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Volumn 8, Issue 1, 2018, Pages

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; HOD PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; HOP PROTEIN, HUMAN; SFTPC PROTEIN, MOUSE; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN;

EID: 85052401221     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-018-31214-x     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 85006151122 scopus 로고    scopus 로고
    • Tissue remodelling in pulmonary fibrosis
    • PID: 27981380
    • Knudsen, L., Ruppert, C. & Ochs, M. Tissue remodelling in pulmonary fibrosis. Cell Tissue Res 367, 607–626 (2017).
    • (2017) Cell Tissue Res , vol.367 , pp. 607-626
    • Knudsen, L.1    Ruppert, C.2    Ochs, M.3
  • 2
    • 0038041946 scopus 로고    scopus 로고
    • Alveolar type I cells: molecular phenotype and development
    • PID: 12428023
    • Williams, M. C. Alveolar type I cells: molecular phenotype and development. Annu Rev Physiol 65, 669–695 (2003).
    • (2003) Annu Rev Physiol , vol.65 , pp. 669-695
    • Williams, M.C.1
  • 3
    • 0021675427 scopus 로고
    • Alveolar type I and type II cells
    • PID: 6598039
    • Ward, H. E. & Nicholas, T. E. Alveolar type I and type II cells. Aust N Z J Med 14, 731–734 (1984).
    • (1984) Aust N Z J Med , vol.14 , pp. 731-734
    • Ward, H.E.1    Nicholas, T.E.2
  • 4
    • 0027996784 scopus 로고
    • Pulmonary surfactant proteins
    • PID: 7929300
    • Kuroki, Y. & Voelker, D. R. Pulmonary surfactant proteins. J Biol Chem 269, 25943–25946 (1994).
    • (1994) J Biol Chem , vol.269 , pp. 25943-25946
    • Kuroki, Y.1    Voelker, D.R.2
  • 5
    • 0035721766 scopus 로고    scopus 로고
    • Alveolar epithelial type II cell: defender of the alveolus revisited
    • PID: 11686863
    • Fehrenbach, H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2, 33–46 (2001).
    • (2001) Respir Res , vol.2 , pp. 33-46
    • Fehrenbach, H.1
  • 6
    • 84879640376 scopus 로고    scopus 로고
    • Type 2 alveolar cells are stem cells in adult lung
    • PID: 23921127
    • Barkauskas, C. E. et al. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest 123, 3025–3036 (2013).
    • (2013) J Clin Invest , vol.123 , pp. 3025-3036
    • Barkauskas, C.E.1
  • 7
    • 18644364557 scopus 로고    scopus 로고
    • Modulation of cardiac growth and development by HOP, an unusual homeodomain protein
    • PID: 12297046
    • Shin, C. H. et al. Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell 110, 725–735 (2002).
    • (2002) Cell , vol.110 , pp. 725-735
    • Shin, C.H.1
  • 8
    • 18644374460 scopus 로고    scopus 로고
    • Hop is an unusual homeobox gene that modulates cardiac development
    • PID: 12297045
    • Chen, F. et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell 110, 713–723 (2002).
    • (2002) Cell , vol.110 , pp. 713-723
    • Chen, F.1
  • 9
    • 33746617492 scopus 로고    scopus 로고
    • Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression
    • PID: 16510470
    • Yin, Z. et al. Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol 291, L191–199 (2006).
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291 , pp. L191-L199
    • Yin, Z.1
  • 10
    • 84954564162 scopus 로고    scopus 로고
    • Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung
    • PID: 26545903
    • Liebler, J. M. et al. Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol 310, L114–120 (2016).
    • (2016) Am J Physiol Lung Cell Mol Physiol , vol.310 , pp. L114-L120
    • Liebler, J.M.1
  • 11
    • 84927914742 scopus 로고    scopus 로고
    • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung
    • Jain, R. et al. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun 6, 6727, 10.1038/ncomms7727 (2015).
