Causes of Elevated Cardiac Troponins in the Emergency Department and Their Associated Mortality

Academic Emergency Medicine

Volumn 23, Issue 11, 2016, Pages 1267-1273

  Meigher, Stephen ^a   Thode, Henry C ^a   Peacock, W Frank ^c   Bock, Jay L ^b   Gruberg, Louis ^b   Singer, Adam J ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; NITROGEN; TROPONIN I; UREA; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; COMORBIDITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ELECTROCARDIOGRAPHY; EMERGENCY WARD; FEMALE; HOSPITAL MORTALITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; RISK FACTOR; STRUCTURED INTERVIEW; TERTIARY HEALTH CARE; UREA NITROGEN BLOOD LEVEL; VERY ELDERLY; BLOOD; CHI SQUARE DISTRIBUTION; HOSPITAL EMERGENCY SERVICE; MIDDLE AGED; MYOCARDIAL INFARCTION; NONPARAMETRIC TEST; RETROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA;

AGED; AGED, 80 AND OVER; BIOMARKERS; CHI-SQUARE DISTRIBUTION; ELECTROCARDIOGRAPHY; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; RETROSPECTIVE STUDIES; RISK FACTORS; STATISTICS, NONPARAMETRIC; TROPONIN I;

EID: 84994475032     PISSN: 10696563     EISSN: 15532712     Source Type: Journal    
DOI: 10.1111/acem.13033     Document Type: Article

References (23)

1. Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;64:e139–228.
2. Segraves JM, Frishman WH. Highly sensitive cardiac troponin assays: a comprehensive review of their clinical utility. Cardiol Rev 2015;23:282–9.
3. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007;28:2525–38.
4. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 2012;60:1581–98.
5. Saaby L, Poulsen TS, Hosbond S, et al. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction. Am J Med 2013;126:789–97.
6. Gilbert EH, Lowenstein SR, Koziol-McLain J, Barta DC, Steiner J. Chart reviews in emergency medicine research: where are the methods? Ann Emerg Med 1996;27:305–8.
7. Kaji AH, Schriger D, Green S. Looking through the retroscope: reducing bias in emergency medicine chart review studies. Ann Emerg Med 2014;64:292–8.
8. Hollander JE, Blomkalns AL, Brogan GX, et al. Standardized reporting guidelines for studies evaluating risk stratification of emergency department patients with potential acute coronary syndromes. Ann Emerg Med 2004;44:589–98.
9. Cullen L, Than M, Brown AF, et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas 2010;22:35–55.
10. Lim W, Qushmaq I, Devereaux PJ, et al. Elevated cardiac troponin measurements in critically ill patients. Arch Intern Med 166:2446–54.
11. Lim W, Cook DJ, Griffith LE, Crowther MA, Devereaue PJ. Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes. Am J Crit Care 2006;15:280–8.
12. Jensen JK, Kristensen SR, Bak S, Atar D, Hoilund-Carlsen PF, Mickey H. Frequency and significance of troponin T elevation in acute ischemic stroke. Am J Cardiol 2007;99:108–12.
13. Maeder M, Fehr T, Rickli H, Amman P. Sepsis-associated myocardial dysfunction: diagnostic and prognostic impact of cardiac troponins and natriuretic peptides. Chest 2006;129:1349–66.
14. Mehta NJ, Kahn IA, Gupta V, Jani K, Gowda RM, Smith PR. Cardiac troponin I predicts myocardial dysfunction and adverse outcomes in septic shock. Int J Cardiol 2004;95:13–17.
15. Wu I, Yu F, Chou J, Lin T, Chen H, Lee C. Predictive risk factors for upper gastrointestinal bleeding with simultaneous myocardial injury. Kaohsiung J Med Sci 2007;23:8–16.
16. Pierpoint GL, McFalls EO. Interpreting troponin elevations: do we need multiple diagnoses? Eur Heart J 2009;30:135–8.
17. Sandoval Y, Smith SW, Thordsen SE, Apple FS. Supply/demand type 2 myocardial infarction: should we be paying more attention? J Am Coll Cardiol 2014;63:2079–87.
18. Alpert JS, Thygesen KA, White HD, Jaffe AS. Diagnostic and therapeutic implications of type 2 myocardial infarction: review and commentary. Am J Med 2014;127:105–8.
19. Smilowitz NR, Naoulou, Sedlis SP. Diagnosis and management of type II myocardial infarction: increased demand for a limited supply of evidence. Curr Atheroscler Rep 2015;17:478.
20. Shah AS, McAllister DA, Mills R, et al. Sensitive troponin assay and the classification of myocardial infarction. Am J Med 2015;128:493–501.e493.
21. Than M, Aldous S, Lord SJ, et al. A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial. JAMA Intern Med 2014;174:51–8.
22. Cullen L, Mueller C, Parsonage WA, et al. Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome. J Am Coll Cardiol 2013;62:1242–9.
23. Than M, Cullen L, Reid CM, et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet 2011;377:1077–84.