The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain

American Journal of Physiology - Endocrinology and Metabolism

Volumn 315, Issue 4, 2018, Pages E531-E542

  Hersom, Maria ^a   Helms, Hans C ^a,b   Schmalz, Christoffer ^b   Pedersen, Thomas Å ^b   Buckley, Stephen T ^b   Brodin, Birger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Blood brain barrier; Cell culture; Endothelium; Neurovascu lar unit; Receptors

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR INHIBITOR; IODINE 125; MESSENGER RNA; PROTEIN KINASE B; UNCLASSIFIED DRUG; PEPTIDE; S961 PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BOVINE; BRAIN CELL; CELL CULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; HORMONE TRANSPORT; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCYTOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; IN VITRO TECHNIQUES; INSULIN; MICE; PEPTIDES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; RNA, MESSENGER; TRANSCYTOSIS;

EID: 85052807657     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00350.2016     Document Type: Article

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