    • (2015) Nat Commun , vol.6
    • Jain, R.1
  • 12
    • 83255193921 scopus 로고    scopus 로고
    • Interconversion between intestinal stem cell populations in distinct niches
    • PID: 22075725
    • Takeda, N. et al. Interconversion between intestinal stem cell populations in distinct niches. Science 334, 1420–1424 (2011).
    • (2011) Science , vol.334 , pp. 1420-1424
    • Takeda, N.1
  • 13
    • 84875475734 scopus 로고    scopus 로고
    • Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+niche cells
    • PID: 23487314
    • Takeda, N. et al. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+niche cells. Development 140, 1655–1664 (2013).
    • (2013) Development , vol.140 , pp. 1655-1664
    • Takeda, N.1
  • 14
    • 84878990582 scopus 로고    scopus 로고
    • Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis
    • PID: 23707782
    • Cheung, W. K. et al. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell 23, 725–738 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 725-738
    • Cheung, W.K.1
  • 15
    • 79955496473 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
    • PID: 21490395
    • Pacheco-Pinedo, E. C. et al. Wnt/beta-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest 121, 1935–1945 (2011).
    • (2011) J Clin Invest , vol.121 , pp. 1935-1945
    • Pacheco-Pinedo, E.C.1
  • 16
    • 84939524556 scopus 로고    scopus 로고
    • Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/beta-catenin-driven trans-differentiation of murine alveolar epithelial cells
    • PID: 26035385
    • Mutze, K., Vierkotten, S., Milosevic, J., Eickelberg, O. & Konigshoff, M. Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/beta-catenin-driven trans-differentiation of murine alveolar epithelial cells. Dis Model Mech 8, 877–890 (2015).
    • (2015) Dis Model Mech , vol.8 , pp. 877-890
    • Mutze, K.1    Vierkotten, S.2    Milosevic, J.3    Eickelberg, O.4    Konigshoff, M.5
  • 17
    • 77449152469 scopus 로고    scopus 로고
    • Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells
    • PID: 19933277
    • Flozak, A. S. et al. Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem 285, 3157–3167 (2010).
    • (2010) J Biol Chem , vol.285 , pp. 3157-3167
    • Flozak, A.S.1
  • 18
    • 67049172467 scopus 로고    scopus 로고
    • Characterization of mouse alveolar epithelial cell monolayers
    • PID: 19329539
    • Demaio, L. et al. Characterization of mouse alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol 296, L1051–1058 (2009).
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.296 , pp. L1051-L1058
    • Demaio, L.1
  • 19
    • 85114065337 scopus 로고    scopus 로고
    • MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis
    • Bauer, Y. et al. MMP-7 is a predictive biomarker of disease progression in patients with idiopathic pulmonary fibrosis. ERJ Open Res 3, 10.1183/23120541.00074-2016 (2017).
    • (2017) ERJ Open Res , vol.3
    • Bauer, Y.1
  • 20
    • 85027886209 scopus 로고    scopus 로고
    • Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo
    • Lehmann, M. et al. Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo. Eur Respir J 50 (2017).
    • (2017) Eur Respir J , vol.50
    • Lehmann, M.1
  • 21
    • 85108819466 scopus 로고    scopus 로고
    • Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis
    • PID: 27942595
    • Xu, Y. et al. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI Insight 1, e90558 (2016).
    • (2016) JCI Insight , vol.1
    • Xu, Y.1
  • 23
    • 33645104610 scopus 로고    scopus 로고
    • Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D
    • PID: 16423272
    • Takahashi, H. et al. Monitoring markers of disease activity for interstitial lung diseases with serum surfactant proteins A and D. Respirology 11(Suppl), S51–54 (2006).
    • (2006) Respirology , vol.11 , pp. S51-S54
    • Takahashi, H.1
  • 24
    • 77953491551 scopus 로고    scopus 로고
    • Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis
    • PID: 20418386
    • Collard, H. R. et al. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 299, L3–7 (2010).
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , pp. L3-L7
    • Collard, H.R.1
  • 25
    • 85020389188 scopus 로고    scopus 로고
    • Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis: A systematic review and meta-analysis
    • Wang, K., Ju, Q., Cao, J., Tang, W. & Zhang, J. Impact of serum SP-A and SP-D levels on comparison and prognosis of idiopathic pulmonary fibrosis: A systematic review and meta-analysis. Medicine (Baltimore) 96, e7083 (2017).
