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An example of a country-wide initiative to improve our understanding of local genetics, using a mix of whole genomes and genotype array data to address population genetics questions through before/after European contact, as well as implications for medical discovery.
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The first work reporting population-level high coverage genomes from indigenous Mexican communities, an important contribution to the broader understanding of genomics for individuals across Latin America.
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Romero-Hidalgo, S., Ochoa-Leyva, A., Garciarrubio, A., Acuna-Alonzo, V., Antunez-Arguelles, E., Balcazar-Quintero, M., Barquera-Lozano, R., Carnevale, A., Cornejo-Granados, F., Fernandez-Lopez, J.C., et al. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing. Nat Commun, 8, 2017, 1005 The first work reporting population-level high coverage genomes from indigenous Mexican communities, an important contribution to the broader understanding of genomics for individuals across Latin America.
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Quantifying admixture in primarily African-descent populations from across the Americas, including many Latin American groups. This paper quantifies the bottleneck mentioned in the Honduran Garifuna population, and provides ancestry estimates across a wide range of populations, along with high-coverage whole genomes.
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