Lupinus mutabilis extract exerts an anti-diabetic effect by improving insulin release in type 2 diabetic goto-kakizaki rats

Nutrients

Volumn 10, Issue 7, 2018, Pages

  Zambrana, Silvia ^a,b   Lundqvist, Lena C E ^c   Mamani, Orlando ^a   Catrina, Sergiu Bogdan ^b,d   Gonzales, Eduardo ^a   Östenson, Claes Göran ^b  

^a UNIVERSIDAD MAYOR DE SAN ANDRÉS   (Bolivia)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d Academic Specialist Center   (Sweden)

Author keywords

Diabetes mellitus type 2 diabetes; Goto kakizaki rats; Insulin secretion; Lupinus mutabilis; Natural product; Nutraceutical

Indexed keywords

CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; HEMOGLOBIN A1C; LUPINUS MUTABILIS EXTRACT; PLANT EXTRACT; PROTEIN KINASE C; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANTIDIABETIC AGENT; GLYCOSYLATED HEMOGLOBIN; INSULIN;

ANIMAL CELL; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN BLOOD LEVEL; INSULIN RELEASE; LUPINUS MUTABILIS; MALE; MASS FRAGMENTOGRAPHY; MEDICINAL PLANT; MTT ASSAY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET CELL; RAT; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECT; EXOCYTOSIS; GLUCOSE TOLERANCE TEST; LUPIN; METABOLISM; PANCREAS ISLET; PHYTOTHERAPY; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; CALCIUM CHANNELS, L-TYPE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; EXOCYTOSIS; GLUCOSE TOLERANCE TEST; GLYCATED HEMOGLOBIN A; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; KATP CHANNELS; LUPINUS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS, WISTAR;

EID: 85050646739     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu10070933     Document Type: Article

References (47)

