Ghrelin improves growth hormone responses to growth hormone-releasing hormone in a streptozotocin-diabetic model of delayed onset

Journal of Endocrinological Investigation

Volumn 30, Issue 4, 2007, Pages 298-305

  Diz Chaves, Y ^a,b   Spuch, C ^a,c   Perez D ^a,d   Mallo, F ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b INSTITUTO CAJAL   (Spain)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Genome Research Institute   (United States)

Author keywords

Diabetes; GH; Ghrelin; GHRH; Rats; Streptozotocin

Indexed keywords

GHRELIN; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE RESPONSE; HYPERGLYCEMIA; HYPERPHAGIA; LOW DRUG DOSE; MALE; METABOLIC DISORDER; MONOTHERAPY; NEWBORN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; POLYDIPSIA; POLYURIA; RAT; STIMULUS RESPONSE; STREPTOZOCIN DIABETES; WEIGHT GAIN;

EID: 34347217428     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03346307     Document Type: Article

References (37)

1. Muller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev 1999, 79: 511-607
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402: 656-60.
3. Peino R, Baldelli R, Rodriguez-García J, et al. Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 2000; 143: R11-4.
4. Takaya K, Ariyasu H, Kanamoto N, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000, 85: 4908-911.
5. Seoane LM, Tovar S, Baldelli R, et al. Ghrelin elicits a marked stimulatory effect on GH secretion in freely-moving rats. Eur J Endocrinol 2000, 143: R7-9.
6. Catalina PF, Mallo F, Andrade MA, Garcia-Mayor RV, Dieguez C. Growth hormone (GH) response to GH-Releasing Peptide-6 in Type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion. J Clin Endocrinol Metab 1998, 83: 3663-7
7. Hansen AP, Johansen K. Diurmal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics. Diabetologia 1970, 6: 27-33.
8. Bluet-Pajot MT, Durand D, Kordon C. Influence of streptozotocin-induced diabetes on growth hormone secretion in the rat. Neuroendocrinology 1983, 36: 307-9.
9. Giustina A, Veldhuis JD. Pathophysiology of the Neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998, 19: 717-97.
10. Diz-Chaves Y, Spuch Calvar C, Perez Tilve D, Mallo Ferrer F. GH responses to GHRH and GHRP-6 in streptozotocin (STZ)-diabetic rats. Life Sci 2003, 73: 3375-85.
11. Ndon JA, Giustina A, Wehrenberg WB. Hypothalamic regulation of impaired growth hormone secretion in diabetic rats. 2. Studies in spontaneously diabetic BB Worcester rats. Neuroendocrinology 1992, 55: 506-11.
12. Ismail I, Lewis M, Peters JR, Scanlon MF. Hypothalamic mediation of reduced GH secretion in diabetic rats: evidence for reduced cholinergic inhibition of somatostatin release. J Neuroendocrinol 1995, 7: 311-8.
13. Bonner-Weir S, Trent DF, Honey RN, Weir GC. Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes 1981, 30: 64-9.
14. Portha B, Levacher C, Picon L, Rosselin G. Diabetogenic effect of streptozotocin in the rat during the perinatal period. Diabetes 1974, 23: 889-95.
15. Portha B, Picon L, Rosselin G. Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes. Diabetologia 1979, 17: 371-7.
16. Portha B, Blondel O, Serradas P, et al. The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabete Metab 1989, 15: 61-75.
17. Ndon JA, Giustina A, Wehrenberg WB. Hypothalamic regulation of impaired growth hormone secretion in diabetic rats. 1. Studies in streptozotocin-induced diabetic rats. Neuroendocrinology 1992, 55: 500-5.
18. Portha B. Transmitted beta-cell dysfunction as a cause for type 2-diabetes. Med Sci (Paris) 2003, 19: 847-53.
19. Blondel O, Bailbe D, Portha B. Relation of insulin deficiency to impaired insulin action in NIDDM adult rats given streptozocin as neonates. Diabetes 1989, 38: 610-7.
20. Cardinal JW, Allan DJ, Cameron DP. Differential metabolite accumulation may be the cause of strain differences in sensitivity to streptozotocin-induced β-cell death in inbred mice. Endocrinology 1998, 139: 2885-91.
21. Joanny P, Peyre G, Steinberg J, et al. Effect of diabetes on in vivo and in vitro hypothalamic somatostatin release. Neuroendocrinology 1992, 55: 485-91.
22. Olchovsky D, Bruno JF, Wood TL, et al. Altered pituitary growth hormone (GH) regulation in streptozotocin-diabetic rats: a combined defect of hypothalamic somatostatin and GH-releasing factor. Endocrinology 1990, 126: 53-61.
23. Lee JG, Bird RC, Oliver EH, Sartin JL. Expression of growth hormone, growth hormone releasing hormone, and somatostatin genes is unperturbed in the streptozotocin-induced diabetic rat. Biochem Cell Biol 1991, 69: 428-32.
24. Kim E, Sohn S, Lee M, Jung J, Kineman RD, Park S. Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes. J Endocrinol 2006, 188: 263-70.
25. Mallo F, Alvarez CV, Benitez L, et al. Regulation of His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6)-induced GH secretion in the rat. Neuroendocrinology 1993, 57: 247-56.
26. Tannenbaum GS, Epelbaum J, Bowers CY. Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology 2003, 144: 967-74.
27. Busiguina S, Argente J, Garcia S, Chowen JA. Anatomically specific changes in the expression of somatostatin, growth hormone-releasing hormone and growth hormone receptor mRNA in diabetic rats. J Neuroendocrinol 2000, 12: 29-39.
28. Hataya Y, Akamizu T, Takaya K, et al. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab 2001, 86: 4552.
29. Micic D, Kendereski A, Sumarac-Dumanovic M, et al. Growth hormone response to GHRH + GHRP-6 in type 2 diabetes during euglycemic and hyperglycemic clamp. Diabetes Res Clin Pract 2004, 63: 37-45.
30. Park S, Peng XD, Frohman LA, Kineman RD. Expression analysis of hypothalamic and pituitary components of the growth hormone axis in fasted and streptozotocin-treated neuropeptide Y (NPY)-intact (NPY+/+) and NPY-knockout (NPY-/-) mice. Neuroendocrinology 2005, 81: 360-71.
31. Korytko AI, Cuttler L. Regulation of GHRH receptor gene expression in the neonatal and adult rat pituitary. Growth Horm IGF Res 2001, 11: 282-8.
32. Gelling RW, Overduin J, Morrison CD, et al. Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding. Endocrinology 2004, 145: 4575-82.
33. Ishii S, Kamegai J, Tamura H, Shimizu T, Sugihara H, Oikawa S. Role of ghrelin in streptozotocin-induced diabetic hyperphagia. Endocrinology 2002, 143: 4934-7.
34. Masaoka T, Suzuki H, Hosoda H, et al. Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Lett 2003, 541: 64-8.
35. 2+ signaling in βcells: Implication in the glycemic control in rodents. Diabetes 2004, 53: 3142-51.
36. Blake AD, Smith RG. Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. J Endocrinol 1991, 129: 11-9.
37. Thompson NM, Davies JS, Mode A, Houston PA, Wells T. Pattern-dependent suppression of growth hormone (GH) pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats. Endocrinology 2003, 144: 4859-67.