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Volumn 39, Issue , 2017, Pages 259-266

Effect of ulinastatin combined with thymosin alpha1 on sepsis: A systematic review and meta-analysis of Chinese and Indian patients

Author keywords

Meta analysis; Sepsis; Ulinastatin

Indexed keywords

HYPERTENSIVE FACTOR; INTERLEUKIN 10; INTERLEUKIN 6; THYMOSIN ALPHA1; TUMOR NECROSIS FACTOR; ULINASTATIN; GLYCOPROTEIN; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; THYMOSIN;

EID: 85008655979     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2016.12.013     Document Type: Review
Times cited : (30)

References (51)
  • 1
    • 84889859020 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • [1] Angus, D.C., van der Poll, T., Severe sepsis and septic shock. N Engl J Med, 369, 2013, 2063.
    • (2013) N Engl J Med , vol.369 , pp. 2063
    • Angus, D.C.1    van der Poll, T.2
  • 2
    • 74949116220 scopus 로고    scopus 로고
    • The surviving sepsis campaign: results of an international guideline–based performance improvement program targeting severe sepsis
    • [2] Levy, M.M., Dellinger, R.P., Townsend, S.R., Linde-Zwirble, W.T., Marshall, J.C., Bion, J., et al. The surviving sepsis campaign: results of an international guideline–based performance improvement program targeting severe sepsis. Crit Care Med 38 (2010), 367–374.
    • (2010) Crit Care Med , vol.38 , pp. 367-374
    • Levy, M.M.1    Dellinger, R.P.2    Townsend, S.R.3    Linde-Zwirble, W.T.4    Marshall, J.C.5    Bion, J.6
  • 3
    • 84873339299 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    • [3] Dellinger, R.P., Levy, M.M., Rhodes, A., Annane, D., Gerlach, H., Opal, S.M., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41 (2013), 580–637.
    • (2013) Crit Care Med , vol.41 , pp. 580-637
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3    Annane, D.4    Gerlach, H.5    Opal, S.M.6
  • 4
    • 34250890817 scopus 로고    scopus 로고
    • Pathophysiology of sepsis
    • [4] Remick, D.G., Pathophysiology of sepsis. Am J Pathol 170 (2007), 1435–1444.
    • (2007) Am J Pathol , vol.170 , pp. 1435-1444
    • Remick, D.G.1
  • 5
    • 77954183132 scopus 로고    scopus 로고
    • Immunotherapy for sepsis—a new approach against an ancient foe
    • [5] Hotchkiss, R.S., Opal, S., Immunotherapy for sepsis—a new approach against an ancient foe. N Engl J Med 363 (2010), 87–89.
    • (2010) N Engl J Med , vol.363 , pp. 87-89
    • Hotchkiss, R.S.1    Opal, S.2
  • 6
    • 70350463588 scopus 로고    scopus 로고
    • Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study
    • [6] Ferrer, R., Artigas, A., Suarez, D., Palencia, E., Levy, M.M., Arenzana, A., et al. Effectiveness of treatments for severe sepsis: a prospective, multicenter, observational study. Am J Respir Crit Care Med 180 (2009), 861–866.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 861-866
    • Ferrer, R.1    Artigas, A.2    Suarez, D.3    Palencia, E.4    Levy, M.M.5    Arenzana, A.6
  • 7
    • 84917706589 scopus 로고    scopus 로고
    • Effect of urinary protease inhibitor (ulinastatin) on cardiopulmonary bypass: a meta-analysis for China and Japan
    • [7] Zhang, Y., Zeng, Z., Cao, Y., Du, X., Wan, Z., Effect of urinary protease inhibitor (ulinastatin) on cardiopulmonary bypass: a meta-analysis for China and Japan. PLoS One, 9, 2014, e113973.
    • (2014) PLoS One , vol.9 , pp. e113973
    • Zhang, Y.1    Zeng, Z.2    Cao, Y.3    Du, X.4    Wan, Z.5
  • 8
    • 84904856949 scopus 로고    scopus 로고
    • An exciting candidate therapy for sepsis: ulinastatin, a urinary protease inhibitor
    • [8] Linder, A., Russell, J.A., An exciting candidate therapy for sepsis: ulinastatin, a urinary protease inhibitor. Intensive Care Med 40 (2014), 1164–1167.