1. Ogurtsova, K.; da Rocha Fernandes, J.D.; Huang, Y.; Linnenkamp, U.; Guariguata, L.; Cho, N.H.; Cavan, D.; Shaw, J.E.; Makaroff, L.E. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res. Clin. Pract. 2017, 128, 40–50. [CrossRef] [PubMed]
2. Alberti, K.G.; Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 1998, 15, 539–553. [CrossRef]
3. Ostenson, C.G. The pathophysiology of type 2 diabetes mellitus: An overview. Acta Physiol. Scand. 2001, 171, 241–247. [CrossRef] [PubMed]
4. Kahn, S.E.; Cooper, M.E.; Del Prato, S. Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future. Lancet 2014, 383, 1068–1083. [CrossRef]
5. Rios, J.L.; Francini, F.; Schinella, G.R. Natural Products for the Treatment of Type 2 Diabetes Mellitus. Planta. Med. 2015, 81, 975–994. [CrossRef] [PubMed]
6. Dahlstrom, E.; Sandholm, N. Progress in Defining the Genetic Basis of Diabetic Complications. Curr. Diabetes Rep. 2017, 17, 80. [CrossRef] [PubMed]
7. Firdous, S.M. Phytochemicals for treatment of diabetes. EXCLI J. 2014, 13, 451–453. [PubMed]
8. Zhang, B.W.; Sang, Y.B.; Sun, W.L.; Yu, H.S.; Ma, B.P.; Xiu, Z.L.; Dong, Y.S. Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study. Biomed. Pharmacother. 2017, 91, 890–898. [CrossRef] [PubMed]
9. Kim, C.S.; Sohn, E.J.; Kim, Y.S.; Jung, D.H.; Jang, D.S.; Lee, Y.M.; Kim, D.H.; Kim, J.S. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J. Ethnopharmacol. 2007, 111, 240–247. [CrossRef] [PubMed]
10. Cicero, A.F.; Borghi, C. Evidence of clinically relevant efficacy for dietary supplements and nutraceuticals. Curr. Hypertens. Rep. 2013, 15, 260–267. [CrossRef] [PubMed]
11. Santini, A.; Novellino, E.; Armini, V.; Ritieni, A. State of the art of Ready-to-Use Therapeutic Food: A tool for nutraceuticals addition to foodstuff. Food Chem. 2013, 140, 843–849. [CrossRef] [PubMed]
12. Magrone, T.; Jirillo, E. Nutraceuticals and prevention of neurodegeneration. Curr. Pharm. Des. 2012, 18, 2–3. [CrossRef] [PubMed]
13. Bahadoran, Z.; Mirmiran, P.; Azizi, F. Dietary polyphenols as potential nutraceuticals in management of diabetes: A review. J. Diabetes Metab. Disord. 2013, 12, 43. [CrossRef] [PubMed]
14. Chirinos-Arias, M.C. Andean Lupin (Lupinus mutabilis Sweet) a plant with nutraceutical and medicinal potential. Rev. Bio Cienc. 2015, 3, 163–172.
15. Jacobsen, S.-E.M.; Mujica, A. El tarwi (Lupinus mutabilis Sweet.) y sus parientes silvestres, in Botánica Económica de los Andes Centrales. Bot. Econ. Andes Cent. 2006, 28, 458–482.
16. Fornasini, M.; Castro, J.; Villacrés, E.; Narváez, L.; Villamar, M.P.; Baldeón, M.E. Hypoglycemic effect of Lupinus mutabilis in healthy volunteers and subjects with dysglycemia. Nutr. Hosp. 2012, 27, 425–433. [PubMed]
17. Baldeon, M.E.; Castro, J.; Villacrés, E.; Narváez, L.; Fornasini, M. Hypoglycemic effect of cooked Lupinus mutabilis and its purified alkaloids in subjects with type-2 diabetes. Nutr. Hosp. 2012, 27, 1261–1266. [PubMed]
18. Ostenson, C.G.; Efendic, S. Islet gene expression and function in type 2 diabetes; studies in the Goto-Kakizaki rat and humans. Diabetes Obes. Metab. 2007, 9 (Suppl. 2), 180–186. [CrossRef] [PubMed]
19. Ling, Z.C.; Efendic, S.; Wibom, R.; Abdel-Halim, S.M.; Ostenson, C.G.; Landau, B.R.; Khan, A. Glucose metabolism in Goto-Kakizaki rat islets. Endocrinology 1998, 139, 2670–2675. [PubMed]
20. Mosen, H.; Salehi, A.; Alm, P.; Henningsson, R.; Jimenez-Feltström, J.; Ostenson, C.G.; Efendic, S.; Lundquist, I. Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 2005, 146, 1553–1558. [CrossRef] [PubMed]
21. Ostenson, C.G.; Khan, A.; Abdel-Halim, S.M.; Guenifi, A.; Suzuki, K.; Goto, Y.; Efendic, S. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 1993, 36, 3–8. [CrossRef] [PubMed]
22. Zambrana, S.; Lundqvist Lena, C.E.; Veliz, V.; Catrina, S.-B.; Gonzales, E.; Östenson, C.-G. Amaranthus caudatus Stimulates Insulin Secretion in Goto-Kakizaki Rats, a Model of Diabetes Mellitus Type 2. Nutrients 2018, 10, 94. [CrossRef] [PubMed]
23. Herbert, V.; Herbert, V.; Lau, K.S.; Gottlieb, C.W.; Bleicher, S.J. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. Metab. 1965, 25, 1375–1384. [CrossRef] [PubMed]
24. Lokman, E.F.; Gu, H.F.; Wan Mohamud, W.N.; Östenson, C.-G. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid. Based Complement. Altern. Med. 2015, 2015, 120572. [CrossRef] [PubMed]
