Rodent models of diet-induced type 2 diabetes mellitus: A literature review and selection guide

Diabetes and Metabolic Syndrome: Clinical Research and Reviews

Volumn 13, Issue 1, 2019, Pages 195-200

  Engel, Holger ^a,b   Xiong, Lingyun ^b   Reichenberger, Matthias A ^d   Germann, Günter ^d   Roth, Christian ^c   Hirche, Christoph ^b  

^a KLINIKUM KASSEL   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Department of Neurology   (Germany)

^d Department of Plastic Surgery ^*  (Germany)

Author keywords

Diabetes; Diabetic animal model; Diet induced; High fat diet; STZ

Indexed keywords

ANIMAL MODEL; HUMAN; LIPID DIET; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT MODEL; ANIMAL; DISEASE MODEL; RODENT;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; HUMANS; RODENTIA;

EID: 85053075784     PISSN: 18714021     EISSN: 18780334     Source Type: Journal    
DOI: 10.1016/j.dsx.2018.07.020     Document Type: Review

References (38)

1. Gutterman, D.D., Vascular dysfunction in hyperglycemia: is protein kinase C the culprit?. Circ Res 90:1 (2002), 5–7.
2. Buettner, R., Parhofer, K.G., Woenckhaus, M., Wrede, C.E., Kunz-Schughart, L.A., Scholmerich, J., et al. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 36:3 (2006), 485–501.
3. Neubauer, N., Kulkarni, R.N., Molecular approaches to study control of glucose homeostasis. ILAR J 47:3 (2006), 199–211.
4. Kawasaki, F., Matsuda, M., Kanda, Y., Inoue, H., Kaku, K., Structural and functional analysis of pancreatic islets preserved by pioglitazone in db/db mice. Am J Physiol Endocrinol Metab 288:3 (2005), E510–E518.
5. Storlien, L.H., James, D.E., Burleigh, K.M., Chisholm, D.J., Kraegen, E.W., Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol 251:5 Pt 1 (1986), E576–E583.
6. Reed, M.J., Meszaros, K., Entes, L.J., Claypool, M.D., Pinkett, J.G., Gadbois, T.M., et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 49:11 (2000), 1390–1394.
7. Kraegen, E.W., James, D.E., Storlien, L.H., Burleigh, K.M., Chisholm, D.J., In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: assessment by euglycemic clamp plus deoxyglucose administration. Diabetologia 29:3 (1986), 192–198.
8. Kraegen, E.W., Clark, P.W., Jenkins, A.B., Daley, E.A., Chisholm, D.J., Storlien, L.H., Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 40:11 (1991), 1397–1403.
9. Cefalu, W.T., Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition. ILAR J 47:3 (2006), 186–198.
10. Srinivasan, K., Ramarao, P., Animal models in type 2 diabetes research: an overview. Indian J Med Res 125:3 (2007), 451–472.
11. Lillioja, S., Mott, D.M., Spraul, M., Ferraro, R., Foley, J.E., Ravussin, E., et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 329:27 (1993), 1988–1992.
12. Warram, J.H., Martin, B.C., Krolewski, A.S., Soeldner, J.S., Kahn, C.R., Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:12 (1990), 909–915.
13. MASEK, J., FABRY, P., High-fat diet and the development of obesity in albino rats. Experientia 15 (1959), 444–445.
14. Oakes, N.D., Cooney, G.J., Camilleri, S., Chisholm, D.J., Kraegen, E.W., Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:11 (1997), 1768–1774.
15. Ahren, B., Gudbjartsson, T., Al-Amin, A.N., Martensson, H., Myrsen-Axcrona, U., Karlsson, S., et al. Islet perturbations in rats fed a high-fat diet. Pancreas 18:1 (1999), 75–83.
16. Junod, A., Lambert, A.E., Stauffacher, W., Renold, A.E., Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest 48:11 (1969), 2129–2139.
17. Bitar, M.S., Wahid, S., Mustafa, S., Al-Saleh, E., Dhaunsi, G.S., Al-Mulla, F., Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes. Eur J Pharmacol 511:1 (2005), 53–64.
18. Chaabo, F., Pronczuk, A., Maslova, E., Hayes, K., Nutritional correlates and dynamics of diabetes in the Nile rat (Acanthi niloticas): a novel model for diet-induced type 2 diabetes and the metabolic syndrome. Nutr Metab (Lond), 7, 2010, 29.
19. Danda, R.S., Habiba, N.M., Rincon-Choles, H., Bhandari, B.K., Barnes, J.L., Abboud, H.E., et al. Kidney involvement in a nongenetic rat model of type 2 diabetes. Kidney Int 68:6 (2005), 2562–2571.