    • (2014) Intensive Care Med , vol.40 , pp. 1164-1167
    • Linder, A.1    Russell, J.A.2
  • 9
    • 53549093061 scopus 로고    scopus 로고
    • Randomized clinical trial to assess the efficacy of ulinastatin for postoperative pancreatitis following pancreaticoduodenectomy
    • [9] Uemura, K., Murakami, Y., Hayashidani, Y., Sudo, T., Hashimoto, Y., Ohge, H., et al. Randomized clinical trial to assess the efficacy of ulinastatin for postoperative pancreatitis following pancreaticoduodenectomy. J Surg Oncol 98 (2008), 309–313.
    • (2008) J Surg Oncol , vol.98 , pp. 309-313
    • Uemura, K.1    Murakami, Y.2    Hayashidani, Y.3    Sudo, T.4    Hashimoto, Y.5    Ohge, H.6
  • 10
    • 85028118000 scopus 로고    scopus 로고
    • Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study
    • [10] Kanai, T., Ishiwata, T., Kobayashi, T., Sato, H., Takizawa, M., Kawamura, Y., et al. Ulinastatin, a urinary trypsin inhibitor, for the initial treatment of patients with Kawasaki disease: a retrospective study. Circulation 124 (2011), 2822–2828.
    • (2011) Circulation , vol.124 , pp. 2822-2828
    • Kanai, T.1    Ishiwata, T.2    Kobayashi, T.3    Sato, H.4    Takizawa, M.5    Kawamura, Y.6
  • 11
    • 77952492404 scopus 로고    scopus 로고
    • Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders
    • [11] Inoue, K., Takano, H., Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders. Expert Opin Investig Drugs 19 (2010), 513–520.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 513-520
    • Inoue, K.1    Takano, H.2
  • 12
    • 84904856863 scopus 로고    scopus 로고
    • Ulinastatin for acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis
    • [12] Leng, Y.X., Yang, S.G., Song, Y.H., Zhu, X., Yao, G.Q., Ulinastatin for acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. World J Crit Care Med 3 (2014), 34–41.
    • (2014) World J Crit Care Med , vol.3 , pp. 34-41
    • Leng, Y.X.1    Yang, S.G.2    Song, Y.H.3    Zhu, X.4    Yao, G.Q.5
  • 13
    • 84893300214 scopus 로고    scopus 로고
    • Beneficial effects of ulinastatin on gut barrier function in sepsis
    • [13] Jiang, L., Yang, L., Zhang, M., Fang, X., Huang, Z., Yang, Z., et al. Beneficial effects of ulinastatin on gut barrier function in sepsis. Indian J Med Res 138 (2013), 904–911.
    • (2013) Indian J Med Res , vol.138 , pp. 904-911
    • Jiang, L.1    Yang, L.2    Zhang, M.3    Fang, X.4    Huang, Z.5    Yang, Z.6
  • 14
    • 0020062607 scopus 로고
    • Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1
    • [14] McClure, J.E., Lameris, N., Wara, D.W., Goldstein, A.L., Immunochemical studies on thymosin: radioimmunoassay of thymosin alpha 1. J Immunol 128 (1982), 368–375.
    • (1982) J Immunol , vol.128 , pp. 368-375
    • McClure, J.E.1    Lameris, N.2    Wara, D.W.3    Goldstein, A.L.4
  • 15
    • 67649094526 scopus 로고    scopus 로고
    • From lab to bedside: emerging clinical applications of thymosin alpha 1
    • [15] Goldstein, A.L., Goldstein, A.L., From lab to bedside: emerging clinical applications of thymosin alpha 1. Expert Opin Biol Ther 9 (2009), 593–608.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 593-608
    • Goldstein, A.L.1    Goldstein, A.L.2
  • 16
    • 84867380502 scopus 로고    scopus 로고
    • Thymosin alpha1 continues to show promise as an enhancer for vaccine response
    • [16] Tuthill, C., Rios, I., De Rosa, A., Camerini, R., Thymosin alpha1 continues to show promise as an enhancer for vaccine response. Ann N Y Acad Sci 1270 (2012), 21–27.
