Spirulina platensis effectively ameliorates anthropometric measurements and obesity-related metabolic disorders in obese or overweight healthy individuals: A randomized controlled trial

Complementary Therapies in Medicine

Volumn 40, Issue , 2018, Pages 106-112

  Yousefi, Reyhaneh ^a   Mottaghi, Azadeh ^b   Saidpour, Atoosa ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Body mass index; hs CRP; Obesity; Spirulina platensis; Triglyceride

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL; BIOLOGICAL PRODUCT;

ADULT; AGE; ALTERNATIVE MEDICINE; ANTHROPOMETRIC PARAMETERS; APPETITE; APPETITE SCORE; ARTHROSPIRA PLATENSIS; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DIET; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; GENDER; HIP CIRCUMFERENCE; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; METABOLIC PARAMETERS; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; RESTRICTED CALORIE DIET; SCORING SYSTEM; SENSITIVITY ANALYSIS; TREATMENT DURATION; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ANTHROPOMETRY; BLOOD; MIDDLE AGED; PATHOPHYSIOLOGY; SPIRULINA;

ADULT; ANTHROPOMETRY; BIOLOGICAL PRODUCTS; BODY MASS INDEX; C-REACTIVE PROTEIN; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; SPIRULINA; TRIGLYCERIDES;

EID: 85052074103     PISSN: 09652299     EISSN: 18736963     Source Type: Journal    
DOI: 10.1016/j.ctim.2018.08.003     Document Type: Article

References (36)

