Intestinal microbiota disruption reduces regulatory T cells and increases respiratory viral infection mortality through increased IFNγ production

Frontiers in Immunology

Volumn 9, Issue JUL, 2018, Pages

  Grayson, Mitchell H ^a,b   Camarda, Lauren E ^a,c   Hussain, Syed Rehan A ^b   Zemple, Sarah J ^a   Hayward, Michael ^a   Lam, Vy ^a   Hunter, Desiré A ^a   Santoro, Jennifer L ^a,b   Rohlfing, Michelle ^a,b   Cheung, Dorothy S ^a,d   Salzman, Nita H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c ADVOCATE CHILDREN S HOSPITAL   (United States)

^d GENENTECH INC   (United States)

Author keywords

Gastrointestinal microbiome; Innate lymphoid cells; Pulmonary immune response; Pulmonary microbiome; Respiratory infection; Virus

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; RNA 16S; STREPTOMYCIN;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL LOAD; BIOINFORMATICS; CYTOKINE RESPONSE; DNA EXTRACTION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SEQUENCE; IMMUNE RESPONSE; INTESTINE FLORA; MALE; MORTALITY; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; VIRAL RESPIRATORY TRACT INFECTION;

EID: 85049830838     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.01587     Document Type: Article

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