Lung tissue gene-expression signature for the ageing lung in COPD

Thorax

Volumn 73, Issue 7, 2018, Pages 609-617

  De Vries, Maaike ^a   Faiz, Alen ^a   Woldhuis, Roy R ^a   Postma, Dirkje S ^a   De Jong, Tristan V ^a   Sin, Don D ^b   Bossé, Yohan ^c,d   Nickle, David C ^e   Guryev, Victor ^a   Timens, Wim ^a   Van Den Berge, Maarten ^a   Brandsma, Corry Anke ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c LAVAL UNIVERSITY   (Canada)

^d UNIVERSITÉ LAVAL   (Canada)

^e MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Copd ; Mechanisms

Indexed keywords

MESSENGER RNA; XEDAR RECEPTOR;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; ATP8A1 GENE; CALCIUM SIGNALING; CELL CONTACT; CHILD; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DOWN REGULATION; EDA2R GENE; EXON; EXTRACELLULAR MATRIX; FEMALE; FRZB GENE; GENE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INTRON; LUNG AGING; LUNG DEVELOPMENT; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MAP4K1 GENE; MGST1 GENE; MTOR SIGNALING; PRIORITY JOURNAL; RIBOSOME; RNA ANALYSIS; RNA SPLICING; SENSITIVITY ANALYSIS; UPREGULATION; VALIDATION PROCESS; ZNF518B GENE;

EID: 85050963526     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2017-210074     Document Type: Article

References (31)

1. G lobal Initiative for Chronic Obstructive Lung Disease. From the Global Strategy for the diagnosis, management and prevention of COPD, 2015. http://www.goldcopd. org/
2. Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 2009;4:435-59
3. I to K, Barnes PJ. COPD as a disease of accelerated lung aging. Chest 2009;135:173-80
4. Mercado N, Ito K, Barnes PJ. Accelerated ageing of the lung in COPD: new concepts. Thorax 2015;70:482-9
5. L ópez-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194-217
6. Meiners S, Eickelberg O, Königshoff M. Hallmarks of the ageing lung. Eur Respir J 2015;45:807-27
7. Savale L, Chaouat A, Bastuji-Garin S, et al. Shortened telomeres in circulating leukocytes of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009;179:566-71
8. A lbrecht E, Sillanpaa E, Karrasch S, et al. Telomere length in circulating leukocytes is associated with lung function and disease. Eur Respir J 2014;43:983-92
9. R utten EP, Gopal P, Wouters EF, et al. Various mechanistic pathways representing the ageing process are altered in COPD. Chest 2015
10. Kanaji N, Basmaé H, Nelson A, et al. Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes. Am J Physiol Lung Cell Mol Physiol 2014;307:L364-L373
11. Hao K, Bossé Y, Nickle DC, et al. Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma. PLoS Genet 2012;8
12. Brandsma CA, van den Berge M, Postma DS, et al. A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD. Thorax 2015;70:21-32
13. R Development Core Team. R: a language and environment for statistical computing, 2011. ISBN:3-900051-07-0
14. Yang J, Huang T, Petralia F, et al. Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. Sci Rep 2015;5:15145
15. Fehrmann RS, Karjalainen JM, Krajewska M, et al. Gene expression analysis identifies global gene dosage sensitivity in cancer. Nat Genet 2015;47:115-25
16. Martin N, Beach D, Gil. Ageing as developmental decay: insights from p16(INK4a.). Trends Mol Med 2014;20:667-74
17. Man AL, Bertelli E, Rentini S, et al. Age-Associated modifications of intestinal permeability and innate immunity in human small intestine. Clin Sci 2015;129:515-27
18. R en WY, Wu KF, Li X, et al. Age-related changes in small intestinal mucosa epithelium architecture and epithelial tight junction in rat models. Aging Clin Exp Res 2014;26:183-91
19. Heijink IH, Noordhoek JA, Timens W, et al. Abnormalities in airway epithelial junction formation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2014;189:1439-42
20. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003;4:517-29
21. Murray MA, Chotirmall SH. The impact of immunosenescence on pulmonary disease. Mediators Inflamm 2015;2015:1-10
22. Sharma G, Hanania NA, Shim YM. The aging immune system and its relationship to the development of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2009;6:573-80
23. Verhelst K, Gardam S, Borghi A, et al. XEDAR activates the non-canonical NF-?B pathway. Biochem Biophys Res Commun 2015;465:275-80
24. T anikawa C, Furukawa Y, Yoshida N, et al. XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway. Oncogene 2009;28:3081-92
25. Williams AE, Perry MM, Moschos SA, et al. microRNA expression in the aging mouse lung. BMC Genomics 2007;8:172
26. Humphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis. Nat Rev Mol Cell Biol 2014;15:802-12
27. Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013;493:338-45
28. Walters HE, Deneka-Hannemann S, Cox LS. Reversal of phenotypes of cellular senescence by pan-mTOR inhibition. Aging 2016;8:231-44
29. T o Y, Ito K, Kizawa Y, et al. Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;182:897-904
30. Barnes PJ. Mechanisms of development of multimorbidity in the elderly. Eur Respir J 2015;45:790-806
31. Silverman EK, Chapman HA, Drazen JM, et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med 1998;157:1770-8.