-266
    • Liu, D.1
  • 13
    • 85053816598 scopus 로고    scopus 로고
    • Ulinastatin did not reduce mortality in elderly multiple organ failure patients: a retrospective observational study in a single center ICU
    • Uchida, M., Abe, T., Ono, K. & Tamiya, N. Ulinastatin did not reduce mortality in elderly multiple organ failure patients: a retrospective observational study in a single center ICU. Acute Med Surg 5, 90–97 (2018)
    • (2018) Acute Med Surg , vol.5 , pp. 90-97
    • Uchida, M.1    Abe, T.2    Ono, K.3    Tamiya, N.4
  • 15
    • 0022256529 scopus 로고
    • APACHE II: A severity of disease classification system
    • COI: 1:STN:280:DyaL2M3otlyqtQ%3D%3D
    • Knaus, W. A., Draper, E. A., Wagner, D. P. & Zimmerman, J. E. APACHE II: A severity of disease classification system. Crit. Care Med. 13, 818–829 (1985)
    • (1985) Crit. Care Med. , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3    Zimmerman, J.E.4
  • 16
    • 60849102446 scopus 로고    scopus 로고
    • Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
    • Minne, L., Abu-Hanna, A. & de Jonge, E. Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review. Crit Care 12, R161 (2008)
    • (2008) Crit Care , vol.12
    • Minne, L.1    Abu-Hanna, A.2    de Jonge, E.3
  • 17
    • 85006201765 scopus 로고    scopus 로고
    • Univariate description and bivariate statistical inference: the first step delving into data
    • Zhang, Z. Univariate description and bivariate statistical inference: the first step delving into data. Ann Transl Med 4, 91–91 (2016)
    • (2016) Ann Transl Med , vol.4 , pp. 91
    • Zhang, Z.1
  • 18
    • 85037994457 scopus 로고    scopus 로고
    • Comparing baseline characteristics between groups: an introduction to the CBCgrps package
    • Zhang, Z., Gayle, A. A., Wang, J., Zhang, H. & Cardinal-Fernández, P. Comparing baseline characteristics between groups: an introduction to the CBCgrps package. Ann Transl Med 5, 484–484 (2017)
    • (2017) Ann Transl Med , vol.5 , pp. 484
    • Zhang, Z.1    Gayle, A.A.2    Wang, J.3    Zhang, H.4    Cardinal-Fernández, P.5
  • 19
    • 85006198872 scopus 로고    scopus 로고
    • Model building strategy for logistic regression: purposeful selection
    • Zhang, Z. Model building strategy for logistic regression: purposeful selection. Ann Transl Med 4, 111–111 (2016)
    • (2016) Ann Transl Med , vol.4 , pp. 111
    • Zhang, Z.1
  • 20
    • 85006189450 scopus 로고    scopus 로고
    • Causal mediation analysis in the context of clinical research
    • Zhang, Z. et al. Causal mediation analysis in the context of clinical research. Ann Transl Med 4, 425–425 (2016)
    • (2016) Ann Transl Med , vol.4 , pp. 425
    • Zhang, Z.1
  • 21
    • 78650085125 scopus 로고    scopus 로고
    • A General Approach to Causal Mediation Analysis
    • Imai, K., Keele, L. & Tingley, D. A General Approach to Causal Mediation Analysis. Psychological Methods 15, 309–334 (2010)
    • (2010) Psychological Methods , vol.15 , pp. 309-334
    • Imai, K.1    Keele, L.2    Tingley, D.3
  • 22
    • 85044519098 scopus 로고    scopus 로고
    • Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: A retrospective analysis
    • COI: 1:CAS:528:DC%2BC1cXitFyiu74%3D
    • Lagoo, J. Y., D’Souza, M. C., Kartha, A. & Kutappa, A. M. Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: A retrospective analysis. J Crit Care 45, 27–32 (2018)
    • (2018) J Crit Care , vol.45 , pp. 27-32
    • Lagoo, J.Y.1    D’Souza, M.C.2    Kartha, A.3    Kutappa, A.M.4
  • 23
    • 84901476727 scopus 로고    scopus 로고
    • Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: A multicenter randomized controlled study
    • COI: 1:CAS:528:DC%2BC2cXmsFaktLY%3D
    • Karnad, D. R. et al. Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: A multicenter randomized controlled study. Intensive Care Med 40, 830–838 (2014)
    • (2014) Intensive Care Med , vol.40 , pp. 830-838
    • Karnad, D.R.1
  • 24
    • 84881148392 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous ulinastatin versus placebo along with standard supportive care in subjects with mild or severe acute pancreatitis
    • PID: 24818336
    • Abraham, P. et al. Efficacy and safety of intravenous ulinastatin versus placebo along with standard supportive care in subjects with mild or severe acute pancreatitis. J Assoc Physicians India 61, 535–538 (2013)
    • (2013) J Assoc Physicians India , vol.61 , pp. 535-538
    • Abraham, P.1
  • 25
    • 84887416628 scopus 로고    scopus 로고
    • The effect of ulinastatin on disbalance of inflammation and immune status in patients with severe sepsis
    • COI: 1:CAS:528:DC%2BC2cXitFGlt7nN, PID: 23660098
    • Wu, T.-J., Zhang, L.-N. & Kang, C.-C. The effect of ulinastatin on disbalance of inflammation and immune status in patients with severe sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 25, 219–223 (2013)
    • (2013) Zhonghua Wei Zhong Bing Ji Jiu Yi Xue , vol.25 , pp. 219-223
    • Wu, T.-J.1    Zhang, L.-N.2    Kang, C.-C.3
  • 26
    • 85042420359 scopus 로고    scopus 로고
    • ADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial
    • Jiang, W. et al. ADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial. Trials 19, 133 (2018)
    • (2018) Trials , vol.19
    • Jiang, W.1
  • 27
    • 85014242260 scopus 로고    scopus 로고
    • Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study
    • Donnelly, J. P., Safford, M. M., Shapiro, N. I., Baddley, J. W. & Wang, H. E. Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) Classification: a retrospective population-based cohort study. Lancet Infect Dis 17, 661–670 (2017)
    • (2017) Lancet Infect Dis , vol.17 , pp. 661-670
    • Donnelly, J.P.1    Safford, M.M.2    Shapiro, N.I.3    Baddley, J.W.4    Wang, H.E.5
  • 28
    • 85017203611 scopus 로고    scopus 로고
    • Impact of Ulinastatin on Outcomes in Acute Burns Patients
    • Abhyankar, S. V. & Vartak, A. M. Impact of Ulinastatin on Outcomes in Acute Burns Patients. J Burn Care Res 1 https://doi.org/10.1097/BCR.0000000000000546 (2017)
    • (2017) J Burn Care Res , vol.1
    • Abhyankar, S.V.1    Vartak, A.M.2
  • 29
    • 85020123692 scopus 로고    scopus 로고
    • Clinical value of the early use of ulinastatin in patients with moderately severe or severe acute pancreatitis
    • COI: 1:STN:280:DC%2BC1crhtVGhsw%3D%3D, PID: 28441856
    • Wang, J. et al. Clinical value of the early use of ulinastatin in patients with moderately severe or severe acute pancreatitis. Zhonghua Yi Xue Za Zhi 97, 1252–1255 (2017)
    • (2017) Zhonghua Yi Xue Za Zhi , vol.97 , pp. 1252-1255
    • Wang, J.1
  • 30
    • 85042739879 scopus 로고    scopus 로고
    • Effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture
    • PID: 29509266
    • Ren, K.-W., Shen, N., Tang, J.-L., Nong, L.-M. & Gu, Y.-Q. Effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture. Eur Rev Med Pharmacol Sci 22, 1126–1132 (2018)
    • (2018) Eur Rev Med Pharmacol Sci , vol.22 , pp. 1126-1132
    • Ren, K.-W.1    Shen, N.2    Tang, J.-L.3    Nong, L.-M.4    Gu, Y.-Q.5
  • 31
    • 85043402743 scopus 로고    scopus 로고
    • Influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with burn-blast combined injuries
    • COI: 1:STN:280:DC%2BC1MvkvVShsw%3D%3D, PID: 29374925
    • Liu, W. & Chai, J. K. Influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with burn-blast combined injuries. Zhonghua Shao Shang Za Zhi 34, 32–39 (2018)
    • (2018) Zhonghua Shao Shang Za Zhi , vol.34 , pp. 32-39
    • Liu, W.1    Chai, J.K.2
  • 32
    • 85053828548 scopus 로고    scopus 로고
    • Ulinastatin Protects Against LPS-Induced Acute Lung Injury by Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators
    • Cao, C. et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury by Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock 1, 10.1097/SHK.0000000000001104 (2018)
    • (2018) Shock , vol.1
    • Cao, C.1
  • 33
    • 85051427510 scopus 로고    scopus 로고
    • Ulinastatin attenuates LPS-induced inflammation in mouse macrophageRAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway
    • Li, S.-T. et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophageRAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway. Acta Pharmacol. Sin. 8, 41988 (2018)
    • (2018) Acta Pharmacol. Sin. , vol.8 , pp. 41988
    • Li, S.-T.1
  • 34
    • 85051205267 scopus 로고    scopus 로고
    • Ulinastatin inhibits high glucose-induced cardiomyocyte apoptosis through activating Akt signaling
    • COI: 1:STN:280:DC%2BB3c7jt1ahsQ%3D%3D, PID: 30058707
    • Long, Y., Zhang, Y., Cai, S.-S., Sun, D.-M. & Li, Y.-H. Ulinastatin inhibits high glucose-induced cardiomyocyte apoptosis through activating Akt signaling. Eur Rev Med Pharmacol Sci 22, 4691–4697 (2018)
    • (2018) Eur Rev Med Pharmacol Sci , vol.22 , pp. 4691-4697
    • Long, Y.1    Zhang, Y.2    Cai, S.-S.3    Sun, D.-M.4    Li, Y.-H.5
  • 35
    • 85042120456 scopus 로고    scopus 로고
    • Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection
    • PID: 29423410
    • Wang, J., Wu, A. & Wu, Y. Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection. Biomed Res Int 2017, 5969657–8 (2017)
    • (2017) Biomed Res Int , vol.2017 , pp. 5969657-5969658
    • Wang, J.1    Wu, A.2    Wu, Y.3
  • 36
    • 85053821297 scopus 로고    scopus 로고
    • Ulinastatin attenuates hyper-permeability of vascular endothelialium cells induced by serum from patients with sepsis
    • PID: 29382417
    • Liu, S. et al. Ulinastatin attenuates hyper-permeability of vascular endothelialium cells induced by serum from patients with sepsis. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33, 1600–1604 (2017)
    • (2017) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.33 , pp. 1600-1604
    • Liu, S.1
  • 37
    • 85041107320 scopus 로고    scopus 로고
    • Xuebijing combined with ulinastation benefits patients with sepsis: A meta-analysis
    • Zheng, J. et al. Xuebijing combined with ulinastation benefits patients with sepsis: A meta-analysis. Am J Emerg Med 36, 480–487 (2018)
    • (2018) Am J Emerg Med , vol.36 , pp. 480-487
    • Zheng, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.