Ultrarapid Rule-out for Acute Myocardial Infarction Using the Generation 5 Cardiac Troponin T Assay: Results From the REACTION-US Study

Annals of Emergency Medicine

Volumn 72, Issue 6, 2018, Pages 654-664

  Nowak, Richard M ^a   Gandolfo, Chaun M ^a   Jacobsen, Gordon ^a   Christenson, Robert H ^c   Moyer, Michele ^a   Hudson, Michael ^b   McCord, James ^b  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b HENRY FORD HEART AND VASCULAR INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN T; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; BLOOD SAMPLING; CARDIAC TROPONIN T ASSAY; CARDIOLOGIST; COMORBIDITY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; ELECTROCARDIOGRAM; EMERGENCY PHYSICIAN; EMERGENCY WARD; FEMALE; FOLLOW UP; HUMAN; INTERRATER RELIABILITY; MAJOR ADVERSE CARDIAC EVENT; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DETERMINATION; SENSITIVITY AND SPECIFICITY; ALGORITHM; BLOOD; DIAGNOSTIC TEST; HEART INFARCTION; METABOLISM; MIDDLE AGED; PRACTICE GUIDELINE; PROSPECTIVE STUDY;

AGED; ALGORITHMS; BIOMARKERS; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PRACTICE GUIDELINES AS TOPIC; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TROPONIN T;

EID: 85051539401     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2018.06.021     Document Type: Article

References (30)

1. Centers for Disease Control and Prevention. National Hospital Ambulatory Medical Care Survey: 2010 Emergency Department Summary Tables. 2010, Centers for Disease Control & Prevention, Ambulatory & Hospital Care Statistics Branch, Washington, DC.
2. Reynolds, K., Go, A.S., Leong, T.K., et al. Trends in incidence of hospitalized acute myocardial infarction in the Cardiovascular Research Network (CVRN). Am J Med 130 (2017), 317–327.
3. Yeh, R.W., Sidney, S., Chandra, M., et al. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med 362 (2010), 2155–2165.
4. Brieger, D., Eagle, K.A., Goodman, S.G., et al. Acute coronary syndromes without chest pain, an underdiagnosed and undertreated high-risk group: insights from the Global Registry of Acute Coronary Events. Chest 126 (2004), 461–469.
5. Slutzman, J.E., Wilson, M., Cutler, D., et al. 188 Costs attributable to emergency department care by diagnosis. Ann Emerg Med 66 (2015), S67–S68.
6. Sun, B.C., Hsia, R.Y., Weiss, R.E., et al. Effects of emergency department crowding on outcomes of admitted patients. Ann Emerg Med 61 (2013), 605–611.
7. Thygesen, K., Alpert, J.S., Jaffe, A.S., Third universal definition of myocardial infarction. Circulation 126 (2012), 2020–2035.
8. Amsterdam, E.A., Wenger, N.K., Brindis, R.G., AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 64 (2014), e139–e228.
9. Keller, T., Zeller, T., Ojeda, F., Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 306 (2011), 2684–2693.
10. Apple, F.S., Pearce, L.A., Smith, S.W., et al. Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem 55 (2009), 930–937.
11. Wildi, K., Reichlin, T., Twerenbold, R., Serial changes in high-sensitivity cardiac troponin I in the early diagnosis of acute myocardial infarction. Int J Cardiol 168 (2013), 4103–4110.
12. Mueller, M., Biener, M., Vafaie, M., Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 58 (2012), 209–218.
13. Reichlin, T., Schindler, C., Drexler, B., et al. One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T. Arch Intern Med 172 (2012), 1211–1218.
14. Neumann, J.T., Sörensen, N.A., Schwemer, T., et al. Diagnosis of myocardial infarction using a high-sensitivity troponin I 1-hour algorithm. JAMA Cardiol 1 (2016), 397–404.
15. Jaeger, C., Wildi, K., Twerenbold, R., et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am Heart J 171 (2016), 92–102.
16. Rubini Gimenez, M., Twerenbold, R., Jaeger, C., et al. One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I. Am J Med 128 (2015), 861–870.
17. Reichlin, T., Twerenbold, R., Wildi, K., et al. Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay. CMAJ 187 (2015), e243–e252.
18. Mueller, C., Giannitsis, E., Christ, M., et al. Multicenter evaluation of a 0-hour/1-hour algorithm in the diagnosis of myocardial infarction with high-sensitivity cardiac troponin T. Ann Emerg Med 68 (2016), 76–87.
19. Body, R., Carley, S., McDowell, G., et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol 58 (2011), 1332–1339.
20. Rubini Giménez, M., Hoeller, R., Reichlin, T., et al. Rapid rule out of acute myocardial infarction using undetectable levels of high-sensitivity cardiac troponin. Int J Cardiol 168 (2013), 3896–3901.
21. Bandstein, N., Ljung, R., Johansson, M., et al. Undetectable high-sensitivity cardiac troponin T level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol 63 (2014), 2569–2578.
22. Body, R., Burrows, G., Carley, S., et al. High-sensitivity cardiac troponin T concentrations below the limit of detection to exclude acute myocardial infarction: a prospective evaluation. Clin Chem 61 (2015), 983–989.
23. Zhelev, Z., Hyde, C., Youngman, E., et al. Diagnostic accuracy of single baseline measurement of Elecsys troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. BMJ, 350, 2015, h15.
24. Body, R., Mueller, C., Giannitsis, E., The use of very low concentrations of high-sensitivity troponin T to rule out acute myocardial infarction using a single blood test. Acad Emerg Med 23 (2016), 1004–1013.
25. Roffi, M., Patrono, C., Collet, J.P., et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J, 37, 2016 267-315.
26. Peacock, W.F., Bauman, B.H., Bruton, D., et al. Efficacy of high-sensitivity troponin T in identifying very-low-risk patients with possible acute coronary syndrome. JAMA Cardiol 3 (2018), 104–111.
27. Phillips JE. Elecsys Troponin T Gen 5 STAT. Available at: https://www.accessdata.fda.gov/cdrh_docs/pdf16/K162895.pdf. Accessed August 1, 2018.
28. Meigher, S., Thode, H.C., Peacock, W.F., et al. Causes of elevated cardiac troponins in the emergency department and their associated mortality. Acad Emerg Med 23 (2016), 1267–1273.
29. McCord J, Cabrera R, Lindahl B, et al. Prognostic utility of a modified HEART score in chest pain patients in the emergency department. Circ Cardiovasc Qual Outcomes. 2017; https://doi.org/10.1161/CIRCOUTCOMES.116.003101.
30. Greenslade, J.H., Carlton, E.W., Van Hise, C., et al. Diagnostic accuracy of a new high-sensitivity troponin I assay and five accelerated diagnostic pathways for ruling out acute myocardial infarction and acute coronary syndrome. Ann Emerg Med 71 (2018), 439–451.e3.