    • (2017) Medicine (Baltimore) , vol.96
    • Wang, K.1    Ju, Q.2    Cao, J.3    Tang, W.4    Zhang, J.5
  • 26
    • 43249084804 scopus 로고    scopus 로고
    • MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis
    • PID: 18447576
    • Rosas, I. O. et al. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med 5, e93 (2008).
    • (2008) PLoS Med , vol.5
    • Rosas, I.O.1
  • 27
    • 39149141572 scopus 로고    scopus 로고
    • Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3
    • PID: 17931953
    • Ask, K. et al. Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol 40, 484–495 (2008).
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 484-495
    • Ask, K.1
  • 28
    • 85020229711 scopus 로고    scopus 로고
    • An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices
    • PID: 28314802
    • Alsafadi, H. N. et al. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol 312, L896–L902 (2017).
    • (2017) Am J Physiol Lung Cell Mol Physiol , vol.312 , pp. L896-L902
    • Alsafadi, H.N.1
  • 29
    • 84896319764 scopus 로고    scopus 로고
    • Alveolar progenitor and stem cells in lung development, renewal and cancer
    • PID: 24499815
    • Desai, T. J., Brownfield, D. G. & Krasnow, M. A. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507, 190–194 (2014).
    • (2014) Nature , vol.507 , pp. 190-194
    • Desai, T.J.1    Brownfield, D.G.2    Krasnow, M.A.3
  • 30
    • 85043359934 scopus 로고    scopus 로고
    • Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
    • PID: 29489752
    • Zacharias, W. J. et al. Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor. Nature 555, 251–255 (2018).
    • (2018) Nature , vol.555 , pp. 251-255
    • Zacharias, W.J.1
  • 31
    • 85011340647 scopus 로고    scopus 로고
    • HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
    • Ren, X. et al. HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma. Nat Commun 8, 14053, 10.1038/ncomms14053 (2017).
    • (2017) Nat Commun , vol.8
    • Ren, X.1
  • 32
    • 84992524643 scopus 로고    scopus 로고
    • Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer
    • PID: 27756570
    • Kikuchi, M. et al. Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer. Cancer Lett 384, 70–78 (2017).
    • (2017) Cancer Lett , vol.384 , pp. 70-78
    • Kikuchi, M.1
  • 33
    • 85006021100 scopus 로고    scopus 로고
    • HOPX functions as a tumour suppressor in head and neck cancer
    • Yap, L. F. et al. HOPX functions as a tumour suppressor in head and neck cancer. Sci Rep 6, 38758, 10.1038/srep38758 (2016).
    • (2016) Sci Rep , vol.6
    • Yap, L.F.1
  • 34
    • 84888327294 scopus 로고    scopus 로고
    • The homeobox only protein homeobox (HOPX) and colorectal cancer
    • PID: 24287901
    • Yamashita, K., Katoh, H. & Watanabe, M. The homeobox only protein homeobox (HOPX) and colorectal cancer. Int J Mol Sci 14, 23231–23243 (2013).
    • (2013) Int J Mol Sci , vol.14 , pp. 23231-23243
    • Yamashita, K.1    Katoh, H.2    Watanabe, M.3
  • 35
    • 67650721786 scopus 로고    scopus 로고
    • Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis
    • PID: 19363140
    • Konishi, K. et al. Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 180, 167–175 (2009).
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 167-175
    • Konishi, K.1
  • 36
    • 79955146233 scopus 로고    scopus 로고
    • A common MUC5B promoter polymorphism and pulmonary fibrosis
    • PID: 21506741
    • Seibold, M. A. et al. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med 364, 1503–1512 (2011).
    • (2011) N Engl J Med , vol.364 , pp. 1503-1512
    • Seibold, M.A.1
  • 37
    • 0035931973 scopus 로고    scopus 로고
    • A mutation in the surfactant protein C gene associated with familial interstitial lung disease
    • PID: 11207353
    • Nogee, L. M. et al. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 344, 573–579 (2001).
