Luminal 5-HT stimulates colonic bicarbonate secretion in rats

British Journal of Pharmacology

Volumn 172, Issue 19, 2015, Pages 4655-4670

  Kaji, I ^a   Akiba, Y ^a   Said, H ^b   Narimatsu, K ^a   Kaunitz, J D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Brentwood Biomedical Research Institute Los Angeles   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; AMILORIDE; ATROPINE; BICARBONATE; CARBONATE DEHYDRATASE; CISAPRIDE; FLUOXETINE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; ONDANSETRON; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; TEGASEROD; TETRODOTOXIN; SEROTONIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CHLORIDE TRANSPORT; COLON MUCOSA; COLONIC SECRETION; CONTROLLED STUDY; GLIA CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBMUCOSA; ANIMAL; COLON; INTESTINE MUCOSA; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BICARBONATES; COLON; INTESTINAL MUCOSA; MALE; NITRIC OXIDE; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 84940962393     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13216     Document Type: Article

References (57)

1. Ahlman H, Bhargava HN, Dahlstrom A, Larsson I, Newson B, Pettersson G, (1981a). On the presence of serotonin in the gut lumen and possible release mechanisms. Acta Physiol Scand 112: 263-269.
2. Ahlman H, DeMagistris L, Zinner M, Jaffe BM, (1981b). Release of immunoreactive serotonin into the lumen of the feline gut in response to vagal nerve stimulation. Science 213: 1254-1255.
3. Akiba Y, Furukawa O, Guth PH, Engel E, Nastaskin I, Kaunitz JD, (2001). Acute adaptive cellular base uptake in rat duodenal epithelium. Am J Physiol Gastrointest Liver Physiol 280: G1083-G1092.
4. 2 in rat duodenum. Gastroenterology 131: 142-152.
5. Akiba Y, Mizumori M, Guth PH, Engel E, Kaunitz JD, (2007). Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats. Am J Physiol Gastrointest Liver Physiol 293: G1223-G1233.
6. Akiba Y, Watanabe C, Mizumori M, Kaunitz JD, (2009). Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 297: G781-G791.
7. Alexander PH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, et al. (2013a). The Concise Guide to PHARMACOLOGY 2013/14: Ligand-gated Ion Channels. Br J Pharmacol 170: 1582-1606.
8. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013b). The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors. Br J Pharmacol 170: 1459-1581.
9. Alexander PH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, et al. (2013c). The Concise Guide to PHARMACOLOGY 2013/14: Ion Channels. Br J Pharmacol 170: 1607-1651.
10. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013d). The Concise Guide to PHARMACOLOGY 2013/14: Transporters. Br J Pharmacol 170: 1706-1796.
11. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013e). The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol 170: 1797-1867.
12. Annison G, Illman RJ, Topping DL, (2003). Acetylated, propionylated or butyrylated starches raise large bowel short-chain fatty acids preferentially when fed to rats. J Nutr 133: 3523-3528.
13. Asfaha S, Bell CJ, Wallace JL, MacNaughton WK, (1999). Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase. Am J Physiol 276: G703-G710.
14. Badria FA, (2002). Melatonin, serotonin, and tryptamine in some Egyptian food and medicinal plants. J Med Food 5: 153-157.
15. 7A receptor. J Biol Chem 273: 17469-17476.
16. Bridges RJ, Rack M, Rummel W, Schreiner J, (1986). Mucosal plexus and electrolyte transport across the rat colonic mucosa. J Physiol 376: 531-542.
17. Bunce KT, Elswood CJ, Ball MT, (1991). Investigation of the 5-hydroxytryptamine receptor mechanism mediating the short-circuit current response in rat colon. Br J Pharmacol 102: 811-816.
18. Bülbring E, Lin RC, (1958). The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J Physiol 140: 381-407.
19. Cho MM, Ziats NP, Pal D, Utian WH, Gorodeski GI, (1999). Estrogen modulates paracellular permeability of human endothelial cells by eNOS- and iNOS-related mechanisms. Am J Physiol 276: C337-C349.
20. Cremon C, Carini G, Wang B, Vasina V, Cogliandro RF, De GR, et al. (2011). Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 106: 1290-1298.
21. Day J, King B, Haque SM, Kellum JM, (2005). A nonneuronal 5-hydroxytryptamine receptor 3 induces chloride secretion in the rat distal colonic mucosa. Am J Surg 190: 736-738.
22. Ekblad E, Mulder H, Uddman R, Sundler F, (1994). NOS-containing neurons in the rat gut and coeliac ganglia. Neuropharmacology 33: 1323-1331.
23. 7 receptor antagonist. J Med Chem 41: 655-657.
24. Freeman SL, MacNaughton WK, (2000). Ionizing radiation induces iNOS-mediated epithelial dysfunction in the absence of an inflammatory response. Am J Physiol Gastrointest Liver Physiol 278: G243-G250.
25. Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, et al. (2003). Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 284: R1269-R1276.