20. Diz-Chaves, Y., Spuch, C., Perez, D., Mallo, F., Ghrelin improves growth hormone responses to growth hormone-releasing hormone in a streptozotocin-diabetic model of delayed onset. J Endocrinol Invest 30:4 (2007), 298–305.
21. Islam, M.S., Choi, H., Nongenetic model of type 2 diabetes: a comparative study. Pharmacology 79:4 (2007), 243–249.
22. Karabatas, L.M., Pastorale, C., de Bruno, L.F., Maschi, F., Pivetta, O.H., Lombardo, Y.B., et al. Early manifestations in multiple-low-dose streptozotocin-induced diabetes in mice. Pancreas 30:4 (2005), 318–324.
23. Kim, E., Sohn, S., Lee, M., Jung, J., Kineman, R.D., Park, S., Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinogenics diabetes. J Endocrinol 188:2 (2006), 263–270.
24. Ramadan, W., Dewasmes, G., Petitjean, M., Loos, N., Delanaud, S., Geloen, A., et al. Spontaneous motor activity in fat-fed, streptozotocin-treated rats: a nonobese model of type 2 diabetes. Physiol Behav 87:4 (2006), 765–772.
25. Sartoretto, J.L., Santos, R.A., Scavone, C., Tostes, R.C., Nigro, D., Carvalho, M.H., et al. The influence of improved glycaemic control with chlorpropamides on microvascular reactivity and nitric oxide synthase activity in diabetic rats. J Pharm Pharmacol 59:8 (2007), 1117–1123.
26. Srinivasan, K., Viswanad, B., Asrat, L., Kaul, C.L., Ramarao, P., Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:4 (2005), 313–320.
27. Sotnikova, R., Skalska, S., Okruhlicova, L., Navarova, J., Kyselova, Z., Zurova, J., et al. Changes in the function and ultrastructure of vessels in the rat model of multiple low dose streptozotocin-induced diabetes. Gen Physiol Biophys 25:3 (2006), 289–302.
28. Sugano, M., Yamato, H., Hayashi, T., Ochiai, H., Kakuchi, J., Goto, S., et al. High-fat diet in low-dose-streptozotocin-treated nephrectomized rats induces all features of human type 2 diabetic nephropathy: a new rat model of diabetic nephropathy. Nutr Metab Cardiovasc Dis 16:7 (2006), 477–484.
29. Takada, J., Machado, M.A., Peres, S.B., Brito, L.C., Borges-Silva, C.N., Costa, C.E., et al. Neonatal streptozotocin-induced diabetes mellitus: a model of insulin resistance associated with loss of adipose mass. Metabolism 56:7 (2007), 977–984.
30. Weng, Y., Shen, F., Li, J., Shen, Y., Zhang, X., Expression changes of mitogen-activated protein kinase phosphatase-1 (MKP-1) in myocardium of streptozotocin-induced diabetic rats. Exp Clin Endocrinol Diabetes 115:7 (2007), 455–460.
31. Wang, H.J., Jin, Y.X., Shen, W., Neng, J., Wu, T., Li, Y.J., et al. Low dose streptozotocin (STZ) combined with high energy intake can effectively induce type 2 diabetes through altering the related gene expression. Asia Pac J Clin Nutr 16:Suppl 1 (2007), 412–417.
32. Zhang, F., Ye, C., Li, G., Ding, W., Zhou, W., Zhu, H., et al. The rat model of type 2 diabetic mellitus and its hypometabolism characters. Exp Anim 52:5 (2003), 401–407.
33. Zhang, H., Chen, S., Deng, X., Yang, X., Huang, X., Danggui-Buxue-Tang decoction has an anti-inflammatory effect in diabetic atherosclerosis rat model. Diabetes Res Clin Pract 74:2 (2006), 194–196.
34. Zhang, H., Chen, S., Deng, X., Yang, X., Huang, X., The effects of Danggui-Buxue-Tang on blood lipid and expression of genes related to foam cell formation in the early stage of atherosclerosis in diabetic GK rats. Diabetes Res Clin Pract 77:3 (2007), 479–481.
35. Bell, R.H. Jr., Hye, R.J., Animal models of diabetes mellitus: physiology and pathology. J Surg Res 35:5 (1983), 433–460.
36. Storlien, L.H., Jenkins, A.B., Chisholm, D.J., Pascoe, W.S., Khouri, S., Kraegen, E.W., Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40:2 (1991), 280–289.
37. Storlien, L.H., Baur, L.A., Kriketos, A.D., Pan, D.A., Cooney, G.J., Jenkins, A.B., et al. Dietary fats and insulin action. Diabetologia 39:6 (1996), 621–631.
38. Rees, D.A., Alcolado, J.C., Animal models of diabetes mellitus. Diabet Med 22:4 (2005), 359–370.