    • (2012) Ann N Y Acad Sci , vol.1270 , pp. 21-27
    • Tuthill, C.1    Rios, I.2    De Rosa, A.3    Camerini, R.4
  • 17
    • 77951826734 scopus 로고    scopus 로고
    • Thymalfasin in the treatment of hepatitis B and C
    • [17] Ciancio, A., Rizzetto, M., Thymalfasin in the treatment of hepatitis B and C. Ann N Y Acad Sci 1194 (2010), 141–146.
    • (2010) Ann N Y Acad Sci , vol.1194 , pp. 141-146
    • Ciancio, A.1    Rizzetto, M.2
  • 18
    • 77950469665 scopus 로고    scopus 로고
    • Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma
    • [18] Maio, M., Mackiewicz, A., Testori, A., Trefzer, U., Ferraresi, V., Jassem, J., et al. Large randomized study of thymosin alpha 1, interferon alfa, or both in combination with dacarbazine in patients with metastatic melanoma. J Clin Oncol 28 (2010), 1780–1787.
    • (2010) J Clin Oncol , vol.28 , pp. 1780-1787
    • Maio, M.1    Mackiewicz, A.2    Testori, A.3    Trefzer, U.4    Ferraresi, V.5    Jassem, J.6
  • 19
  • 20
    • 79959551122 scopus 로고    scopus 로고
    • Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice
    • [20] Wan, J., Shan, Y., Shan, H., Li, G., Wang, T., Guan, J., et al. Thymosin-alpha1 promotes the apoptosis of regulatory T cells and survival rate in septic mice. Front Biosci (Landmark Ed) 16 (2011), 3004–3013.
    • (2011) Front Biosci (Landmark Ed) , vol.16 , pp. 3004-3013
    • Wan, J.1    Shan, Y.2    Shan, H.3    Li, G.4    Wang, T.5    Guan, J.6
  • 21
    • 84943538077 scopus 로고    scopus 로고
    • Effects of combined thymosin and hydrocortisone on immune response in septic mice
    • [21] Zhang, D., Zhou, Y., Cheng, Q., Effects of combined thymosin and hydrocortisone on immune response in septic mice. Int J Clin Exp Med 8 (2015), 12989–12994.
    • (2015) Int J Clin Exp Med , vol.8 , pp. 12989-12994
    • Zhang, D.1    Zhou, Y.2    Cheng, Q.3
  • 22
    • 84872263573 scopus 로고    scopus 로고
    • The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial
    • [22] Wu, J., Zhou, L., Liu, J., Ma, G., Kou, Q., He, Z., et al. The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial. Crit Care, 17, 2013, R8.
    • (2013) Crit Care , vol.17 , pp. R8
    • Wu, J.1    Zhou, L.2    Liu, J.3    Ma, G.4    Kou, Q.5    He, Z.6
  • 23
    • 84987924231 scopus 로고    scopus 로고
    • The efficacy of thymosin alpha1 as immunomodulatory treatment for sepsis: a systematic review of randomized controlled trials
    • [23] Liu, F., Wang, H.M., Wang, T., Zhang, Y.M., Zhu, X., The efficacy of thymosin alpha1 as immunomodulatory treatment for sepsis: a systematic review of randomized controlled trials. BMC Infect Dis, 16, 2016, 488.
    • (2016) BMC Infect Dis , vol.16 , pp. 488
    • Liu, F.1    Wang, H.M.2    Wang, T.3    Zhang, Y.M.4    Zhu, X.5
  • 24
    • 85042435283 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of the septic shock by therapy of ulinastatin
    • [24] Feng, L.Z.Z.Q., Meta-analysis of the efficacy of the septic shock by therapy of ulinastatin. Chin J Clinicans (Electronic Edition) 7 (2013), 904–911.
    • (2013) Chin J Clinicans (Electronic Edition) , vol.7 , pp. 904-911
    • Feng, L.Z.Z.Q.1
  • 25
    • 85013689872 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of the septis by treatment of xuebijin combined with ulinastatin
    • [25] Zhou, G.S.H.B., Ye, L.J., Zhang, L., Ma, L.X., Gao, L., Yao, G.H., et al. Meta-analysis of the efficacy of the septis by treatment of xuebijin combined with ulinastatin. J Guangdong Med Coll 32 (2014), 626–628.
