High-sensitivity cardiac troponin T concentrations below the limit of detection to exclude acute myocardial infarction: A prospective evaluation

Clinical Chemistry

Volumn 61, Issue 7, 2015, Pages 983-989

  Body, Richard ^a,b   Burrows, Gillian ^c   Carley, Simon ^b,d   Cullen, Louise ^e   Than, Martin ^f   Jaffe, Allan S ^g   Lewis, Philip S ^c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c STOCKPORT NHS FOUNDATION TRUST   (United Kingdom)

^d MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

^e ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^f UNIVERSITY OF OTAGO   (New Zealand)

^g MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH SENSITIVITY CARDIAC TROPONIN T; TROPONIN T; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART DISEASE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; HUMAN; IMMUNOASSAY ANALYZER; LENGTH OF STAY; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PERCUTANEOUS CORONARY INTERVENTION; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; THORAX PAIN; ACUTE DISEASE; AGED; BLOOD; CHEST PAIN; EVALUATION STUDY; MIDDLE AGED; MYOCARDIAL INFARCTION; RECEIVER OPERATING CHARACTERISTIC;

NUCLEOPOLYHEDROVIRUS;

ACUTE DISEASE; AGED; BIOLOGICAL MARKERS; CHEST PAIN; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; LENGTH OF STAY; LIMIT OF DETECTION; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; TROPONIN T;

EID: 84937417944     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2014.231530     Document Type: Article

References (17)

1. Apple FS, Collinson PO, for the IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2011;58:54-61.
2. Reichlin T, Hochholzer W, Bassetti S, Seuer S, Stelzig C, Hartwiger S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009;361:858-67.
3. Korley FK, Jaffe AS. Preparing the United States for high-sensitivity cardiac troponin assays. J Am Coll Cardiol 2013;61:1753-8.
4. Bjurman C, Larsson M, Johanson P, Petzold M, Lindahl B, Fu MLX, et al. Small changes in troponin T levels are common in patients with non-ST-segment elevation myocardial infarction and are linked to higher mortality. J Am Coll Cardiol 2013;62:1231-8.
5. Kavsak PA, Newman AM, Lustig V, MacRae AR, Palomaki GE, Ko DT, et al. Long-term health outcomes associated with detectable troponin I concentrations. Clin Chem 2007;53:220-7.
6. Body R, Carley S, McDowell G, Jaffe AS, France M, Cruickshank K, et al. Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay. J Am Coll Cardiol 2011;58:1332-9.
7. Bandstein N, Ljung R, Johansson M, Holzmann MJ. Undetectable high sensitivity troponin T level in the emergency department and risk of myocardial infarction. J Am Coll Cardiol 2014;63:2569-78.
8. Body R, Carley SD, Burrows G, Mackway-Jones K. The Manchester Acute Coronary Syndromes (MACS) decision rule to reduce unnecessary admissions for cardiac chest pain: derivation and external validation [Abstract]. Acad Emerg Med 2012;19:744.
9. Mansour M, Clark L, Kavsak PA. Effect of freeze-thaw and refrigeration conditions on high-sensitivity troponin T concentrations. Ann Clin Biochem 2012;49:101-2.
10. Apple, FS, Jaffe, AS. Clinical implications of a recent adjustment to the high-sensitivity cardiac troponin T assay: user beware. Clin Chem 2012;58:1599-600.
11. Kavsak PA, Xuesong W, Ko DT, MacRae AR, Jaffe AS. Short- and long-term risk stratification using a next-generation, high-sensitivity research cardiac troponin I (hs-cTnI) assay in an emergency department chest pain population. Clin Chem 2009;55:1809-15.
12. Agresti A, Coull B. Approximate is better than "exact" for interval estimation of binomial proportions. Am Stat 1998;52:119-26.
13. Mueller M, Biener M, Vafaie M, Doerr S, Keller T, Blankenberg S, et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 2011;58:209-18.
14. Body R, Carley S, McDowell G, Pemberton P, Burrows G, Cook G, et al. The Manchester Acute Coronary Syndromes (MACS) decision rule for suspected cardiac chest pain: derivation and external validation. Heart 2014;100:1462-8.
15. Greenslade JH, Kavsak P, Parsonage W, Shortt C, Than M, Pickering JW, et al. Combining presentation high-sensitivity cardiac troponin I and glucose measurements to rule-out an acute myocardial infarction in patients presenting to emergency department with chest pain. Clin Biochem 2014;48:288-91.
16. Kavsak PA, Hill SA, McQueen MJ, Devereaux PJ. Implications of adjustment of high-sensitivity cardiac troponin T assay. Clin Chem 2013;59:574-6.
17. Kavsak P, Worster A. Dichotomizing high sensitivity cardiac troponin T results and important analytical considerations. J Am Coll Cardiol 2012;59:1570.