The hypolipidaemic effects of Spirulina (Arthrospira platensis) supplementation in a Cretan population: A prospective study

Journal of the Science of Food and Agriculture

Volumn 94, Issue 3, 2014, Pages 432-437

  Mazokopakis, Elias E ^a,b   Starakis, Ioannis K ^c   Papadomanolaki, Maria G ^d   Mavroeidi, Niki G ^b   Ganotakis, Emmanuel S ^b  

^a Naval Hospital of Crete   (Greece)

^b UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^c UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^d TECHNICAL UNIVERSITY OF CRETE   (Greece)

Author keywords

Arthrospira platensis; Food supplement; Hyperlipidaemia; Lipids; Spirulina

Indexed keywords

ARTHROSPIRA PLATENSIS; SPIRULINA;

ANTILIPEMIC AGENT; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT MEDICINAL PRODUCT; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTHROSPIRA PLATENSIS; ARTICLE; BLOOD; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DYSLIPIDEMIA; FEMALE; GREECE; HUMAN; HYPERLIPIDEMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDY; SPIRULINA; TREATMENT OUTCOME; YOUNG ADULT;

ARTHROSPIRA PLATENSIS; FOOD SUPPLEMENT; HYPERLIPIDAEMIA; LIPIDS; SPIRULINA;

ADOLESCENT; ADULT; BLOOD PRESSURE; BODY MASS INDEX; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DYSLIPIDEMIAS; FEMALE; GREECE; HUMANS; HYPOLIPIDEMIC AGENTS; MALE; MIDDLE AGED; PLANT PREPARATIONS; PROSPECTIVE STUDIES; SPIRULINA; TREATMENT OUTCOME; TRIGLYCERIDES; YOUNG ADULT;

EID: 84892679060     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.6261     Document Type: Article

References (42)