    • (2014) J Guangdong Med Coll , vol.32 , pp. 626-628
    • Zhou, G.S.H.B.1    Ye, L.J.2    Zhang, L.3    Ma, L.X.4    Gao, L.5    Yao, G.H.6
  • 26
    • 85017601956 scopus 로고    scopus 로고
    • Meta-analysis of the clinical efficacy of the septis by treatment of ulinastatin
    • [26] Yang, G.D.A., Li, J., Zhang, J., Zhang, M.Z., Meta-analysis of the clinical efficacy of the septis by treatment of ulinastatin. Zhejiang J Clin Med 15 (2013), 197–199.
    • (2013) Zhejiang J Clin Med , vol.15 , pp. 197-199
    • Yang, G.D.A.1    Li, J.2    Zhang, J.3    Zhang, M.Z.4
  • 27
    • 84904857843 scopus 로고    scopus 로고
    • Ulinastatin: is it worth using in severe sepsis?
    • [27] Saigal, S., Kapoor, G., Ulinastatin: is it worth using in severe sepsis?. Intensive Care Med, 40, 2014, 1185.
    • (2014) Intensive Care Med , vol.40 , pp. 1185
    • Saigal, S.1    Kapoor, G.2
  • 28
    • 84901476727 scopus 로고    scopus 로고
    • Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study
    • [28] Karnad, D.R., Bhadade, R., Verma, P.K., Moulick, N.D., Daga, M.K., Chafekar, N.D., et al. Intravenous administration of ulinastatin (human urinary trypsin inhibitor) in severe sepsis: a multicenter randomized controlled study. Intensive Care Med 40 (2014), 830–838.
    • (2014) Intensive Care Med , vol.40 , pp. 830-838
    • Karnad, D.R.1    Bhadade, R.2    Verma, P.K.3    Moulick, N.D.4    Daga, M.K.5    Chafekar, N.D.6
  • 29
    • 84957430576 scopus 로고    scopus 로고
    • Ulinastatin and/or thymosin alpha1 for severe sepsis: a systematic review and meta-analysis
    • [29] Feng, Z., Shi, Q., Fan, Y., Wang, Q., Yin, W., Ulinastatin and/or thymosin alpha1 for severe sepsis: a systematic review and meta-analysis. J Trauma Acute Care Surg 80 (2016), 335–340.
    • (2016) J Trauma Acute Care Surg , vol.80 , pp. 335-340
    • Feng, Z.1    Shi, Q.2    Fan, Y.3    Wang, Q.4    Yin, W.5
  • 30
    • 84975222172 scopus 로고    scopus 로고
    • The efficacy and immunomodulatory effects of ulinastatin and thymosin alpha1 for sepsis: a systematic review and meta-analysis
    • [30] Wang, F.Y., Fang, B., Qiang, X.H., Yu, T.O., Zhong, J.R., Cao, J., et al. The efficacy and immunomodulatory effects of ulinastatin and thymosin alpha1 for sepsis: a systematic review and meta-analysis. Biomed Res Int, 2016, 2016, 9508493.
    • (2016) Biomed Res Int , vol.2016 , pp. 9508493
    • Wang, F.Y.1    Fang, B.2    Qiang, X.H.3    Yu, T.O.4    Zhong, J.R.5    Cao, J.6
  • 31
    • 84948470722 scopus 로고    scopus 로고
    • Ulinastatin- and thymosin alpha1–based immunomodulatory strategy for sepsis: a meta-analysis
    • [31] Han, D., Shang, W., Wang, G., Sun, L., Zhang, Y., Wen, H., et al. Ulinastatin- and thymosin alpha1–based immunomodulatory strategy for sepsis: a meta-analysis. Int Immunopharmacol 29 (2015), 377–382.
    • (2015) Int Immunopharmacol , vol.29 , pp. 377-382
    • Han, D.1    Shang, W.2    Wang, G.3    Sun, L.4    Zhang, Y.5    Wen, H.6
  • 32
    • 84922163028 scopus 로고    scopus 로고
    • Thymosin alpha1 based immunomodulatory therapy for sepsis: a systematic review and meta-analysis
    • [32] Li, C., Bo, L., Liu, Q., Jin, F., Thymosin alpha1 based immunomodulatory therapy for sepsis: a systematic review and meta-analysis. Int J Infect Dis 33 (2015), 90–96.