25. Hoa, N.K.; Norberg, A.; Sillard, R.; Van Phan, D.; Thuan, N.D.; Dzung, D.T.; Jörnvall, H.; Ostenson, C.-G. The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. J. Endocrinol. 2007, 192, 389–394. [CrossRef] [PubMed]
26. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55–63. [CrossRef]
27. Catrina, S.-B.; Catrina, A.I.; Sirzen, F.; Griffithis, W.; Bergman, T.; Bigerfeldal, D.; Coculescu, M.; Mutt, V. A cytotoxic, apoptotic, low-molecular weight factor from pineal gland. Life Sci. 1999, 65, 1047–1057. [CrossRef]
28. Drakenberg, K.; Ostenson, C.-G.; Sara, V. Circulating forms and biological activity of intact and truncated insulin-like growth factor I in adult and neonatal rats. Acta Endocrinol. 1990, 123, 43–50. [CrossRef] [PubMed]
29. 2 as assessed by in vitro and in vivo studies in type 2 diabetic GK rats. J. Inorg. Biochem. 2014, 131, 115–122. [CrossRef] [PubMed]
30. OECD, Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents. OECD Publishing. Available online: https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecdtg407-2008 (accessed on 10 May 2013).
31. Girija, K.; Lakshman, K.; Udaya, C.; Sabhya, S.G.; Divya, T. Anti-diabetic and anti-cholesterolemic activity of methanol extracts of three species of Amaranthus. Asian Pac. J. Trop. Biomed. 2011, 1, 133–138. [CrossRef]
32. 2, on insulin secretion in pancreatic islets of type 2 diabetic Goto-Kakizaki rats. J. Inorg. Biochem. 2016, 154, 29–34. [CrossRef] [PubMed]
33. Guemes-Vera, N.; Peña Bautista, R.J.; Jimenez-Martinez, C.; Davila-Ortiz, G.; Calderon-Dominguez, G. Effective detoxification and decoloration of Lupinus mutabilis seed derivatives, and effect of these derivatives on bread quality and acceptance. J. Sci. Food Agric. 2008, 88, 1135–1143. [CrossRef]
34. Torres Tello, F.; Nagata, A.; Dreifuss Spiegel, W. Methods of eliminating alkaloids from the seeds of Lupinus mutabilis Sweet. Arch Latinoam. Nutr. 1980, 30, 200–209. [PubMed]
35. Ortiz, C.; Gross, R.; von Baer, E. The lupine, a contribution to nutrition in the Andes. 2. The quality of proteins in Lupinus mutabilis compared to Lupinus albus, Lupinus luteus and Soja max. Z. Ernahrungswiss. 1975, 14, 229–233. [CrossRef] [PubMed]
36. Schoeneberger, H.; Gross, R.; Cremer, H.D.; Elmadfa, I. Composition and protein quality of Lupinus mutabilis. J. Nutr. 1982, 112, 70–76. [CrossRef] [PubMed]
37. Ortega Duarte, A.; Martin-Sanchez, F.J.; Gonzalez-Castillo, J.; Ruiz-Artacho, P. Lupinus mutabilis (chocho) water intoxication. Med. Clin. 2013, 140, 43–44. [CrossRef] [PubMed]
38. Garcia Lopez, P.M.; de la Mora, P.G.; Wysocka, W.; Maiztegui, B.; Alzugaray, M.E.; Del Zotto, H.; Borelli, M.I. Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion. Eur, J. Pharmacol. 2004, 504, 139–142. [CrossRef] [PubMed]
39. Kroc, M.; Rybiński, W.; Wilczura, P.; Kamel, K.; Kaczmarek, Z.; Barzyk, P.; Święcicki, W. Quantitative and qualitative analysis of alkaloids composition in the seeds of a white lupin (Lupinus albus L.) collection. Genet. Resour. Crop Evolut. 2017, 64, 1853–1860. [CrossRef]
40. Wiedemann, M.; Gurrola-Díaz, C.M.; Vargas-Guerrero, B.; Wink, M.; García-López, P.M.; Düfer, M. Lupanine Improves Glucose Homeostasis by Influencing KATP Channels and Insulin Gene Expression. Molecules 2015, 20, 19085–19100. [CrossRef] [PubMed]
41. Paolisso, G.; Sgambato, S.; Passariello, N.; Pizza, G.; Torella, R.; Tesauro, P.; Varricchio, M.; D’Onofrio, F. Plasma glucose lowering effect of sparteine sulphate infusion in non-insulin-dependent (type 2) diabetic subjects. Eur. J. Clin. Pharmacol. 1988, 34, 227–232. [CrossRef] [PubMed]
42. Muoio, D.M.; Newgard, C.B. Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol. 2008, 9, 193–205. [CrossRef] [PubMed]
43. 2+ channels. J. Membr. Biol. 2004, 200, 57–66. [CrossRef] [PubMed]
44. 2+. J. Gener. Physiol. 2004, 124, 653–662. [CrossRef] [PubMed]
45. Ahren, B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat. Rev. Drug Discov. 2009, 8, 369–385. [CrossRef] [PubMed]
46. Bobkiewicz-Kozlowska, T.; Dworacka, M.; Kuczyński, S.; Abramczyk, M.; Kolanoś, R.; Wysocka, W.; Garcia Lopez, P.M.; Winiarska, H. Hypoglycaemic effect of quinolizidine alkaloids—Lupanine and 2-thionosparteine on non-diabetic and streptozotocin-induced diabetic rats. Eur. J. Pharmacol. 2007, 565, 240–244. [CrossRef] [PubMed]
47. Lokman, F.E.; Gu, H.F.; Wan Mohamud, W.N.; Yusoff, M.M.; Chia, K.L.; Ostenson, C.-G. Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evid. Based Complement. Altern. Med. 2013, 2013, 727602. [CrossRef] [PubMed]