The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies

Veterinary Microbiology

Volumn 219, Issue , 2018, Pages 226-233

  Murphy, B G ^a   Perron, M ^b   Murakami, E ^b   Bauer, K ^a   Park, Y ^b   Eckstrand, C ^a   Liepnieks, M ^a   Pedersen, N C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

Cell culture; EC50; Experimental infection; Feline infectious peritonitis (FIP); FIP virus (FIPV); GS 441524; Laboratory cats; Nucleoside analog; Pharmacokinetics; Tri phosphorylation

Indexed keywords

GS 441524; MELOXICAM; NUCLEOSIDE ANALOG; NUCLEOSIDE TRIPHOSPHATE; UNCLASSIFIED DRUG; ANTIVIRUS AGENT; NUCLEOSIDE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; CRFK CELL LINE; CYTOTOXICITY; DOMESTIC CAT; DRUG BLOOD LEVEL; FELINE INFECTIOUS PERITONITIS; GENE EXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; RNA VIRUS; TISSUE CULTURE; VIRUS REPLICATION; ANIMAL; ASCITES FLUID; CAT; CELL CULTURE; CHEMISTRY; CORONAVIRUS INFECTION; DRUG EFFECT; FELINE CORONAVIRUS; IMMUNOLOGY; MACROPHAGE; SEROTYPE; VETERINARY MEDICINE; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; ASCITIC FLUID; CATS; CELLS, CULTURED; CORONAVIRUS INFECTIONS; CORONAVIRUS, FELINE; FELINE INFECTIOUS PERITONITIS; MACROPHAGES; NUCLEOSIDES; SEROGROUP; VIRUS REPLICATION;

EID: 85052331308     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2018.04.026     Document Type: Article

References (18)

1. Bryan, A.K., Hecht, V.C., Shen, W., Payer, K., Grover, W.H., Manalis, S.R., Measuring single cell mass, volume, and density with dual suspended microchannel resonators. Lab Chip 14 (2014), 569–576.
2. Cho, A., Saunders, O.L., Butler, T., Zhang, L., Xu, J., Vela, J.E., Feng, J.Y., Ray, A.S., Kim, C.U., Synthesis and antiviral activity of a series of 1’-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg. Med. Chem. Lett. 22 (2012), 2705–2707.
3. De Clercq, E., Antivirals and antiviral strategies. Nat. Rev. Micro. 2 (2004), 704–720.
4. de Groot-Mijnes, J.D., van Dun, J.M., van der Most, R.G., de Groot, R.J., Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease. J. Virol. 79 (2005), 1036–1044.
5. de Wilde, A.H., Snijder, E.J., Kikkert, M., van Hemert, M.J., Host factors in coronavirus replication. Current Topics in Microbiology and Immunology, 2017, Springer, Berlin, Heidelberg, 1–42, 10.1007/82_2017_25.
6. Fischer, Y., Ritz, S., Weber, K., Sauter-Louis, C., Hartmann, K., Randomized, placebo controlled study of the effect of propentofylline on survival time and quality of life of cats with feline infectious peritonitis. J. Vet. Int. Med. 25 (2011), 1270–1276.
7. Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Weerasekara, S., Hua, D.H., Groutas, W.C., Chang, K.O., Pedersen, N.C., Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor. PLoS Pathog., 12, 2016, e1005531.
8. Kipar, A., Meli, M.L., Feline infectious peritonitis: still an enigma?. Vet. Pathol. 51 (2014), 505–526.
9. Murphy, B., Vapniarsky, N., Hillman, C., Castillo, D., McDonnel, S., Moore, P., Luciw, P.A., Sparger, E.E., FIV establishes a latent infection in feline peripheral blood CD4+ T lymphocytes in vivo during the asymptomatic phase of infection. Retrovirology, 9, 2012, 12.
10. Pedersen, N.C., An update on feline infectious peritonitis: virology and immunopathogenesis. Vet. J. 201 (2014), 123–132.
11. Pedersen, N.C., An update on feline infectious peritonitis: diagnostics and therapeutics. Vet. J. 201 (2014), 133–141.
12. Pedersen, N.C., Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Eckstrand, C., Groutas, W.C., Bannasch, M., Meadows, J.M., Chang, K.O., Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis. J. Feline Med. Surg. 20 (2017), 378–392.
13. Pedersen, N.C., Eckstrand, C., Liu, H., Leutenegger, C., Murphy, B., Levels of feline infectious peritonitis virus in blood, effusions, and various tissues and the role of lymphopenia in disease outcome following experimental infection. Vet. Micro. 175 (2015), 157–166.
14. Pedersen, N.C., Liu, H., Gandolfi, B., Lyons, L.A., The influence of age and genetics on natural resistance to experimentally induced feline infectious peritonitis. Vet. Immunol. Immunopathol. 28 (2014), 152–154.
15. Ritz, S., Egberink, H., Hartmann, K., Effect of feline interferon-omega on the survival time and quality of life of cats with feline infectious peritonitis. J. Vet. Int. Med. 21 (2007), 1193–1197.
16. Sheahan, T.P., Sims, A.C., Graham, R.L., Menachery, V.D., Gralinski, L.E., Case, J.B., Leist, S.R., et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci. Transl. Med., 9, 2017, 10.1126/scitranslmed.aal3653.
17. Tekes, G., Thiel, H.J., Feline coronaviruses: pathogenesis of feline infectious peritonitis. Adv. Virus Res. 96 (2016), 193–218.
18. Warren, T.K., Jordan, R., Lo, M.K., Ray, A.S., Mackman, R.L., Soloveva, V., Siegel, D., et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 531 (2016), 381–385.