1. Mazokopakis EE, Karefilakis CM, Tsartsalis AN, Milkas AN and Ganotakis ES, Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine 15:525-527 (2008).
2. Deng R and Chow TJ, Hypolipidemic, antioxidant, and antiinflammatory activities of microalgae Spirulina. Cardiovasc Ther 28:e33-e45 (2010).
3. Braunwald E, Shattuck Lecture-Cardiovascular medicine at the turn of the millennium: Triumphs, concerns and opportunities. N Engl J Med 337:1360-1369 (1997).
4. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al., and the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart disease and stroke statistics-2012 update: A report from the American Heart Association. Circulation 125:e2-e220 (2012).
5. European Association for Cardiovascular Prevention & Rehabilitation, Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al., and the ESC Committee for Practice Guidelines (CPG) 2008-2010 and 2010-2012 Committees, ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 32:1769-1818 (2011).
6. Elisaf M, Pitsavos Ch, Liberopoulos E and Athyros V, Guidelines of the Hellenic society of atherosclerosis for the diagnosis and treatment of dyslipidemia. Hellenic J Atherosclerosis 2:163-168 (2011).
7. Panagiotakos DB, Fitzgerald AP, Pitsavos C, Pipilis A, Graham I and Stefanadis C, Statistical modelling of 10-year fatal cardiovascular disease risk in Greece: the HellenicSCORE (a calibration of the ESC SCORE project). Hellenic J Cardiol 48:55-63 (2007).
8. Juárez-Oropeza MA, Mascher D, Torres-Durán PV, Farias JM and Paredes-Carbajal MC, Effects of dietary Spirulina on vascular reactivity. J Med Food 12:15-20 (2009).
9. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP), Adult Treatment Panel III. JAMA 285:2486-2497 (2001).
10. World Health Organization, Obesity: Preventing and Managing the Global Epidemic, report WHO/NUT/NCD/98.1. WHO, Geneva (1998).
11. Friedewald WT, Levy RI and Fredrickson DS, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499-502 (1972).
12. Lauer RM, Lee J and Clarke WR, Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study. Pediatrics 82:309-318 (1988).
13. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al., and the National Heart, Lung, and Blood Institute, American College of Cardiology Foundation and American Heart Association, Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Circulation 110:227-239 (2004).
14. Project available on http://www.heartscore.org/greece/Pages/Welcome.aspx
15. Austin MA, Hokanson JE and Edwards KL, Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 81:7B-12B (1998).
16. Nakaya N, Homma Y and Goto Y, Cholesterol lowering effect of Spirulina. Nutr Rep Int 37:1329-1337 (1988).
17. Torres-Duran PV, Ferreira-Hermosillo A and Juarez-Oropeza MA, Antihyperlipemic and antihypertensive effects of Spirulina maxima in an open sample of Mexican population: A preliminary report. Lipids Health Dis 6:1-8 (2007).
18. Ramamoorthy A and Premakumari S, Effect of supplementation of Spirulina on hypercholesterolemic patients. J Food Sci Technol 33:124-128 (1996).
19. Mani UV, Desai S and Iyer U, Studies on the long-term effect of Spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceuticals, Funct Med Foods 2:25-32 (2000).
20. Parikh P, Mani U and Iyer U, Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J Med Food 4:193-199 (2001).
21. Lee EH, Park JE, Choi YJ, Huh KB and Kim WY, A randomized study to establish the effects of Spirulina in type 2 diabetes mellitus patients. Nutr Res Pract 2:295-300 (2008).
22. Samuels R, Mani UV, Iyer UM and Nayak US, Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephrotic syndrome. J Med Food 5:91-96 (2002).
23. Park HJ, Lee YJ, Ryu HK, Kim MH, Chung HW and Kim WY, A randomized double-blind, placebo-controlled study to establish the effects of Spirulina in elderly Koreans. Ann Nutr Metab 52:322-328 (2008).
24. Kurdikeri SM, Effect of spirulina on lipid profile of hyperlipidemics. MS thesis. University of Agricultural Sciences, Dharwad (2006).
25. Nagaoka S, Shimizu K, Kaneko H, Shibayama F, Morikawa K, Kanamaru Y, et al., A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J Nutr 135:2425-2430 (2005).
26. Han LK, Li DX, Xiang L, Gong XJ, Kondo Y, Suzuki I, et al., Isolation of pancreatic lipase activity-inhibitory component of Spirulina platensis and it reduce postprandial triacylglycerolemia. Yakugaku Zasshi 126:43-49 (2006).
27. Grattan RP, Spirulina: A source of dietary gamma linolenic acid? J Sci Food Agric 47:85-93 (1989).
28. Hornych A, Oravec S, Girault F, Forette B and Horrobin DF, The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects. Bratisl Lek Listy 103:101-107 (2002).
29. Horrobin DF, Nutritional and medical importance of gamma-linolenic acid. Prog Lipid Res 31:163-194 (1992).
30. Horrobin DF and Huang YS, The role of linoleic acid and its metabolites in the lowering of plasma cholesterol and the prevention of cardiovascular disease. Int J Cardiol 17:241-255 (1987).
31. Kei A, Athyros V, Ganotakis E, Ioannidis I, Bilianou H, Pappas St, et al., Nicotinic acid/laropiprant. The Greek clinical experience. Hellenic J Atherosclerosis 3:11-17 (2012).
32. Anitha L and Chandralekha K, Effect of supplementation of Spirulina on blood glucose, glycosylated hemoglobin and lipid profile of male noninsulin dependent diabetics. Asian J Exp Biol Sci 1:36-46 (2010).
33. Anuradha V and Vidhya D, Impact of administration of spirulina on the blood glucose levels of selected diabetic patients. Indian J Nutr Dietet 38:40-44 (2001).
34. Babu DY, Hypoglycaemic effects of algae spirulina in non-insulin dependent diabetes mellitus (NIDDM) patients. MS thesis. Bharathiar University, Coimbatore (1989).
35. Parikh P, Glycemic index of spirulina supplemented recipes in NIDDM subjects. MS thesis. Department of Foods and Nutrition, Faculty of Home Science, M.S. University of Baroda, Baroda (1996).
36. Ahmedi S, Glycemic index of spirulina supplemented recipes. MS thesis. Department of Foods and Nutrition, Faculty of Home Science, M.S. University of Baroda, Baroda (1997).
37. Deshmukh S, Glycemic index of spirulina supplemented meals. MS thesis. Department of Foods and Nutrition, Faculty of Home Science, M.S. University of Baroda, Baroda (1998).
38. Layam A and Reddy CLK, Antidiabetic property of Spirulina. Diabetol Croat 35:29-33 (2006).
39. Becker EW, Jakover B, Luft D and Schmuelling RM, Clinical and biochemical evaluations of the alga Spirulina with regard to its application in the treatment of obesity: A double-blind cross-over study. Nutr Rep Int 33:565-574 (1986).
40. Switzer L, Spirulina: The Whole Food Revolution, Bantam Books, New York (1982).
41. Kunsman JE, Collins MA, Field RA and Miller GJ, Cholesterol content of beef bone marrow and mechanically deboned meat. J Food Sci 46:1785-1788 (1981).
42. Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ, et al., Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 307:1302-1309 (2012).