26. Gershon MD, Tack J, (2007). The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132: 397-414.
27. Glisic R, Koko V, Todorovic V, Drndarevic N, Cvijic G, (2006). Serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats. Regul Pept 136: 30-39.
28. Green CL, Ho W, Sharkey KA, McKay DM, (2004). Dextran sodium sulfate-induced colitis reveals nicotinic modulation of ion transport via iNOS-derived NO. Am J Physiol Gastrointest Liver Physiol 287: G706-G714.
29. 4 receptors accelerates propulsive motility and inhibits visceral hypersensitivity. Gastroenterology 142: 844-854.
30. Jakab RL, Collaco AM, Ameen NA, (2011). Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestine. Am J Physiol Gastrointest Liver Physiol 300: G82-G98.
31. Kadowaki M, Gershon MD, Kuwahara A, (1996). Is nitric oxide involved in 5-HT-induced fluid secretion in the gut? Behav Brain Res 73: 293-296.
32. 4-mediated anion secretion in human and rat colon. Am J Physiol Gastrointest Liver Physiol 302: G690-G701.
33. Kang S, Kang K, Lee K, Back K, (2007). Characterization of tryptamine 5-hydroxylase and serotonin synthesis in rice plants. Plant Cell Rep 26: 2009-2015.
34. Kellum J, McCabe M, Schneier J, Donowitz M, (1983). Neural control of acid-induced serotonin release from rabbit duodenum. Am J Physiol 245: G824-G831.
35. 4 receptors. Am J Physiol 277: G515-G520.
36. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). Animal research: Reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol 160: 1577-1579.
37. Ly D, Kang K, Choi JY, Ishihara A, Back K, Lee SG, (2008). HPLC analysis of serotonin, tryptamine, tyramine, and the hydroxycinnamic acid amides of serotonin and tyramine in food vegetables. J Med Food 11: 385-389.
38. MacEachern SJ, Patel BA, McKay DM, Sharkey KA, (2011). Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus. J Physiol 589: 3333-3348.
39. Martel F, Monteiro R, Lemos C, (2003). Uptake of serotonin at the apical and basolateral membranes of human intestinal epithelial (Caco-2) cells occurs through the neuronal serotonin transporter (SERT). J Pharmacol Exp Ther 306: 355-362.
40. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
41. Ning Y, Zhu JX, Chan HC, (2004). Regulation of ion transport by 5-hydroxytryptamine in rat colon. Clin Exp Pharmacol Physiol 31: 424-428.
42. Nobles M, Diener M, Rummel W, (1991). Segment-specific effects of the heat-stable enterotoxin of E. coli on electrolyte transport in the rat colon. Eur J Pharmacol 202: 201-211.
43. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al; NC-IUPHAR. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledge base of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-D1106.
44. Sjölund K, Sandén G, Håkanson R, Sundler F, (1983). Endocrine cells in human intestine-an immunocytochemical study. Gastroenterology 85: 1120-1130.
45. Smith AJ, Chappell AE, Buret AG, Barrett KE, Dong H, (2006). 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. FASEB J 20: 2486-2495.
46. Stoner MC, Kellum JM, (2001). Both serotonin and a nitric-oxide donor cause chloride secretion in rat colonocytes by stimulating cGMP. Surgery 130: 236-241.
47. Stoner MC, Scherr AM, Lee JA, Wolfe LG, Kellum JM, (2000). Nitric oxide is a neurotransmitter in the chloride secretory response to serotonin in rat colon. Surgery 128: 240-245.
48. Takahashi M, Fukuda K, Ohata T, Sugimura T, Wakabayashi K, (1997). Increased expression of inducible and endothelial constitutive nitric oxide synthases in rat colon tumors induced by azoxymethane. Cancer Res 57: 1233-1237.
49. 3 exchanger SLC26A3 (DRA) in rodent cecum and colon. Am J Physiol Gastrointest Liver Physiol 299: G358-G367.
50. Tamai H, Gaginella TS, (1993). Direct evidence for nitric oxide stimulation of electrolyte secretion in the rat colon. Free Radic Res Commun 19: 229-239.
51. Tsukamoto K, Ariga H, Mantyh C, Pappas TN, Yanagi H, Yamamura T, et al. (2007). Luminally released serotonin stimulates colonic motility and accelerates colonic transit in rats. Am J Physiol Regul Integr Comp Physiol 293: R64-R69.
52. Wade PR, Chen J, Jaffe B, Kassem IS, Blakely RD, Gershon MD, (1996). Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract. J Neurosci 16: 2352-2364.
53. Wilson KT, Xie Y, Musch MW, Chang EB, (1993). Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther 266: 224-230.
54. 2 in nitroprusside-stimulated rat colonic ion transport. Am J Physiol 270: C832-C840.
55. 3 receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159: 1623-1625.
56. Young HM, McConalogue K, Furness JB, De VJ, (1993). Nitric oxide targets in the guinea-pig intestine identified by induction of cyclic GMP immunoreactivity. Neuroscience 55: 583-596.
57. 2+ signaling using an enabling chimeric G-protein. Eur J Pharmacol 472: 33-38.