Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice

PLoS Pathogens

Volumn 14, Issue 8, 2018, Pages

  Koestner, Wolfgang ^a   Spanier, Julia ^a   Klause, Tanja ^a   Tegtmeyer, Pia K ^a   Becker, Jennifer ^a   Herder, Vanessa ^b   Borst, Katharina ^a   Todt, Daniel ^c   Lienenklaus, Stefan ^a   Gerhauser, Ingo ^b   Detje, Claudia N ^a   Geffers, Robert ^d   Langereis, Martijn A ^e   Vondran, Florian W R ^d   Yuan, Qinggong ^a   van Kuppeveld, Frank J M ^e   Ott, Michael ^a   Staeheli, Peter ^f,g   Steinmann, Eike ^c   Baumgärtner, Wolfgang ^b   Wacker, Frank ^a   Kalinke, Ulrich ^a   more..

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e UTRECHT UNIVERSITY   (Netherlands)

^f UNIVERSITY OF FREIBURG   (Germany)

^g UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; BETA INTERFERON; GAMMA INTERFERON; INTERFERON 3 RECEPTOR; INTERFERON RECEPTOR; MESSENGER RNA; TRIACYLGLYCEROL LIPASE; TYPE I INTERFERON RECEPTOR; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; COXSACKIE VIRUS INFECTION; COXSACKIEVIRUS B3; CYTOKINE RESPONSE; ENZYME ACTIVITY; GENE INDUCTION; HEPATITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INTERFERON INDUCTION; LIVER CELL; LIVER NECROSIS; LIVER PROTECTION; MACROPHAGE; MOUSE; MRNA EXPRESSION LEVEL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN EXPRESSION LEVEL; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; VERO CELL LINE; VIROGENESIS; VIRUS DISSEMINATION; VIRUS HEPATITIS; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CHLOROCEBUS AETHIOPS; COMPLICATION; ENTEROVIRUS B; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; KNOCKOUT MOUSE; LIVER; METABOLISM; NECROSIS; PATHOLOGY; VIROLOGY;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS B, HUMAN; HEPATOCYTES; HUMANS; INTERFERON-BETA; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NECROSIS; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; VERO CELLS; VIRAL LOAD;

EID: 85053079971     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1007235     Document Type: Article

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