    • (2001) N Engl J Med , vol.344 , pp. 573-579
    • Nogee, L.M.1
  • 38
    • 8544245673 scopus 로고    scopus 로고
    • Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF
    • PID: 15516475
    • Lawson, W. E. et al. Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax 59, 977–980 (2004).
    • (2004) Thorax , vol.59 , pp. 977-980
    • Lawson, W.E.1
  • 39
    • 34250614359 scopus 로고    scopus 로고
    • Adult-onset pulmonary fibrosis caused by mutations in telomerase
    • PID: 17460043
    • Tsakiri, K. D. et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci USA 104, 7552–7557 (2007).
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7552-7557
    • Tsakiri, K.D.1
  • 40
    • 84916200736 scopus 로고    scopus 로고
    • Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis
    • PID: 25333685
    • Yang, I. V. et al. Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 190, 1263–1272 (2014).
    • (2014) Am J Respir Crit Care Med , vol.190 , pp. 1263-1272
    • Yang, I.V.1
  • 41
    • 84925156003 scopus 로고    scopus 로고
    • Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung
    • PID: 25215577
    • Huang, S. K., Scruggs, A. M., McEachin, R. C., White, E. S. & Peters-Golden, M. Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lung. PLoS One 9, e107055 (2014).
    • (2014) PLoS One , vol.9
    • Huang, S.K.1    Scruggs, A.M.2    McEachin, R.C.3    White, E.S.4    Peters-Golden, M.5
  • 42
    • 0035141395 scopus 로고    scopus 로고
    • Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)
    • PID: 11215282
    • Barbas-Filho, J. V. et al. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP). J Clin Pathol 54, 132–138 (2001).
    • (2001) J Clin Pathol , vol.54 , pp. 132-138
    • Barbas-Filho, J.V.1
  • 43
    • 54049115076 scopus 로고    scopus 로고
    • Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
    • PID: 18635891
    • Korfei, M. et al. Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 178, 838–846 (2008).
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 838-846
    • Korfei, M.1
  • 44
    • 84870951352 scopus 로고    scopus 로고
    • Role of Sonic Hedgehog in idiopathic pulmonary fibrosis
    • PID: 23023967
    • Bolanos, A. L. et al. Role of Sonic Hedgehog in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 303, L978–990 (2012).
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.303 , pp. L978-L990
    • Bolanos, A.L.1
  • 45
    • 33745183811 scopus 로고    scopus 로고
    • Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    • PID: 16710477
    • Jenkins, R. G. et al. Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 116, 1606–1614 (2006).
    • (2006) J Clin Invest , vol.116 , pp. 1606-1614
    • Jenkins, R.G.1
  • 46
    • 65249088418 scopus 로고    scopus 로고
    • WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis
    • PID: 19287097
    • Konigshoff, M. et al. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest 119, 772–787 (2009).
    • (2009) J Clin Invest , vol.119 , pp. 772-787
    • Konigshoff, M.1
  • 47
    • 79955789007 scopus 로고    scopus 로고
    • Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs
    • PID: 21319792
    • Korfei, M. et al. Comparative proteomic analysis of lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and lung transplant donor lungs. J Proteome Res 10, 2185–2205 (2011).
    • (2011) J Proteome Res , vol.10 , pp. 2185-2205
    • Korfei, M.1
  • 48
    • 0034011982 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS)
    • American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am J Respir Crit Care Med 161, 646–664 (2000).
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 646-664
  • 49
    • 84941934548 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo
    • PID: 26151196
    • Ota, C. et al. Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosis in vivo. Exp Lung Res 41, 422–434 (2015).
    • (2015) Exp Lung Res , vol.41 , pp. 422-434
    • Ota, C.1
  • 50
    • 84939531447 scopus 로고    scopus 로고
    • Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures
    • PID: 25929950
    • Uhl, F. E. et al. Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures. Eur Respir J 46, 1150–1166 (2015).
    • (2015) Eur Respir J , vol.46 , pp. 1150-1166
    • Uhl, F.E.1


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