    • (2015) Int J Infect Dis , vol.33 , pp. 90-96
    • Li, C.1    Bo, L.2    Liu, Q.3    Jin, F.4
  • 33
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • [33] Bone, R.C., Balk, R.A., Cerra, F.B., Dellinger, R.P., Fein, A.M., Knaus, W.A., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101 (1992), 1644–1655.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6
  • 34
    • 0037396875 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    • [34] Levy, M.M., Fink, M.P., Marshall, J.C., Abraham, E., Angus, D., Cook, D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 29 (2003), 530–538.
    • (2003) Intensive Care Med , vol.29 , pp. 530-538
    • Levy, M.M.1    Fink, M.P.2    Marshall, J.C.3    Abraham, E.4    Angus, D.5    Cook, D.6
  • 35
  • 37
    • 84887416628 scopus 로고    scopus 로고
    • The effect of ulinastatin on disbalance of inflammation and immune status in patients with severe sepsis
    • [37] Wu, T.J., Zhang, L.N., Kang, C.C., The effect of ulinastatin on disbalance of inflammation and immune status in patients with severe sepsis. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 25 (2013), 219–223.
    • (2013) Zhonghua Wei Zhong Bing Ji Jiu Yi Xue , vol.25 , pp. 219-223
    • Wu, T.J.1    Zhang, L.N.2    Kang, C.C.3
  • 38
    • 64249123043 scopus 로고    scopus 로고
    • Clinical effects of ulinastatin and thymosin alpha1 on immune-modulation in septic patients
    • [38] Su, L., Meng, F.S., Tang, Y.Q., Wen, Q., Liu, Y.S., Tang, L.Q., et al. Clinical effects of ulinastatin and thymosin alpha1 on immune-modulation in septic patients. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21 (2009), 147–150.
    • (2009) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue , vol.21 , pp. 147-150
    • Su, L.1    Meng, F.S.2    Tang, Y.Q.3    Wen, Q.4    Liu, Y.S.5    Tang, L.Q.6
  • 39
    • 75749148392 scopus 로고    scopus 로고
    • Immunotherapy improves immune homeostasis and increases survival rate of septic patients
    • [39] Huang, S.W., Chen, J., Ouyang, B., Yang, C.H., Chen, M.Y., Guan, X.D., Immunotherapy improves immune homeostasis and increases survival rate of septic patients. Chin J Traumatol 12 (2009), 344–349.
    • (2009) Chin J Traumatol , vol.12 , pp. 344-349
    • Huang, S.W.1    Chen, J.2    Ouyang, B.3    Yang, C.H.4    Chen, M.Y.5    Guan, X.D.6
  • 40
    • 58349089304 scopus 로고    scopus 로고
    • A new immunomodulatory therapy for severe sepsis: ulinastatin plus thymosin {alpha} 1
    • [40] Li, Y., Chen, H., Li, X., Zhou, W., He, M., Chiriva-Internati, M., et al. A new immunomodulatory therapy for severe sepsis: ulinastatin plus thymosin {alpha} 1. J Intensive Care Med 24 (2009), 47–53.
    • (2009) J Intensive Care Med , vol.24 , pp. 47-53
    • Li, Y.1    Chen, H.2    Li, X.3    Zhou, W.4    He, M.5    Chiriva-Internati, M.6
  • 41
    • 68249138156 scopus 로고    scopus 로고
    • Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study
    • [41] Chen, H., He, M.Y., Li, Y.M., Treatment of patients with severe sepsis using ulinastatin and thymosin alpha1: a prospective, randomized, controlled pilot study. Chin Med J (Engl) 122 (2009), 883–888.
    • (2009) Chin Med J (Engl) , vol.122 , pp. 883-888
    • Chen, H.1    He, M.Y.2    Li, Y.M.3
  • 42
    • 50949088722 scopus 로고    scopus 로고
    • Thymosin alpha1– and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria
    • [42] Zhang, Y., Chen, H., Li, Y.M., Zheng, S.S., Chen, Y.G., Li, L.J., et al. Thymosin alpha1– and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria. J Infect Dis 198 (2008), 723–730.
    • (2008) J Infect Dis , vol.198 , pp. 723-730
    • Zhang, Y.1    Chen, H.2    Li, Y.M.3    Zheng, S.S.4    Chen, Y.G.5    Li, L.J.6
  • 43
    • 34247463353 scopus 로고    scopus 로고
    • Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with ulinastatin and maipuxin
    • [43] Cooperative Group of Immunomodulatory Therapy of Sepsis, Lin, H.Y., Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with ulinastatin and maipuxin. Zhonghua Yi Xue Za Zhi 87 (2007), 451–457.
