Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting

Circulation

Volumn 135, Issue 22, 2017, Pages 2091-2101

  Natarajan, Pradeep ^a,b,c   Young, Robin ^d   Stitziel, Nathan O ^e   Padmanabhan, Sandosh ^f,g,h   Baber, Usman ⁱ   Mehran, Roxana ⁱ   Sartori, Samantha ⁱ   Fuster, Valentin ⁱ   Reilly, Dermot F ^j   Butterworth, Adam ^d   Rader, Daniel J ^k   Ford, Ian ^g   Sattar, Naveed ^f   Kathiresan, Sekar ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF GLASGOW   (United Kingdom)

^g UNIVERSITY OF GLASGOW   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^j MERCK RESEARCH LABORATORIES   (United States)

^k UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

humans; hydroxymethylglutaryl CoA reductase inhibitors; polymorphism, genetic; primary prevention; vascular calcification

Indexed keywords

ANTIHYPERTENSIVE AGENT; DNA; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; DNA SEQUENCE; GENETIC IDENTIFICATION; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; POLYGENIC RISK SCORE; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; ADOLESCENT; AGED; COHORT ANALYSIS; COST OF ILLNESS; FEMALE; GENETICS; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PROCEDURES; RISK FACTOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; COHORT STUDIES; COST OF ILLNESS; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; PRIMARY PREVENTION; RISK FACTORS; YOUNG ADULT;

EID: 85018477382     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.024436     Document Type: Article

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