1. Global status report on noncommunicable diseases 2014., 2014, 298 Geneva, ISBN: 978 92 4 156485 4.
2. Ng, M., Fleming, T., Robinson, M., et al. global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013. Lancet 384:9945 (2014), 766–781.
3. Park, H.S., Park, J.Y., Yu, R., Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract 69:1 (2005), 29–35.
4. Shah, A., Mehta, N., Reilly, M.P., Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr 32:6 (2008), 638–644.
5. Bullo, M., Casas-Agustench, P., et al. Inflammation, obesity and comorbidities: the role of diet. Public Health Nutr. 10:10A (2007), 1164–1172.
6. Mahdavi, R., Alizadeh, M., Namazi, N., Farajnia, S., Changes of body composition and circulating adipokines in response to nigella sativa oil with a calorie restricted diet in obese women. J Herbal Med 6:2 (2016), 67–72.
7. Serban, M.C., Sahebkar, A., Dragan, S., et al. A systematic review and meta-analysis of the impact of spirulina supplementation on plasma lipid concentrations. Clin Nutr 35:4 (2016), 842–851.
8. Lee, E.H., Park, J.E., Choi, Y.J., Huh, K.B., Kim, W.Y., A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients. Nutr Res Pract 2:4 (2008), 295–300.
9. Ismail, M., Hossain, M.F., Tanu, A.R., Shekhar, H.U., Effect of spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients. Biomed Res Int, 2015, 2015, 486120.
10. Zeinalian, R., Farhangi, M.A., Shariat, A., Saghafi-Asl, M., The effects of Spirulina Platensis on anthropometric indices, appetite, lipid profile and serum vascular endothelial growth factor (VEGF) in obese individuals: a randomized double blinded placebo controlled trial. BMC Complement Altern Med, 17(1), 2017, 225.
11. Park, H.J., Lee, Y.J., Ryu, H.K., Kim, M.H., Chung, H.W., Kim, W.Y., A randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly Koreans. Ann Nutr Metab 52:4 (2008), 322–328.
12. Miczke, A., SzulInska, M., Hansdorfer-Korzon, R., Kregielsk-Narozna, M., Suliburska, J., Walkowiak, J., Effects of spirulina consumption on body weight, blood pressure, and endothelial function in overweight hypertensive Caucasians: a double-blind, placebo-controlled, randomized trial. Eur Rev Med Pharmacol Sci 20:1 (2016), 150–156.
13. Deng, R., Chow, T.J., Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina. Cardiovasc Ther 28:4 (2010), e33–45.
14. Riss, J., Decorde, K., Sutra, T., et al. Phycobiliprotein C-phycocyanin from spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. J Agric Food Chem 55:19 (2007), 7962–7967.
15. Ku, C.S., Yang, Y., Park, Y., Lee, J., Health benefits of blue-green algae: prevention of cardiovascular disease and nonalcoholic fatty liver disease. J Med Food 16:2 (2013), 103–111.
16. Skrypnik, K., Suliburska, J., Skrypnik, D., Pilarski, Ł Reguła, J., Bogdański, P., The genetic basis of obesity complications. Acta scientiarum polonorum Technologia alimentaria, 16(1), 2017.
17. Mazokopakis, E.E., Starakis, I.K., Papadomanolaki, M.G., Mavroeidi, N.G., Ganotakis, E.S., The hypolipidaemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: a prospective study. J Sci Food Agric 94:3 (2014), 432–437.
18. Toughan, H., Khalil, S.R., El-Ghoneimy, A.A., Awad, A., Seddek, A.S., Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp (Cyprinus carpio L.). Ecotoxicol Environ Saf 149 (2018), 135–142.
19. Szulinska, M., Gibas-Dorna, M., Miller-Kasprzak, E., et al. Spirulina maxima improves insulin sensitivity, lipid profile, and total antioxidant status in obese patients with well-treated hypertension: a randomized double-blind placebo-controlled study. Eur Rev Med Pharmacol Sci 21 (2017), 2473–2481.
20. W, J.J., Designing clinical research: an epidemiologic approach. 2th ed., 2001.
21. Mahan, K., Escott, S., Raymond, J., Krause's food and the nutrition care process. 13 ed, 2012.
22. Hammond, K.A., Dietary and clinical assessment. Krause's Food Nutr Ther, 2000, 372.
23. Aadahl, M., Jorgensen, T., Validation of a new self-report instrument for measuring physical activity. Med Sci Sports Exerc. 35:7 (2003), 1196–1202.
24. Wilson, M.M., Thomas, D.R., Rubenstein, L.Z., et al. Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82:5 (2005), 1074–1081.
25. Fujimoto, M., Tsuneyama, K., Fujimoto, T., Selmi, C., Gershwin, M.E., Shimada, Y., Spirulina improves non-alcoholic steatohepatitis, visceral fat macrophage aggregation, and serum leptin in a mouse model of metabolic syndrome. Dig Liver Dis 44:9 (2012), 767–774.
26. Mazokopakis, E.E., Papadomanolaki, M.G., Fousteris, A.A., Kotsiris, D.A., Lampadakis, I.M., Ganotakis, E.S., The hepatoprotective and hypolipidemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population with non-alcoholic fatty liver disease: a prospective pilot study. Ann Gastroenterol, 27(4), 2014, 387.
27. Jung, U.J., Choi, M.S., Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 15:4 (2014), 6184–6223.
28. Sears, B., Ricordi, C., Anti-inflammatory nutrition as a pharmacological approach to treat obesity. J Obes, 2011, 2011.
29. Hassan, H.A., El-Gharib, N.E., Obesity and clinical riskiness relationship: therapeutic management by dietary antioxidant supplementation–a review. Appl Biochem Biotechnol 176:3 (2015), 647–669.
30. Wu, Q., Liu, L., Miron, A., Klimova, B., Wan, D., Kuca, K., The antioxidant, immunomodulatory, and anti-inflammatory activities of spirulina: an overview. Arch Toxicol, 2016.
31. Vazquez-Velasco, M., Gonzalez-Torres, L., Lopez-Gasco, P., et al. Effects of glucomannan/spirulina-surimi on liver oxidation and inflammation in zucker rats fed atherogenic diets. J Physiol Biochem 71:4 (2015), 611–622.
32. Stepien, M., Kujawska-Luczak, M., Szulinska, M., et al. Beneficial dose-independent influence of Camellia sinensis supplementation on lipid profile, glycemia, and insulin resistance in an NaCl-induced hypertensive rat model. J Physiol Pharmacol, 69(2), 2018.
33. Torres-Duran, P.V., Ferreira-Hermosillo, A., Juarez-Oropeza, M.A., Antihyperlipemic and antihypertensive effects of spirulina maxima in an open sample of Mexican population: a preliminary report. Lipids Health Dis, 6, 2007, 33.
34. Cancello, R., Tordjman, J., Poitou, C., et al. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes 55:6 (2006), 1554–1561.
35. Joffe, Y.T., Collins, M., Goedecke, J.H., The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids. Nutrition 5:5 (2013), 1672–1705.
36. Torres-Durán, P., Miranda-Zamora, R., Paredes-Carbajal, M., et al. Studies on the preventive effect of Spirulina maxima on fatty liver development induced by carbon tetrachloride, in the rat. J Ethnopharmacol 64:2 (1999), 141–147.