Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 33, 2018, Pages 8418-8423

  Kayama, Hisako ^a,b   Kohyama, Masako ^a,c   Okuzaki, Daisuke ^c   Motooka, Daisuke ^c   Barman, Soumik ^a,b   Okumura, Ryu ^a,b   Muneta, Masato ^a   Hoshino, Katsuaki ^d   Sasaki, Izumi ^e   Ise, Wataru ^a   Matsuno, Hiroshi ^a   Nishimura, Junichi ^a   Kurosaki, Tomohiro ^a   Nakamura, Shota ^c   Arase, Hisashi ^a,c   Kaisho, Tsuneyasu ^a,e,f   Takeda, Kiyoshi ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

^c OSAKA UNIVERSITY   (Japan)

^d KAGAWA UNIVERSITY   (Japan)

^e WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^f Institute of Physical and Chemical Research   (Japan)

Author keywords

Heme; Inflammation; Intestinal macrophage; IRF5; Spi C

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; DEXTRAN SULFATE; HEME; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; CX3CR1 PROTEIN, MOUSE; CYTOKINE; DNA BINDING PROTEIN; SPIC PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL LINEAGE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DOWN REGULATION; DRUG MECHANISM; ENTERITIS; GENE CONTROL; GENE INDUCTION; HOMEOSTASIS; IL1A GENE; IL6 GENE; INTESTINE CELL; LYMPHOCYTE COUNT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; TH17 CELL; ADMINISTRATION AND DOSAGE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; IMMUNOLOGY; INTESTINE; IRON INTAKE; PHYSIOLOGY;

ANIMALS; COLITIS; CX3C CHEMOKINE RECEPTOR 1; CYTOKINES; DEXTRAN SULFATE; DNA-BINDING PROTEINS; HEME; INTESTINES; IRON, DIETARY; MACROPHAGES; MICE; MICE, INBRED C57BL; TOLL-LIKE RECEPTORS; TRANSCRIPTION FACTOR RELA;

EID: 85052724547     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1808426115     Document Type: Article

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