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , pp. 451-457
    • Cooperative Group of Immunomodulatory Therapy of Sepsis1    Lin, H.Y.2
  • 44
    • 84859001212 scopus 로고    scopus 로고
    • The Cochrane Collaboration's tool for assessing risk of bias in randomised trials
    • [44] Higgins, J.P., Altman, D.G., Gotzsche, P.C., Juni, P., Moher, D., Oxman, A.D., et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, 2011, d5928.
    • (2011) BMJ , vol.343 , pp. d5928
    • Higgins, J.P.1    Altman, D.G.2    Gotzsche, P.C.3    Juni, P.4    Moher, D.5    Oxman, A.D.6
  • 45
    • 84880302096 scopus 로고    scopus 로고
    • Comparative assessment of cytokines and other inflammatory markers for the early diagnosis of neonatal sepsis—a case control study
    • [45] Prashant, A., Vishwanath, P., Kulkarni, P., Sathya Narayana, P., Gowdara, V., Nataraj, S.M., et al. Comparative assessment of cytokines and other inflammatory markers for the early diagnosis of neonatal sepsis—a case control study. PLoS One, 8, 2013, e68426.
    • (2013) PLoS One , vol.8 , pp. e68426
    • Prashant, A.1    Vishwanath, P.2    Kulkarni, P.3    Sathya Narayana, P.4    Gowdara, V.5    Nataraj, S.M.6
  • 46
    • 77149174519 scopus 로고    scopus 로고
    • Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis
    • [46] Suarez-Santamaria, M., Santolaria, F., Perez-Ramirez, A., Aleman-Valls, M.R., Martinez-Riera, A., Gonzalez-Reimers, E., et al. Prognostic value of inflammatory markers (notably cytokines and procalcitonin), nutritional assessment, and organ function in patients with sepsis. Eur Cytokine Netw 21 (2010), 19–26.
    • (2010) Eur Cytokine Netw , vol.21 , pp. 19-26
    • Suarez-Santamaria, M.1    Santolaria, F.2    Perez-Ramirez, A.3    Aleman-Valls, M.R.4    Martinez-Riera, A.5    Gonzalez-Reimers, E.6
  • 47
    • 84255194001 scopus 로고    scopus 로고
    • Immunosuppression in patients who die of sepsis and multiple organ failure
    • [47] Boomer, J.S., To, K., Chang, K.C., Takasu, O., Osborne, D.F., Walton, A.H., et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 306 (2011), 2594–2605.
    • (2011) JAMA , vol.306 , pp. 2594-2605
    • Boomer, J.S.1    To, K.2    Chang, K.C.3    Takasu, O.4    Osborne, D.F.5    Walton, A.H.6
  • 48
    • 84874256945 scopus 로고    scopus 로고
    • Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
    • [48] Hotchkiss, R.S., Monneret, G., Payen, D., Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 13 (2013), 260–268.
    • (2013) Lancet Infect Dis , vol.13 , pp. 260-268
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 50
    • 77951660671 scopus 로고    scopus 로고
    • Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide
    • [50] Inoue, K., Takano, H., Yanagisawa, R., Yoshikawa, T., Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide. J Clin Biochem Nutr 43 (2008), 139–142.
    • (2008) J Clin Biochem Nutr , vol.43 , pp. 139-142
    • Inoue, K.1    Takano, H.2    Yanagisawa, R.3    Yoshikawa, T.4
  • 51
    • 77950862024 scopus 로고    scopus 로고
    • 2,2′-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced peripheral blood mononuclear cells
    • [51] Rupesh, K.R., Priya, A.M., Sundarakrishnan, B., Venkatesan, R., Lakshmi, B.S., Jayachandran, S., 2,2′-Bipyridyl based copper complexes down regulate expression of pro-inflammatory cytokines and suppress MAPKs in mitogen induced peripheral blood mononuclear cells. Eur J Med Chem 45 (2010), 2141–2146.
    • (2010) Eur J Med Chem , vol.45 , pp. 2141-2146
    • Rupesh, K.R.1    Priya, A.M.2    Sundarakrishnan, B.3    Venkatesan, R.4    Lakshmi, B.S.5    Jayachandran, S.6


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