A randomized double-blind, placebo-controlled study to establish the effects of spirulina in elderly Koreans

Annals of Nutrition and Metabolism

Volumn 52, Issue 4, 2008, Pages 322-328

  Park, Hee Jung ^a   Lee, Yun Jung ^b   Ryu, Han Kyoung ^b   Kim, Mi Hyun ^c   Chung, Hye Won ^d   Kim, Wha Young ^b  

^a CJ Corporation   (South Korea)

^b Ewha Womans University   (South Korea)

^c Kyungpook National University   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

Author keywords

Aging; Antioxidant status; Immune response; Lipid profile; Spirulina supplementation

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; IMMUNOMODULATING AGENT; INTERLEUKIN 2; INTERLEUKIN 6; PLACEBO; PROBIOTIC AGENT; SUPEROXIDE DISMUTASE;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; FUNCTIONAL FOOD; HUMAN; IMMUNOMODULATION; KOREA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPIRULINA;

AGED; AGED, 80 AND OVER; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HEALTH FOOD; HUMANS; HYPERCHOLESTEROLEMIA; INTERLEUKIN-2; INTERLEUKIN-6; KOREA; MALE; MIDDLE AGED; SEX FACTORS; SPIRULINA;

SPIRULINA;

EID: 49549089757     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151486     Document Type: Article

References (38)

1. Belay A, Ota Y, Miyakawa K, Shimamatsu H: Current knowledge on potential health benefits of spirulina. J Appl Phycol 1993;5:235-241.
2. Salazar M, Chamorro G, Salazar S, Steele C: Effect of Spirulina maxima consumption on reproductive and peri- and postnatal development in rats. Food Chem Toxicol 1996;34:353-359.
3. Chamorro G, Salazar S, Castillo L, Steele C, Salazar M: Reproductive and peri- and postnatal evaluation of Spirulina maxima in mice. J Appl Phycol 1997;9:107-112.
4. Salazar M, Martinez E, Madrigal E, Ruiz LE, Chamorro G: Subchronic toxicity study in mice fed Spirulina maxima. J Ethnopharmacol 1998;62:235-241.
5. Kato T, Takemoto K, Katayama H, Kuwabara Y: Effects of spirulina (Spirulina platensis) on dietary hypercholesterolemia in rats. J Jap Soc Nutr Food Sci 1984;37:323-332.
6. Ishii K, Katoh T, Okuwaki Y, Hayashi O: Influence of dietary Spirulina platensis on IgA level in human saliva. J Kagawa Nutr Univ 1999;30:27-33.
7. Qureshi MA, Kidd MT, Ali RA: Spirulina platensis extract enhances chicken macrophage functions after in vitro exposure. J Nutr Immunol 1995;3:35-44.
8. Dainippon Ink & Chemicals, Inc (DIC): Antitumoral agents containing phycobilin. Japanese Patent #58-65216, 1983.
9. Pinero Estrada JE, Bermejo Descos P, Villar dell Fresno AM: Antioxidant activity of different fractions of Spirulina platensis extract. Farmaco 2001;56:497-500.
10. Hirata T, Tanaka M, Ooike M, Tsunomura T, Sakaguchi M: Antioxidant activities of phycocyanobilin prepared from Spirulina platensis. J Appl Phycol 2000;12:435-439.
11. Mani UV, Desai S, Iyer UM: Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut Funct Med Foods 2000;2:25-32.
12. Benedetti S, Benvenuti F, Pagliarani S, Francogli S, Scoglio S, Canestrari F: Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae. Life Sci 2004;75:2353-2362.
13. Bhat VB, Madyastha KM: C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro. Biochem Biophys Res Commun 2000;1:20-25.
14. Hayashi O, Katoh T, Okuwaki Y: Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol 1994;40:431-441.
15. Voss P, Siems W: Clinical oxidation parameters of aging. Free Radic Res 2006;40:1339-1349.
16. Lelliott C, Vidal-Puig AJ: Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 2004;28:22-28.
17. Vasto S, Candore G, Balistreri CR, Caruso M, Colonna-Romano G, Grimaldi MP, Listi F, Nuzzo D, Lio D, Caruso C: Inflammatory networks in aging, age-related disease and longevity. Mech Ageing Dev 2007;128:83-91.
18. Parikh P, Mani U, Iyer UM: Role of spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus. J Med Food 2001;4:193-199.
19. Romana I, Bellitti MR, Nicolaus DD, Lama-Lica-Manca MC: Lipid profile, a useful chemotaxonomic marker for classification of a new cyanobacterium in Spirulina genus. Phytochem 2000;54:289-296.
20. 12 compounds from edible algae. J Nutr Sci Vitaminol 2002;48:325-331.
21. Kuhad A, Tirkey N, Pilkhwal S, Chopra K: Effect of spirulina, a blue green algae, on gentamicin-induced oxidative stress and renal dysfunction in rats. Fund Clin Pharmacol 2006;20:121-128.
22. Samuels R, Mani UV, Iyer UM, Nagaak US: Hypocholesterolemic effects of spirulina in patients with hyperlipidemic nephritic syndrome. J Med Food 2002;5:91-96.
23. Nagaoka S, Shimizu K, Kaneko H, Shibayama F, Morikawa K, Kanamaru Y, Otsuka A, Hirahashi T, Kato T: A novel protein C-phycocyanin plays a role in the hypocholesterolemic action of Spirulina platensis concentrate in rats. J Nutr 2005;135:2425-2430.
24. Korean Nutrition Society: Nutrition Information Center. Nutritional Assessment Program CAN pro 3.0, 2006.
25. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
26. Lauer RM, Lee J, Clarke WR: Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study. Pediatrics 1988;82:309-318.
27. Yagi K: Assay for blood plasma or serum; in Methods in Enzymology. New York, Academic Press, 1984, vol 105, pp 328-331.
28. Marklund S, Marklund G: Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974;47:469-474.
29. Sheri ZC, Keen CL, Hurley LS: Superoxide dismutase activity and lipid peroxidation in the rat: developmental correlation effected by manganese deficiency. J Nutr 1983;113:2498-2504.
30. Kim WY, Park JY: The effects of spirulina on lipid metabolism, antioxidant capacity and immune function in Korean elderly. Kor J Nutr 2003;36:287-297.
31. Nakaya N, Homma Y, Goto Y: Cholesterol-lowering effect of spirulina. Nutr Rep Int 1988;37:1329-1337.
32. De Rivera C, Miranda-Zamora R, Diaz-Zagoya JC, Oropeza M: Preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat. Life Sci 1993;53:57-61.
33. Hosoyamada Y, Takai T, Kato T: Effects of water-soluble and insoluble fractions of spirulina on serum lipid components and glucose tolerance in rats. J Jpn Soc Nutr Food Sci 1991;44:273-277.
34. Miranda MS, Cintra R, Barros SBM, Mancini-Filho J: Antioxidant activity of the microalga Spirulina maxima. Braz J Med Biol Res 1998;31:1075-1079.
35. Mao TK, van de Water J, Gershwin ME: Effect of spirulina on the secretion of cytokines from peripheral blood mononuclear cells. J Med Food 2000;3:135-140.
36. Adler WH 3rd: Immune function in the elderly. Geriatrics 1989:44(suppl A):7-10.
37. Thoman ML, Weigle WO: Lymphokines and aging: interleukin-2 production and activity in aged animals. J Immunol 1981:127:102-106.
38. Rabinowich H, Goses Y, Reshef T, Klajman A: Interleukin-2 production and activity in aged humans. Mech Ageing Dev 1985:32:2113-216.